著者
Reiji Kojima Ryoji Shinohara Megumi Kushima Hideki Yui Sanae Otawa Sayaka Horiuchi Kunio Miyake Hiroshi Yokomichi Yuka Akiyama Tadao Ooka Zentaro Yamagata the Japan Environment and Children’s Study Group
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20230210, (Released:2023-11-04)
参考文献数
33
被引用文献数
1

Background: In regions with a high prevalence of peanut allergy (PA), there is a consensus that the introduction of peanuts in early infancy is preventive against the development of PA. However, few studies have investigated whether the introduction of peanuts to infants is associated with PA in regions with a low prevalence of PA, including Japan.Methods: We used data from 74,240 mother–child pairs who participated in the Japan Environment and Children’s Study, a prospective birth cohort recruited between January 2011 and March 2014. A logistic regression model was used to analyze the association between infantile peanut introduction and PA at the age of 4 years with non-infantile peanut introduction as the reference group, adjusted for potential confounders.Results: The percentage of infantile peanut introduction was 4.9% (n=3294) and 286 (0.4%) participants had allergic symptoms to peanuts at 4 years of age. Of all participants, 129 (0.2%) had PA at 4 years of age, which was defined as allergic symptoms and sensitization to peanuts. Those with infantile peanut introduction had a lower prevalence of PA than those without infantile peanut introduction, although this did not reach statistical significance (adjusted odds ratio: 0.53, 95% confidence interval, 0.17–1.68). Sensitivity analysis using IgE-mediated symptoms caused by peanuts as the outcome showed a similar result in relation to infantile peanut introduction.Conclusions: In countries with a low prevalence of PA, the effect of infantile peanut introduction on PA prevention was unclear.
著者
児玉 由布子 藤井 秀比古 川口 智子 中嶋 義記
出版者
一般社団法人 日本小児精神神経学会
雑誌
小児の精神と神経 (ISSN:05599040)
巻号頁・発行日
vol.59, no.4, pp.385-392, 2020 (Released:2020-01-06)
参考文献数
14

半年前の溶連菌感染症の罹患後,急性の強迫行為と摂食制限を呈し,低血糖と脱水症状に至った6歳女児例を報告する.特に誘引なく,朝の着替え,朝食のやり直し行為が始まり,次第に強迫行為が長くなり,食事も摂れなくなったため当科へ紹介入院となった.低血糖および脱水所見を認め,A群溶血性レンサ球菌(GAS)抗原検査は陰性,頭部MRI,髄液検査にて明らかな異常を認めなかった.入院後,補液を開始し,低血糖と脱水症状の改善とともに,強迫行為と摂食の回復がみられ退院となった.その後症状なく経過していたが,約1年半後に同様の強迫行為が出現した.外来にて経過観察し1か月ほどで自然軽快した.経過中に施行したGAS抗原検査は陽性,咽頭培養にてSt. pyogenesを検出した.臨床経過から,溶連菌感染に関連した自己免疫性神経疾患である小児自己免疫性溶連菌関連性精神神経障害(Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections;PANDAS)や,明らかな先行感染がなく急性発症するOCD症状を包括した疾患概念としての小児急性発症神経精神症候群(Pediatric Acute-onset Neuropsychiatric Syndrome;PANS)が疑われた.今後の類似症例の蓄積が望まれる.
著者
Natsumi MARUYAMA Isuzu FUKUNAGA Tomoaki KOGO Tsutomu ENDO Wataru FUJII Masami KANAI-AZUMA Kunihiko NAITO Koji SUGIURA
出版者
The Society for Reproduction and Development
雑誌
Journal of Reproduction and Development (ISSN:09168818)
巻号頁・発行日
pp.2023-021, (Released:2023-11-06)
被引用文献数
2

Senescent cells play a detrimental role in age-associated pathogenesis by producing factors involved in senescence-associated secretory phenotype (SASP). The present study was conducted to examine the possibility that senescent cells are present in aged ovaries and, if so, to determine the tissue region where senescent cells accumulate using a mouse model. Female mice at 2–4 and 8–10 months were used as reproductively young and aged models, respectively; the latter included mice with and without reproductive experience. Cells positive for senescence-associated β-galactosidase (SA-β-Gal) staining, one of the markers of cellular senescence, were detected in the stromal region of aged, but not young, ovaries regardless of reproductive experience. Likewise, the localization of cells expressing CDKN2A (cyclin dependent kinase inhibitor 2A), another senescence marker, in the stromal region of aged ovaries was detected with immunohistochemistry. CDKN2A expression detected by western blotting was significantly higher in the ovaries of aged mice with reproductive experience than in those without the experience. Moreover, cells positive for both γH2AX (a senescence marker) and fluorescent SA-β-Gal staining were present in those isolated from aged ovaries. In addition, the transcript levels of several SASP factors were significantly increased in aged ovaries. These results suggest that senescent cells accumulate in the ovarian stroma and may affect ovarian function in aged mice. Additionally, reproductive experience may promote accumulation.
著者
久保田 萌々 藤川 真樹 鈴木 真樹史
出版者
一般社団法人 産業応用工学会
雑誌
産業応用工学会論文誌 (ISSN:2189373X)
巻号頁・発行日
vol.11, no.1, pp.54-64, 2023 (Released:2023-03-15)
参考文献数
9

We propose a Multi-model CAPTCHA that is composed of one sentence with typo and multiple pictures. This CAPTCHA utilizes human's three abilities (inferring the meaning of the sentence with typo, understanding the meaning of pictures, and linking the meaning of the sentence and corresponding picture), and it is based on a hypothesis, "the longer of the sentence with typo, the time could be longer for a machine to link the meaning of the sentence and corresponding picture (= the shorter of the time of linking, the higher of the probability of human)." We found three findings from our experiment: (1) Examinees were able to link the meaning of the sentence to corresponding picture even there were some pictures with similar composition, (2) Typoglycemia is likely to be appeared on a sentence constructed by short and familiar words, (3) The time for linking was not exponentially increased even the length of the sentence was getting long (= It was not getting difficult for users in this situation).
著者
浅川 和宏
出版者
特定非営利活動法人 組織学会
雑誌
組織科学 (ISSN:02869713)
巻号頁・発行日
vol.52, no.4, pp.4-12, 2019-06-20 (Released:2019-10-30)
参考文献数
29
被引用文献数
1

世界の経営研究の国際標準化の流れの中,日本の経営学は独自路線を維持しつつも変化の兆しも見え始めている.このような状況の下,日本の経営研究にとって目指すべき質の高い論文の要件とは何だろうか.本稿はこの論点を,日本的文脈に根差した知見と,国際標準を満たした水準の2つの側面から検討する.第一に,何よりもまず国際標準をクリアする必要がある点,第二に,その国際標準を満たした後は,むしろ日本的文脈に根差した知見は国際的な文脈で極めて有力な武器になりうる点を論じている.国際標準を満たしたうえで,日本独自のユニークな視点をフルに活かして世界に貢献しうる論文を,国際化時代における質の高い論文と考えたい.
著者
深井 宣男
出版者
日本鳥類標識協会
雑誌
日本鳥類標識協会誌 (ISSN:09144307)
巻号頁・発行日
vol.28, no.1, pp.22-28, 2016 (Released:2016-10-05)
参考文献数
19

アオバズクNinox scutulataの齢の識別について論じた.標識調査で捕獲された個体と標本の写真,文献の生態写真を用いて比較した結果,幼鳥の尾羽は,やや先細りする形状で,先端の淡色部が内側の淡色帯とほぼ同じ色で太いのに対し,成鳥では先細りしない丸い形状で,先端の淡色部が内側の淡色帯より白くて細かった.幼鳥は秋に尾羽を換羽しないため,生まれた翌年に尾羽を換羽するまでは尾羽の特徴で齢の識別が可能である.
著者
内田 孝紀
出版者
一般社団法人 日本風力エネルギー学会
雑誌
風力エネルギー (ISSN:03876217)
巻号頁・発行日
vol.39, no.4, pp.A_53-A_60, 2015 (Released:2016-09-30)

Because a significant portion of the topography in Japan is characterized by steep, complex terrain, which results in a complex spatial distribution of wind speed, great care is necessary for selecting a site for the construction of Wind Turbine Generators (WTGs). We have developed a Computational Fluid Dynamics (CFD) model for unsteady flow called Research Institute for Applied Mechanics, Kyushu University, COMputational Prediction of Airflow over Complex Terrain (RIAM-COMPACTR). The RIAM-COMPACTR CFD model is based on Large-Eddy Simulation (LES) technique. In this paper, the numerical wind simulation over the Shiratakiyama wind farm was executed using the high resolution elevation data. In order to reproduce terrain-induced turbulence numerically, it is shown that both of the horizontal grid resolution and the time increment are extremely important. As a result, the numerical results also showed that it is possible to reproduce energy cascade of actual terrain-induced turbulence well in the frequency-wavenumber domain.
著者
Hiroshi SASAKI Takane IMADA Shinichi TAKATA
出版者
THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES
雑誌
TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, SPACE TECHNOLOGY JAPAN (ISSN:13473840)
巻号頁・発行日
vol.7, no.ists26, pp.Tk_77-Tk_82, 2009 (Released:2010-08-06)
被引用文献数
1

The H-II Transfer Vehicle (HTV) is an unmanned transfer vehicle that will rendezvous with manned facilities and deliver up to six tons of cargo. HTV is a key space transportation system technology in Japan together with the H-IIA/H-IIB launch vehicle and is designed to fully satisfy the manned safety requirements of the International Space Station (ISS) program. Therefore, the technology and its system acquired through HTV development and operation will be widely utilized in future manned transportation and lunar and planetary exploration missions.
著者
前田 拓真 大井川 秀聡 小野寺 康暉 佐藤 大樹 鈴木 海馬 栗田 浩樹
出版者
一般社団法人 日本脳卒中の外科学会
雑誌
脳卒中の外科 (ISSN:09145508)
巻号頁・発行日
vol.51, no.5, pp.397-404, 2023 (Released:2023-10-04)
参考文献数
12

神経外視鏡手術が脳神経外科臨床にも導入され,その有用性が報告されている.当科では2021年から脳血管外科手術を神経外視鏡化するプロジェクトに取り組み,2022年は大部分の手術を神経外視鏡下で行っている.今回,顕微鏡手術からの移行期における脳動脈瘤手術の治療成績を検討した.対象は2021年1月から2022年8月までに当院で開頭手術を行った未破裂脳動脈瘤連続134例のうち,開頭クリッピング術を行った132例とした.神経外視鏡と顕微鏡の両群間で患者背景,セットアップ時間,手術時間,周術期合併症の有無,退院時予後について後方視的に検討を行った.神経外視鏡は75例(55.1%)で選択された.両群間で年齢・性別などの患者背景に有意差を認めなかった.両群で専攻医の執刀率が最も高く(65.3% vs. 59.0%),セットアップ時間(63分 vs. 62分),手術時間(295分 vs. 304分),周術期合併症(5.3% vs. 3.3%),退院時予後良好(97.3% vs. 95.1%)は両群間で有意差を認めなかった.アンケート調査では,画質(78.9%),明るさ(84.2%),操作性(73.7%),教育(57.9%)などにおいて,神経外視鏡がより高い評価を得た.一方で,助手の操作性については課題も明らかとなった.神経外視鏡は高画質,デジタルズームによる従来以上の強拡大,head-up surgeryによる疲労軽減,接眼レンズをもたない小型なカメラで視軸の自由度が大きいなどのメリットを有する.神経外視鏡は開頭クリッピング術においても有用であり,trainer,traineeの経験がともに少ない初期経験においても,許容可能な治療成績であった.
著者
Ayaka SHIBANO Hidehito KIMURA Shun TATEHARA Tatsuya FURUKAWA Kazuki INOUE Yuichi FUJITA Hiroaki NAGASHIMA Shunsuke YAMANISHI Tadashi NOMURA Ken-ichi NIBU Takashi SASAYAMA
出版者
The Japan Neurosurgical Society
雑誌
NMC Case Report Journal (ISSN:21884226)
巻号頁・発行日
vol.9, pp.243-247, 2022-12-31 (Released:2022-08-20)
参考文献数
12
被引用文献数
3

Owing to recent advances in medical optical technology, a high-definition (4K) three-dimensional (3D) exoscope has been developed as an alternative tool to using conventional microscopes for microscopic surgery, and its efficacy for neurosurgery has been reported. We report a case who underwent simultaneous surgery aiming for en bloc resection of an anterior skull base malignancy with concurrent exoscopic transcranial and endoscopic endonasal approaches using a 4K 3D exoscope. The patient was a 76-year-old woman who underwent en bloc resection for an anterior skull base olfactory neuroblastoma 13 years ago. After confirming the recurrence of progressive olfactory neuroblastoma, tumor resection was again decided to be performed. As with the first procedure, surgery was performed in an en bloc manner, using both transcranial and endonasal approaches. Exoscope provided enough space above the surgical field to allow us to perform transcranial and endonasal surgeries simultaneously. Moreover, the surgeons could maintain a comfortable posture throughout the procedure, and total tumor removal was successfully achieved without any abnormal event. To our knowledge, this is the first report of the introduction of an exoscope aiming for en bloc resection of an anterior skull base malignancy while performing simultaneous surgery with both transcranial and endonasal approaches. We believe that the more cases are accumulated, the more efficacy of a 4K 3D exoscope will be elucidated.
著者
新北 成実 寺田 竜太
出版者
公益社団法人 日本水産学会
雑誌
日本水産学会誌 (ISSN:00215392)
巻号頁・発行日
pp.23-00020, (Released:2023-11-07)
参考文献数
37

鹿児島湾のアマモ場の分布の現況を把握するため,2021年に湾内外の77か所において調査を行った。調査は潜水または海岸踏査によって海草の生育範囲を確認し,群落内に無作為に設置した方形枠で被度を記録した。その結果,湾内ではアマモ,コアマモ,ヤマトウミヒルモが見られ,湾外ではこれらに加えてオオウミヒルモ,カワツルモが見られた。アマモ場の面積は湾内で4.39 ha,湾外4か所を含めても6.46 haとなり,湾内のアマモ場の面積は2006年の調査時の11.6%,1978年の2.4%まで減少していた。
著者
池田 光穂
出版者
日本文化人類学会
雑誌
日本文化人類学会研究大会発表要旨集 日本文化人類学会第51回研究大会 (ISSN:21897964)
巻号頁・発行日
pp.B16, 2017 (Released:2017-05-26)

この発表では、ラテンアメリカ(とりわけ中央アメリカ)における人種=民族カテゴリーに関するエスノグラフィーやエスノヒストリーを再検討しつつ、私自身がその地を訪れてきた際に参照してきた文献にもとづく知識が私のフィールド経験とどのように交錯してきたのかについて考察する。