著者
Hideki Origuchi Haruki Itoh Shin-ichi Momomura Ryuji Nohara Hiroyuki Daida Takashi Masuda Masahiro Kohzuki Shigeru Makita Kenji Ueshima Masatoshi Nagayama Kazuto Omiya Hitoshi Adachi Yoichi Goto
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.84, no.3, pp.427-435, 2020-02-25 (Released:2020-02-25)
参考文献数
21
被引用文献数
17

Background:There is little evidence regarding the effect of outpatient cardiac rehabilitation (CR) on exercise capacity or the long-term prognosis in patients after coronary artery bypass graft surgery (CABG). This study aimed to determine whether participation in outpatient CR improves exercise capacity and long-term prognosis in post-CABG Japanese patients in a multicenter cohort.Methods and Results:We enrolled 346 post-CABG patients who underwent cardiopulmonary exercise testing during early (2–3 weeks) and late (3–6 months) time points after surgery. They formed the Active (n=240) and Non-Active (n=106) CR participation groups and were followed for 3.5 years. Primary endpoint was a major adverse cardiac event (MACE): all-cause death or rehospitalization for acute myocardial infarction/unstable angina/worsening heart failure. Peak oxygen uptake at 3–5 months from baseline was significantly more increased in Active than in Non-Active patients (+26±24% vs. +19±20%, respectively; P<0.05), and the MACE rate was significantly lower in Active than Non-Active patients (3.4% vs. 10.5%, respectively; P=0.02). Multivariate Cox proportional hazard analysis showed that participation in outpatient CR was a significant prognostic determinant of MACE (P=0.03).Conclusions:This unique study showed that a multicenter cohort of patients who underwent CABG and actively participated in outpatient CR exhibited greater improvement in exercise capacity and better survival without cardiovascular events than their counterparts who did not participate.
著者
米元 俊一
出版者
別府大学会
雑誌
別府大学紀要 = Memoirs of Beppu University (ISSN:02864983)
巻号頁・発行日
no.58, pp.119-136, 2017-02

蒸留器の最初は香料蒸留であり、その後酒に応用された。西への流れは香料と酒蒸留がセットで発展したが東への流れは香料蒸留が徐々に少なくなり、特に雲南に入ってからは蒸し器を応用した蒸留器で造った蒸留酒が主になった。現在、世界の蒸留器の伝播・発生においてニーダムの学説が主流だが、東南および東アジアでは調理上の蒸し文化が酒の製造における原料の蒸しに、さらにその延長上で蒸留に応用され蒸留酒が生まれた。蒸留器(特に本格焼酎)の発生にもう一つの別ルートがあったと考える。
著者
柴 隆大 佐々木 孝 牧野 育代 川上 幸治 加藤 幾雄 内田 和美 小林 稔秀 金子 公幸
出版者
日本毒性学会
雑誌
日本毒性学会学術年会 第39回日本毒性学会学術年会
巻号頁・発行日
pp.P-60, 2012 (Released:2012-11-24)

【目的】p-クレゾールはチロシンが腸内細菌によって代謝されることで生成する腸内腐敗産物の一種であり、免疫毒性を有することが示唆されている。本発表では、腸管で産生されるp-クレゾールが細胞性免疫応答に及ぼす影響に着目して検討した結果を報告する。【方法】BALB/cマウスの食餌中にチロシンを負荷することで、血中のp-クレゾール濃度が高値となるp-クレゾール高産生モデルを構築した。このモデルにアレルギー性接触性皮膚炎を誘導することで、細胞性免疫応答に対するp-クレゾールの影響を評価した。さらに、ex vivoおよびin vitroにおいて、マウス脾臓細胞のサイトカイン産生に対するp-クレゾールの影響を評価した。【結果】p-クレゾール高産生モデルマウスでは、接触性皮膚炎反応が有意に低下した。この接触性皮膚炎反応は血中p-クレゾール濃度との間に負の相関が認められた。Ex vivoでは、菌体刺激に対する脾臓細胞のIL-12産生能と、血中p-クレゾール濃度との間に負の相関が認められた。また、in vitroでは、p-クレゾールは菌体刺激により産生されるIL-12とIFN-γを抑制した。さらに、p-クレゾールは抗CD3抗体刺激によるIFN-γの産生を抑制し、IL-4の産生を促進した。【考察】経口摂取したチロシンによって腸内で産生されるp-クレゾールは、細胞性免疫応答を抑制した。また、p-クレゾールは細胞性免疫に対して促進的な作用をもつIL-12とIFN-γの産生を抑制し、抑制的な作用をもつIL-4の産生を促進した。これらの結果から、p-クレゾールはサイトカイン産生を変化させることで、細胞性免疫応答に対して抑制的に作用することが示唆された。
著者
鈴木 昌
出版者
一般社団法人 日本内科学会
雑誌
日本内科学会雑誌 (ISSN:00215384)
巻号頁・発行日
vol.102, no.4, pp.994-996, 2013 (Released:2014-04-10)
被引用文献数
1
著者
郭 龍旻 山中 敏正
出版者
Japan Society of Kansei Engineering
雑誌
日本感性工学会論文誌 (ISSN:18840833)
巻号頁・発行日
vol.10, no.2, pp.131-140, 2011 (Released:2011-12-09)
参考文献数
17

This experiment started to find the answer to the question like ‘There might be a common stereotype image when people think of a certain object’. In the experiment three different types of character expression (Kanji, Hiragana, and Katakana) for ‘chair’ were shown to the object. The object was to sketch the first image brought up when they heard of the word. Through the experiment it was able to find how Japanese think of the object based on their use experience in past. From the result of the experiment most of the Japanese regard the shape of the chair from past memory of early learning period. On the other hand experience of using certain shape of the chair during school years have affected bringing stereotype image up of the object.
著者
山田 大輝 武市 昇
出版者
一般社団法人 日本航空宇宙学会
雑誌
日本航空宇宙学会論文集 (ISSN:13446460)
巻号頁・発行日
vol.68, no.1, pp.38-46, 2020 (Released:2020-02-06)
参考文献数
18

In this study, a model of uncertainty of estimated time of arrival on a cruise route is derived, and its effectiveness for ground-based 4D trajectory management is demonstrated. Uncertainty of estimated time of arrival inevitably increases because of fluctuations in meteorological conditions, even though the Mach number, flight altitude and direction are controlled constant. Actual flight data and numerical weather forecasts are processed to obtain a large collection of flight and meteorological conditions and flight time error. Through the law of uncertainty propagation, an uncertainty model of estimated time of arrival is derived as a function of the Mach number, flight distance, wind, and temperature. The coefficients of the model are determined through cluster analysis and linear regression analysis. It is clearly demonstrated that the proposed model can estimate the uncertainty of estimated time of arrival without underestimation or overestimation at an arbitrary flight distance, even under moderate or severe weather conditions. Through numerical analysis of a 4D trajectory management using actual track data, it has been clearly demonstrated that the proposed model is able to improve both safety and efficiency of 4D trajectory management simultaneously.
著者
高松 由子 土居 義岳
出版者
日本建築学会
雑誌
日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日
vol.69, no.578, pp.191-198, 2004-04-30 (Released:2017-02-09)
参考文献数
50
被引用文献数
1 1

The Asiatic Society (established in Calcutta in 1784) published their magazine The Asiatic Researches (vol.I-XX, 1788-1839). In the latter part of the 18th century, the linguist W. Chambers, the mathematician R. Burrow and the astronomer J. Goldingham presented the monographs relative to Indian Architecture to The Asiatik Researches. They were not the specialist in Architecture, although, at "Chambers's monograph," there is a idea which the ruins at Mahabalipuram was built by the sryle of Architecture in the Ancient North India. At "Burrow's monograph," there is a view which the architecture and the pillar in India was perceived to have the identity and the universality with those in Ancient Egypt and Europe. At "Goldingham's monograph, there is a idea which there was the origin of cave in the Ancient India, and which the Cave at Elephanta was copied from the system of this original. At three monographs, there was the near idea of the theory on origin in the views on India Architecture, and this idea had been known to the members of the Society.
出版者
Motilal Banarsidass
巻号頁・発行日
1995