著者

Yasuo Okumura Koichi Nagashima Masaru Arai Ryuta Watanabe Katsuaki Yokoyama Naoya Matsumoto Takayuki Otsuka Shinya Suzuki Akio Hirata Masato Murakami Mitsuru Takami Masaomi Kimura Hidehira Fukaya Shiro Nakahara Takeshi Kato Wataru Shimizu Yu-ki Iwasaki Hiroshi Hayashi Tomoo Harada Ikutaro Nakajima Ken Okumura Junjiroh Koyama Michifumi Tokuda Teiichi Yamane Yukihiko Momiyama Kojiro Tanimoto Kyoko Soejima Noriko Nonoguchi Koichiro Ejima Nobuhisa Hagiwara Masahide Harada Kazumasa Sonoda Masaru Inoue Koji Kumagai Hidemori Hayashi Kazuhiro Satomi Yoshinao Yazaki Yuji Watari on behalf of the AF Ablation Frontier Registry

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.12, pp.2418-2427, 2019-11-25 (Released:2019-11-25)

参考文献数

27

被引用文献数

17

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Background:The safety of discontinuing oral anticoagulant (OAC) after ablation for atrial fibrillation (AF) in Japanese patients has not been clarified.Methods and Results:A study based on the Atrial Fibrillation registry to Follow the long-teRm Outcomes and use of aNTIcoagulants aftER Ablation (AF Frontier Ablation Registry) was conducted. Data were collected from 3,451 consecutive patients (74.1% men; age, 63.3±10.3 years) who had undergone AF ablation at any of 24 cardiovascular centers in Japan between August 2011 and July 2017. During a 20.7-month follow-up period, OAC therapy was discontinued in 1,836 (53.2%) patients; 51 patients (1.5%) suffered a stroke/transient ischemic attack (TIA), 71 (2.1%) suffered major bleeding, and 36 (1.0%) died. Patients in whom OAC therapy was discontinued were significantly younger than those in whom OACs were continued, and their CHA2DS2-VASc scores were significantly lower. The incidences of stroke/TIA, major bleeding, and death were significantly lower among these patients. Upon multivariate adjustment, stroke events were independently associated with relatively high baseline CHA2DS2-VASc scores but not with OAC status.Conclusions:Although the incidences of stroke/TIA, major bleeding, and death were relatively low among patients for whom OAC therapy was discontinued, stroke/TIA occurrence was strongly associated with a high baseline stroke risk rather than with OAC status. Thus, discontinuation of OAC therapy requires careful consideration, especially in patients with a high baseline stroke risk.

著者

Taichiro Mizokami Takeshi Uwatoko Takashi Furukawa Eiji Higashi Yusuke Sakaki Natsuki Suetsugi Yuichiro Takamatsu Kenichi Matsumoto Hiroshi Takashima Hiroshi Sugimori Shuji Sakata

出版者

The Japanese Society for Neuroendovascular Therapy

雑誌

Journal of Neuroendovascular Therapy (ISSN:18824072)

巻号頁・発行日

vol.12, no.6, pp.314-319, 2018 (Released:2018-06-20)

参考文献数

20

被引用文献数

2 4

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Objective: We report the mechanical thrombectomy (MT) of posterior circulation large vessel occlusion (pc-LVO) in which the transradial approach (TRA) was selected as an initial approach route to reduce the duration of treatment.Case Presentation: We performed MT using the TRA for four patients with pc-LVO between November 2015 and March 2017. The TRA was used as an initial approach route in patients in whom preoperative MRI showed that the right vertebral artery (VA) was predominant. In all patients, the procedure could be accomplished without changing the approach route. Thrombolysis in Cerebral Infarction (TICI) 2b or better recanalization was achieved in all patients (100%), and TICI 3 recanalization in three patients (75%). Mean time from radial artery puncture to initial intracranial angiography and to the effective recanalization was 7.3 ± 1.5 and 28.8 ± 6.2 minutes, respectively. There was no complication at the site of puncture.Conclusion: Recanalization was promptly and effectively achieved by the MT of pc-LVO using the TRA. The results suggest that TRA can be utilized as an initial access route in patients in whom an approach to the right VA is possible.

著者

和泉 浩 IZUMI Hiroshi

出版者

秋田大学教育文化学部

雑誌

秋田大学教育文化学部研究紀要 人文科学・社会科学 = MEMOIRS OF FACULTY OF EDUCATION AND HUMAN STUDIES AKITA UNIVERSITY HUMANITIES & SOCIAL SCIENCES (ISSN:24334979)

巻号頁・発行日

no.74, pp.13-25, 2019-03-01

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This article reconsiders relatively recent critical arguments about Raymond Murray Schafer's concept of 'soundscape', especially the arguments of two articles: Ari Y. Kelman (2010) 'Rethinking the Soundscape: A Critical Genealogy of a Key Term in Sound Studies' and Stefan Helmreich (2010) 'Listening against Soundscapes', in order to re-explore 'rich vein of scholarship of sound' (Kelman) in the concept of soundscape.Attending 'to the invention of Schafer's idea in order to wrestle with its redefinition', Kelman criticizes Schafer's bias against noise and his confusion of sound and listening, but Kelman does not consider deeply the definition of soundscape. This article reconsiders the definition of soundscape through rethinking Schafer's explanation in The Tuning the World, Helmreich's discussions of 'soundscape', 'immersion' and 'transduction', Steven Feld's 'acoustemology', Tim Ingold's 'against soundscape', and Paul Rodaway's 'aural geography', in that it situates the concept of soundscape in developments of studies on sound. This article also makes clear the concept of soundscape is not in conflicts with 'transduction', 'acoustemology' and 'immersion', and it needs to be connected with a central and traditional problem of social theories: the relationships between the individual and the social, and depending on how to make this connection, there are possibilities to develop various conceptions of soundscapes.

著者

KASHU SHIMABUKURO YOSHIO MIZUNO KEN KURITA MASAHARU TSUCHIYA HIROSHI YOSHIMATSU

出版者

The Keio Journal of Medicine

雑誌

The Keio Journal of Medicine (ISSN:00229717)

巻号頁・発行日

vol.24, no.4, pp.275-287, 1975 (Released:2009-03-27)

参考文献数

17

被引用文献数

3 3

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Histological findings of the thymuses extirpated in 15 cases of Hashimoto's disease and 27 cases of focal chronic lymphoid thyroiditis were described. Hyperplasia of spindle-shaped epithelial cells were more prominent in the thymus of Hashimoto's disease (9/15, 60.0%). Thymic lymphoid follicles were demonstrated more frequently in focal chronic lymphoid thyroiditis (22/27, 81.5%). Plasma cell, which was ascertained by Methyl Green Pyronin stain was found in 10 out of 15 cases with Hashimoto's disease (66.6%) and in 16 out of 27 cases with focal chronic lymphoid thyroiditis (59.3%).The incidence of mononuclear cell which contained immunoglobulin or gammaglobulin in the thymuses was 62.5% (5 out of 8 patients) and 66.6% (4 out of 6 patients) in Hashimoto's disease and focal chronic thyroiditis, respectively.A long-term observation after thymectomy disclosed that the titrations of antibodies to thyroglobulin as well as thyroid microsome gradually decreased and came negative within one or two years, particularly in focal chronic lymphoid thyroiditis.It might be concluded that the thymus of Hashimoto's disease and focal chronic lymphoid thyroiditis was involved in proliferation of antibody forming cells and providing antigen reactive cells to induce immunopathy of thyroid and any other tissues.

著者

Hiroshi Katoh

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.31, no.10, pp.776-779, 2019 (Released:2019-10-19)

参考文献数

15

被引用文献数

6

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[Purpose] In clinical settings, patients with knee osteoarthritis often complain of pain at gait initiation. In the present study, we aimed to determine the differences in the center of foot pressure and lower extremity muscle activity at gait initiation in healthy volunteers compared to patients with medial knee osteoarthritis. [Participants and Methods] The study comprised of 10 females without medial knee osteoarthritis (healthy group) and 10 females with medial knee osteoarthritis (medial knee osteoarthritis group). We measured the center of foot pressure trajectory and muscle activity onset times of the tibialis anterior and internal gastrocnemius at gait initiation. Moreover, we examined the effects of insole use in the medial knee osteoarthritis group. [Results] The posterior center of foot pressure displacement was significantly smaller in the medial knee osteoarthritis group (barefoot and insole) than in the healthy group. The anterior center of foot pressure displacement significantly improved with insole use. The muscle activity onset time of the tibialis anterior was significantly delayed in the medial knee osteoarthritis group (barefoot) than in the healthy group. [Conclusion] Postural control decreased at gait initiation in the medial knee osteoarthritis group.

著者

Shiho Amagasa Shigeru Inoue Hiroshi Murayama Takeo Fujiwara Hiroyuki Kikuchi Noritoshi Fukushima Masaki Machida Sebastien Chastin Neville Owen Yugo Shobugawa

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20190141, (Released:2019-10-26)

参考文献数

45

被引用文献数

22

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Background: Physical activity can help to protect against cognitive decline in older adults. However, little is known about the potential combined relationships of time spent in sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with indices of cognitive health. We examined the cross-sectional associations of objectively-determined sedentary and physically-active behaviors with an indicator of cognitive function decline (CFD) in older adults.Methods: A randomly-recruited sample of 511 Japanese older adults (47% male; aged 65-84 years) wore a tri-axial accelerometer (HJA-750C, Omron) for seven consecutive days in 2017. Cognitive function was assessed by interviewers using the Japanese version of Mini-Mental State Examination, with a score of ≤23 indicating CFD. Associations of sedentary and physically-active behaviors with CFD were examined using a compositional logistic regression analysis based on isometric log-ratio transformations of time use, adjusting for potential confounders.Results: Forty one (9.4%) of the participants had an indication of CFD. Activity compositions differed significantly between CFD and normal cognitive function (NCF); the proportion of time spent in MVPA was 39.1% lower, relatively to the overall mean composition in those with CFD, and was 5.3% higher in those with NCF. There was a significant beneficial association of having a higher proportion of MVPA relative to other activities with CFD. LPA and SB were not associated with CFD when models were corrected for time spent in all activity behaviors.Conclusions: Larger relative contribution of MVPA was favorably associated with an indicator of CFD in older adults.

著者

杉山 洋 すぎやま ひろし Sugiyama Hiroshi 佐藤 由似 さとう ゆに Sato Yuni

出版者

独立行政法人国立文化財機構奈良文化財研究所

雑誌

奈文研ニュース

巻号頁・発行日

no.74, pp.4-5, 2019-09

著者

坂本 比呂志 有村 博紀 Hiroshi Sakamoto Hiroki Arimura

雑誌

人工知能学会誌 = Journal of Japanese Society for Artificial Intelligence (ISSN:09128085)

巻号頁・発行日

vol.16, no.2, pp.233-238, 2001-03-01

著者

Hirotsugu Atarashi Hiroshi Inoue Masatake Fukunami Kaoru Sugi Chikuma Hamada Hideki Origasa for the Sinus Rhythm Maintenance in Atrial Fibrillation Randomized Trial (SMART) Investigators

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.66, no.6, pp.553-556, 2002 (Released:2002-05-25)

参考文献数

9

被引用文献数

6 20

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A multicenter, placebo-controlled, randomized, double-blind trial compared the preventive effect of aprindine and digoxin on the recurrence of atrial fibrillation (AF) with placebo, and also compare the effectiveness of these 2 drugs in the prevention of AF. Patients with symptomatic paroxysmal or persistent AF who had converted to sinus rhythm (SR) were randomly assigned aprindine (40 mg/day), digoxin (0.25 mg/day) or placebo and followed up on an outpatient basis every 2 weeks for 6 months. Of the 141 patients from 36 participating centers, 47 were given aprindine, 47 digoxin, and 47 were on placebo. After the 6-month follow-up, the Kaplan-Meier estimates of the percentage of patients remaining free of recurrent symptomatic AF on aprindine, digoxin and placebo were 33.3%, 29.2% and 21.5%, respectively. In patients remaining in SR for 15 days after from the start of follow-up, freedom from recurrence was significantly more prevalent in the aprindine group than in the placebo group (p=0.0414), but there was no significant difference between the digoxin and placebo groups. The rate of adverse events was similar in the 3 groups. In conclusion, neither aprindine nor digoxin had a significant effect on preventing relapse of symptomatic AF; however, recurrence of AF occurred later with aprindine than with placebo or digoxin. (Circ J 2002; 66: 553 - 556)

著者

吹田浩 スライマーン・アラーエルディーン監修 = ed. by Hiroshi Suita Soliman Alaaeldin

出版者

関西大学国際文化財・文化研究センター

巻号頁・発行日

2015

著者

鈴木 浩 スズキ ヒロシ Hiroshi Suzuki

雑誌

ルター研究 = Luther Studies

巻号頁・発行日

vol.7, pp.103-117, 2001-09-24

著者

鈴木 浩 Hiroshi Suzuki

雑誌

神学研究 (ISSN:05598478)

巻号頁・発行日

no.65, pp.1-6, 2018-03-02

著者

加藤 浩平 藤野 博 Kohei KATO Hiroshi FUJINO 加藤 浩平(東京学芸大学 特別支援科学講座 支援方法学分野) 藤野 博(東京学芸大学 特別支援科学講座 支援方法学分野) Kohei KATO(Tokyo Gakugei University) Hiroshi FUJINO(Tokyo Gakugei University)

出版者

東京学芸大学学術情報委員会

雑誌

東京学芸大学紀要. 総合教育科学系 (ISSN:18804306)

巻号頁・発行日

vol.69, no.2, pp.277-284, 2018-02

著者

下羅 弘樹 横田 裕思 松井 宏樹 野田 五十樹 柴山 明寛 羽田 靖史 目黒 淳一 Hiroki Shimora Hiroshi Yokota Hiroki Matsui Itsuki Noda Akihiro Shibayama Yashusi Hada Jun-ichi Meguro

雑誌

SIG-SAI = SIG-SAI

巻号頁・発行日

vol.3, no.2, pp.1-7, 2007-11-26

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災害時情報共有のためのプロトコル、およびそのプロトコルを扱うサーバシステムを提案する。災害時において情報共有をいかに行うかは迅速な災害対応を行う上で重要であるが、実際の災害現場では紙ベースあるいは閉鎖的なシステムによる情報管理が行われており、十分な情報共有が行なわれていない。提案するシステムは、プロトコルとしてオープンな標準規格を用い、既存システムを柔軟に接続する事ができる。

著者

Yuki HOSHINO Takanori INDEN Riko OTAKA Daisuke FUKUI Hiroshi SATOH Masaaki KATAYAMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0339, (Released:2019-10-08)

被引用文献数

1

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Phenobarbital (PB) decreases the cyclosporine (CsA) blood level in humans. However, the interaction of PB with CsA has not been reported in cats. This study investigated the effects of multiple doses of PB on the pharmacokinetics of CsA in three healthy cats. The treatments included oral CsA 5 mg/kg alone and oral CsA 5 mg/kg plus PB 5 mg/kg for 4 weeks. Co-administration of PB with CsA resulted in significant decreases in the oral bioavailability of CsA though both the first pass and elimination phases. These preliminary results suggest that oral administration of multiple doses of PB increases the required CsA dosage in CsA-based immunosuppressive therapy in cats.

著者

Tomioka Shinri Kakui Keiichi Kajihara Hiroshi

雑誌

Zoological Science (ISSN:02890003)

巻号頁・発行日

vol.35, no.5, pp.436-445, 2018-10

被引用文献数

4

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Capitellids have emerged as monophyletic in most but not all recent molecular phylogenies, indicating that more extensive taxon sampling is necessary. In addition, monophyly of most or all capitellid genera was questionable, as some diagnostic characters vary ontogenetically within individuals. We tested the monophyly of Capitellidae and eight capitellid genera using phylogenetic analyses of combined 18S, 28S, H3, and COI gene sequences from 36 putative capitellid species. In our trees, Capitellidae formed a monophyletic sister group to Echiura, and Capitella was also monophyletic, separated by a long branch from other capitellids. Well-supported clades each containing representatives of different genera, or containing a subset of species within a genus, indicated that Barantolla, Heteromastus, and Notomastus are likely not monophyletic. We mapped three morphological characters traditionally used to define capitellid genera (head width relative to width of first segment, number of thoracic segments, and number of segments with capillary chaetae) onto our tree. While Capitella showed unique character states, states in the other genera were decidedly not phylogenetically informative. Morphology-based capitellid taxonomy will require a fine-scale reevaluation of character states and detection of new characters.

著者

Toru Miyoshi Hiroyuki Hao Akira Oshita Hideo Kawakami Toshiharu Maeda Hiroshi Matsuoka

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0543, (Released:2019-09-28)

著者

Shunsuke Nakamori Jun Takahashi Sumiko Hyuga Jinwei Yang Hiroaki Takemoto Takuro Maruyama Naohiro Oshima Nahoko Uchiyama Yoshiaki Amakura Masashi Hyuga Takashi Hakamatsuka Yukihiro Goda Hiroshi Odaguchi Toshihiko Hanawa Yoshinori Kobayashi

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.42, no.9, pp.1538-1544, 2019-09-01 (Released:2019-09-01)

参考文献数

34

被引用文献数

12

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The analgesic effect of Ephedra Herb (EH) is believed to be derived from the anti-inflammatory action of pseudoephedrine (Pse). We recently reported that ephedrine alkaloids–free EH extract (EFE) attenuates formalin-induced pain to the same level as that achieved by EH extract (EHE), which suggests that the analgesic effect of EH may not be due to ephedrine alkaloids (EAs). To examine the contribution of EAs to the analgesic effect of EH, mice were injected with formalin to induce a biphasic pain reaction (first phase, 0–5 min; second phase, 10–45 min) at various time points after oral administration of the following test drugs: ephedrine (Eph), Pse, “authentic” EHE from Tsumura & Co. (EHE-Ts), EFE, and EHE that was used as the source of EFE (EHE-To). Biphasic pain was suppressed at 30 min after administration of Eph, EHE-Ts, and EHE-To. At 6 h after administration of EFE, EHE-To, and Pse—and at 4 to 6 h after administration of EHE-Ts—only second-phase pain was suppressed; however, the effect of Pse at 6 h was not significant. These results suggested that EHE has a biphasic analgesic effect against biphasic formalin-induced pain: in the first phase of analgesia (30 min after administration), biphasic pain is suppressed by Eph; in the second phase of analgesia (4–6 h after administration), second-phase pain is alleviated by constituents other than EAs, although Pse may partially contribute to the relief of second-phase pain.

著者

林 健一 佐藤 寛 Kenichi Hayashi Hiroshi Sato 中央学院大学社会システム研究所 中央学院大学社会システム研究所

雑誌

中央学院大学社会システム研究所紀要 = Bulletin of the Social System Research Institute Chuo Gakuin University (ISSN:13462083)

巻号頁・発行日

vol.15, no.2, pp.13-29, 2015-03-01

著者

田村 博 大高 悦裕 Hiroshi TAMURA Yoshihiro OHTAKA

出版者

静岡理工科大学

雑誌

静岡理工科大学紀要 = The Bulletin of the Shizuoka Institute of Science and Technology (ISSN:09195440)

巻号頁・発行日

vol.25, pp.127-133, 2018-01-31