著者

Shin-ichi Ishikawa Ryo Motoya Satoko Sasagawa Takahito Takahashi Isa Okajima Yasuchika Takeishi Cecilia A. Essau

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.236, no.2, pp.115-122, 2015 (Released:2015-05-30)

参考文献数

37

被引用文献数

2 10

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On March 11, 2011, the Great East Japan Earthquake devastated the Tohoku region, which led to a tsunami and a nuclear disaster. While these three disasters caused tremendous physical damage, their psychological impact remains unclear. The present study evaluated traumatic responses, internalizing (i.e., anxiety and depression), and externalizing (i.e., anger) symptoms among Japanese young people in the immediate aftermath and 2.5 years later. A total of 435 undergraduates were recruited from universities in three differentially exposed regions: Fukushima, Tokyo, and Kyoto. They completed a set of questionnaires retrospectively (i.e., September to December 2013) to measure their traumatic responses, anxiety and depressive symptoms, functional impairment, and anger immediately after the disaster and 2.5 years later. Participants in Tokyo had the highest level of traumatic response and internalizing symptoms immediately after the earthquake, whereas those in Fukushima had significantly higher levels of trait anger, anger-in (holding one’s anger in), and anger-out (expressing one’s anger externally). In Kyoto, the levels of anxiety and depression after 2.5 years were significantly higher than they were immediately after the disasters. In conclusion, anger symptoms were high among young people who lived at or near the center of the disasters, while anxiety and depression were high among those who lived far away from the disasters. These findings suggest the importance of providing mental health services to young people who did not live near the disaster area as well as to those living in the directly affected area.

著者

Junko Kuramoto Akio Kawamura Tomohisa Dembo Tokuhiro Kimura Keiichi Fukuda Yasunori Okada

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-15-0197, (Released:2015-06-18)

参考文献数

21

被引用文献数

4 25

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Background:Patent foramen ovale (PFO) can cause ischemic stroke because of paradoxical embolism. Autopsy studies have shown that the prevalence of PFO is 25% in whites or blacks. However, there is a paucity of data on the prevalence of PFO in Asians. The aim of this study was to clarify the prevalence of PFO in the Japanese population.Methods and Results:We reviewed 52,717 autopsy reports, which were collected and edited by the Japanese Society of Pathology from 2009 to 2012. Next, we inspected consecutive 103 formalin-fixed specimens that had already been examined by certified pathologists from 2009 to 2013 to find PFO and atrial septal aneurysm (ASA). ASA was defined as ≥10 mm protrusion of the septum into the left or the right atrium. In the database of the Japanese Society of Pathology, the incidence of PFO was 0.08% (43/52,717). Inspection of heart specimens disclosed that the prevalence of PFO was 13.6% (14/103). None of the PFO cases was reported at the original autopsy. PFO was more frequently found in the subjects with ASA (50%) than in those without ASA (9.7%) (P=0.004).Conclusions:PFO is under-reported in autopsy reports. Re-evaluation of heart specimens disclosed that theprevalence of PFO was 13.6%. The prevalence was lower than reported in the past.

著者

Aliye Bastug Bircan Kayaaslan Sumeyye Kazancioglu Halide Aslaner Ayse But Esragul Akinci Meltem Arzu Yetkin Selim Eren Hurrem Bodur

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2014.566, (Released:2015-06-12)

参考文献数

17

被引用文献数

2 15

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Crimean-Congo hemorrhagic fever is a life threatening illness. We aimed to detect the effect of the leukocyte counts on survival. This is the first study analyzing the relationship between mortality and leukocyte counts. A total of 220 patients were evaluated retrospectively. The mortality rate was found 16.4%. The analysis of relationship between leukocyte counts and mortality rates showed us some important clues for pathogenesis. ROC curve analysis revealed that if the leukocyte counts on admission were ≥ 2950/mm3, mortality rate could be predicted with 62.1% sensitivity. In consideration of the mean hospitalization length in fatal cases (4.3 days), third-admission day leukocyte counts were compared. Increase of the neutrophils and decrease of the lymphocytes and monocytes were found as significant risk factors for mortality (p = 0.01, p = 0.037, p = 0.001). The mortality risk was found 8-12 folds higher in patients with upper levels of cut- off for leukocytes (2950 µl), LDH (967 U/L) and aPTT (42.4 s), ALT (>119.5 u /l) which were determined as an independent predictors of mortality. The depletion of monocytes, lymphocytes and the increase of neutrophil counts were correlated with poor outcome. These results suggest the importance of mononuclear immune response for survival in CCHF.

著者

宮田 桂司 本田 一男

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.104, no.3, pp.143-152, 1994 (Released:2007-02-06)

参考文献数

50

被引用文献数

5 10

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The pharmacology of 5-HT and the classification of 5-HT receptors have become increasingly complex. However, recent advances have produced a new nomenclature system for 5-HT receptors. 5-HT3 receptors are neuronal receptors coupled directly to cation channels. Recently, many selective 5-HT3-receptor antagonists including tropisetron, zacopride, ondansetron, granisetron, zatosetron, nazasetron, YM060 and YM114 (KAE-393) have been developed. Many actions attributable to the 5-HT3-receptor have been described in both the peripheral and central nervous systems, and clinical trials are already showing the potential use of these 5-HT3 receptor antagonists in a number of disorders of the gastrointestinal tract and central nervous system, such as nausea and vomiting induced by cancer chemotherapy, anxiety, depression, schizophrenia and migraine. In addition, endogenous 5-HT is suggested to be one of the substances that mediate stress-induced responses in gastrointestinal function, i.e., increase in fecal pellet output and diarrhea. Moreover, YM060, YM114 (KAE-393) and granisetron have been reported to inhibit restraint stress and 5-HT-induced increases in fecal pellet output and diarrhea in rats and mice, indicating that endogenous 5-HT may mediate stress-induced changes in bowel function through the 5-HT3 receptor. Therefore, 5-HT3-receptor antagonists are new therapeutic drugs for stress-induced gastrointestinal dysfunctions like irritable bowel syndrome (IBS).

著者

荒木 信幸

出版者

社団法人 日本伝熱学会

雑誌

伝熱 (ISSN:13448692)

巻号頁・発行日

vol.43, no.178, pp.2-8, 2004 (Released:2010-12-16)

参考文献数

27

著者

北川 浩

出版者

公益社団法人 日本材料学会

雑誌

材料 (ISSN:05145163)

巻号頁・発行日

vol.21, no.230, pp.969-977, 1972-11-15 (Released:2009-06-03)

参考文献数

26

被引用文献数

1 1

著者

岡田 貢 林 文子 松下 愛 香西 克之 長坂 信夫

出版者

一般財団法人 日本小児歯科学会

雑誌

小児歯科学雑誌 (ISSN:05831199)

巻号頁・発行日

vol.37, no.2, pp.373-373, 1999-04-01 (Released:2013-01-18)

参考文献数

2

著者

佐々木 清

出版者

日本爬虫両棲類学会

雑誌

爬虫両棲類学会報 (ISSN:13455826)

巻号頁・発行日

vol.2005, no.1, pp.9-12, 2005-03-31 (Released:2010-06-28)

参考文献数

11

著者

山下 傳吉

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.6, no.5, pp.252-258, 1894-05-25 (Released:2010-10-13)

著者

Kohei Ogawa Osamu Komagata Toshihiko Hayashi Kentaro Itokawa Shigeru Morikawa Kyoko Sawabe Takashi Tomita

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2015.038, (Released:2015-06-12)

参考文献数

21

被引用文献数

8

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The objective of this study was to clarify the efficacy of a currently-available DEET repellent against tick species in Japan. We performed two different field trials: “human trap,” and “flag-dragging.” In total, 482 ticks were collected from white flannel cloths in field studies. The species of collected ticks consisted of Ixodes persulcatus and I. ovatus which accounted for 5.3 and 94.7% in the human trap test and 31.4 and 68.6% in the flag-dragging test, respectively. The repellency levels of DEET-treated flannel cloths in the human trap and flag-dragging tests were 84.0 and 99.7%, respectively. The escape time of I. persulcatus and I. ovatus female adults from DEET-treated flannel cloth was measured. Median escape times for I. persulcatus and I. ovatus on DEET-treated flannel cloth were 48 s (95% CI: 30–96) and 10 s (95% CI: 5–24), respectively. In contrast, many ticks remained on untreated flannel for 10 min after mounting. These results indicate that DEET repellents appear to prevent tick bites and that the use of DEET repellents against ticks is effective as a personal protective measure.

著者

高橋 幸利

出版者

日本神経学会

雑誌

臨床神経学 (ISSN:0009918X)

巻号頁・発行日

vol.52, no.11, pp.836-839, 2012 (Released:2012-11-29)

参考文献数

9

被引用文献数

2 1

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感染などにともなう免疫反応によって脳炎症状がおこる2次性脳炎(脳症)には,自然免疫が関与するものと,獲得免疫が関与するものが存在する.後者の内で細胞表面抗原に対する自己抗体の関与する脳炎では比較的予後が良いとされる.抗NMDA型Glutamate receptor(GluR)抗体の関与する脳炎は,小児から40歳までくらいの成人に多く,辺縁系症状で発病,抗体がNMDA型GluRの内在化をおこし,NMDA型GluR拮抗作用―機能抑制をもたらし,脳炎症状を起こすと考えられている.抗voltage-gated potassium channel(VGKC)抗体の関与する脳炎には抗Leucine-rich glioma-inactivated 1(LGI1)抗体および抗contactin-associate protein(CASPR)2抗体による脳炎があるが,男性に多い.α-enolaseのN末に対する抗体(抗NAE抗体)による橋本脳症の臨床特徴は幅広く,抗TPO抗体スクリーニング陽性例では抗NAE抗体による確定診断が必要である.

著者

James H. Diaz Chih-yang Hu

出版者

日本熱帯医学会

雑誌

Tropical Medicine and Health (ISSN:13488945)

巻号頁・発行日

vol.37, no.3, pp.79-95, 2009 (Released:2009-09-30)

参考文献数

72

被引用文献数

1 1

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Seafood is an important source of dietary protein worldwide, especially for coastal and island dwellers who now comprise 70% of the world’s population. Besides being high in protein and providing 40% of the world’s protein intake, seafood is low in cholesterol and saturated fatty acids and contains unique long-chain omega-3 polyunsaturated fatty acids (PUFAs). Two seafood PUFAs, eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) inhibit platelet aggregation and reduce mortality from myocardial infarction (MI) and ischemic stroke. Although the United States (U.S.) scientific community has recommended a Mediterranean-type diet, based on beneficial PUFAs in seafood, the European scientific community has cautioned that the increasing methylmercury levels in seafood may counteract any cardioprotective effects of PUFAs and actually increase risks of MI. This review describes the health benefits of seafood consumption and makes recommendations for the safe selection and preparation of seafood. In addition, this review describes the burden of seafood-borne diseases, separates seafood-borne toxic, heavy metal, and pesticide poisonings from seafood-borne infectious diseases; and makes recommendations for the management and prevention of seafood-borne illnesses. With the exception of some of the toxic seafood-borne illnesses, most seafood-borne infectious diseases, heavy metal poisonings, and pesticide poisonings can be prevented by careful selection and preparation of fresh seafood and adherence to weekly seafood consumption advisories, especially for those at highest risk of methylmercury poisoning, such as women who are pregnant, breastfeeding, or of child-bearing age, and children age seven and younger. A balanced diet combining protein from a variety of sources, including carefully selected and prepared seafood, along with natural antioxidants from fruits and vegetables is recommended to prevent seafood-borne diseases and to promote health and longevity.

著者

Yi X. Chan Matthew W. Knuiman Joseph Hung Mark L. Divitini David J. Handelsman John P. Beilby Brendan McQuillan Bu B. Yeap

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ15-0196, (Released:2015-06-13)

被引用文献数

1 21

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Clarifying the relationship of sex hormones to preclinical atherosclerosis could illuminate pathways by which androgens are associated with cardiovascular events and mortality. Our aim was to determine hormone profiles associated with carotid intima-media thickness (CIMT) and carotid atheroma, in men with and without known coronary artery disease (CAD). We included 492 community-based men aged 20-70 years (Group A) and 426 men with angiographically proven CAD aged <60 years (Group B). Fasting early morning sera were assayed for testosterone (T), dihydrotestosterone (DHT) and estradiol (E2) using mass spectrometry. CIMT and carotid plaque were assessed ultrasonographically. Mean (±SD) age was Group A: 53.8±12.6 and Group B: 49.6±5.1 years. Higher T was associated with reduced CIMT (-0.011 mm per 1-SD increase, p=0.042) and lower prevalence of carotid plaque (odds ratio [OR] per 1-SD increase, 0.68, p=0.012) in Group A, but not B. E2 was associated with increased CIMT in Group A (0.013 mm, p=0.011) but not B. Higher DHT and E2 were associated with reduced carotid plaque in Group B (DHT: OR=0.77, p=0.024; E2: OR=0.75, p=0.008), but not A. In community-dwelling men, higher T is associated with favourable CIMT and lower prevalence of carotid plaque, while higher E2 is associated with worse CIMT. In men with CAD, higher DHT or E2 are associated with less carotid plaque. T, DHT and E2 are differentially associated with preclinical carotid atherosclerosis in a cardiovascular phenotype-specific manner. Interventional studies are needed to examine effects of exogenous T and its metabolites DHT and E2, on atherogenesis.

著者

石黒 辰雄

出版者

一般社団法人 電子情報通信学会

雑誌

電子情報通信学会 基礎・境界ソサイエティ Fundamentals Review (ISSN:18820875)

巻号頁・発行日

vol.4, no.4, pp.276-281, 2011-04-01 (Released:2011-04-01)

参考文献数

4

著者

Mitsuhiro IRIE Yoshinori TAKEUCHI Yuzo OHTAKE Hitomi SUZUKI Nao NAGATA Takuma MIYOSHI Yumiko KAGAWA Tetsushi YAMAGAMI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0096, (Released:2015-06-12)

被引用文献数

2 21

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A 13-year-old spayed mixed-breed dog was diagnosed with a gastrointestinal stromal tumor (GIST) after histopathological examination of an abdominal mass. Five months after surgical resection of the tumor, we detected the recurrence of GIST with multiple disseminated abdominal lesions. A sequence analysis of cDNA obtained from a biopsy of the recurrent tumors revealed a mutation within exon 9 of the c-kit gene (1523A>T, Asn508Ile), which has been shown to cause ligand-independent phosphorylation of the KIT protein in GISTs and canine mast cell tumors (MCTs). Upon detection of the recurrent tumors, we initiated treatment with imatinib mesylate (10 mg/kg, q 24 hr). After 2 months, the dog achieved complete remission. Our findings indicate that canine GIST, and possibly MCT, may be responsive to molecular-targeted therapy.

著者

Masaya IGASE Kenji BABA Takako SHIMOKAWA-MIYAMA Shunsuke NOGUCHI Takuya MIZUNO Masaru OKUDA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0180, (Released:2015-06-11)

被引用文献数

5

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A 6-year-old spayed female Jack Russell Terrier presented with a 1-month history of lethargy, anorexia, vomiting, and weight loss. The dog was fed beef and chicken jerky treats daily in addition to a commercial diet. Laboratory tests revealed azotemia, hypokalemia, hyperchloremia, metabolic acidosis, and glucosuria with normoglycemia. Urine amino acid analysis showed significant amino acid loss into the urine. Thus, Fanconi syndrome was diagnosed, and based on the case history and extensive diagnostic testing, excessive consumption of jerky treats was strongly suspected as the cause. Glucosuria resolved 7 days after the withdrawal of jerky treats and fluid therapy. Aminoaciduria was substantially, but not completely, improved 3 months after diagnosis. Mild azotemia remained, suggesting chronic renal disease. To the best of our knowledge, this is the first reported case of Fanconi syndrome following the consumption of jerky treats in Japan.

著者

Seiya MAEHARA Yoshiki ITOH Sho HOSHINO Miri HAYASHI Yosuke ITO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0647, (Released:2015-06-13)

被引用文献数

4

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The purpose of this study was to evaluate the dark adaptation time in canine electroretinography (ERG) using a contact lens electrode with a built-in LED. Twelve eyes of six normal laboratory beagle dogs were used and exposed to steady room light at 500 lux for 30 min for light adaption. ERG was recorded at different time points during dark adaptation in sedated and light-adapted beagles. The stimulus intensity was 0.0096 cd/m2/sec. The b-wave amplitude increased significantly until 25 min of dark adaptation, whereas no significant changes in amplitudes were observed after 30 min. Dark adaptation for more than 25 min would be necessary for accurate ERG in canine ERG using a contact lens electrode with a built-in LED.

著者

大墨 竜也 竹中 彰治 坂上 雄樹 若松 里佳 寺尾 豊 大島 勇人 興地 隆史

出版者

特定非営利活動法人 日本歯周病学会

雑誌

日本歯周病学会会誌 (ISSN:03850110)

巻号頁・発行日

vol.56, no.3, pp.291-301, 2014-09-19 (Released:2015-02-18)

参考文献数

49

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本研究では,リステリン®の刺激性や使用感の改善を意図して開発された新規アルコール非含有洗口液®ナチュラルケア;N 群)の Streptococcus mutans 人工バイオフィルムに対する浸透性と殺菌能を既存洗口液[Listerine® Zero(Z 群),リステリン®フレッシュミント(F 群)および 0.12%グルコン酸クロルヘキシジン含有洗口液(CHG 群)]との比較により評価した。人工バイオフィルムはガラスベースディッシュ上で 24 時間嫌気培養することにより作製した。洗口液の浸透性は calcein-AM で染色したバイオフィルムの底面の蛍光消失を共焦点レーザー顕微鏡で経時的に解析することにより評価した。殺菌能は 30 秒作用後の生菌数測定およびバイオフィルム底面の Live/Dead 染色像により評価した。その結果,各洗口液とも 50%蛍光消失時間はバイオフィルムの厚みと正の相関を示し,N 群の浸透速度はZおよびF群と同等かつ CHG 群より有意に高値であった。 生菌数はN,ZおよびF群は同等で共に CHG 群より有意に低値であった。また, Live/Dead 染色像はN,ZおよびF群とも 99%以上が propidium iodide (PI)陽性細菌であり陽性率は CHG 群より有意に高かった。以上の結果から,N 群の浸透性と殺菌能は,Z 群および F 群と同等かつ CHG 群より有意に優れていることが示された。 日本歯周病学会会誌(日歯周誌)56(3):291-301,2014

著者

横坂 康彦

出版者

The Japan Society of Christian Studies

雑誌

日本の神学 (ISSN:02854848)

巻号頁・発行日

vol.49, pp.227-232, 2010-09-17 (Released:2012-01-30)

著者

濱岸 五郎 坂田 政弘 山下 敦弘 増谷 健 井上 益孝 志水 英二

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.121, no.5, pp.921-927, 2001-05-01 (Released:2008-12-19)

参考文献数

7

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We have newly developed two types of 15" high resolution non-glasses 3-D displays, the one is no cross-talk 3-D display using the double image splitter technology and the other is 2-D/3-D full compatible display using the image splitter and the controllable scattering shutter technology. In this time, in the 2-D/3-D full compatible display, controllable scattering shutter is united with image splitter in order to realize simple construction and short viewing distance of the non-glasses 3-D image. Those displays adopted newly developed head tracking system. The head tracking system detects the viewer's head position without special attachment and adjusts the images automatically. So it can expands the stereoscopic area. With this combination of larger screen, higher resolution and head tracking system, the display enables viewer to have more realistic and enjoyable images.