著者

水谷 直人 石田 祐也 松井 博和 矢野 賢一 高橋 利道

出版者

一般社団法人 日本機械学会

雑誌

ロボティクス・メカトロニクス講演会講演概要集

巻号頁・発行日

vol.2016, pp.2P2-07b2, 2016

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<p>Vehicle performance tests are conducted to evaluate factors of vehicle performance such as fuel consumption and durability. Robotic drivers are often used in these tests to ensure that performance evaluate is reproducible. When the driver selects the gear ratio in Manual transmission, speed control performance is degraded during changing gear, because a torque transmission between the engine and wheels is cut during this sequence. In this paper, we realized the driving while considering shift changes by the robotic driver. First, we modeled the lack of a driving force. We then derived a target vehicle speed waveform using the lack of a driving force model. Finally, we performed vehicle tests using a robotic driver. We confirmed that the proposed system was effective based on the results of actual vehicle tests.</p>

著者

伊達 聖伸

出版者

木鐸社

雑誌

年報政治学 (ISSN:05494192)

巻号頁・発行日

vol.2013, no.1, pp.122-144, 2013

著者

Kazufumi KASUYA Nobuyuki TANAKA Fumi OSHIMA Nozomi FUJISAWA Megumi SAITO Katsunori TAGAMI Hidekazu NIWA Kazumi SASAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0656, (Released:2019-04-24)

被引用文献数

2

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Strangles is a commonly diagnosed and important infectious disease of equids worldwide, caused by Streptococcus equi subsp. equi. We determined the SeM genotypes of S. equi isolated from imported horses at the Japanese border within the past 8 years, which allowed us to classify 12 strains isolated from these horses from each exporter into four allelic groups. These alleles were different from the alleles of past isolates found in Japan. Furthermore, four strains classified into the same allele were isolated from horses from one exporter over several years. In this study, S. equi isolates from different exporters had different SeM alleles. Attention to the hygiene status of farms will be necessary to prevent the incursion of strangles.

著者

明周之〓撰

巻号頁・発行日

vol.[5], 1000

著者

Shinsuke Mii Atsushi Guntani Eisuke Kawakubo Hirofumi Shimazoe Masaru Ishida

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0005, (Released:2019-04-25)

参考文献数

30

被引用文献数

17

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Background:Nutritional status has been reported to be a predictor of the outcomes of critical limb ischemia. However, there have been no reports of the association between nutritional status and the prognosis of patients with intermittent claudication (IC). The aim of this study was to examine whether or not the geriatric nutritional risk index (GNRI) is independently associated with the long-term outcomes of elderly patients following open bypass for IC.Methods and Results:The preoperative nutritional status of patients aged ≥65 years undergoing infrainguinal bypass for IC between 1991 and 2017 was retrospectively evaluated using the GNRI. Patients were divided into 3 groups based on the GNRI: Group I (normal nutritional risk), GNRI >98; Group II (low nutritional risk), GNRI 92 to ≤98; Group III (moderate to high nutritional risk), GNRI <92. The amputation-free survival (AFS), overall survival, and freedom from cardiovascular death up to 5 years were calculated by Kaplan-Meier method and a multivariate analysis was performed to detect independent predictors of each outcome. Group I showed superior outcomes to Group III for each of the 3 outcomes and the multivariate analysis showed that GNRI was an independent predictor of AFS.Conclusions:The GNRI was independently associated with the AFS of elderly patients who underwent open bypass for IC.

著者

森本 史郎 安部 りょう子 福原 厚子 松村 靖夫

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.74, no.2, pp.239-249, 1978

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ラットにおけるmetolazone(MET)の利尿作用についてhydrochlorothiazide(HCT)と比較検討し,次の結果を得た.1)雄性ラットにおいて,METは0.O1mg/kgの経口投与から有意な利尿作用を示し,尿中Na排泄の増加をきたした.このNa利尿作用は,投与量0.01~0・5mg/kgまではほぼ用量依存的に増強されたが,さらに1~5mg/kgに増量しても作用強度に増大が認められなかった.尿中K排泄の増加も0.01mg/kgの投与から有意に増加したが,Naに比べて軽度であり,尿中Na/Kの上昇が認められた.METによる最大利尿効果は,対照尿量と比較して約2.5倍で,HCTよりやや強い程度であったが,最小有効量からみるとHCTの20倍強力であった.2)雄性ラットにおけるMET腹腔内投与による利尿作用は,最小有効量,作用強度ともに経口投与の場合とほぼ同じで,HCT腹腔内投与群に比べてやや強いNa利尿作用を示した.最少有効量から比較すると,METはHCTより10倍強力であった.3)これらMETおよびHCTの利尿作用には,雌雄両性ラットの間で有意差が認められなかった.4)METの経口投与あるいは腹腔内投与で,電解質排泄増加に一致して滲透圧クリアランスは著明に増加した.自由水再吸収量には増加傾向が認められたが有意なものではなかった.5)METは腎血漿流量,糸球体濾過量に明らかな影響を与えず,腎尿細管に直接作用し,電解質の再吸収を抑制することにより利尿作用を発揮するものと考える.

著者

御園生 尭久 吉見 武義 福田 利弘 小林 淳一 長尾 幸徳

出版者

公益社団法人 日本化学会

雑誌

日本化学会誌 (ISSN:03694577)

巻号頁・発行日

vol.1978, no.11, pp.1526-1531, 1978

被引用文献数

2

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1,8-ナフタレンジカルボキシミド[1a]およびN-メチル換-1,8-ナフタレンジカルボキシミド(X=H,OCH₃,0H,NH₂,SO₃Na)[Ib~f]をパラジウム触媒を用いて水素化することにより,[1f]の場合を除き,それぞれ相当するテトラヒドロ誘導体である1,2,3,4-テトラヒドロー1,8-ナフタレンジカルボキシミド[2a](収率77%),およびN-メチルー5-置換-1,2,3,4-テトラヒドロー1,8-ナフタレンジカルボキシミド(X=H,OCH₃,0H,NH₂)[2b~e](収率b:82%,c:62%,d:68%,e:78%)を得ることができた。<BR>さらに[1a]を同じ触媒でより強い条件で水素化するとデカリンー1,8-ジカルボキシミド[3]が得られることを確認した。また[2a]および[2b]を塩化アセチルで処理すると,それらのアシル誘導体である3-アセトキシー5,6-ジヒドロー4荏ベンゾ[de]インキノリンー1-オン[4a],および3-アセトキシー2-メチルー5,6-ジヒドロ-4-ベンゾ[de]インキノリンー1-オン[4b]を生じた。

著者

He Miao Jianjun Gao Zishuo Mou Baolei Wang Li Zhang Li Su Yantao Han Yepeng Luan

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2019.01055, (Released:2019-04-25)

参考文献数

31

被引用文献数

7

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Histone deacetylase is an important member of epigenetics and a well validated target for anti-cancer drug discovery. In this study, we designed and synthesized a series of twenty-one novel hydroxamic acid-based histone deacetylase inhibitors with 4-piperidin-4-yl-triazole as the core skeleton. Most target compounds displayed excellent inhibition rates toward histone deacetylases at the concentration of 1 μM. Among them, the inhibition rates of two compounds MH1-18 and MH1-21 exceeded 90%. Furthermore, these two compounds selectively inhibited the activity of histone deacetylase 6 with low IC50 values. The high potency of them toward histone deacetylase 6 was rationalized by molecular docking studies. We found that MH1-18 and MH1-21 moderately inhibited the proliferation of four human cancer cell lines SGC-7901, NCI-H226, MCF-7, and HL-60. However, MH1-21 showed potent efficacy in suppressing the migration of MCF-7 cells. Results obtained in the current study shed light on designing potent HDAC6 inhibitors as anti-cancer agents.

著者

亀沢 誠 小原 和子 橘 芳純

出版者

公益社団法人 日本化学会

雑誌

日本化学会誌 (ISSN:03694577)

巻号頁・発行日

vol.1985, no.1, pp.138-140, 1985

被引用文献数

2

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It has previously been reported that 7, 7'-dihydroxy-4, 4'-dimethyl-3, 4-dihydro-4, 6'-bicoumarin C 4 J was obtained from the reaction of resorcinol [1] J with methyl acetoacetate [2]. The reaction of [5], diacetate of [4] with aluminum chloride has no w been studied.<BR>The products were found to be 2, 4-diacetylresorcinol [6], 4, 6-diacetylresorcinol [7], 2, 4, 6-triacetylresorcinol [8] and 4, 6-dimethyl-2 H, 8 H-benzo [1, 2-b : 5, 4-b'] dipyran-2, 8-dione mainly on the spectroscopic evidence. Expected Fries reaction products of [5] [9] were not obtained.<BR>The plausible mechanism for the formation of [6]&sim;[9] is discussed briefly (Scheme 3).

著者

Yasunori KOYATA Kiyoko WATANABE Toshizo TOYAMA Haruka SASAKI Nobushiro HAMADA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.19-0067, (Released:2019-04-23)

被引用文献数

3

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Periodontal disease is a significant problem in companion animals such as dogs and cats. However, there is little information available about fimbriae association of periodontal disease in companion animals. In this study, we have purified and characterized a fimbriae from P. salivosa ATCC 49407. The molecular mass of this protein was approximately 60-kDa, as estimated by SDS-PAGE. Immunogold electron microscopy revealed that anti-60-kDa fimbrial serum bound to fimbria on the cell surface of P. salivosa ATCC 49407. However, fimbriae of P. gingivalis and P. gulae were not labeled with the same antibody. Immunoelectron-microscopic studies and immunoblot analysis revealed that antigenicity and molecular weight were distinct from previously reported Porphyromonas fimbrial proteins. The amino acid sequence of the N-terminal 15 residues of the 60-kDa fimbrillin protein revealed only 3 of 15 residues identical to other Porphyromonas species fimbrillin proteins. Thus, the N-terminal amino acid sequence of the 60-kDa fimbrillin protein of P. salivosa clearly differed from previously reported fimbrillin proteins. The level of adherence of the P. salivosa was 1.81%. It was confirmed that P. salivosa can adheres to human cells. These results suggest that the 60-kDa fimbriaeof P. salivosa ATCC 49407 is a new type of fimbria and may have an important factor in the adherence host cells. We suggest that the surface structure of P. salivosa may have a role in the colonization of this organism in periodontal pockets in companion animals.

著者

矢野一郎著

出版者

日本青年館

巻号頁・発行日

1924

著者

Kazutaka Aoki Haruhiro Sato Yasuo Terauchi

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ19-0041, (Released:2019-04-23)

被引用文献数

14

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Elevation of postprandial plasma glucose is correlated with an increase in cardiovascular events, and alpha-glucosidase inhibitors (αGIs) are effective at reducing postprandial glucose levels. In Japan, the αGIs acarbose, voglibose, and miglitol have been available since 1993, 1994, and 2006, respectively. Dipeptidyl peptidase-4 (DPP-4) inhibitors are also effective at reducing postprandial glucose levels, and they have been available in Japan since 2009. A combination therapy of αGI, miglitol, and the DPP-4 inhibitor, sitagliptin, is more effective at decreasing postprandial glucose levels than monotherapy with either miglitol or sitagliptin. Moreover, the combination therapy of miglitol and sitagliptin is more effective at increasing postprandial active glucagon-like peptide-1 (GLP-1) levels than monotherapy. Peptide YY (PYY) has appetite-suppressing and gastric-emptying effects similar to GLP-1. In healthy individuals, miglitol increases the postprandial total PYY; however, combination therapy of miglitol and vildagliptin does not change postprandial total PYY levels. αGIs are typically prescribed to be taken just before a meal, which can result in decreased drug adherence. Different patterns of αGI intake were examined, and the results showed that miglitol or acarbose administration after a meal is effective. The effects of taking miglitol dissolved in water during a meal appeared to be similar to that of taking miglitol as a tablet just before a meal. The long-term effects of taking miglitol dissolved in water should be evaluated in future studies. αGIs may be effective even when they are not taken before a meal, and a more flexible administration may improve drug adherence.

著者

佐藤 志津子 Shizuko SATO

出版者

埼玉学園大学

雑誌

埼玉学園大学紀要. 人間学部篇 = Bulletin of Saitama Gakuen University. Faculty of Humanities (ISSN:13470515)

巻号頁・発行日

vol.5, pp.183-193, 2005-12-01

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日本語を母国語とする人が、英語音 /r/を発音する場合の問題点と調音法。調音器官からのアプローチ。

著者

Indishe Prabath Senanayake In-Young Yeo Natthachet Tangdamrongsub Garry R Willgoose Gregory R Hancock Tony Wells Bin Fang Venkataraman Lakshmi Jeffrey P Walker

出版者

日本地球惑星科学連合

雑誌

日本地球惑星科学連合2019年大会

巻号頁・発行日

2019-03-14

著者

永井 豊実

出版者

城西大学経済学会

雑誌

城西人文研究 (ISSN:02872064)

巻号頁・発行日

vol.31, pp.1-18, 2012

著者

松原 凱男 山田 茂治 吉原 正邦 前嶋 俊壽

出版者

公益社団法人 日本化学会

雑誌

日本化学会誌 (ISSN:03694577)

巻号頁・発行日

vol.1987, no.7, pp.1312-1316, 1987

被引用文献数

4

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4-phenylr4H-1,3,4-thiadiazin-5(6H)-one[1]および5,6-dihydro-4-pheny1-4H-1,3,4-thiadiazin-5-o1[2]の<SUP>1</SUP>H-NMR,<SUP>13</SUP>C-NMR,IRおよびUVスペクトルの結果,ならびに拡張.Huckelも分子軌道計算を行ない,結合次数,電荷分布およびHOMO結合軌道の様子を求めた結果かちそれぞれの共鳴安定構造について検討した。[1]の構造は,硫黄原子から3-位窒素原子へ,また4-位窒素からカルポニル酸素へそれぞれ電荷が偏りその結果,3pπ-2pπ-2pπ 系と2pπ-2pπ-2Pπ 系と2種類の連続し喪共鳴安定構造の存在が示きれた。一方,[2]の構造は,硫黄原子から4-位窒素原子へ電荷が偏りその結果,ブタジエン型3pπ-2pπ-2pπ-2pπ 系の大きな共鳴安定構造の存在が示された。そこでこの共鳴構造の異なりが反応性にどのように影響を与えるかについて検討した。[1]は通常り求核剤,求電子剤およびラジカル試荊とはまったく反応性を示さなかった。しかし[2]は弱酸およびヨウ化メチルなどの求電子剤と容易に反応を起こし,分離困難な多くの生成物を与えた。また[2]はアルコール,アミンおよびチオールなどの求核剤とは触媒なしで容易に反応を起こし,それぞれ対応する置換化合物を与えた。このオキソおよびヒドロキシル置換基の違いだけで反応性がまったく異なった結果は共鳴講造の寄与の違いで説明され,また,[2]と求核剤との反応は,ヒドロキシル酸素と5-位炭素間の切断で生じる5,6-ジヒドロニ4H-1,3,4-チアジアジニウムカ与オン中間体を経由する機構を強く支持した。

著者

Kazuki TAKAHASHI Pablo J. ROSS Ken SAWAI

出版者

THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

雑誌

Journal of Reproduction and Development (ISSN:09168818)

巻号頁・発行日

pp.2019-039, (Released:2019-04-25)

被引用文献数

9

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Zinc finger and SCAN domain containing 4 (Zscan4) is a gene that is specifically expressed during zygotic genome activation (ZGA) in mouse preimplantation embryos, and a reduction of Zscan4 transcripts leads to developmental failure. In mouse embryonic stem cells (ESCs), Zscan4 is expressed transiently in as little as 1–5% of the cell population. Zscan4 has also been shown to enhance the efficiency of mouse induced pluripotent stem cells (iPSCs) generation and their quality. Although ZSCAN4 plays important roles in murine embryos and stem cells, its expression and role in bovine embryos is unknown. This study examines ZSCAN4 transcripts in bovine embryos at various developmental stages and attempts to elucidate the functions of ZSCAN4 during bovine preimplantation development. ZSCAN4 transcripts were found to be upregulated at the 8- and 16-cell stages. We next attempted ZSCAN4 downregulation in bovine early embryos by RNA interference and evaluated developmental competency and transcripts levels of genes involved in ZGA and iPSCs generation. Although the bovine embryos injected with ZSCAN4-siRNA could develop to the 8-cell stage, very few were developing beyond the 16-cell stage. PIWIL2 expression was reduced in ZSCAN4 downregulated embryos. It is possible that ZSCAN4 downregulated embryos fail to regulate gene expression during ZGA. Our results indicate that ZSCAN4 is an important factor for the preimplantation development of bovine embryos.

著者

児玉 淳一

出版者

一般社団法人 資源・素材学会

雑誌

Journal of MMIJ (ISSN:18816118)

巻号頁・発行日

vol.135, no.4, pp.31-32, 2019-04-30 (Released:2019-04-27)

著者

阪本 憲司 沖増 英治 雨村 明倫

出版者

福山大学

雑誌

福山大学附属内海生物資源研究所報告 (ISSN:09178147)

巻号頁・発行日

vol.5, pp.1-15, 1994-12

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因島近海から未知の有用微細藻類の探索を行い,35℃でも増殖可能な耐高温性を示す微細藻SY-4を分離した。SY-4は,直径5μmの単細胞で,浮遊性を示し,繊毛や鞭毛の類を持っていない。増殖は,細胞の2分裂によって行う。SY-4は,原核細胞で,同化色素にフィコシアニン,アロフィコシアニンなどの色素蛋白質を含有していることから,藍藻の一種シネコキスチス属(Synechocystis)に属することが判った。SY-4は,ナンノクロロプシス用施肥培地で,培養温度25℃,塩分濃度10‰,pH7付近の条件下で,最も良好な増殖を示した。A microalga, SY-4, capable of growing well at 35℃ was isolated from the Mekari Strait, Seto inland sea. SY-4 was characteristic of procaryote and unicellular spherocyte (4-5 μm in diameter) containing phycobiliprotein, and was classified into a blue-green alga (cyanobacterium), Synechocystis. SY-4 grew autotrophically and utilized ammonium sulfate more efficiently than sodium nitrate. Its optimum temperature, salinity and pH for growth were 25℃, 10‰ and 7, respectively

著者

Yan Gao Chuanqi Zhang Yisi Liu Min Wang

出版者

International Research and Cooperation Association for Bio & Socio-Sciences Advancement

雑誌

BioScience Trends (ISSN:18817815)

巻号頁・発行日

pp.2019.01021, (Released:2019-04-24)

参考文献数

27

被引用文献数

30

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Circular RNA (circRNA) is a class of endogenous non-coding RNAs that are closely related to the pathogenesis of many human diseases, particularly cancer. However, the characterization of circRNAs in high-grade serous ovarian cancer (HGSOC) remains unknown. This study aimed to investigate the expression profile of circRNAs in HGSOC. Expression profiles of circRNAs differential expression based on circRNAs High-throughput sequencing were identified in 3 HGSOC specimens and 3 normal ovarian tissues. A total of 710 differentially expressed circRNAs were found (354 expressions up-regulated and 356 expressions down-regulated). CircRNA sequencing data were verified by qRT-PCR in HGSOC tissue and benign ovarian lesions. Differential expression of 7 circRNAs (circRNA385, circRNA2058, circRNA3336, circRNA2606, circRNA1656, circRNA1312 and circRNA7474) in HGSOC tissue was confirmed by qRT-PCR. Among them, circRNA1656 showed the highest fold change. qRT-PCR was used to verify the expression of circRNA1656 in ovarian cancer cell lines. In order to analyze the relationship between circRNA1656 expression and clinical pathological biological characteristics of HGSOC, qRT-PCR was used to verify the expression of circRNA1656 in 60 HGSOC tissues compared with 60 benign ovarian lesions. The expression of circRNA1656 was down-regulated in HGSOC tissues and ovarian cancer cell lines, and correlated with the FIGO stage of HGSOC. circRNA1656 has the potential to serve as a novel tumor marker for HGSOC.