1 0 0 0 OA 度日閑言

著者
古賀, 茶渓
出版者
巻号頁・発行日
vol.[15],
著者
森本 哲 古川 裕 和田 紀子 澤田 淳
出版者
日本小児保健協会
雑誌
小児保健研究 (ISSN:00374113)
巻号頁・発行日
vol.54, no.6, pp.718-723, 1995-11-30
参考文献数
13
被引用文献数
3
著者
沢田 誠吾 八重樫 隆 古田 富雄 横倉 輝男 宮坂 貞
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.41, no.2, pp.310-313, 1993-02-15 (Released:2008-03-31)
参考文献数
22
被引用文献数
13 20

7-Ethylcamptothecin (1d), a model which does not have any site on the A-ring for further modification was converted into water-soluble derivatives by opening the E-ring lactone. 1d was heated in N, N-dimethylenediamine to yield amide 2a, and this was then acylated to furnish 3a-q, which were soluble in water as their HCl salts. The propionyl (3b), butyryl (3c) and methylthiopropionyl (3h) derivatives showed higher activity than the sodium salt of 1d. The acyl group makes the derivatives more lipophilic, and ease of hydrolysis of amide 2a to 1d is thought to be necessary for significant activity.
著者
八重樫 隆 沢田 誠吾 古田 富雄 横倉 輝男 山口 健太郎 宮坂 貞
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.41, no.5, pp.971-974, 1993-05-15 (Released:2008-03-31)
参考文献数
10
被引用文献数
6 10

The structure of the N-amino pyridone (4a) obtained by the reaction of camptothecin (1a) with hydrazine was determined by X-ray crystallography. A mixture of 7-etylcamptothecin (1b) and hydrazine hydrate was stirred at room temperature, and the hydrazide (2b) was isolated as its diacetate 2c. Treatment of the 17-O-acetyl amide (5a) with hydrazine gave 1b (74% yield) and the N-amino lactam 6 (11% yield). Compounds with bulky acyl groups, 5c-e, gave 6 in modest yields. The N-amino lactam 6 was smoothly dehydrated into the pyridone 4d by refluxing in hydrazine hydrate.
著者
八重樫 隆 野方 健一郎 沢田 誠吾 古田 富雄 横倉 輝男 宮坂 貞
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.40, no.1, pp.131-135, 1992-01-25 (Released:2008-03-31)
参考文献数
19
被引用文献数
9 10

Water-soluble derivatives having the lactone ring intact were synthesized starting from 7-ethyl-10-hydroxycamptothecin (1). Glycosides (2) of the phenolic hydroxyl group of 1 were obtained by reaction with acetylated α-bromosugars in acetone or aqueous acetone in the presence of potassium carbonate, followed by deprotection.Phosphates (3) were prepared by reaction of 1 with phosphoryl chloride in pyridine or with dibenzylchlorophosphoridate.Sulfates (4) were obtained by reaction of 1 with sulfur trioxide-pyridine complex in the presence of a tertiary amine.The organic ammonium salts of monophosphate (3p) and sulfates (4a and 4b) showed significant activity against L1210 in vivo.
著者
沢田 誠吾 松岡 俊一 野方 健一郎 永田 洋 古田 富雄 横倉 輝男 宮坂 貞
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.39, no.12, pp.3183-3188, 1991-12-25 (Released:2008-03-31)
参考文献数
28
被引用文献数
39 57

20(S)-Camptothecin derivatives having nitro, amino, chloro, bromo, hydroxyl and methoxyl groups in the A-ring were synthesized. B-Ring hydrogenated camptothecin (2a) was converted into 10-hydroxycamptothecin (6e) by treatment with lead tetraacetate in trifluoroacetic acid. 10-Substituted derivatives (6) were obtained by a photoreaction of N-oxides (9). The cytotoxicity o the A-ring modified camptothecins was evaluated against KB cells in vitro and leukemia L1210 in mice. 7-Ethyl-10-hydroxycamptothecin (6i) was identified as a potential derivative for further modification.
著者
中山 智英 長谷川 直人 小西 和哉 阿部島 滋樹 市村 龍之助 金古 裕之
出版者
Japan Surgical Association
雑誌
日本臨床外科学会雑誌 (ISSN:13452843)
巻号頁・発行日
vol.67, no.9, pp.2101-2104, 2006-09-25 (Released:2009-01-22)
参考文献数
15

症例は3歳,男児. 2005年8月6日午後7時20分,自宅で玩具にて遊んでいる際,単5乾電池2個にて動いていた玩具の電池カバーがはずれており,そのうち1個を飲み込んだのを母親が目撃した.同日7時30分に当院救急外来を受診.救急外来到着時,呼吸苦や腹部症状はみられなかったが,腹部単純X線写真にて上腹部に誤飲した乾電池と思われる1×3cm大の陰影を確認.母親からの病歴聴取とあわせ乾電池の誤飲と診断した.透視下造影検査を行ったところ上部小腸まで乾電池が進んでいたため,緊急手術を施行した.下腹部正中切開にて開腹し,直視下に小腸まで進んでいた乾電池を確認.用手的に回盲部まで進め,虫垂切除術を施行し,虫垂切除断端より乾電池を摘出した.小児の筒型乾電池誤飲症例は報告が少なく,治療法も確立されていない.われわれは小児の筒型乾電池誤飲症例に対し,虫垂切除術を施行し摘出しえた1例を経験したので報告する.
著者
沢田 誠吾 岡島 悟 相山 律男 野方 健一郎 古田 富雄 横倉 輝雄 杉野 栄一 山口 健太郎 宮坂 貞
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.39, no.6, pp.1446-1454, 1991-06-25 (Released:2008-03-31)
参考文献数
18
被引用文献数
144 197

Nevel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HC1 salts wiht the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors.The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.
著者
沢田 誠吾 野方 健一郎 古田 富雄 横倉 輝男 宮坂 貞
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.39, no.10, pp.2574-2580, 1991-10-25 (Released:2008-03-31)
参考文献数
14
被引用文献数
44 56

A radical substitution reaction of 20(S)-camptothecin (1) with methanol furnished 7-hydroxymethylcamptothecin (2). Reaction of 1 with primary alcohols higher than methanol gave 7-alkylcamptothecins (4), of which alkyl groups were one carbon less than the alcohols used and also 7-hydroxyalkylcamptothecins (5). For the preparation of 7-alkylcamptothecin (4), aldehydes were used as a radical source and several alkylated derivatives were synthesized. 7-Acyloxymethyl derivatives (6), 7-carbaldehyde (7), iminomethyl derivatives (10), acid (11), esters (12) and amides (13) were synthesized starting from 2. 7-Ethyl-(4b) and 7-propylcamptothecin (4c), acyloxymethyl compounds 6a, 6c and ethyl ester (12b) exhibited higher antitumor activity than 1 against L1210 in mice.
著者
來村 徳信 笠井 俊信 吉川 真理子 高橋 賢 古崎 晃司 溝口 理一郎
出版者
一般社団法人 人工知能学会
雑誌
人工知能学会論文誌 (ISSN:13460714)
巻号頁・発行日
vol.17, no.1, pp.73-84, 2002 (Released:2002-04-04)
参考文献数
19
被引用文献数
4 4

In conceptual design, a designer decomposes a required function into sub-functions, so-called functional decomposition, using a kind of functional knowledge representing achievement relations among functions. Aimin at systematization of such functional knowledge, we proposed ontologies that guide conceptualization of artifacts from the functional point of view. This paper discusses its systematic description based on the functional ontologies. Firstly, we propose a new concept named “way of achievement” as a key concept for its systematization. Categorization of typical representations of the knowledge and organization as is-a hierarchies are also discussed. Such concept, categorization, and functional ontologies make the functional knowledge consistent and applicable to other domains. Next, the implementation of the functional ontologies and their utility on description of the knowledge are shown. Lastly, we discuss development of a knowledge-based system to help human designers redesign an existin artifact. The ontology of functional concepts and the systematic description of functional knowledge enable the supporting system to show designers a wide range of alternative ways and then to facilitate innovative redesign.
著者
古川
出版者
公益社団法人日本薬学会
雑誌
藥學雜誌 (ISSN:00316903)
巻号頁・発行日
no.104, pp.698-705, 1890-10-26
著者
高古堂, 主人
出版者
小幡宗左衛門
巻号頁・発行日
vol.[2], 1770
著者
渡邊 香織 本岡 夏子 古川 洋子 渡邊 友美子
出版者
一般社団法人 日本女性心身医学会
雑誌
女性心身医学 (ISSN:13452894)
巻号頁・発行日
vol.18, no.2, pp.256-263, 2013-11-30 (Released:2017-01-26)

【目的】本研究は,縦断的調査により妊娠期の身体活動量を明らかにし,不安および分娩経過との関連性を検討することを目的とした.【方法】対象は妊娠の経過が正常である初産婦28名であり,分娩経過との関連についての検討は37週以降の経膣分娩をした20名(正常分娩)を対象とした.また,帝王切開などの8名を異常分娩として,正常分娩との比較を行った.身体活動量(歩数,活動強度・時間)は,妊娠20週より分娩前日までの期間に,連続して生活習慣記録機を装着して得られたデータを対象とした.身体活動量は活動強度の低い順から,強度1〜3を低強度,4〜6を中強度,7〜9を高強度とそれぞれの身体活動に分類し時間を求めた.不安は妊娠13〜18週,妊娠24〜27週,妊娠32〜36週の3回,State-Trait Anxiety Inventory(以下STAI)の測定を実施した.【結果】歩数について回帰分析の結果,正常分娩であった妊婦では「歩数=8,719.73-55.76×妊娠週数」(p<0.001,Adjusted R^2=.646),異常分娩であった妊婦では「歩数=8,966.29-62.37×妊娠週数」(p<0.05, Adjusted R^2=.913)の回帰式が得られた.妊娠32〜36週のSTAIと妊娠末期の身体活動量との相関では,STAI状態不安と平均歩数,及び中強度身体活動時間に中程度の負の相関を認め,分娩所要時間と体重増加量,及び状態不安に中程度の正の相関を認めた.さらに「分娩所要時間(分)=693.43+69.97×体重増加量-7.24×妊娠末期の妊娠中期に対する歩数の比率」の重回帰式が得られた(p<0.05,Adjusted R^2=.339).【結論】妊娠中期以降の歩数は,妊娠週数を重ねるに従い減少すること,妊娠中の歩数よりも妊娠経過に伴う身体活動量の減少率と体重増加量が分娩所要時間に影響することが明らかになった.また,日常生活に中強度以上の身体活動に相当する早歩きを取り入れることで,妊娠期の不安を軽減できる可能性が示唆された.
著者
古川 博文 松井 紀久男 島田 英樹
出版者
一般社団法人 資源・素材学会
雑誌
資源と素材 (ISSN:09161740)
巻号頁・発行日
vol.121, no.9, pp.446-455, 2005 (Released:2007-02-24)
参考文献数
6
被引用文献数
1 3

India is the third largest coal producer in the world and has substantial coal reserves. It produced about 340 million tons of coal in 2002-2003. Open cast production accounts for 80% of the total output and the remaining 20% is from underground. The share of the underground output in the total production is expected to remain at the current level through 2010 even as the coal production increases. Despite its huge resource of coal, the quality of Indian coal is not so good. A considerable amount of good quality coal deposits in India lies in the thickness range of 5-12 m. However, an appropriate mining method for such thick seams could not be developed so far.The coal's share of total electric power generation in India is 75.5% in 2001. Because it is a reliable, domestic, and low-cost source of fuel, coal has played and will continue to play a significant role in the development of the Indian economy. Production, processing, and consumption of coal, however, can have significant environmental impacts, if not properly managed.The paper describes the present situation of the Indian coal mining industry, discusses problems in thick seam mining methods, and proposes a new mining method for thick seams considering today's environmental issues in Indian coal mining.