著者

丸山 佳重 丸山 倫夫 高田 俊範 原口 通比古 宇野 勝次

出版者

The Japanese Respiratory Society

雑誌

日本胸部疾患学会雑誌 (ISSN:03011542)

巻号頁・発行日

vol.32, no.1, pp.84-89, 1994-01-25 (Released:2010-02-23)

参考文献数

14

被引用文献数

1

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六君子湯による薬剤性間質性肺炎の1例を報告した. 症例は79歳, 女性で間質性肺炎の疑いで入院した. 労作時息切れと咳嗽, 胸部X線上両肺の容積減少とびまん性粒状網状影認めた. 薬剤性間質性肺炎を疑い, 全内服薬を中止すると共に, プレドニン治療を開始したところ, 臨床症状, 検査所見, 胸部X線・CT上に改善を認めた. 経気管支肺生検では間質性肺炎像を呈し, リンパ球刺激試験・白血球遊走阻止試験では六君子湯に対し陽性を示した. 当薬剤による薬剤性間質性肺炎の報告は本邦で第1例目と思われる.

著者

鈴木 和恵 立花 昭生 畠山 忍 岡野 弘

出版者

The Japanese Respiratory Society

雑誌

日本胸部疾患学会雑誌 (ISSN:03011542)

巻号頁・発行日

vol.33, no.2, pp.156-159, 1995-02-25 (Released:2010-02-23)

参考文献数

11

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シロスタゾールによる薬剤性肺炎の1例を経験したので報告する. 症例は73歳男性. 3回目の急性心筋梗塞を発症し, シロスタゾールの内服が開始された. 約70日後に呼吸困難, 乾性咳嗽, 発熱が出現した. 高度の低酸素血症と胸部X線, 胸部CTでびまん性スリガラス様濃度上昇を認めた. 薬剤性肺炎を疑い, 硝酸イソソルビド (冠動脈拡張剤) を除くすべての薬剤の中止とステロイド治療を施行し, 改善した. シロスタゾールのリンパ球刺激試験は陽性であり, 同剤による薬剤性肺炎と考えられた. これまでにシクロスタゾールによる薬剤性肺炎の報告はみられず, 本症例が第一例と思われる.

著者

長谷川 大 南須原 康行 真木 健裕 三浦 巧 別役 智子 檜澤 伸之 西村 正治 小野塚 久夫 筒井 裕之

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.95, no.7, pp.1362-1364, 2006-07-10 (Released:2009-03-27)

参考文献数

7

被引用文献数

2

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症例は70歳男性. 発作性心房細動に対し, コハク酸シベンゾリン (シベノール®) の服用を開始したところ, 15日目ごろより労作時呼吸困難を自覚し, 25日目に胸部異常陰影を指摘された. 抗生剤投与にて改善がみられないため, 我々はコハク酸シベンゾリンによる薬剤性肺炎も疑い, 同剤を中止した上でステロイド治療を施行した. 肺炎の改善を認めたが発作性心房細動が再発したため, 慎重な観察の下同剤を再開したところ肺炎の再増悪を認めた. 以上よりコハク酸シベンゾリンによる薬剤性肺炎と診断した.

著者

Hideyuki Yamamoto Sayomi Higa-Nakamine Nobuhiro Noguchi Noriko Maeda Yutaka Kondo Seikichi Toku Ichiro Kukita Kazuhiro Sugahara

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

pp.13R11CP, (Released:2014-02-19)

参考文献数

28

被引用文献数

2 17

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Four transmembrane tyrosine kinases constitute the ErbB protein family: epidermal growth factor receptor (EGFR) or ErbB1, ErbB2, ErbB3, and ErbB4. In general, the structure and mechanism of the activation of these members are similar. However, significant differences in homologous desensitization are known between EGFR and ErbB4. Desensitization of ligand-occupied EGFR occurs by endocytosis, while that of ErbB4 occurs by selective cleavage at the cell surface. Because ErbB4 is abundantly expressed in neurons from fetal to adult brains, elucidation of the desensitization mechanism is important to understand neuronal development and synaptic functions. Recently, it has become clear that heterologous desensitization of EGFR and ErbB4 are induced by endocytosis and cleavage, respectively, similar to homologous desensitization. It has been reported that heterologous desensitization of EGFR is induced by serine phosphorylation of EGFR via the p38 mitogen-activated protein kinase (p38 MAP kinase) pathway in various cell lines, including alveolar epithelial cells. In contrast, the protein kinase C pathway is involved in ErbB4 cleavage. In this review, we will describe recent advances in the desensitization mechanisms of EGFR and ErbB4, mainly in alveolar epithelial cells and hypothalamic neurons, respectively.

著者

小川 浩三

出版者

法制史学会

雑誌

法制史研究 (ISSN:04412508)

巻号頁・発行日

vol.2007, no.57, pp.217-220, 2007 (Released:2013-04-01)

著者

池田 香織 高原 志保 孫 徹 岩倉 敏夫 松岡 直樹 小林 宏正 石原 隆

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.50, no.2, pp.129-135, 2007 (Released:2009-05-20)

参考文献数

16

被引用文献数

6

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糖尿病治療薬による重症低血糖症が最近増加している可能性がある.われわれは,2003年から2005年の3年間に当院救急外来にて薬剤性低血糖による意識障害と診断された2型糖尿病患者50例の特徴を検討した.男性29例,女性21例,年齢は75.6±10.0歳と高齢で,スルホニル尿素薬(SU薬)使用36例,インスリン使用13例,併用1例であった.HbA1c≤6.0%の症例が23例と多く,低血糖症の原因は主に,ハイリスク患者へのSU薬の適用と過剰な投与,腎機能障害,肝機能障害,食事摂取不足であった.ハイリスク患者とは高齢患者や腎機能低下患者である.24例の意識状態が昏睡であり,推定昏睡時間が10時間を超えた3例については治療後も脳障害が残った.患者の増加や高齢化に伴って,糖尿病治療の現場は専門医以外の医療現場に広がりつつあり,特に高齢者や腎機能低下患者に関する適切なガイドラインの普及が必要である.

著者

細谷 雄一

出版者

日本EU学会

雑誌

日本EU学会年報 (ISSN:18843123)

巻号頁・発行日

vol.2001, no.21, pp.34-63,249, 2001-09-30 (Released:2010-05-21)

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Since 1980s, “European integration history”, which has been developed mainly by the European Community Liason Committee of Historians with using newly opend archives, has revealed many new historical evidences. Research on the relations between the Schuman Plan and Britain is one of the biggest issues of that development. However, the study on the “Eden Plan” has been rarely mentioned in the hitherto studies. The study on the Schuman Plan has been usually explained with the development of the Franco-German reconciliation. In this article, it was argued that the relationship between Britain and France was the most important aspect of the beginning of the European integration between 1948 and 1950. The Schuman Plan can be best understood by seeing the Anglo-Franco cooperation and conflict in the period. The year 1948 was marked by several important events such as the establishment of the Brussels Treaty, the Congress of Europe at The Hague, and Georges Bidault's plan on the “European Assembly”. Then in this avricle, the “Eden Plan” was discussed.The “Eden Plan” tells us many important aspects of the relations between the Schuman Plan and Britain in the early 1950s. First, it can be said that Anthony Eden was much more constructive and supportive towards the Schuman Plan than Winston S. Churchill or Harold Macmillan, who were usually regarded as the eminent “Pro-European” Conservatives. Anthony Eden tried to save the Schuman Plan, while finding the best answer to link the British Commonwealth to the Schuman Plan. Eden's approach could be the best possible British plan to join the European integration movement planned by Monnet. However, because of the suspicion of Jean Monnet towards British Government's intention, Monnet refused this possible important contribution by British Foreign Secretary. With the failure of the two Monnet's plans of political integration, the European Defence Community and European Political Community, in 1954, Monnet faced the stalemate of his own approach without having Britain inside.Thus, it is important to see the history of the relations between Britain and France from 1948 to 1954 to understand the beginning of European integration. Too narrow approach to study the Schuman Plan often ignores the origins of the Schuman Plan and the possible Britain's close relation to the plan. If Monnet showed a little more tolerance to Britain's approach, and if Britain showed a little bolder advancement to the integration, the later history of European integration should have been developed through the Anglo-France cooperation.

著者

藁谷 敏晴

出版者

日本哲学会

雑誌

哲学 (ISSN:03873358)

巻号頁・発行日

vol.1981, no.31, pp.223-234, 1981-05-01 (Released:2009-07-23)

著者

丸山 公一 中村 純也 吉見 享祐

出版者

一般社団法人 日本鉄鋼協会

雑誌

鉄と鋼 (ISSN:00211575)

巻号頁・発行日

vol.100, no.3, pp.414-420, 2014 (Released:2014-02-28)

参考文献数

22

被引用文献数

2

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Conventional time-temperature-parameter (TTP) methods often overestimate long-term creep rupture life of high Cr ferritic steels. The cause of the overestimation is examined paying attention to temperature and stress dependence of creep rupture life of Gr.91, 92 and 122 steels. In stress-rupture data of all the three steels there are four regions with different values of stress exponent n for rupture life. Activation energies Q for rupture life in the regions take at least three different values. The values of n and Q decrease in a longer-term region. The decrease in Q value is the cause of the overestimation of long-term rupture life predicted by the conventional TTP methods unable to deal with the change in Q value. Therefore, before applying a TTP analysis to stress-rupture data, the data should be divided into several data sets so that Q value is unique in each divided data set. When this multi-region analysis is adopted, all the data points of the steels can be described with higher accuracy, and their long-term rupture life can be evaluated more correctly.

著者

浜口 登

出版者

日本国際経済学会

雑誌

The International Economy (ISSN:21866074)

巻号頁・発行日

vol.1995, no.1, pp.89-91, 1995-02-28 (Released:2010-07-07)

著者

田村 すゞ子

出版者

日本言語学会

雑誌

言語研究 (ISSN:00243914)

巻号頁・発行日

vol.1978, no.74, pp.37-56, 1978-10-31 (Released:2010-11-26)

参考文献数

1

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The dialect dealt with in this paper is the one spoken in Rankin Inlet. N. W. T., which the author learned in 1977 from Mr. S. T. Mallon of the Government of N. W. T. and others, most of whom were native speakers of the dialect.

著者

Rafael MORAN-MUÑOZ J. A. IBANCOVICHI Eduardo GUTIERREZ-BLANCO Carlos M. ACEVEDO-ARCIQUE J. Mauro VICTORIA MORA Francisco J. TENDILLO Martin SANTOS-GONZALEZ Kazuto YAMASHITA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0407, (Released:2014-02-27)

被引用文献数

3 21

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The aim of this study was to determine the effects of lidocaine (LIDO) and dexmedetomidine (DEX) or their combination (LIDO–DEX), administered by constant-rate infusion (CRI), on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Seven healthy mongrel dogs were used with a 2-week washout interval between treatments in this study. Anesthesia was induced with propofol and maintained with sevoflurane in oxygen and MAC of sevoflurane was determined after 90 min equilibration period in the dogs (SEV-MACBASAL). Then, sevoflurane MAC was determined again in the dogs after 45 min equilibration period of one of the following treatments: an intravenous loading dose of lidocaine 2 mg/kg followed by 6 mg/kg/hr CRI (SEV-MACLIDO); an intravenous loading dose of dexmedetomidine 2 µg/kg followed by 2 µg/kg/hr CRI (SEV-MACDEX); or their combination (SEV-MACLIDO-DEX). These SEV-MACs were determined in duplicate. Data were analyzed using ANOVA and post hoc Tuckey test when appropriate. The SEV-MACBASAL was 1.82 ± 0.06%, SEV-MACLIDO was 1.38 ± 0.08%, SEV-MACDEX was 1.22 ± 0.10%, and SEV-MACLIDO-DEX was 0.78 ± 0.06%. The CRI administration of lidocaine, dexmedetomidine and their combination produced a significant reduction in the MAC of sevoflurane by 26.1 ± 9.0% (P<0.0001), 43.7 ± 11.8% (P<0.0002) and 54.4 ± 9.8% (P<0.0001), respectively. The MAC reduction was significantly greater after the CRI combination of lidocaine and dexmedetomidine when compared with lidocaine CRI (P<0.0001) or dexmedetomidine CRI treatments (P<0.025).

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.77, no.9, pp.844-845, 2011-09-05 (Released:2012-03-05)

著者

Yoko Miyasaka

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.77, no.7, pp.1681-1683, 2013 (Released:2013-06-25)

参考文献数

15

被引用文献数

2 2

著者

石井 博之

出版者

理学療法科学学会

雑誌

理学療法科学 (ISSN:13411667)

巻号頁・発行日

vol.18, no.2, pp.95-98, 2003 (Released:2003-07-18)

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私が滞在したマレイシアとマラウイでは身体障害者が使用している補装具にも,また支給方法にも違いがみられた。特にマラウイにおいては経済的にも物的にも決して豊かではない状況で,現地で入手可能な材料を用いて補装具が作製されており,そのアイディアには驚かされた。今回,この2国における補装具・車椅子の現状と支給方法を紹介する。

著者

川名 国男

出版者

公益財団法人 山階鳥類研究所

雑誌

山階鳥類学雑誌 (ISSN:13485032)

巻号頁・発行日

vol.42, no.1, pp.96-101, 2010-09-30 (Released:2012-12-04)

参考文献数

3

被引用文献数

1

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The song of the Japanese Night Heron Gorsachius goisagi has long been known from its distinctive low, carrying call which sounds like ‘ivoh—’. The actual status of the song, however, has little been studied. The author conducted a comparative survey of the song at song posts and during the breeding period at breeding sites in Tokyo in 2008, using a digital voice recorder and a digital video camera to record the song. The study documented the song at song posts during night for 10 consecutive nights. The song usually continued from sunset until next morning and in an extreme case, lasted for 10 hours. However, once a breeding pair was established, they immediately stopped singing and thereafter, the song was not observed during the breeding period regardless of day or night. Results of this study suggest that the singing activity of the Japanese Night Herons is done intensively at night for a short period from immediately after their arrival in Japan up until pair formation occurs, and that thereafter, no singing occurs either during the daytime or at night. The Japanese Night Heron derived its common name from the belief that it was a nocturnal species. This might be because male birds sing intensively only at night. However, the results of the present and previous studies revealed that this species to forage exclusively during the daytime both in the breeding and non-breeding seasons. This species can therefore be considered diurnal, except for short periods.

著者

Stefano TETÈ Vincenzo Luca ZIZZARI Bruna BORELLI Marianna DE COLLI Susi ZARA Roberto SORRENTINO Antonio SCARANO Enrico GHERLONE Amelia CATALDI Fernando ZARONE

出版者

日本歯科理工学会

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

vol.33, no.1, pp.7-15, 2014-01-30 (Released:2014-02-01)

参考文献数

34

被引用文献数

5 31

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Human gingival fibroblasts (HGFs) were cultured onto CAD/CAM zirconia (Group A), CAD/CAM zirconia after polishing (Group B), CAD/CAM lithium disilicate after polishing (Group C), and feldspathic ceramic (Group D) to evaluate their proliferation and adhesion potential. After 3 h, HGF adhesion was similar in all groups. Later, HGFs closely adhered to surfaces, particularly onto groups B, C and D, acquiring an elongated shape. Proliferation assay showed no differences in cell viability among the groups after 24 h, while significant increase was shown after 72 h in Groups B and C. After 24 h, similar Collagen I levels were found in all groups, while after 72 h Groups B and C revealed a deep reduction in respect to the 24 h level. In vitro, HGF behavior may reflect variability in soft tissue response to different surface materials for prosthetic restorations, and support that polished zirconia is able to achieve a better integration in vivo in respect to the other materials.

著者

Francesc Codony Mariana Fittipaldi Esther López Jordi Morató Gemma Agustí

出版者

日本微生物生態学会 / 日本土壌微生物学会 / Taiwan Society of Microbial Ecology / 植物微生物研究会

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.27, no.4, pp.529-532, 2012 (Released:2012-12-07)

参考文献数

20

被引用文献数

9 20

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Waddlia chondrophila is an emerging pathogen considered as a potential agent of abortion in humans and bovines, and is related with human respiratory disease. Despite these findings, the infection source and transmission pathways have not been identified. The evidence of growth into amoeba suggests water as a possible environmental source. The presence of Waddlia chondrophila was determined in drinking and well water samples (n=70) by quantitative PCR (Q-PCR). Positive results were observed in 10 (25%) of the 40 well samples analyzed; therefore, well water could be a potential reservoir and possible infection source of Waddlia chondrophila in animals and humans.

著者

吉田 寛 田尻 孝 真々田 裕宏 谷合 信彦 平方 敦史 川野 陽一 水口 義昭 清水 哲也 高橋 翼

出版者

日本門脈圧亢進症学会

雑誌

日本門脈圧亢進症学会雑誌 (ISSN:13448447)

巻号頁・発行日

vol.8, no.3, pp.185-188, 2002-12-15 (Released:2012-09-24)

参考文献数

9

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内視鏡的静脈瘤結紮術 (EVL) の意義と適応を検討した.対象は, 初回にEVLを施行した80例で, 後日EVL追加した34例 (EVL群) と後日1%ASによる内視鏡的硬化療法 (EIS) を追加した46例 (EVL+EIS群) の2群に分類した. (EVL, EVL+EIS) (mean±SD) (1) 完全消失率 (94.1, 93.5%) (NS), 治療回数 (2.5±0.5, 3.1±1.0回) (p<0.005), 総結紮数 (22.1±8.2, 13.2±4.9) (p<0.0001). (2) 累積初回再発率は有意にEVL群で高率 (p<0.05). (3) 再発例 (30例, 36例) (NS) に対する追加治療再入院回数 (1.8±0.6, 2.9±1.2回) (p<0.0001).うち手術, 塞栓術を追加例 (3例, 12例) (p<0.05) であった.EVL群では再発率は高率だが, 少ない追加治療回数にてコントロール可能であった.-方EVL+EIS群は, 内視鏡治療の限界例が多かった.EVLは, 当初より再発を念頭にいれ, 追加治療も含めて一連の治療法と考えれば, 良好な長期成績が得られ, first choiceの治療法になりうる.

著者

Keiya KOBAYASHI Yasutomo HORI Syuuichi CHIMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0554, (Released:2014-02-24)

被引用文献数

1 7

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The detailed information between plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations and dogs with pulmonic stenosis (PS) are still unknown. The aim of the present study was to investigate the clinical utility of measuring plasma NT-proBNP concentrations in dogs with PS and to determine whether plasma NT-proBNP concentration could be used to assess disease severity. This retrospective study enrolled 30 client-owned, untreated dogs with PS (asymptomatic [n=23] and symptomatic [n=7]) and 11 healthy laboratory beagles. Results of physical examination, thoracic radiography, and echocardiography were recorded. Plasma NT-proBNP concentrations were measured using commercial laboratories. Compared to the healthy control dogs, cardiothoracic ratio was significantly increased in dogs with both asymptomatic and symptomatic PS. Similarly, the ratio of the main pulmonary artery to aorta was significantly decreased in dogs with both asymptomatic and symptomatic PS. The pulmonic pressure gradient in the symptomatic PS dogs was significantly higher than those in the asymptomatic PS dogs. Plasma NT-proBNP concentration was significantly elevated in the symptomatic PS dogs compared to the healthy control dogs and the asymptomatic PS dogs. Furthermore, the Doppler-derived pulmonic pressure gradient was significantly correlated with the plasma NT-proBNP concentration (r=0.78, r 2=0.61, P<0.0001). Plasma NT-proBNP concentration>764 pmol/l to identify severe PS had a sensitivity of 76.2% and specificity of 81.8%. The plasma NT-proBNP concentration increased by spontaneous PS, i.e. right-sided pressure overload, and can be used as an additional method to assess the severity of PS in dogs.