著者

藤本 竜輔 安藤 元一 小川 博 Ryusuke FUJIMOTO ANDO Motokazu OGAWA Hiroshi

巻号頁・発行日

vol.55, no.4, pp.290-296,

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野外調査の難しい種である半水生のカワネズミChimarrogale platycephalaにおける生息確認調査の効率を向上させることを目的として,捕獲個体の死亡率を低減するためのワナ改良をおこなった。同時に調査に適した季節および適切なワナ設置間隔を検討した。従来型カゴワナを24時間ごとに見回ると捕獲個体は全て死亡し,2時間毎に見回っても毛皮の水濡れが防げなかった。ホースで退避室を接続したカゴワナでは24時間毎の見回りでも64%の生存率が得られたが,ワナから脱出しようとして負傷する個体があった。さらに見回り時間を6時間毎にすると生存率は100%になり,捕獲個体の水濡れおよび負傷が防げた。本種は春~秋のどの季節にも調査が可能であり,その捕獲率は平均2.1%であった。ワナ列長1,000m以下の調査をおこなったところ,およそ470mあたり1頭の割合で捕獲された。ワナ設置間隔を100m以下に縮めても捕獲効率に差がなかったことから,ワナは100m程度の長い間隔で設置することが効率的であると考えられた。本種が捕獲された地点においては遅くとも調査4日目以内に捕獲があったことから,生息の有無を判断するためには連続4日間以上の調査が必要であることが示された。

著者

Hiroshi Hara

出版者

The Botanical Society of Japan

雑誌

植物学雑誌 (ISSN:0006808X)

巻号頁・発行日

vol.48, no.576, pp.889-906, 1934 (Released:2007-05-24)

著者

Hiroshi Yoshikura

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.72, no.6, pp.359-367, 2019 (Released:2019-11-21)

参考文献数

17

被引用文献数

1 2

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From 1995 to 2000, the mortality rates of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients < 54 years of age have declined; however, since 2000, deaths of HIV/AIDS patients aged > 55 have started to increase. Although deaths directly linked to infections have declined since 2005, those related to malignancy, encephalopathy, interstitial pneumonia, wasting syndrome, etc. persisted. In 10 years from 1999–2004 to 2010–2017, the age at death shifted by 5 years towards an older age in the general population and in patients with HIV/AIDS (mainly males), adult T-cell leukemia, or Creutzfeldt-Jakob disease. Among these, HIV/AIDS patients and the general population exhibited an unequivocal gender difference. As of 2011–2016, the median of the deaths of the HIV/AIDS patients was 52.5 years for males and 70 years for females, while the median of the deaths of the general population was 75 years for males and 85 years for females. Hence, male HIV/AIDS patients died 22.5 years earlier and female HIV/AIDS patients 15 years earlier than did the general population. A common denominator of HIV/AIDS-related deaths and deaths among the general population could be CD4+T cells as these cells are primary targets of HIV, and a decline in naïve CD4+T cell count is a hallmark of aging.

著者

Hiroshi Yoshikura

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.72, no.1, pp.23-30, 2019-01-31 (Released:2019-01-23)

参考文献数

16

被引用文献数

3 7

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In Japan, HIV infection is classified as “HIV” or “AIDS” depending upon whether the infection was detected before or after the development of AIDS. In male homosexuals, in the plot of the number of “AIDS” notified annually versus the that of “HIV” notified annually, the plot fell on a straight line with a slope close to 1. When the number of “HIV” no longer increased, that of “AIDS” also stopped increasing. The number of “HIV” notified in one region or age group was correlated with that of other regions or age groups, respectively. However, no such correlation was observed among male heterosexuals. “HIV” was detected more frequently among male homosexuals and females than among male heterosexuals. The rate of “AIDS” detection increased with age in all infection categories. Our analysis, supported by findings of other studies, suggested that the higher rate of “HIV” detection among male homosexuals and females was attributed to the increased risk of receptive sexual intercourse, while the higher rate of “AIDS” detection among the elderly people was attributed to immunological senescence.

著者

小池 聡 島村 博 森川 博之 Satoshi Koike Hiroshi Shimamura Hiroyuki Morikawa

出版者

人工知能学会 ; 2014-

雑誌

人工知能 = journal of the Japanese Society for Artificial Intelligence (ISSN:21882266)

巻号頁・発行日

vol.30, no.2, pp.193-198, 2015-03-01

著者

Yasumitsu Maejima Keita Iga Hiroshi Niino

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.2, pp.80-83, 2006 (Released:2006-06-29)

参考文献数

10

被引用文献数

2

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Upper-tropospheric vortices having a horizontal wavelength of 300-400 km were observed on water vapor images of the Japanese geostationary satellite (MTSAT-1). Grid point values predicted by the Regional Spectral Model of the Japan Meteorological Agency show that the vortices were located along a zonal belt with strong cyclonic shear and horizontal convergence. A quasi-geostrophic linear stability analysis of the basic flow having horizontal and vertical shear shows that the fastest growing mode has a horizontal wavelength, a phase speed and a growth rate that reasonably agree with those of the satellite observation. The amplitude of the fastest growing mode is confined to a region having a meridional width of 2 degrees and a vertical depth of 2 km. An energy budget analysis shows that barotropic instability is the dominant generation mechanism for the growing mode.

著者

Hayakawa Hiroshi Kumura Keiko Sekiguchi Mutsuo

出版者

社団法人 日本生化学会

雑誌

The Journal of Biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.84, no.5, pp.1155-1164, 1978

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Uracil-DNA glycosylase, which acts specifically on uracil-containing DNA, was purified 250-fold from an extract of <i>Escherichia coli</i> 1100. The enzyme releases free uracil from DNA, producing alkali-labile apyrimidinic sites in the DNA. The enzyme is active on both native and heat-denatured DNA of phage PBS1, which contains uracil in place of thymine. &phi;X174 DNA which had been treated with bisulfite and then at alkaline pH was susceptible to the action of uracil-DNA glycosylase. Since DNA treated with bisulfite alone was less susceptible to the enzyme, it is likely that the enzyme recognizes deaminated cytosine, namely uracil, but not bisulfite adducts of uracil and cytosine in the treated DNA. DNA treated with nitrite or hydroxylamine was not attacked by the enzyme. Enzyme activity acting on bisulfite-treated DNA was absent from an extract of <i>E. coli</i> mutant BD10 (<i>ung</i>). The mutant exhibited higher sensitivity to bisulfite than did the wild-type strain and was unable to reactivate phage T1 pre-exposed to bisulfite and weak alkali.

著者

MORIO Atsushi MIYAMOTO Hideaki IZUMI Hiroshi HOSODA Yasuyuki FUKUCHI Yoshinosuke

雑誌

International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology (ISSN:13419625)

巻号頁・発行日

vol.5, no.4, pp.247-252, 2000-08-01

参考文献数

29

被引用文献数

1

著者

ZHUO-FENG XIE YUKINOBU ICHIKAWA HIROSHI SUEMUNE KIYOSHI SAKAI

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.5, pp.1812-1816, 1987-05-25 (Released:2009-10-19)

参考文献数

9

被引用文献数

4 7

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The conversion of (+) -limonen-10-ol (7) into the key intermediate for the synthesis of carbacyclin (1), (+) - (1S, 2R, 3R, 5R) -3-acetoxy-2-methoxycarbony1-7-oxobicyclo [3.3.0] octane (2), is described. The cis-3, 4-disubstituted cyclopentanone prepared from 7 via a sequence of reactions involving Rh (I) -catalyzed cyclization could be converted to the 3-acetylbicyclo [3.3.0] oct-2-ene skeleton, which was subjected to 1, 4-addition reaction with CN-. The resulting cyano compound was transformed into the key intermediate 2 through appropriate modification of the substituents on the five-membered ring. This synthetic method provides a new route to carbacyclin.

著者

Nobutaka AKAZAWA Hiroyasu KOIZUMI Hiroshi NOGAWA Akihisa KODAIRA Michael F. BURROW Hideo MATSUMURA

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2018-152, (Released:2019-05-09)

参考文献数

28

被引用文献数

8

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The purpose of the current study was to evaluate the effect of etching with potassium hydrogen difluoride (KHF2) and ammonium hydrogen difluoride (NH4HF2) on the bond strength of a self-polymerizing methyl methacrylate resin (MMA-TBB) bonded to zirconia. Zirconia disks were prepared using the following surface treatment: no treatment, alumina blasting, and etching with KHF2 or NH4HF2. The specimens were bonded with the MMA-TBB. The shear bond (Ø=5 mm) strength was measured. The surface free energies of the specimens were determined by measuring contact angles. The KHF2 and NH4HF2 groups exhibited higher shear bond strength and surface free energy than did the alumina blasting and no treatment groups. Compared with alumina blasting, etching with KHF2 and NH4HF2 exhibited superior bonding ability of mechanical retention to zirconia.

著者

Atsushi Katoh Hisashi Kai Haruhito Harada Hiroshi Niiyama Hisao Ikeda

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.58, no.6, pp.926-932, 2017-11-01 (Released:2017-12-12)

参考文献数

36

被引用文献数

20

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Glucosamine, used to treat osteoarthritis, has been shown to have anti-inflammatory and anti-atherosclerotic effects in experimental studies. A recent cohort study has demonstrated that the use of glucosamine was significantly associated with decreased total mortality. Vascular endothelial function is a potent surrogate marker of atherosclerosis and cardiovascular mortality where oxidative stress could participate. Therefore, we investigated whether glucosamine improves vascular endothelial function and intracellular redox state. We examined the effects of oral glucosamine administration (3000 mg/day) for 4 weeks on flow-mediated vasodilation (FMD) and intraerythrocyte glutathione parameters in 20 volunteers. Nineteen age-matched volunteers served as controls. Glucosamine administration significantly increased FMD (from 7.0 ± 2.3 to 8.7 ± 2.3%, P = 0.022). In the control group, FMD did not change. Glucosamine administration significantly increased intraerythrocyte total glutathione levels (from 212.9 ± 46.2 to 240.6 ± 49.4 μmol/L, P = 0.006), intraerythrocyte reduced form of glutathione (GSH) levels (from 124.7 ± 42.6 to 155.2 ± 47.7 μmol/L; P = 0.004) and intraerythrocyte GSH/oxidized form of glutathione (GSSG) ratios (from 3.18 ± 1.64 to 3.88 ± 1.61, P = 0.04). In the control group, any glutathione parameters did not change. Moreover, a stepwise multivariate analysis revealed percent change of GSH/GSSG is the only independent predictor for those of FMD (standardized β = 0.58, P = 0.007) in the glucosamine group. Glucosamine administration improved FMD in association with amelioration of intraerythrocyte GSH/GSSG ratios. These results suggest that oral glucosamine administration might improve vascular endothelial function by modulating intracellular redox state.

著者

Takako Honjo Hiroshi Sano

出版者

Japan Council for Renewable Energy

雑誌

グランド再生可能エネルギー国際会議論文集 (ISSN:24340871)

巻号頁・発行日

pp.23, 2018 (Released:2019-03-07)

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Japan started full-scale renewable energy after two oil shocks. The government take the efforts into the Sunshine plan (new energy) and Moonlight plan (energy conservation). We promoted research and development of industry, academia and government collaboration. However, MITI just focused on sunlight only in renewable energy in 1993. Since 2005, it was a dark ages for renewable energy, partly excluding biomass. The introduction of renewable energy is now progressing with the introduction of the FIT system in 2012.

著者

Rommaneeya LEELA-ARPORN Hiroshi OHTA Masahiro TAMURA Noriyuki NAGATA Kazuyoshi SASAOKA Angkhana DERMLIM Khoirun NISA Keitaro MORISHITA Noboru SASAKI Kensuke NAKAMURA Satoshi TAKAGI Kenji HOSOYA Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0673, (Released:2019-04-08)

被引用文献数

2

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A definitive diagnosis of focal liver lesions (FLLs) requires invasive procedures for histopathologic examination. Thus, a simpler noninvasive diagnostic method, such as conventional ultrasonography combined with clinical data, is needed for the prediction of liver malignancy. The objective of this study was to examine the diagnostic accuracy of clinical data and ultrasonographic (US) features to differentiate benign and malignant liver lesions. Medical records and US images from dogs with FLLs that underwent abdominal US and histopathologic examinations following surgery or liver biopsy were retrospectively reviewed. Clinical data, including signalment, clinical signs and laboratory findings, and the US features of liver lesions that could act as predictive factors were assessed using univariate and multivariate analyses to evaluate the associations between predictive factors and liver malignancy. Based on the histopathologic results, 55 dogs with malignant lesions and 28 dogs with benign lesions were included in the study. The results of univariate analysis showed that several US features and platelet count were significantly associated with liver malignancy. Multivariate analysis revealed that the platelet count (thrombocytosis; odds ratio [OR]: 4.13, 95% confidence intervals [CI]: 1.81–9.41), lesion size (4.1 cm or greater; OR: 23.83, 95% CI: 3.74–151.95) and echotexture of FLLs (heterogenous; OR: 8.44; 95% CI: 1.37–51.91) were independent predictors for differentiating benign and malignant liver lesions, suggesting that a combination of clinical data and US findings of FLLs could predict liver malignancy in dogs.

著者

Angkhana DERMLIM Tatsuyuki OSUGA Kensuke NAKAMURA Tomoya MORITA Khoirun NISA Kazuyoshi SASAOKA Rommaneeya LEELA-ARPORN Noriyuki NAGATA Masahiro TAMURA Noboru SASAKI Hiroshi OHTA Mitsuyoshi TAKIGUCHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0012, (Released:2019-05-15)

被引用文献数

7

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The purpose of this study was to evaluate the cardiac acute volume loading effect on left atrial (LA) strain and strain rate (SR) parameters derived from two-dimensional speckle tracking echocardiography (2D-STE) in healthy dogs. Six healthy beagles were anesthetized and subjected to increase cardiac preload by intravenous infusion with lactated Ringer solution at 150 ml/kg/hr for 90 min. A Swan-Ganz catheter was placed to directly measure the mean pulmonary capillary wedge pressure (PCWP). Echocardiography was performed before (baseline) and at 15, 30, 45, 60, 75, and 90 min after acute volume loading began. Apical 4-chamber images focused on the LA were digitally recorded for later strain and SR analysis via 2D-STE. Acute volume loading significantly increased from baseline during LA strain and SR as assessed by the speckle tracking–based technique during reservoir and conduit function at 15 to 90 min after volume load began, and strain indices representing booster pump function were enhanced at 45 to 90 min. In addition, acute volume loading resulted in a significantly greater PCWP after fluid infusion. On multiple regression analysis, quadratic regression analysis was a better fit for the relationship between PCWP and all LA functional indices. Our findings indicated that LA function analyzed by strain and SR was enhanced during cardiac acute volume loading in healthy dogs. The change in strain and SR during acute volume loading should be interpreted with caution during the diagnosis of heart diseases related to volume overload.

著者

高中 健一郎 山縣 瑞恵 安藤 元一 小川 博 TAKANAKA Kenichiro Mizue YAMAGATA Motokazu ANDO Hiroshi OGAWA

巻号頁・発行日

vol.56, no.2, pp.111-117,

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側溝に落下して死亡する小型哺乳類が多いことから,本研究では側溝の深さと側溝内の水位が小型哺乳類の脱出成功率にどのように影響するかを調べると共に,保全対策として脱出用スロープの形状を検討した。脱出できなくなる道路側溝の深さは,モグラ類(ヒミズ,アズマモグラおよびコウベモグラ)では15cm, ジネズミでは24cm, スミスネズミおよびハタネズミは30cmであった。アカネズミおよびヒメネズミは深さ30cmの溝からは概ね脱出可能であり,静かな環境では深さ45cmからも一部の個体が脱出できた。脱出に際して地上性のアカネズミはよじ登りよりもジャンプを用いる傾向が強く,半樹上性のヒメネズミはよじ登りを多用した。側溝内に止水がある場合,ネズミ類は小さな側溝からは水位にかかわらず脱出できたが,大きな側溝ではスミスネズミやハタネズミは水位1cm以上で,アカヤズミとヒメネズミは水位5cm以上で脱出できない個体が現れた。ネズミ類の保護対策としては側溝の深さをできるだけ浅くすることが望ましく,モグラ類についてはスロープ付き側溝を用いることが望ましい。スロープには1.5~4.5cm間隔で段差を付け,傾斜角度を45°以下にするとともに,スロープを側壁で挟んで通路幅を5cm程度にとどめることが望ましい。

著者

Naoki Tamada Kazuhiko Nakayama Kenichi Yanaka Hiroyuki Onishi Yuto Shinkura Yu Taniguchi Hiroto Kinutani Yasunori Tsuboi Kazuhiro P. Izawa Seimi Satomi-Kobayashi Hiromasa Otake Hiroshi Tanaka Toshiro Shinke Yutaka Okita Noriaki Emoto Ken-ichi Hirata

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.1, no.5, pp.228-234, 2019-05-10 (Released:2019-05-10)

参考文献数

27

被引用文献数

4

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Background:While hemodynamics and exercise capacity in patients with chronic thromboembolic pulmonary hypertension (CTEPH) can be improved by invasive therapy such as pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA), there has been little data on the health-related quality of life (HRQOL) in such patients.Methods and Results:This single-center and observational study compared the impact of invasive therapy on HRQOL. We utilized the Medical Outcome Study 36-Item Short Health Survey (SF-36) to measure HRQOL and compared HRQOL changes after PEA and BPA. A total of 48 patients were diagnosed with CTEPH. Of these, 39 patients completed questionnaires before and after invasive therapy. The PEA group (n=15) and the BPA group (n=24) had similar improvements in clinical parameters. With regard to HRQOL score, both groups had fairly low scores in physical functioning (PF), role physical (RP), general health (GH), social functioning (SF), role emotional (RE), and physical component summary (PCS) at baseline. PF, GH, vitality (VT), mental health (MH), and PCS had significant improvements in the PEA group while PCS and all subscales except for bodily pain (BP) had significant improvements in the BPA group. Furthermore, changes between baseline and follow-up were not significantly different between the 2 groups.Conclusions:BPA for patients who are ineligible for PEA can recover HRQOL to a similar level to that achieved by PEA.

著者

Yasuo Tsuru Mizuki Miura Shinichi Shirai Masaomi Hayashi Kenji Taninobu Hiroshi Takiguchi Shinya Ito Mariko Yano Tomohiro Kawaguchi Takashi Morinaga Akihiro Isotani Shinichi Kakumoto Katsuhiro Seo Yoshio Arai Genichi Sakaguchi Kenji Ando

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.18-484, (Released:2019-04-25)

参考文献数

18

被引用文献数

3

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Aortic complex rupture is one of the most critical complications associated with transcatheter aortic valve implantation (TAVI). Its incidence is rare, and its mechanism varies by case; therefore, it is difficult to identify the predictors of complex rupture. Herein, we report a clinical case series of aortic complex rupture. Within our cohort, the frequency of complex rupture was 0.8% (4/497 consecutive patients) with an in-hospital mortality of 0. Among these four patients with complex rupture, two underwent emergent thoracotomy and surgical hemostasis without a heart-lung machine and surgical aortic valve replacement, whereas the other two were conservatively managed. The case overview revealed the following similarities: all the patients were elderly, small women; balloon-expandable valves were used; the annulus area was small with heavily calcified leaflet; and aggressive treatment strategy was used (i.e., oversizing and post-dilatation). In such cases, TAVI should be performed with a careful strategy. Once aortic complex rupture occurs, damage can be minimized through cooperation with an institutional heart team and calm management.

著者

Yasufumi Kijima Teiji Akagi Yoichi Takaya Satoshi Akagi Koji Nakagawa Kengo Kusano Shunji Sano Hiroshi Ito

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.1, pp.227-234, 2015-12-25 (Released:2015-12-25)

参考文献数

29

被引用文献数

8 35

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Background:A therapeutic strategy in patients with atrial septal defect (ASD) and significant pulmonary arterial hypertension (PAH) remains controversial. This study aimed to assess the effect of PAH-specific medications and subsequent transcatheter shunt closure (ie, a treat and repair strategy) in these patients.Methods and Results:Among 646 patients with ASD, 22 patients (mean age of 56±20 years) who had PAH [mean pulmonary artery pressure ≥25 mmHg and pulmonary vascular resistance (PVR) ≥3 Wood units] underwent successful transcatheter ASD closure. Prior to the procedure, 8 patients received PAH-specific medications (PHM group) and 14 patients did not (non-PHM group). Initially, the PHM group had higher PVR compared with non-PHM group (9.6±3.8 vs. 4.2±1.0 Wood units, P<0.01). After treatment with PAH-specific medications, PVR in this group decreased to 4.0±0.8 Wood units (P<0.01). No adverse events were observed in either the PHM or non-PHM group during or after the transcatheter procedure. In the PHM group, during a treatment period of 52±48 months, the World Health Organization Functional Classification significantly improved (3.0±0.5 to 2.0±0.0, P<0.01), as well as in the non-PHM group (2.1±0.6 to 1.5±0.5, P<0.01).Conclusions:Treat and repair strategy provided substantial improvement and no worsening of the WHO-FC, even in patients with ASD and significant PAH. Long-term hemodynamic follow-up is mandatory to evaluate the ultimate efficacy and safety of this new strategy. (Circ J 2016; 80: 227–234)

著者

Teruhiko Imamura Koichiro Kinugawa Minoru Ono Osamu Kinoshita Norihide Fukushima Akira Shiose Yoshiro Matsui Kenji Yamazaki Yoshikatsu Saiki Akihiko Usui Hiroshi Niinami Goro Matsumiya Hirokuni Arai Yoshiki Sawa

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-18-1215, (Released:2019-04-24)

参考文献数

35

被引用文献数

7

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Background:Hemocompatibility-related adverse events (HRAEs) are substantial issues in patients with left ventricular assist devices (LVADs). Atrial fibrillation (AF) is associated with worse prognosis in patients with heart failure (HF), but its effect on HRAEs following LVAD implantation remain uncertain.Methods and Results:Data from the Japanese Mechanically Assisted Circulatory Support registry of consecutive patients who received HeartMate II LVADs and were followed for 1 year were retrospectively reviewed. Among 190 patients, 23 had AF and 167 had sinus rhythm. The AF group had comparable baseline characteristics with the non-AF group except for their higher age (53 vs. 42 years, P<0.001). Following LVAD implantation, most cases of AF (73%) persisted. Antiplatelet therapy, anticoagulation therapy, and LVAD speed following LVAD implantation were comparable between groups (P>0.05 for all). The 1-year survival free from HRAEs was comparable between groups (83% vs. 76%, P=0.52). Event rates of the breakdown of HRAEs were comparable between groups except for a relatively higher rate of surgically managed pump thrombosis in the AF group (0.16 vs. 0.04, incidence rate ratio 3.75, 95% confidence interval 0.87–16.1, P=0.075). These trends still remained with propensity score-matched comparison.Conclusions:Existence of AF had no effect on the development of HRAEs following LVAD implantation. The need to aggressively treat AF before or after LVAD implantation needs further investigation.

著者

Shiro Uemura Hiroshi Okamoto Michikazu Nakai Kunihiro Nishimura Yoshihiro Miyamoto Satoshi Yasuda Nobuhiro Tanaka Shun Kohsaka Kazushige Kadota Yoshihiko Saito Hiroyuki Tsutsui Issei Komuro Yuji Ikari Hisao Ogawa Masato Nakamura

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0004, (Released:2019-04-24)

参考文献数

33

被引用文献数

17

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Background:Primary percutaneous coronary intervention (pPCI) is strongly recommended by guidelines for patients presenting with acute myocardial infarction (AMI), but its applications in elderly patients are less clear.Methods and Results:The JROAD-DPC is a Japanese nationwide registry for patients with cardiovascular diseases combined with an administrative claim-based database. Among 2,369,165 records from 2012 to 2015, data for 115,407 AMI patients were extracted for this study. Elderly patients (≥75 years) comprised 45,645 subjects (39.6%), and received pPCI less frequently (62.2%) than younger patients (79.2%, P<0.001). Clinical variables such as higher age, female sex, higher Killip class, and renal dysfunction, but not functional status on admission, were predictors of non-application of pPCI. Endpoint 30-day mortality increased with aging, and was significantly higher in elderly patients (10.7%) than in younger patients (3.8%, P<0.001). Indeed, pPCI was independently associated with lower 30-day mortality only in subgroups of patients aged ≥60 years. Propensity score-matching analysis confirmed a similar reduction in endpoint 30-day mortality with pPCI in elderly patients. Duration of hospitalization was significantly shorter and functional ability on discharge was significantly better in elderly patients who underwent pPCI.Conclusions:Elderly patients with AMI underwent pPCI less frequently, but it was consistently associated with better clinical outcome in these patients. Our findings support the proactive application of pPCI for elderly AMI patients when they are eligible for an invasive strategy.