著者

Rebecca C. REGAN Robert M. GOGAL Jr James P. BARBER R. Cary TUCKFIELD Elizabeth W. HOWERTH Jessica A. LAWRENCE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0537, (Released:2014-09-15)

被引用文献数

9

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Loperamide is a peripheral opiate agonist that can cause apoptosis and G2/M arrest in human cancer cell lines and may sensitize cells to chemotherapy. The objectives of this study were to investigate the effects of loperamide on viability, apoptosis and cell cycle kinetics in canine cancer cells and to establish whether the drug sensitizes cells to doxorubicin. Cell viability was assessed using Alamar Blue. Cell death and cell cycle were studied using flow cytometry with 7-Aminoactinomycin-D (7-AAD) and propidium iodide (PI), respectively. Loperamide decreased cell viability in a dose-dependent fashion and was most effective against canine osteosarcoma cells. In all cell lines, it induced a dose and time dependent apoptosis and resulted in accumulation in G0/G1. When co-incubated with doxorubicin, loperamide induced a synergistic cell kill in canine carcinoma cells. Investigation is warranted into the role of loperamide in the treatment of canine cancer.

著者

中野 秀俊 石田 祐三

出版者

一般社団法人 レーザー学会

雑誌

レーザー研究 (ISSN:03870200)

巻号頁・発行日

vol.20, no.8, pp.631-637, 1992-08-29 (Released:2010-03-17)

参考文献数

15

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Self-induced transparency (SIT) is a kind of coherent transient phenomena in two-level atomic system. The optical pulse with an area that is an integer multiple of 2π, which causes SIT in an absorber, is stable and a kind of soliton. Thus SIT is expected to be useful in pulse compression and pulse shaping. In this paper, we discuss some problems in experiments of SIT and surveys the experimental results of SIT. It is also described the recent experimental results of coherent nonlinear pulse propagation in BiI3 crystal using tunable sub-picosecond pulses.

著者

長谷川 三千子

出版者

日本哲学会

雑誌

哲学 (ISSN:03873358)

巻号頁・発行日

vol.1973, no.23, pp.162-173, 1973-05-01 (Released:2009-07-23)

参考文献数

10

著者

Özge TURNA YILMAZ TSF TOYDEMIR İ KIRŞAN B DOKUZEYLUL Z GUNAY E KARACAM

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0112, (Released:2014-09-20)

被引用文献数

5

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The analgesic effect of wound infiltration with bupivacaine was evaluated in cats undergoing bilateral mastectomy. Twenty-one female cats with mammary gland tumors were anesthetized with propofol and oxygen-isoflurane anesthesia following premedication with atropine. In the trial group (Group I; n=11), 30 ml of saline containing 2 mg/kg of bupivacaine was infiltrated topically into the surgical wound right after removal of the mammary glands, whereas only saline solution was infiltrated in the control group (Group II; n=10). At the same time, carprofen (4 mg/kg) was also administered subcutaneously in both groups. Behavioral signs of pain were monitored during the recovery period after general anaesthesia. In order to examine the behavioral changes associated with acute pain, a questionnaire was prepared and given to the owners to be completed 4 hr and then 10 hr after the operation. According to the owners’ anwers to the questionnaire, a pain score was specified using a “numerical rating scale” for each cat. Although some cats showed mild to moderate pain, the pain score recorded at 4 hr after the operation was significantly lower in Group I (P<0.001). No significant difference was found at 10 hr after the operation between the groups. The incidence of vocalization, aggression and convulsion within 2 hr after the operation were also lower in Group I. In conclusion, wound infiltration with bupivacaine before incisional closure provided reliable analgesia at least 4 hr after bilateral radical mastectomy in cats.

著者

山下 裕之 上田 洋 高橋 裕子 三森 明夫

出版者

社団法人 日本感染症学会

雑誌

感染症学雑誌 (ISSN:03875911)

巻号頁・発行日

vol.86, no.3, pp.306-309, 2012-05-20 (Released:2013-04-12)

参考文献数

17

被引用文献数

2 5 1

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The patient was a 74-year old male who presented with a skin rash, cough, and impaired consciousness. Adiffuse, systemic, dark red rash was observed and he was admitted. Varicella infection was diagnosed based on the varicella-zoster virus (VZV)-IgM levels. The extremely high VZV- IgG levels observed were unlikely to be present inaninitial infection and the infection was thought to be a reoccurrence. Diffuse nodular shadows measuring ≤5mm indiameter were observed on chest computed tomography (CT) ; this was consistent with the typical imaging findings of varicella pneumonia. The cerebrospinal fluid (CSF) was positive for CSF VZV-IgM antibody, CSF VZV-PCR, and CSF antibody titer index. A diagnosisofvaricella meningitis was made. When both respiratory and neurological symptoms are observed inpatients with varicella infection, it is necessary to consider a combined diagnosis of varicella pneumonia and varicella meningitis/encephalitis and perform chest imaging and a CSF examination. Repeated asymptomaticre-infection isconsidered necessary in order to maintaina life long immunity to varicella ; however, the opportunities for asymptomaticre-infection are decreasing with the declining birth rate and trend toward small families. As a result, reoccurrences of varicella infection in the elderly are expected to increase with rapidlyincreasing longevity.

著者

林 相熏

出版者

日本社会情報学会

雑誌

日本社会情報学会全国大会研究発表論文集 日本社会情報学会 第26回全国大会

巻号頁・発行日

pp.195-200, 2011 (Released:2012-03-20)

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This paper shows how relationships in network affect information diffusion and what kind of bridge devotes to rewire network. There are patterns of bridge which can be found in tweets of Twitter or posts of Facebook over communities. This study depends on serveral social network analysis and previous studies of Granovetter, Milgram and Burt. Research objectives are international students of China and Korea studying in Japan, and this research implies to figure out how bridge can help communicate between different cliques.

著者

Kiwamu HANAZONO Shinya FUKUMOTO Yoshio KAWAMURA Yoshifumi ENDO Tsuyoshi KADOSAWA Hidetomo IWANO Tsuyoshi UCHIDE

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0032, (Released:2014-09-16)

被引用文献数

2 27

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Transitional cell carcinoma (TCC), a urinary bladder tumor with high mortality, is encountered commonly in dogs. Whereas overexpression of epidermal growth factor receptor (EGFR) is associated with development of human urinary bladder cancer, information on EGFR expression in canine TCC is lacking. In this study, EGFR protein and mRNA expression in canine normal bladder (n=5), polypoid cystitis (n=5) and TCC (n=25) were examined by immunohistochemistry and real-time polymerase chain reaction. EGFR protein expression was significantly higher in TCC than that in normal healthy bladder (P<0.001) and polypoid cystitis (P<0.005). High EGFR protein expression was significantly (P<0.01) associated with TCC with a sensitivity of 72% and specificity of 100%. Comparative analysis of protein and mRNA expression levels in TCC showed significant positive correlation (r=0.88, P<0.05) between mRNA and protein expression. These findings suggest that intense expression of EGFR protein could be used as a marker to help canine TCC diagnosis.

著者

佐藤 卓 松本 文雄 安部 隆司 二瓶 直子 小林 睦生

出版者

日本衛生動物学会

雑誌

衛生動物 (ISSN:04247086)

巻号頁・発行日

vol.63, no.3, pp.195-204, 2012-09-30 (Released:2013-07-06)

参考文献数

19

被引用文献数

1 1

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It was previously reported that the northern limits of geographic distribution of Ae. albopictus in Japan are Akita and Iwate Prefectures. In this study, we carried out larval surveillance from 2009 to 2010 to clarify the present distribution of the mosquito in Iwate Prefecture and to analyze the relationship between climatic conditions and the northern distribution of Ae. albopictus by the geographic information systems (GIS). Distribution of Ae. albopictus was found in 34 collection sites from 7 cities and 2 towns in this study. Around the collection sites in Senboku 2 Chome, Morioka City where Ae. albopictus larvae were collected in 2009, an intensive investigation was carried out in 2010, and more than 20 colonies of Ae. albopictus were collected. This suggests that Ae. albopictus population has been established in Morioka City. The relationships between climatic conditions and distribution of Ae. albopictus in Iwate Prefecture were analyzed using 1 km mesh climate data from 2006 to 2010, and the following conditions were suggested for the presence of Ae. albopictus populations: >10.8°C annual mean temperature, >-1.4°C daily mean temperature in January, >185 days/year with >10.8°C mean daily temperature and >1,350 degree days of effective accumulated temperature per year.

著者

田中 睦都 田中 順子 田中 昌博

出版者

大阪歯科学会

雑誌

大阪歯科学会例会抄録 第535回大阪歯科学会例会(歯科医学76巻1号)

巻号頁・発行日

pp.44-45, 2013 (Released:2013-04-30)

著者

宇佐見 和子 池原 研 ロバート ジェンキンズ 芦 寿一郎

出版者

日本堆積学会

雑誌

堆積学研究 (ISSN:1342310X)

巻号頁・発行日

vol.73, no.1, pp.37-43, 2014-06-30 (Released:2014-09-04)

参考文献数

47

被引用文献数

1 1

著者

Tomohiko Takasaki

出版者

日本熱帯医学会

雑誌

Tropical Medicine and Health (ISSN:13488945)

巻号頁・発行日

vol.39, no.4SUPPLEMENT, pp.S13-S15, 2011 (Released:2012-04-01)

参考文献数

10

被引用文献数

16 29

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Several dengue outbreaks occurred in Japan from 1942 to 1945. Dengue fever emerged in Nagasaki in August 1942 and soon spread to other cities such as Sasebo, Hiroshima, Kobe and Osaka, recurring every summer until 1945 and constituting the greatest outbreak in the temperate zone. Domestic outbreaks have not been reported in Japan since then. However, the number of imported dengue cases has increased year by year: 868 imported cases were reported in Japan between 1999 and 2010 according to the Infectious Diseases Control Law. Moreover, 406 imported cases were confirmed to be dengue virus infection among 768 dengue suspected cases received at NIID from 2003 to 2010. A total of 142 cases (35.6%), 103 cases (25.8%) and 62 cases (15.5%) were noted in the 20–29, 30–39 and 40–49 age groups, respectively. Infecting dengue virus serotypes were determined for 280 of the 406 cases. The number of cases infected with each of the 4 serotypes was 98 (35%) with type 1, 78 (28%) with type 3, 72 (26%) with type 2, and 32 (11%) with type 4. Sixty percent of dengue cases were imported from July to October, the summer vacation season in Japan.

著者

杉谷 昭

出版者

法制史学会

雑誌

法制史研究 (ISSN:04412508)

巻号頁・発行日

vol.1968, no.18, pp.150-151, 1968-10-20 (Released:2009-11-16)

著者

佃 為成

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.99, no.1, pp.32-42, 1990-02-25 (Released:2010-11-18)

参考文献数

39

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The geologic feature of the northern Fossa Magna region is characterized by a well developed folded belt system. Recent microseismicity over 10 years and historic earthquakes reveal that there are seismic zones pararell to the axes of this structure: Itoigawa-Shizuoka Tectonic Line, the western side of Shinano River, the western margin of the Central Belt of Uplift, and the eastern margin of the Central Belt of Uplift. The last zone was recently recognized by the earthquake sequence with the main shock of M 4.9 in 1986. The fcal mechanism solutions and other geologic and geodetic evidence indicate the region is compressed in the direction perpendicular to the folded belts. We can also find seismic activity lines perpendicular to or oblique to these folding axes: the Chikumagawa Tectonic Line separates the Central Belt of Uplift with a left lateral offset of 10km; the seismic line along the eastern side of the volcanic line of Myoko-san, Kurohime-yama and Iizuna-yama makes the eastern edge of the seismic gap around the northern end of the Itoigawa-Shizuoka Line.A 20-25 years recurrence time is found in the occurrence of the major earthquake events in the central part of the northern Fossa Magna in recent 140 years.Seismic active regions are grouped into some rectangular blocks with their bases being either pararell or perpendicular to the folded belts. The activity in a block became active nearly simultaneously, and it sometimes migrated to other blocks with some delay time. The high activity migrated from the block region around the Chikumagawa Tectonic Line to both the northern activity block around the Japan Sea coast and the active region in the southern Fossa Magna during the period from 1986 to 1987.The migration of the seismic activity along the Fossa Magna region may be due to delayed transmission of the stress field in the viscoelastic or elastoviscous medium. The exponential time dependence of the decay rate of the Matsushiro swarm activity for a long period more than 20 years since 1965 is found to be reasonably interpreted by the relaxation process of stresses within the elastoviscous medium. The viscosity changed from 1.1×1019 poise to 2.7×1020 poise as time elapsed. The first value is comparable with that of a ground surface rock body estimated by secular ground tilts and strains. The latter is the same order of the values obtained in the long period second creep experiments using granite and gabbro. The Matsushiro region is one of the region where the viscosity might have been very low due to numerous micro-cracks.

著者

水野 喜信 山岡 俊樹

出版者

Japanese Society for the Science of Design

雑誌

日本デザイン学会研究発表大会概要集

巻号頁・発行日

pp.121, 2014 (Released:2014-07-04)

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本論文では、「大切な人を守る」意思を重視した未来の選択についての論考および、そこから考えられる理論について述べる。普段生きている場合については、意思を意識して生きることはそれほどないかもしれないが、意思は選択と密接にかかわっている。選択肢や選択は意思に依存しているが、「大切な人を守る」意思による選択は、現実(R)全体に影響を及ぼし、全体最適な選択となる可能性がある。このことに関連して、「配偶者も子供も家族も自分もみんなも守る」意思による選択を提案した。今後は「大切な人を守る」意思による未来の選択について、より具体的に調査する予定である。

著者

高山 義武

出版者

岡山医学会

雑誌

岡山醫學會雜誌 (ISSN:00301558)

巻号頁・発行日

vol.56, no.2, pp.171-193, 1944-02-29 (Released:2010-01-14)

参考文献数

48

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Bezüglich des Blutbildes bei Dengue verfügt die Literatur über zahlreiche Beobachtungen, welche jedoch in den Ergebnissen etwas verschieden lauten und somit nicht wenig freies Feld für weitere Untersuchungen noch offen lassen. Was aber das Bild des Knochenmarks bei Dengue anbetrifft, so findet der Verf. in der Literatur keinen Fall veröffentlicht. Bei der Infektion des Denguefiebers, welche im letzten Sommer in der Stadt Nagasaki stattfand, hat der Verf. in 37 Fällen den Verlauf der Krankheit täglich verfolgt, dabei die Verschiebungen des Blutbildes beobachtet und in anderen 10 Fallen das Bild des Knochenmarks untersucht. Dadurch hat er folgende Ergebnisse erhalten.1. Bei den einzelnen Erythrozyten werden weder im peripheren Blut noch im Knochenmark erhebliche Variationen beobachtet.2. Die Zahl der Leukozyten erfährt von Anfang der Krankheit an eine Abname, welche vom 2. Krankheitstage in erheblichem Masse auft itt und im 4. und 5. Tage das Maximum erreicht, um nach Ablauf dieser Tage rasch zur Norm zurückzukommen.3. Neutrophile Leuközyten nehmen nach Ablauf des 1. Tages, wo sie eine geringe Zunahme zeigen, in starkem Masse ab und kommen nur langsam zur Norm zuruck. Bei ihnen besteht die Linksverschiebung der Kerne, auch die sog. Vergiftungsgranula und die Degeneration der Vakuolen sind in der Regel hochgradig aufgetreten. Es wurde auch beider Gruppe der neutrophilen Leukozyten des Knochenmarks eine auffallend betrachtliche Reifungsstörung festgestellt, welche wahrscheinlich darin begründen lässt, dass trotz der hochgradigen Degeneration der Vakuolen in denjungen Knochenmarkszellen die alteren Zellen des Knochenmarks keine quantitative Abnahme erleiden, die während segmentierten neutrophilen Leukozyten eine erhebliche Abnahme erfahren. Nach dem Erachten des Verfassers soll die Verringerung der neutrophilen Leukozyten im peripheren Blut gewiss einer afferenten und einer efferenten Natur sein.4. Eosinophile Leukozyten vermehren sich allmählich mit der kleinen Ausnahme, dass sie nur im Verlauf des 2. Tages verschwinden. Es liegt aber die Annahme nahe, dass bei den Eosinophilen keine Leukozytose nach der Infektion stattfindet.5. Die grossen Mononuclearen nehmen im Frühstadium relativ etwas zu, um nach Ablauf diesen Stadiums eine absolute Zunahme zu zeigen, welche 2-3 Wochen nach der Abfieberung noch fortschreitet, während im Knochenmark keine Zunahme der betr. Zellen beobachtet wird. 6. Lymphozyten nehmen schon von dem 1. Tag an beträchtlich ab, nach der Entfieberung aber tritt postinfektiöse Lymphozytose in rascher Folge auf. 7. Eine übermässige Vermehrung der Plasmazellen, welche transitorisch im Stadium des mit Schwellung der Lymphdruse einhergehenden Exanthems in besonders hohem Masse stattfindet, ist in 38, 25-3, 5% der gesamten Fälle beobachtet.8. Es wurde festgestellt, dass die Blutplättchen um das Stadium des Exanthems abnehmen.

著者

Shogo Tokuyama Kazuo Nakamoto

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.8, pp.1174-1178, 2011-08-01 (Released:2011-08-01)

参考文献数

57

被引用文献数

17 41

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Fatty acids, which are the essential nutrients for humans, are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a range of biological phenomena. Recently, an increasing number of physiologic and pharmacologic reports on fatty acids have improved our understanding of the association of fatty acids with certain diseases. It has also become apparent that functional properties of fatty acids are modulated by factors such as the amount of individual fatty acid intake and their distribution among organs. Recently, the functional relationship between polyunsaturated fatty acids and pain has been the focus of many studies. Both basic and clinical studies have shown that a dietary intake of n-3 series polyunsaturated fatty acids results in a reduction in the pain associated with rheumatoid arthritis, dysmenorrhea, inflammatory bowl disease, and neuropathy. In addition, levels of n-6 series polyunsaturated fatty acids are high in patients with chronic pain. These results indicate that polyunsaturated fatty acids play a vital role in pain regulation. In this review, we summarize a number of basic and clinical studies on polyunsaturated fatty acids and their association with pain.

著者

中野 浩司 佐藤 真弘 津田 綾子 關谷 悠 森 勝伸 板橋 英之

出版者

公益社団法人 日本分析化学会

雑誌

分析化学 (ISSN:05251931)

巻号頁・発行日

vol.59, no.9, pp.829-837, 2010 (Released:2010-11-11)

参考文献数

39

被引用文献数

3 6 3

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The speciations of heavy metals (Cu, Zn, Pb, Cd and Cr) in bottom sediment soils collected from Kusaki dam-lake in Gunma Prefecture were considered to be in the solubility with the type of ligands, by a sequential extraction procedure with five fractionations. Through these procedures, a large amount of Cu in Kusaki dam-lake sediment was in a fraction bound to organic matter ; those of Zn and Pb were in an oxide fraction bound to iron and manganese oxides, and those of Cd and Cr were in the exchangeable fraction and in the residual fraction, respectively. The composition of species in a heavy metal was almost the same without any regard to the collection periods for two and a half years, the particle size of the sediment soils and the collection points. The total concentrations of heavy metals in the sediment soil at Kusaki dam-lake was still high at this stage, compared with those at Kanto loam and Black soil (Kurobokudo). From the distributions of each fraction for analyte heavy metals, the ratios of heavy metals with long-term leaching were estimated.

著者

丸木 恵祐

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.37, no.1, pp.24-44,129, 1986-06-30 (Released:2009-11-11)

参考文献数

11

被引用文献数

1 1

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人間の日常経験の形態とその意味を社会的状況との関連で考察する人びとにとって、E・ゴッフマンのドラマツルギーは、きわめて刺激的である。ドラマツルギーは演劇の比喩を用いて、社会的相互作用の主観的事実と客観的事実を同時に記述するアプローチである。それは、舞台上の「人物」が劇場外の広い世界と何のかかわりもなく既成の台本の産物と見なされるように、「自己」を劇場、つまり社会的状況という閉鎖的体系の中に呈示された人工物と見なす。本稿では、行為者が状況適合性のルールにふさわしく自己を呈示し、自己の行為を他者に有意味なものにするために利用する「形態」に注目する。そのことによって、ゴッフマンが行為者の創造的主観性を強調するシンボリック相互作用論の流れをくみながら、なぜ禁域とされてきた状況の客観的側面にふみこみ、社会的事実の拘束性を説くデュルケムの偏見に染まって行ったのかが明らかにされる。その際、外見上の個々の経験の背後に潜み「形態」に意味を付与する「構造」が確認できよう。

著者

Dah-Renn FU Daiki KATO Ai WATABE Yoshifumi ENDO Tsuyoshi KADOSAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0245, (Released:2014-08-25)

被引用文献数

2 10

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Apoptosis, Ki-67 and survivin expression have been reported as prognostic values in human cancer treated with radiation therapy. The aim of this study was to evaluate the correlation between the outcome of canine nasal carcinomas treated with radiation therapy and these cancer markers. The apoptotic index (AI) was evaluated with TUNEL assays, and an immunohistochemical evaluation was performed on Ki-67 and survivin in 33 biopsy samples taken before treatment. Median survival times were estimated using Kaplan-Meier curves and the log-rank method. The AI ranged from 0 to 0.7%, and the percentage of Ki-67-positive cells defined as the proliferative index (PI) ranged from 0.8 to 77% in all samples. Neither the AI nor the PI had a significant relationship with survival time (P=0.056 and 0.211). Survivin expression was detected in 84.9% of samples of canine nasal carcinoma. Dogs with high survivin expression were associated with poorer response to treatment and had shorter survival times (P=0.017 and 0.031). Advanced-stage tumors were also significantly associated with a high level of survivin (P=0.026). Overexpression of survivin was shown to be an unfavorable prognostic factor in dogs with nasal carcinomas treated with radiation therapy.

著者

濱住 啓之

出版者

一般社団法人 映像情報メディア学会

雑誌

映像情報メディア学会誌 (ISSN:13426907)

巻号頁・発行日

vol.64, no.5, pp.658-661, 2010-05-01 (Released:2012-03-28)

参考文献数

8