著者
谷重遠 講
出版者
茨城多左衞門
巻号頁・発行日
vol.[2], 1720
著者
南高 純一 猪野 真弓 佐藤 邦雄 森川 重則
雑誌
全国大会講演論文集
巻号頁・発行日
vol.39, pp.2242-2243, 1989-10-16
被引用文献数
1

我々は,音楽分野で一般的に使われている慨念をルールとして記述し,メロディーの特徴を分析したり,作曲する際に,それらの音楽知識や,分析結果を使用して,音楽性に富むメロディーが生成可能な自動作曲システム-MAGIC(Music system for ArranGement and Intelligent Composition)を作成している。すでに,リズム,和声,調性,構造,楽式を考慮した自動作曲システ〔1〕〔2〕を実現しているが,今回アヴェイラブルノートの考え方を導入し,和声の知識をより豊かにすることにより,ジャズ,ポップスなどの曲風(ジャンルの特徴を扱えるようにした。リズムについては,すでに曲風の特徴をある程度とらえられていた〔1〕ので,本報告では,和声処理を中心に報告する。
著者
漆谷 真
出版者
日本神経治療学会
雑誌
神経治療学 (ISSN:09168443)
巻号頁・発行日
vol.34, no.2, pp.72-78, 2017 (Released:2017-07-25)
参考文献数
32

TAR DNA–binding protein 43kDa (TDP–43) is a hallmark protein for amyotrophic lateral sclerosis (ALS), consisting of ubiquitinated and phosphorylated cytosolic inclusions in affected regions, namely TDP–43 proteinopathy. TDP–43 is physiologically located in the nucleus and plays diverse roles to maintain the RNA homeostasis, including pro–mRNA splicing, microRNA processing, non–coding RNA stabilization, mRNA transport, and the stress granule formation. Multiple cascades, basically causing a loss of these functions, have been proposed as TDP–43–linked ALS pathogenesis ; however, the mislocalization and aggregate formation of TDP–43 is considered to underlie various pathogenic pathways, ultimately leading to motor neuron death. A cell–to–cell spreading theory is attracting huge attention to explain the rapid regional progression of the paralysis, although in vivo evidence is still lacking. Recent knowledge highlights the stress granules as responsible sites of TDP–43 inclusion formation. The stress granules contain mRNA with chains of ribosomes, together with stress granule–related proteins, such as TIA1 and TDP–43, in which RNA translation is inhibited transiently until stress conditions are recovered. The disruption of this reversibility is implicated in the irreversible inclusion formation. A proportion of familial ALS patients carries genetic mutations in the TDP–43 gene, the most of which are concentrated at the carboxyl prion–like domain. Although the pathomechanisms regarding how mutant TDP–43 causes ALS remain elusive, it is reported that mutant TDP–43 impairs proteasome activity, resulting in the accumulation of aberrant TDP–43. Moreover, several genetic mutations other than TDP–43, such as C9ORF72, MATR3, hnRNP1, UBQLN2, STSM1, VCP, and OPTN cause TDP–43 proteinopathy. Importantly, transgenic mice expressing cytosolic TDP–43 show the similar phenotype of ALS, and the inhibition of the transgene restore the paralysis of the mice. These line of evidence indicate the huge potential of misfolded TDP–43 as a therapeutic target. Capturing the early structural conversion to pathogenic forms is a promising therapeutic avenue to overcome ALS.
著者
漆谷 真 守村 敏史
出版者
滋賀医科大学
雑誌
基盤研究(B)
巻号頁・発行日
2014-04-01

我々は以前に筋萎縮性側索硬化症の原因蛋白質であるTDP-43の2つのRNA認識部位(RRM1とRRM2)内の配列を抗原とし、異所性局在型や凝集体形成型のTDP-43のみを認識する抗体を作出した。本研究ではこれらの抗体を用いて、TDP-43凝集体の形成を阻止する低分子化合物の同定や一本鎖抗体(scFv)を作製し細胞内のTDP-43凝集体の除去効果を検証した。RRM1抗体を用いた競合ELISA法によってTDP-43の異常会合界面に結合し凝集体形成を阻止する化合物を同定した。RRM2を抗原とし蛋白質分解シグナルを持つscFvはTDP-43凝集体と特異的に結合し分解促進し細胞死を抑える成果が得られた。
著者
福田 哲也 蔵永 瞳
出版者
日本感情心理学会
雑誌
感情心理学研究 (ISSN:18828817)
巻号頁・発行日
vol.25, no.Supplement, pp.ps08-ps08, 2017 (Released:2017-11-28)
参考文献数
2
著者
海津 浩一 村田 裕斗 光延 裕紀 植西 亮介 日下 正広 木村 真晃
出版者
一般社団法人 日本機械学会
雑誌
日本機械学会論文集 (ISSN:21879761)
巻号頁・発行日
vol.84, no.858, pp.17-00550-17-00550, 2018 (Released:2018-02-25)
参考文献数
14
被引用文献数
1

In order to ensure the safety of passengers in the event of an accident, side member and crash box are mounted on automobiles. Cylindrical tubes, rectangular pipes and hat-shaped members have been examined as structural members that subjected to an axial compressive load. However, these structures have problems that the initial peak load is very high and the load rapidly decreases due to buckling during crushing. To solve the problems, we proposed a cellular solid with mimetic woody structure as a new structural member. Some woods have no initial sharp peak load and have a plateau region which the load is constant in the relationship between the load and the displacement, when the impulsive load are applied to them. We considered that those features were suitable for structural members like a side member or a crash box. The basic cell was a square block with a side length of 10 millimeters and it had a hole in the center. The cellular solid was constituted by combining some basic cells. Therefore, a homogeneous cellular solid was fabricated by making small holes in the aluminum cube. From results obtained from the impact crushing test and simulation by the FEM software LS-DYNA®, it was demonstrated that the proposed cellular solid had crushing characteristics similar to the wood, and the energy absorption characteristics were influenced by the shape and arrangement of the cells. As a result, it was shown that the results of experiment and analysis substantially corresponded. Since the load during crushing depended on the shape and arrangement of the cells, the possibility of controlling the energy absorption characteristics was shown.
著者
馮 青
出版者
中央大学政策文化総合研究所
雑誌
中央大学政策文化総合研究所年報 (ISSN:13442902)
巻号頁・発行日
no.20, pp.119-136, 2016

This paper focuses on YASUMI Saburo (1880‒1965), Vice-admiral of Japanese Imperial Navy and one of the "China Hands" and his "Plan for Chinese Naval Reconstruction", proposed to Chinese Naval authorities during Taisho decade. He had a unique idea for National Defense, which emphasized cooperation between Japan and China and opposed to U.S. or German influence in the East Asia. This paper further pointed these points: (1) The moderates in Japanese Navy regarded Japanese military expansion toward China since the Twenty-One Demands as mistakes and useless for consolidating Japan's endurable defense power. (2) The moderates also insisted on the need to improve Chinese national power, especially reconstructing her Navy. (3) Yasumi's plan for Chinese Naval Reconstruction turned to be a root for the interchanges among Sino-Japanese navies during 1930s. The author fully uses Japanese and Chinese first-hand materials, such as Admiral Yasumi's personal collections and his oral history.
著者
大江 準三
雑誌
情報処理
巻号頁・発行日
vol.45, no.10, pp.1054-1056, 2004-10-15

最近の自動車開発においては,環境への適応,安全性能向上,さらには情報通信技術によるつながる機能の高性能化など,社会と高度に共存するための機能開発が進められている.本稿では,いつでも,どこへでも安全・安心・快適に移動できる自動車の魅力をさらに進化させた情報通信技術を中心とした最新技術について解説を行う.
著者
泉澤 恵
出版者
日経BP社
雑誌
日経ドラッグインフォメーションpremium
巻号頁・発行日
no.110, pp.59-64, 2006-12-10

OTCの催眠鎮静剤は、ストレスなどにより自律神経のバランスが乱れ、緊張感やイライラが高まったり、寝付きが悪くなるなどの精神神経症状を改善することを目的とした製品である。抗ヒスタミン剤(塩酸ジフェンヒドラミン)、サンソウニン(酸棗仁)など依存性がなく催眠・鎮静作用を有する成分を主とする製剤と、カノコソウ、ホップなどマイルドな鎮静・精神安定作用を有する生薬成分を…