著者
Takako ENDO Hikari KAWAI Norio KONNO
出版者
東北大学大学院情報科学研究科ジャーナル編集委員会
雑誌
Interdisciplinary Information Sciences (ISSN:13409050)
巻号頁・発行日
vol.23, no.1, pp.57-64, 2017 (Released:2017-03-31)
参考文献数
22
被引用文献数
2

This study is motivated by the previous work [14]. We treat 3 types of the one-dimensional quantum walks (QWs), whose time evolutions are described by diagonal unitary matrices except at one defected point. In this paper, we call the QW defined by diagonal unitary matrices, ``the diagonal QW'', and we consider the stationary distributions of general 2-state diagonal QW with one defect, 3-state space-homogeneous diagonal QW, and 3-state diagonal QW with one defect. One of the purposes of our study is to characterize the QWs by the stationary measure, which may lead to answer the basic and natural question, ``What are stationary measures for one-dimensional QWs?''. In order to analyze the stationary distribution, we focus on the corresponding eigenvalue problems and the definition of the stationary measure.
著者
Yusuke HIGUCHI Norio KONNO Iwao SATO Etsuo SEGAWA
出版者
東北大学大学院情報科学研究科ジャーナル編集委員会
雑誌
Interdisciplinary Information Sciences (ISSN:13409050)
巻号頁・発行日
vol.23, no.1, pp.75-86, 2017 (Released:2017-03-31)
参考文献数
23
被引用文献数
1

In this paper we discuss the periodicity of the evolution matrix of Szegedy walk, which is a special type of quantum walk induced by the classical simple random walk, on a finite graph. We completely characterize the periods of Szegedy walks for complete graphs, compete bipartite graphs and strongly regular graphs. In addition, we discuss the periods of Szegedy walk induced by a non-reversible random walk on a cycle.
著者
加藤 佐知子 竹原 健二 新田 知恵子 大田 えりか
出版者
一般社団法人 日本助産学会
雑誌
日本助産学会誌 (ISSN:09176357)
巻号頁・発行日
vol.30, no.1, pp.110-119, 2016 (Released:2016-09-01)
参考文献数
19
被引用文献数
1

目 的 本研究では電子カルテを用いて,切迫流早産で入院した妊婦を対象に実施されてきた,「衣服による体幹への締め付けを回避する保健指導」が早産のリスク低減にもたらす効果を検討することを目的とした。対象と方法 本研究のデザインは電子カルテのデータを用いた後ろ向き研究である。本研究の対象は2011年4月1日から2013年3月31日の時点で,調査協力施設に切迫流早産の診断を受けて入院をしていた妊婦230人のうち,対象基準を満たした208人とした。入院期間中に看護師や助産師が「衣服による体幹への締め付けを回避する保健指導」を実施した者を保健指導実施群,実施されなかった者を対照群とした。すべてのデータは電子カルテから収集された。結 果 対象者の基本属性では,平均年齢が34.7歳(標準偏差(SD):5.0),経産婦が103人(49.8%)であった。保健指導が実施された保健指導実施群は150人(72.1%)であった。二変量解析の結果,保健指導の実施の有無は,妊娠34週未満の早産(p=0.077),妊娠37週未満の早産(p=0.875)のいずれとも統計学的に有意な関連は認められなかった。しかし,先行研究の知見をもとに,社会経済的な要因や過去の受診歴などの交絡因子の影響を調整した多変量解析では,保健指導実施群の妊娠34週未満の早産に対するAdjusted Odds Ratio(AOR)は0.15(95% Confidence Interval(CI):0.04-0.57)と妊娠34週未満の早産のリスクを低下させることが示された。妊娠37週未満の早産との関連は示されなかった(AOR:0.67(95%CI: 0.28-1.60))。結 論 衣服による体幹への締め付けを回避する保健指導が妊娠34週未満の早産のリスクを低下させる可能性が示唆された。本研究は探索的な研究であり,サンプルサイズが小さいことや,対象者の無作為割付をおこなっていないなどの限界がある。今後,無作為化比較試験のような,この保健指導の有効性をより強く証明するような研究の実施が求められる。
著者
香月 歩 奥山 信一
出版者
日本建築学会
雑誌
日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日
vol.82, no.731, pp.251-261, 2017 (Released:2017-01-30)
参考文献数
22
被引用文献数
1

This paper aims to clarify the framework of the image of places in contemporary society through the analysis of words on sightseeing brochures of the towns which promote themselves as Shokyoto (little Kyoto). These towns attempt to enhance their historical value by borrowing the image of Kyoto, old Japanese capital city. They have obtained unique historical image which have transformed from that of Kyoto. Local governments and tourist offices of these towns have published sightseeing brochures to express their historical attractions. Therefore, the framework of their image can be read from them. Firstly, the contents of historical attraction of each town were examined from two aspects of words on sightseeing brochures; Value Objects and their history (Fig. 1, 2 and 3, Table 1 and 2). Hierarchical relations between Value Objects were considered to capture the whole historical attraction of each town, which are composed of all Value Objects in each sightseeing brochure. These relations were analyzed from the context and the appearance frequency of Value Objects in the text, we found 56 groups of hierarchically-linked Value Objects (Value Groups) (Fig. 4 and 5). Consequently, a set of Value Groups can be recognized as the whole historical attraction of each town from words on the sightseeing brochures. Secondly, according to the content of Value Object which is on the top of hierarchy, the characters of each Value Group were classified into following four categories; whole-of-town type, space-of-town type, life-in-town type, and periphery-of-town type. Space-of-town type and life- in-town type were classified further into four categories; linear-space type, spotted-space type, activity type and article type (Fig. 6). Thirdly, in order to capture the whole historical attraciton of each town, the set of Value Groups in each sightseeing brochure was considered, and 6 patterns were extracted (Table 3). We found characteristic relations between combinations of Value Groups and geographical distribution of the towns; towns located to the east of Kyoto tend to include whole-of-town type, and towns located to the west of Kyoto tend to include space-of-town type. These results suggest the difference of the meaning of Kyoto between eastern and western part of Japan. Finally, all the results above were compared with those of Koedo (little Edo), which were investigated in the previous report (Fig. 7, 8, 9 and 10). As a result, characteristic frameworks of the image of Shokyoto and Koedo were found relatively: The pattern which consists of several whole-of-town types (pattern ウ), and the pattern which includes periphery-of-town type (pattern P) were peculiar to Shokyoto. Meanwhile, the pattern which consists of single life-in-town type (pattern III), and the pattern which consists of several space-of-town types ( pattern IV) were peculiar to Koedo. These results suggest distinctive frameworks of the image of Shokyoto and Koedo: The framework of Shokyoto is a metaphorical image of Kyoto, which overlook the whole character of the town. On the other hand, the framework of Koedo is a metonymic image of Edo, which highlights either spatial or cultural character of the town.
著者
伊藤 美登里
出版者
日本社会学会
雑誌
社会学評論 (ISSN:00215414)
巻号頁・発行日
vol.46, no.1, pp.62-76, 1995-06-30 (Released:2009-10-19)
参考文献数
25
被引用文献数
1

著書『イデオロギーとユートピア』に見られる K. マンハイムのペシミズムは, 彼が述べるような次の時代の真理としてのユートピアに導かれて社会を変革し, 形成するという, 「近代史の発展をつらぬく構造形式」が成立しなくなりつつあるという事態, ユートピアの消失という事態にたいする彼の危機感の表明であったが, それと同時にこのユートピアの創造者として, 近代社会において政治的・文化的に圧倒的な優位を誇っていた教養市民層が, 大衆社会の到来とともに没落の危機に瀕し, 「ユートピアの担い手」としての自己像すら危うくなりつつあることへの危機感の現れでもあったと考えられる。イギリス亡命後のマンハイムの理論の変化は, 上述の事態を解決しようとするなかで生じてきたものである. 彼は, 大衆社会において民主主義をうまく機能させる唯一の方法として「自由のための計画」を提唱した. 彼にとってそれは, 近代社会を形作ってきた「近代ユートピア」の存立が不可能となった時代において可能であるところの, 別の型の「ユートピア」であった.また, 「自由に浮動するインテリゲンツィア」にかわって, 「計画者としてのエリート」という役割を知識人に与えることで, 彼は知識人存在の新たな存在形式を創出しようとしたと見ることができよう。
著者
Kazuo NAKASHIMA Kazuhiro SUENAGA
出版者
JARQ編集委員会
雑誌
Japan Agricultural Research Quarterly: JARQ (ISSN:00213551)
巻号頁・発行日
vol.51, no.1, pp.1-10, 2017-01-01 (Released:2017-01-31)
参考文献数
75
被引用文献数
19

Crop damage due to environmental stresses, including drought, high salinity, and high temperature, occurs worldwide. Therefore, genetically modifying plants to increase their environmental stress tolerance is an important global issue. In this paper, we discuss recent developments in basic and applied research aimed at genetically improving crop environmental stress tolerance. First, we review the progress made in understanding the environmental stress-tolerance mechanisms in plants, using Arabidopsis or rice as models. Then, we discuss our international collaboration to genetically modify crops such as rice, wheat, sugarcane and soybean that entails greenhouse- or field-based drought-tolerance tests. Finally, we assess the future prospects for developing stress-tolerant varieties
著者
大住 倫弘 今井 亮太 森岡 周
出版者
日本認知心理学会
雑誌
日本認知心理学会発表論文集 日本認知心理学会第12回大会
巻号頁・発行日
pp.116, 2014 (Released:2014-10-05)

近年,視覚的身体像を操作するリハビリテーションアプローチが慢性疼痛患者に応用されてきている.しかし,視覚的身体像を操作することによって「不快な身体情緒」が生じてしまうと鎮痛効果が得られにくいことも考えられている.そこで今回,ラバーハンド錯覚手法を応用して,健常者の視覚的身体像を操作した時に惹起される不快な身体情緒が痛みを変化させるのかについて調査した.不快な身体情緒を惹起させるような,「傷ついたラバーハンド」,「毛深いラバーハンド」,「腕がねじれているラバーハンド」を作成した.そして,各ラバーハンドに身体所有感の錯覚を生じさせた時の,不快感および痛み閾値を測定した.その結果,「傷ついたラバーハンド」と「毛深いラバーハンド」に不快感は生じたが,痛みが増悪したのは「傷ついたラバーハンド」のみであった.このことから,痛みという文脈における不快な身体情緒が痛みを変化させることが明らかとなった.
著者
加賀谷 早織 角田 孝彦 森山 達哉
出版者
公益社団法人 日本皮膚科学会
雑誌
日本皮膚科学会雑誌 (ISSN:0021499X)
巻号頁・発行日
vol.116, no.3, pp.331-334, 2006-03-20 (Released:2014-12-10)

症例1:36歳女性.夕食にフキノトウの天ぷらを摂取後,のどがかゆくなり,嘔吐した.さらに咽頭の腫脹,呼吸困難,蕁麻疹が出現した.CAP-RAST(class)では,ヨモギ3,ブタクサ1,スギ3,カモガヤ0.症例2:50歳女性.春と秋に花粉症症状あり.フキノトウの天ぷらを摂取後,上腹部不快感と鼻閉感があり,その後口腔内のしびれと全身に蕁麻疹が出現した.CAPRAST(class)では,ヨモギ3,ブタクサ2,スギ4,カモガヤ0.両症例について,フキノトウの小花,苞のprick to prick testで陽性が確認された.両症例とも花粉がついている雄株で陽性を示し,花粉に重要な抗原があることが考えられた.患者血清を用いて行った免疫ブロットでは,15 kDaと20 kDa付近のアレルゲンが検出された.
著者
友清 芳二 松村 晶
出版者
一般社団法人 資源・素材学会
雑誌
Journal of MMIJ (ISSN:18816118)
巻号頁・発行日
vol.133, no.3, pp.58-67, 2017-03-01 (Released:2017-03-31)
参考文献数
44

Transmission electron microscopy has been playing an important role in research and development of nanotechnology which is common and fundamental in various fields of science and technology such as energy, environmental sciences, information and telecommunications, and life sciences and etc. A transmission electron microscope (TEM) provides us with crystallographic information and positional information from a local area of specimen. Furthermore information on local chemical composition and atomic bonding state is obtained provided the TEM is equipped with an X-ray energy dispersive spectrometer (XEDS) and an electron energy loss spectrometer (EELS). The image resolution and special resolution of elemental analysis have been improved to an atomic level together with the development of an analytical TEM that has a field emission gun, an aberration corrector and a function of scanning TEM (STEM). It has been possible to extract high quality and various information on substance and materials, owing to the development of electron detectors and imaging techniques of STEM. Objects of TEM observation have been widely spread after the development of related techniques such as preparation of TEM samples and controlling of specimen environment (heating, cooling, gas pressure, stress application etc.). We introduce recent trend of transmission electron microscopy and demonstrate some applications to green nanotechnology which is closely related to development of renewable energy, energy saving, energy storing, saving of rear resource, removal of harmful substance from air and water and so on.
著者
木下 尚樹 安原 英明
出版者
一般社団法人 資源・素材学会
雑誌
Journal of MMIJ (ISSN:18816118)
巻号頁・発行日
vol.133, no.3, pp.53-57, 2017-03-01 (Released:2017-03-31)
参考文献数
16

It is of significant importance to safely isolate the radioactive wastes from the human environments. Entombment of the wastes in deep subsurface may be a plausible solution on this issue, and will be adopted in the countries where the nuclear power plants are in operation. Before burying them in the targeted rocks, the longterm evolution of the mechanical and the hydraulic properties of the targeted rocks should be predicted with a certain precision. To this end, in this study we examined the change of the apparent secant elastic modulus and the permeability of a single fracture in the Berea sandstone and the Horonobe mudstone samples under the relatively high temperature and confining pressure conditions. The apparent secant elastic modulus of the mudstone increased with the increase of the holding time and specifically, the values at 90 ºC were greater than those at 25 ºC, while that of the sandstone little increased with time. In contrast, the permeability of both the mudstone and sandstone samples monotonically decreased with time, and the rates of the permeability reduction were close among all the samples. The increase of the elastic modulus and the decrease of the permeability may be attributed to the chemomechanical processes such as pressure solution and the mechanisms explaining the changes should be clarified. Although the mechanisms are still ambiguous, the increase of the elastic modulus and the permeability reduction with time may improve the integrity of the targeted rocks.
著者
木下 尚樹 安原 英明 矢田部 龍一 加賀山 肇
出版者
一般社団法人 資源・素材学会
雑誌
Journal of MMIJ (ISSN:18816118)
巻号頁・発行日
vol.133, no.3, pp.45-52, 2017-03-01 (Released:2017-03-31)
参考文献数
17
被引用文献数
1

Rockfall is an important geo-hazard of mountainous area in Japan and has gained greater attention and recognition due primarily to the severe accidents and mortalities happening in roadways and railways. Rock fall countermeasures are classified into preventive works and protectors. In rock protectors that have high rigidity, there are rock protecting fence, rock protecting wall and rock shed, etc. On the other hand, there is a pocket type rock net which excels in the application condition of the topography and absorbs energy by deforming itself. The standard absorbable energy of the pocket type rock net is 100 kJ. Then, the rock net is designed so that the absorbed energy exceeds the falling rock energy. However, in recently, many types of rock net such as high energy type and long span type have been developed, and there are cases where conventional design methods cannot be applied. In this study, the performance of a long span pocket type rock net was evaluated by dynamic analysis. Firstly, the physical properties of the rock net members were identified by comparing the results of the real scale field experiments with the dynamic analyses. Then, the relationships between the displacement of the net and the net width, the maximum tensional force of a horizontal rope and the rope position, etc. were evaluated by the dynamic analyses. Typically, these evaluations by conventional design methods are laborious and are carried out using the results of real scale field experiments. However, the current study revealed that the predictions by the dynamic, numerical analyses showed the validity of the performance evaluation by this means.
著者
田崎 慎治
出版者
一般社団法人 日本健康心理学会
雑誌
健康心理学研究 (ISSN:09173323)
巻号頁・発行日
vol.20, no.1, pp.56-63, 2007-06-25 (Released:2014-03-28)
参考文献数
31
被引用文献数
1 1

Relationships among the drive for thinness, health consciousness, other psychological factors and eating behaviors in college students (n = 128: 79 male; mean BMI = 21.33: 109 female; mean BMI = 20.48) was investigated. They completed the Contour Drawing Rating Scale, the Sense of Health Scale, the Self-Esteem Scale, the Japanese version of STAI and the Japanese version of DEBQ. Results from Structural Equation Modeling indicated that for female students, the drive for thinness was influenced by BMI, and health consciousness was influenced by the drive for thinness via self-esteem and trait anxiety. Moreover, restraint in eating was influenced by the drive for thinness, whereas other eating behaviors were related to the drive for thinness via self-esteem and trait anxiety. In male students, there was a significant relationship between the drive for thinness and restraint in eating. These results suggest that there are gender differences between the drive for thinness and self-esteem, trait anxiety, and health consciousness.
著者
加藤 珠理 松本 麻子 勝木 俊雄 岩本 宏二郎 中村 健太郎 石尾 将吾 向井 譲 吉丸 博志
出版者
日本森林学会
雑誌
日本森林学会大会発表データベース 第125回日本森林学会大会
巻号頁・発行日
pp.303, 2014 (Released:2014-07-16)

‘枝垂桜’は野生のサクラであるエドヒガンから生じた突然変異体であると考えられ、筆者らが行ったこれまでの研究成果においても、その可能性は支持されている。現在、‘枝垂桜’には複数の系統が存在するが、それらの起源は原種であるエドヒガンから、一回だけ生じた変異個体に由来するものか、それとも、独立に生じたいくつかの変異個体に由来するものかはわかっていない。また、原種である野生のエドヒガンについても、どの地域のエドヒガンがもとになって、‘枝垂桜’が生じたのかについてはわかっていない。この研究では、‘枝垂桜’の起源に関する様々な疑問を解決するために、‘枝垂桜’とその原種であるエドヒガンの関係を集団遺伝学的手法に基づいて評価し、考えられうる可能性を示したいと思う。研究材料としては、全国各地から収集され、多摩森林科学園で保存・管理されている‘枝垂桜’を用いた。比較のために用いるエドヒガンは複数の地域からサンプリングした集団を用いた。SSRマーカーを用いたDNA分析により、‘枝垂桜’とエドヒガン集団の遺伝構造について比較解析を行っており、本発表ではその結果について報告する。
著者
Tomohiro Oishi Tetsuo Taguchi Tokushi Nakano Shoji Sudo Hiroaki Kuwajima Shibata RVGE Study Group
出版者
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
雑誌
Japanese Journal of Infectious Diseases (ISSN:13446304)
巻号頁・発行日
vol.67, no.4, pp.304-306, 2014 (Released:2014-07-24)
参考文献数
9
被引用文献数
6 13

The occurrence of severe rotavirus gastroenteritis (RVGE) in children under 3 years of age before and after the introduction of rotavirus vaccine was prospectively surveyed in three pediatric clinics in Shibata City, Niigata Prefecture, Japan, during the 2011 and 2012 RVGE epidemic seasons. In this observational study, a significantly lower occurrence of severe RVGE among severe gastroenteritis cases was observed in 2012. The incidence rate of severe RVGE among outpatients in 2012 was significantly lower than that in 2011. Despite the significant reduction in severe RVGE, the results must be interpreted with caution because the surveillance period is short and requires extension to conclude whether the reduction in the incidence of severe RVGE is a direct effect of rotavirus vaccination. Therefore, we will continue the survey to evaluate the impact of vaccination.
著者
Nobuya Hamanoue Makito Tanabe Tomoko Tanaka Yuko Akehi Junji Murakami Takashi Nomiyama Toshihiko Yanase
出版者
(社)日本内分泌学会
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
pp.EJ16-0619, (Released:2017-03-30)
被引用文献数
5

An age-associated androgen decrease and its pathological conditions are defined as late-onset hypogonadism (LOH). Among the various symptoms associated with LOH, a visceral fat increase is strongly associated with relatively low levels of testosterone. However, few studies have investigated the relationship between the Aging Males’ Symptoms (AMS) scores and metabolic abnormalities. Thus, we aimed to clarify this relationship by investigating the relationship between AMS scores and various markers in blood. During routine health examinations in 241 middle-aged males (52.7±7.5 years of age, mean±SD), 150 males (62.2%) displayed higher AMS values than normal. No statistical association was observed between total AMS scores and any testosterone value. All mental, physical and sexual AMS subscales were significantly positively correlated with insulin levels and HOMA-IR. Only sexual subscale scores were significantly inversely associated with free or bioavailable testosterone level. Males with insulin resistance (HOMA-IR≥2.5) demonstrated significantly higher AMS scores than those with normal insulin sensitivity (HOMA-IR<2.5). AMS values were positively correlated with fasting blood glucose, insulin and HOMA-IR values. Interestingly, univariate and multivariate analyses revealed that HOMA-IR≥2.5 was a significant predictor for detection of moderately severe AMS values (AMS≥37), whereas AMS≥37 was not a predictor of metabolic syndrome by International Diabetes Federation (IDF) criterion. In conclusion, almost 60% of healthy male subjects displayed abnormal AMS scores. AMS values were not associated with testosterone values but rather were related to insulin resistance, particularly in subjects with moderately severe AMS values. Insulin resistance-related general unwellness might be reflected by AMS values.
著者
池山 豊
出版者
一般社団法人 色材協会
雑誌
色材協会誌 (ISSN:0010180X)
巻号頁・発行日
vol.74, no.11, pp.576-583, 2001-11-20 (Released:2012-11-20)
参考文献数
50
著者
野口 義紘 林 勇汰 吉田 阿希 杉田 郁人 江崎 宏樹 齊藤 康介 臼井 一将 加藤 未紗 舘 知也 寺町 ひとみ
出版者
一般社団法人日本医薬品情報学会
雑誌
医薬品情報学 (ISSN:13451464)
巻号頁・発行日
vol.18, no.4, pp.277-283, 2017-02-28 (Released:2017-03-17)
参考文献数
20

Objective: Elderly patients commonly experience adverse drug events (ADEs) owing to their poor drug metabolizing and excretion ability, and these often cause multiple organ dysfunction syndrome.  Therefore, it is important that we identify the adverse drug events early on during prognosis.  We searched for oral medicines that might exacerbate the prognosis of ADEs in elderly patients.Methods: The objects under analysis were oral medicines that were registered in the Japanese Adverse Drug Event Report database (JADER).  The associations between the elderly/non-elderly patients and exacerbation risk/non-exacerbation risk were analyzed by risk ratios (RR).  The signal detection of exacerbation risk was defined as 95% confidence interval of lower limit of risk ratio>1 and χ2≥4.Results: The oral medicines that might markedly exacerbate the prognosis of ADEs in the elderly patients in comparison with the ADEs of young patients included 84 items, of which 63 have not been described as potentially inappropriate medicines in all guidelines for medical treatment of the elderly patients.Conclusion: In this study, while we could not search for oral medicines having a high risk of ADEs, we were able to search for oral medicines that might exacerbate the prognosis of ADEs in elderly patients.  This result could contribute to the proper use of medicines in the elderly patients.
著者
大鳥 徹 井上 知美 細見 光一 中川 博之 高島 敬子 近藤 尚美 高田 亜美 伊藤 栄次 中山 隆志 和田 哲幸 石渡 俊二 前川 智弘 船上 仁範 中村 真也 窪田 愛恵 平出 敦 松山 賢治 西田 升三
出版者
日本社会薬学会
雑誌
社会薬学 (ISSN:09110585)
巻号頁・発行日
vol.35, no.2, pp.94-101, 2016-12-10 (Released:2017-02-09)
参考文献数
12

In the areas of home medical care and self-medication, the role of the pharmacist is growing, partly as a result of Japan’s aging society and the need to reduce medical costs. In response, the Kinki University Faculty of Pharmacy implemented a physical assessment practical training seminar in order to improve the physical assessment skills of practicing pharmacists. A series of questionnaires were conducted among pharmacists to investigate their perceptions of physical assessment practical training seminars. The results of the questionnaires were analyzed using Customer Satisfaction (CS) analysis and text mining. Based on a 5-point scale (1-low∼5-high), questionnaires revealed satisfaction for physical assessment practical training seminars was 4.6±0.6 (Ave.±S.D.). CS analysis revealed that the items “lectures” and “case seminars” had the highest level of satisfaction. However, items showing low levels of satisfaction were “auscultation of respiratory sounds” and “SBAR (Situation, Background, Assessment, Recommendation).” Results of text mining suggested a relationship between “physical assessment” and “difficult”. Analysis of the questionnaires showed a high level satisfaction with physical assessment practical training seminars, notably physical assessment practice methods. However, CS analysis and text mining indicate the finer techniques of physical assessment were difficult to acquire.