著者

大関 健一 青柳 宏 Kenichi OZEKI Hiroshi AOYAGI

出版者

宇都宮大学共同教育学部

雑誌

宇都宮大学共同教育学部研究紀要.第1部 = The Research Bulletin of the Cooperative Faculty of Education Utsunomiya University. Section 1 (ISSN:24325546)

巻号頁・発行日

no.71, pp.251-292, 2021-03-31

著者

森谷 美穂 橋本 璃乃 前田 桜 松木 亨 関 健二郎

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学会年会要旨集 第93回日本薬理学会年会 (ISSN:24354953)

巻号頁・発行日

pp.3-P-293, 2020 (Released:2020-03-18)

---

Re-experiencing trauma by overgeneralization is a hallmark of PTSD which is high comorbidity with depression. We thus studied the relation from overgeneralization to depression. Mice were subjected to context A with electric shock as a conditioning which was followed by unconditioned context B using a different, but similar box in 3h on Day1 and was followed by re-exposure to context A (Group ABA) or B (Group ABB) on Day2. Group ABA and ABB mice exhibited the longer freezing in context A and B on Day2. However, the mice which was not exposed to context B on Day1 (Group A-B) showed the shorter freezing time in context B on Day2, indicating that the overgeneralization was induced by experiencing the context B after the conditioning in 3 h. Group ABB mice exhibited the longer immobility time of tail suspension test (TST) than Group ABA and A-B. Freezing time in the first half of the test in context B and immobility time of TST in Group ABB were negatively correlated with the staying time of center zone in the box during the context B on Day1. In contrast, the freezing and immobility time of TST in Group ABA have positive correlation with the time of center zone during context B on Day1. These results suggest that the PTSD and depression may depend on the coping style during unconditioned context within a few hours after the trauma.

著者

横関 康祐 渡邉 賢三 取違 剛 関 健吾

出版者

公益社団法人 日本コンクリート工学会

雑誌

コンクリート工学 (ISSN:03871061)

巻号頁・発行日

vol.54, no.5, pp.531-536, 2016 (Released:2017-05-01)

参考文献数

20

被引用文献数

3 3

著者

金子 明裕 佐野 元昭 尾関 健二 大箸 信一

出版者

日本生物工学会

雑誌

日本生物工学会大会講演要旨集

巻号頁・発行日

vol.66, 2014

著者

石井 孝弘 小橋 一雄 竹嶋 理恵 長谷川 辰男 大関 健一郎 舩山 朋子 鈴木 幹夫 本間 信生 近藤 知子

雑誌

帝京科学大学紀要 = Bulletin of Teikyo University of Science (ISSN:18800580)

巻号頁・発行日

vol.12, pp.129-139, 2016-03-31

著者

横関 健三

出版者

公益社団法人 日本化学会

雑誌

化学と教育 (ISSN:03862151)

巻号頁・発行日

vol.47, no.7, pp.478-482, 1999-07-20 (Released:2017-07-11)

参考文献数

6

---

グルタミン酸発酵が誕生して約40年が経過した。この間, アミノ酸の製法開発は発酵法と酵素法を中心にめざましい発展を遂げ, 現在ではタンパク質を構成する20種類の天然型アミノ酸はもとより, 非天然型アミノ酸の製造も可能となった。グルタミン酸発酵の生誕以来, 数多くの技術革新に支えられ, アミノ酸の世界市場は1500∿2000億円規模を形成するに至った。本稿では, 工業的な観点からの代表的な製造法を紹介する。

著者

小関 健太郎 森田 武史 山口 高平

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会全国大会論文集 第34回全国大会(2020)

巻号頁・発行日

pp.4H3GS402, 2020 (Released:2020-06-19)

---

Linked Dataや知識グラフの観点から,知識の共有や意味内容に基づく処理の実現を目的としてさまざまな規模や領域のオントロジーが構築されている.これに伴って異なるオントロジーの統合とその利用が研究されているが,特にドメイン知識と一般知識の連携を目的として,教科オントロジーや法律オントロジーのようなドメインオントロジーと,日本語WikipediaオントロジーやYAGO等の大規模汎用オントロジーとの統合が注目されている.そこで本研究では,両者の統合における課題を考察し,信頼性や対象範囲のギャップに関する課題に対して,これらの課題を考慮したクラス階層の自動マージ手法を提案する.提案手法では,一方のオントロジーの知識を他方の知識に優先させる非対称な統合によって知識の訂正を行うことに加えて,普遍的・一般的な概念を体系化したオントロジーである上位オントロジーを導入することで,対象範囲によらず共通する上位階層での整合性の改善を図る.この際上位オントロジーの統一が必要となるが,上位階層を変更した大規模汎用オントロジーを新たに事前構築し評価を行った.

著者

二階堂 満 吉田 祐希 古関 健一 福村 卓也 渡邊 崇 戸谷 一英

出版者

一般社団法人 粉体工学会

雑誌

粉体工学会誌 (ISSN:03866157)

巻号頁・発行日

vol.55, no.9, pp.483-491, 2018-09-10 (Released:2018-10-25)

参考文献数

14

被引用文献数

1

---

This study is aimed to develop a beneficial use of disposed seashells. Sanriku region in Iwate prefecture has an issue of disposals of seashells. In this study, we mechanochemically ground seashells under dry or wet conditions. We used a planetary ball mill, a tumbling ball mill, and a converge mill as mechanochemical grinding machine. After the grinding, we examined the heavy metal absorbencies of the ground materials, and of the compounds with seashell-origin hydroxyapatite (HAP). As a result, followings were found out: 1) When seashell-origin hydroxyapatite was used, it showed adequate heavy metal absorbency (Cd, Pb). 2) When mechanochemically ground scallop seashells without HAP were used, it showed adequate heavy metal absorbency (Cd, Pb). 3) When the scallop seashells are ground for long time under dry condition (mechanochemical grinding), the material tends to be amorphous, and its heavy metal absorbency becomes greater.

著者

井川 恭子 井川 資英 小関 健由

出版者

特定非営利活動法人 日本歯周病学会

雑誌

特定非営利活動法人 日本歯周病学会学術大会 プログラムおよび講演抄録集 日本歯周病学会50周年記念大会プログラムおよび講演抄録集

巻号頁・発行日

pp.45, 2007 (Released:2007-08-31)

著者

藤井 史子 尾関 健二 神田 晃敬 浜地 正昭 布川 弥太郎

出版者

公益財団法人 日本醸造協会

雑誌

日本醸造協会誌 (ISSN:09147314)

巻号頁・発行日

vol.87, no.10, pp.757-759, 1992-10-15 (Released:2011-09-20)

参考文献数

5

被引用文献数

24 28

---

麹の酵素を失活させるため熱風乾燥した麹 (水分含量10%以下) を粉砕し, 糖化酵素剤ででんぷん等を消化除去せず, そのまま50mM燐酸緩衝液 (pH7.0) にて洗浄後, Yatalaseを作用させ, 生成したG1cNAc量をReissigらの方法により定量し菌体量を算出することで, 簡便に麹中の菌体量の定量が可能となった。また, 製麹時間毎の麹中の菌体量の推定も, 酸分解で生じるグルコサミン量と良好に一致した。

著者

有路 智恵 関 健介 金子 哲也

出版者

日本民族衛生学会

雑誌

民族衛生 (ISSN:03689395)

巻号頁・発行日

vol.80, no.3, pp.144-150, 2014 (Released:2014-07-23)

参考文献数

17

被引用文献数

3

---

Chie ARIJI1, Kensuke SEKI2 and Tetsuya KANEKO2Introduction : The low pass rate of candidates from the Republic of Indonesia taking the Japanese National Nurse Examination is a matter of national concern. We analyzed their answers to examination questions, and extracted weak points.Methods : We asked Indonesian examinees to reproduce their own answers to 50 compulsory questions in the 100th national examination (2011). They were also requested to extract difficult words, and evaluate the effectiveness of Japanese and English ruby.Results : Data from 42 examinees were analyzed. The only significant difference between two groups of examinees with and without sufficient scores was the years of their stay in Japan. There was no significant difference associated with the occupational or educational history. Japanese and English were judged as meaningless by both high-and middle-scoring groups. A total of 92 difficult words were extracted, and 80% of them were everyday language rather than medical terms. The rate of correctly answered questions with the extracted, difficult words in the text body or appropriate answers was significantly lower.Conclusions : Difficult common words clearly had a negative impact on candidates' score in the national examination, suggesting that daily active communication in Japanese would promote their progress toward passing the examination.

著者

水関 健司 笹井 芳樹

雑誌

臨床神経学 (ISSN:0009918X)

巻号頁・発行日

vol.42, no.11, 2002-11-01

著者

堤 竹蔵 今井 俊吾 山田 勝久 山田 武宏 笠師 久美子 小林 正紀 井関 健

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.139, no.7, pp.1055-1061, 2019-07-01 (Released:2019-07-01)

参考文献数

20

被引用文献数

2

---

Linezolid (LZD), an antimicrobial agent against methicillin-resistant Staphylococcus aureus, demonstrates good bone and joint penetration, and is used for prosthetic bone and joint infections. Recently, we observed vomiting in several patients administered LZD. However, there are few reports on the incidence rate of, and risk factors for, LZD-induced nausea and vomiting. In this study, we aimed to verify the relationship between LZD administration and vomiting. Patients administered LZD at the Department of Orthopedic Surgery of Hokkaido University Hospital between November 2008 and December 2017 were enrolled in the study. The primary endpoint was the comparison of the vomiting rate between patients administered LZD (LZD group) and those administered other antibiotics (non-LZD group). For the secondary endpoint, to verify the risk factors of vomiting, a univariate logistic regression analysis was performed. In total, 130 patients were included in this study; 77 patients in the LZD group, and 53 in the non-LZD group. Vomiting occurred in 18 patients in the LZD group and 4 patients in the non-LZD group (23.4% and 7.5%, respectively); this was significantly higher in the LZD group. In the univariate logistic regression analysis, LZD administration, gender (female), age ≥65 years, renal impairment (creatinine clearance <60 mL/min) and concomitant use of rifampicin were extracted as potential risk factors of vomiting. The results of this study reveal a possible relationship between LZD administration and vomiting.

著者

井藤 達也 高岡 和夫 竹本 功 秦 温信 井上 勝一 佐々木 健太郎 平野 剛 井関 健 菅原 満 宮崎 勝巳

出版者

The Japanese Society of Clinical Pharmacology and Therapeutics

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.33, no.2, pp.47-52, 2002-03-31 (Released:2010-06-28)

参考文献数

13

---

The purpose of this study was to evaluate the distribution of CPT-11 and its active metabolite, SN-38, in pleural and pericardial fluid after intravenous administration.Two patients with lung cancer were treated with intravenous CPT-11 (60 mg/m2) on days 1, 8, and 15. The CPT-11 was detected in the pleural fluid 1.5 hr after the begining of intravenous infusion, and the level reached the maximum 24 hrs later. Similarly, the active metabolite SN-38 was detected in the pleural fluid 1.5 hr after the begining of intravenous infusion, and SN-38 concentration in the pleural fluid was almost as high as that in plasma 24 hrs later. These results suggest that intravenously administered CPT-11 may penetrate the thoracic cavity and may be metabolized to SN-38 there. The proportions of maximum concentrations of CPT-11 and SN-38 in the pleural fluid to the corresponding plasma levels were 20.4% and 28.5%, respectively. In addition, the AUCs of the lactone form SN-38 were much lower than those of the carboxyl form in the pleural fluid.CPT-11, SN-38 and SN-38 glucronide showed similar pharmacokinetics in the pericardium as that in plasma.

著者

尾関 健二

出版者

Brewing Society of Japan

雑誌

日本醸造協会誌 (ISSN:09147314)

巻号頁・発行日

vol.106, no.8, pp.505, 2011 (Released:2017-02-22)

著者

澤井 俊宏 新美 敦 山田 陽一 渡邊 和代 小関 健司 中井 英貴 本田 雅規 藤本 雄大 野阪 泰弘 上田 実

出版者

公益社団法人 日本口腔インプラント学会

雑誌

日本口腔インプラント学会誌 (ISSN:09146695)

巻号頁・発行日

vol.9, no.1, pp.97-102, 1996-03-31 (Released:2017-11-05)

参考文献数

10

---

In the severely atrophic maxilla, prosthetic rehabilitation is difficult. However, rehabilitation using osseointegrated implants with bone grafting can resolve this problem. Among the various methods of bone graft to the maxilla, sinus lift is commonly used. This report presents two cases of oral rehabilitation using osseointegrated implants with the sinus lift. In case 1, grafted bone was harvested from the mental region of the mandible, and implantation was performed at the same time as the autogenous corticocancellous bone block graft. In case 2, grafted bone was harvested from the alveolar bone in the anterior region of the mandible, and implantation was performed secondarily after the autogenous particulate bone graft. Bone biopsy for histological analysis was performed in the above two cases. In both cases, new trabecular bone was observed in the augmented sinus floor. However, the trabeculae were more dense on the alveolar side than in the central area. In the case with splintered bone, empty bone lacunae were seen in the grafted region.

著者

矢野 育子 井関 健 東海林 徹 青山 隆夫 木津 純子 中村 均 藤井 俊志 渡邊 美智留 野田 幸裕 脇屋 義文 森田 邦彦 手嶋 大輔 二神 幸次郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.35, no.1, pp.43-49, 2009 (Released:2010-02-07)

参考文献数

8

被引用文献数

1 1

---

With the introduction of 6-year pharmacy educational program in 2006,a provision was made to assign pharmacist faculties having working experience as pharmacists in pharmacy schools.In October 2007,we conducted a survey to investigate the situation of pharmacist faculties.We sent a questionnaire to 247 pharmacist faculties in 66 pharmacy schools and the response rate was 84.9%.The faculties consisted of professors (43%),associate professors (23%) and lecturers (23%),and 77% of them had a Ph.D.degree.In a typical week,the major activities they engaged in were educational activities (20.6 hrs),research (12.2 hrs) and management (9.6 hrs).While the average time they were occupied by clinical practice was 3.5 hrs,67% of them did not do any.Half of the faculties did not conduct any research with students or graduate students in their own schools,and in 2007 only 55% applied for Grant-in-aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology of Japan.Twenty-six percent said they were very satisfied or satisfied with their work on a five-point scale,and 44% rated their degree of satisfaction as fair.In conclusion,our survey showed that most pharmacy faculties are not sufficiently engaged in clinical practice and do not spend much time in clinical research.We hope that its results will promote discussions among pharmacy personnel concerning the role of pharmacist faculties so that even better clinical pharmacy education may be provided to students in pharmacy schools.

著者

石坂 正大 石川 良太 伊藤 詩峰 遠藤 沙紀 君島 未紗 鯉沼 夢 佐藤 克己 関 健吾 田野 勝也 千明 龍太郎 淵田 悟

出版者

理学療法科学学会

雑誌

理学療法科学 (ISSN:13411667)

巻号頁・発行日

vol.31, no.4, pp.581-584, 2016

---

〔目的〕コンプレッションウェアの着用が酸素摂取量および心拍数に及ぼす影響を明らかにする.〔対象と方法〕対象は健常男性26名とした.対象者に対しトレッドミルでの心肺運動負荷試験を行い,裸とコンプレッションウェア着用の2つの着衣条件で酸素摂取量,心拍数,呼吸交換比,呼吸数を測定した.〔結果〕心肺運動負荷試験の運動前,中,後の心拍数(回/分)はそれぞれ,裸で84.4±11.8,156.9±12.3,110.2±22.1,着用時で81.2±11.9,151.7±14.7,102.0±10.4となり,後者の着衣条件で有意に低い値を示した.酸素摂取量,呼吸交換比,呼吸数では着衣条件間の有意な差がみられなかった.〔結語〕コンプレッションウェアの着用は酸素摂取量には影響しないが,運動時の心拍数を低下させる. <br>

著者

関 健 谷野 亮爾

出版者

科学評論社

雑誌

精神科 (ISSN:13474790)

巻号頁・発行日

vol.13, no.6, pp.502-505, 2008-12

被引用文献数

1

著者

鹿嶋 功貴 関 健太 上村 靖司

出版者

公益社団法人 日本雪氷学会/日本雪工学会

雑誌

雪氷研究大会講演要旨集 雪氷研究大会(2015・松本) (ISSN:18830870)

巻号頁・発行日

pp.214, 2015 (Released:2016-02-29)