著者

Akihito Endo Sanae Okada Hidetoshi Morita

出版者

公益財団法人 応用微生物学・分子細胞生物学研究奨励会

雑誌

The Journal of General and Applied Microbiology (ISSN:00221260)

巻号頁・発行日

vol.53, no.3, pp.191-200, 2007 (Released:2007-08-29)

参考文献数

37

被引用文献数

8 31 32

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Diversity and compositions of the Lactobacillus, Streptococcus, and Bifidobacterium group in the feces of six healthy, actively racing horses (Thoroughbreds) were analyzed by using PCR-denaturing gradient gel electrophoresis (DGGE) and real-time PCR with primer sets specific for each group. PCR-DGGE analysis of the feces showed that Lactobacillus equi, Lactobacillus johnsonii, a phylogenetic relative of Lactobacillus salivarius, a phylogenetic relative of Lactobacillus gastricus, and Weissella confusa were predominant in almost all of the feces tested, and Streptococcus bovis/Streptococcus equinus was predominant in the Streptococcus group. The Bifidobacterium group was not detected by single-PCR but atypical species of the group were found in three of the six Thoroughbreds tested by nested-PCR. Calculation and estimation of lactic acid bacteria and bifidobacteria revealed that lactic acid bacteria were predominant in the feces and bifidobacteria were minor. These results indicate that the community of lactic acid bacteria and bifidobacteria in horse feces are unique because of the presence of specific species for horse feces and a minority of the Bifidobacterium group. Repeated tests of the feces from the same horse over 3 months showed that the diversity and composition of lactic acid bacteria and bifidobacteria in the feces was basically stable throughout the test period.

著者

Quan Feng Liu Jang Ho Lee Young-Mi Kim Soojin Lee Yoon Ki Hong Soojin Hwang Youngje Oh Kyungho Lee Hye Sup Yun Im-Soon Lee Songhee Jeon Young-Won Chin Byung-Soo Koo Kyoung Sang Cho

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

pp.b15-00459, (Released:2015-10-10)

参考文献数

58

被引用文献数

3 37

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder, characterized by progressive neuronal loss with amyloid β-peptide (Aβ) plaques. Despite several drugs currently used to treat AD, their beneficial effects on AD progress remains under debate. Here, we established a rapid in vivo screening system using Drosophila AD models to assess the neuroprotective activities of medicinal plants that have been used in traditional Chinese medicine. Among 23 medicinal plants tested, the extracts from five plants, Coriandrum sativum, Nardostachys jatamansi, Polygonum multiflorum (P. multiflorum), Rehmannia glutinosa, and Sorbus commixta (S. commixta), showed protective effects against the Aβ42 neurotoxicity. We further characterized the neuroprotective activity of ethanol extracts from P. multiflorum and S. commixta. Aβ42-expressing flies that we used showed AD neurological phenotypes, such as decreased survival and motility and increased cell death and reactive oxygen species level. However, feeding these flies extracts from P. multiflorum or S. commixta showed strong suppression of such phenotypes. Similar results were observed in human cells, so that the treatment of P. multiflorum and S. commixta extracts increased the viability of Aβ-treated SH-SY5Y cells. Moreover, 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside, one of the main constituents of P. multiflorum, also showed similar protective activity against Aβ42 cytotoxicity in both Drosophila and human cells. Taken together, our results suggest that both P. multiflorum and S. commixta have therapeutic potential for the treatment of neurodegenerative diseases, such as AD.

著者

鶴田 格 藤原 佑哉

出版者

地域農林経済学会

雑誌

農林業問題研究 (ISSN:03888525)

巻号頁・発行日

vol.51, no.1, pp.50-55, 2015-06-25 (Released:2015-07-04)

参考文献数

9

被引用文献数

1

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This paper examines the sociological factors in the in-situ conservation of traditional varieties of sorghum in the Yamato Highlands, Nara prefecture. In village A, red sorghum is still grown to color red bean rice, an auspicious food used in celebrations. A village enterprise dedicated to food processing plays a key role in red sorghum production. Elderly females grow this crop to dye other products bright red, the color favored by fellow villagers. In the adjacent village B, which has no enterprises, the same red sorghum is grown by some households but strictly for domestic consumption. In both cases, social relations based on reciprocity within the neighborhood and family are important factors in maintaining this kind of traditional food and crop.

著者

前田 一行 中嶋 佑一 市川 雛代 鬼頭 良幸 古﨑 貴大 斎藤 臣雄 本山 高幸 長田 裕之 小林 哲夫 木村 真

出版者

日本マイコトキシン学会

雑誌

マイコトキシン (ISSN:02851466)

巻号頁・発行日

vol.64, no.1, pp.69-74, 2014-01-31 (Released:2014-06-21)

参考文献数

21

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赤かび病菌Fusarium graminearumはトリコテセン系かび毒を産生し穀類を汚染する病原菌である.トリコテセン類は安定性が高く,分解・除去が困難であるため,かび毒の産生そのものを制御する手段の確立が望まれている.我々は赤かび病菌のトリコテセン系かび毒の産生制御に向けた制御化合物の探索を行っている.理化学研究所天然物化合物バンク(NPDepo)から供与される化合物を直接,毒素誘導条件下の菌体に処理してトリコテセン産生への影響を調べる方法に加え,化合物アレイを用いてトリコテセン生合成酵素の阻害剤を探索している.本稿では,これらの手法によって現在までに得られつつある有用化合物に関する活性評価と作用機作についての概要を紹介する.

著者

ベル 裕紀

出版者

日本文化人類学会

雑誌

日本文化人類学会研究大会発表要旨集 日本文化人類学会第48回研究大会 (ISSN:21897964)

巻号頁・発行日

pp.81, 2014 (Released:2014-05-11)

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韓国は、非熟練労働者の海外からの受け入れを行っている。この制度の下では事業所の変更が厳しく制限され、移住労働者にとっては、韓国人支援団体とのネットワークが、劣悪な労働条件や賃金未払、時には暴力から逃れるために、必要不可欠である。このネットワークを通じての移住労働者の集中とその結果生じたを支援団体の機能不全を解決するために、互助組織が形成されていった過程をカンボジア人の事例を通じて見ていく。

著者

上田 真寿美 安部 保子 薮内 ふじ江

出版者

日本発育発達学会

雑誌

発育発達研究 (ISSN:13408682)

巻号頁・発行日

vol.1996, no.24, pp.1-7, 1996-07-01 (Released:2010-03-16)

参考文献数

32

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This study was to investigate the effects of exercise experienced in youth on the genital function from menarche to menopause. One thousand and seven females after menopause aged from 45 to 88 completed the questionnaires. The results were as follows.1) The age of menarche became significantly younger as years went on.2) Females who had exercised in youth was significantly ahead of those who had not exercised in youth in menarche. The age of menarche was significantly earlier in more exercised group than in less exercised group.3) The frequency of pregnancy and delivery became significantly lower as years wore on.4) Although the period from menarche to menopause tended to get longer, there were no effects of the exercise experienced in youth on it.5) There were no effects of the exercise experienced in youth on the age of menopause and menopausal disorder.

著者

古松 弥生 柳 許子

出版者

一般社団法人 日本繊維製品消費科学会

雑誌

繊維製品消費科学 (ISSN:00372072)

巻号頁・発行日

vol.16, no.3, pp.77-85, 1975-03-25 (Released:2010-09-30)

参考文献数

5

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ジャージーの特性を損なわず, 外観が美しく物理的性質の優れた縫い目を得る家庭縫製の最適条件を見いだすため実験を行なった.今回の実験計画の範囲では針目数, 縫い目方向, 編み地, 縫い目形式, 縫い糸等の影響が見られた.針目数は外観の3目/cm, 平面摩耗強度の5目/cmを除き他はほとんど7目/cmが良い.縫い目方向は外観, 引張り強度にはコース方向, 破裂強度, 平面摩耗強度, 引張り伸度にはウェール方向の縫合で良い結果を得た.編み地は縫いずれ率, 平面摩耗強度, 引張り伸度等には厚手ウェルトリップルが良い.縫い目形式は破裂にはジグザグ縫い, 平面摩耗強度には直線縫いが良い.縫い糸は破裂には上糸ポリエステルフィラメント・下糸ウーリーナイロン及び上糸下糸ともレジロンが好ましく, 縫い縮み率, 平面摩耗強度には上糸下糸ともポリエステルフィラメントが良い等, 衣服の用途, 縫合箇所により縫合条件を選択したい.しかし縫合布の引張り, 破裂に対し編み地の損傷はなく縫い糸切断が容易であった事から, 編み地に比較してニット用レジロン初め市販の家庭用ミシン糸は極めて弱く, 丈夫な縫い糸の市販が望まれる.

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.58, no.8, pp.652-655, 2015-11-01 (Released:2015-11-01)

著者

玉置 司 植村 賢介 岡田 晃 宇野 義幸

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.78, no.1, pp.72-76, 2012-01-05 (Released:2012-07-05)

参考文献数

15

被引用文献数

3

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Plasma nitriding treatment is very effective for the hardening of precision metal parts. Especially, high density plasma nitriding can efficiently generate a high density ion with installed hollow cathode, which decreases the damage of the workpiece. As a result, the parts can be cleaned, etched, heated, and nitrided effectively. In this study, an improvement of surface integrity of stainless steel SUS440C is experimentally investigated by nitriding. The experimental analysis made it clear that the surface hardness of workpiece increased due to the generation of nitrided layer even under the low temperature condition like 513K. The nitrided layer was hardened with an increase of process temperature and process time, until a maximum surface hardness of 1700HV.

出版者

公益財団法人 日本学術協力財団

雑誌

学術の動向 (ISSN:13423363)

巻号頁・発行日

vol.20, no.6, pp.6_96-6_97, 2015-06-01 (Released:2015-10-02)

参考文献数

1

著者

木俣 勲 井関 基弘

出版者

環境技術学会

雑誌

環境技術 (ISSN:03889459)

巻号頁・発行日

vol.26, no.9, pp.549-554, 1997-09-30 (Released:2010-03-18)

参考文献数

17

被引用文献数

1 1

著者

吹田 隆道

出版者

JAPANESE ASSOCIATION OF INDIAN AND BUDDHIST STUDIES

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.33, no.2, pp.547-548, 1985-03-25 (Released:2010-03-09)

著者

Takamichi Fukita

出版者

JAPANESE ASSOCIATION OF INDIAN AND BUDDHIST STUDIES

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.35, no.1, pp.490-488, 1986-12-25 (Released:2010-03-09)

著者

吹田 隆道

出版者

JAPANESE ASSOCIATION OF INDIAN AND BUDDHIST STUDIES

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.40, no.2, pp.960-956, 1992-03-20 (Released:2010-03-09)

被引用文献数

1

著者

柏原 豊 西田 好徳 馬場 信男

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.115, no.5, pp.659-664, 1995-04-20 (Released:2008-12-19)

参考文献数

2

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We have developed a multimedia information system for railroad passengers, that can retrieve graphics and full-color images as well as alphanumeric data. This system consists of a host computer, user terminals, and workstations for creating and editing information pages. These components are linked through a high-speed Ethernet LAN. The user terminals requires high-speed response, so JPEG compression is used in full-color images to reduce the time required to transmit images from the host computer.In September 1993, experimental user terminals were set up in Kintetsu Namba Station, Uehonmachi Station and Abenobashi Station. The tourist information on the Shima Spain Village and Ise-Shima National Park provided by these user terminals has been highly evaluated by users.

著者

司会:岡本 美孝 演者:藤枝 重治

出版者

一般社団法人 日本耳鼻咽喉科学会

雑誌

日本耳鼻咽喉科学会会報 (ISSN:00306622)

巻号頁・発行日

vol.118, no.4, pp.453-454, 2015-04-20 (Released:2015-06-05)

著者

栗田 かほる 望月 優花 国分 秀也 厚田 幸一郎

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.11, pp.1307-1315, 2015 (Released:2015-11-01)

参考文献数

14

被引用文献数

2

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The dose of a transdermal fentanyl patch is proportional to its application site area. Therefore, the absorption of fentanyl may decrease if the patch detaches, leading to insufficient analgesia. Sixteen healthy volunteers were enrolled in a study to investigate the appropriate application sites and clinical utility of three transdermal fentanyl patches available in Japan. Three placebos, Fentanyl 1-day (Fentos; Fen), Fentanyl 3-day (Durotep; Dur), and Generic Fentanyl 3-day (HMT) were administered using a crossover study design. The placebos were applied to 11 different sites, including both sides of the upper arm, abdomen, back, thigh, chest, and the middle of the chest. We determined the patch detachment area and incidence of patch-induced itching every 24 h and evaluated differences between each application site using the Wilcoxon signed-rank test. Significant patch detachment was observed on the abdomen and upper arms with Fen, on the abdomen and chest with Dur, and on the chest with HMT compared with that at other sites (p<0.005). Although no significant difference in itching was observed between regions when administering Fen, itching significantly increased on the chest and back when using Dur and on the abdomen when using HMT as compared with that at other sites (p<0.05). Our results indicate that the three transdermal Fen patches exhibit different adhesive properties and local adverse events, indicating that the application site should be cautiously selected for each patch type.

著者

Hideharu Hagiya Hiroko Ogawa Yusuke Takahashi Kosuke Kimura Kan Hasegawa Fumio Otsuka

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.21, pp.2775-2777, 2015 (Released:2015-11-01)

参考文献数

13

被引用文献数

9

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We herein present a rare case of Actinomyces turicensis bacteremia that was caused by pyometra. The patient was successfully treated with transvaginal drainage and antibiotic therapy. A literature review in MEDLINE showed that there have been only 8 previously reported cases of A. turicensis bacteremia. This infection frequently occurs in patients with visceral abscesses, and blood culture examinations usually reveal a polymicrobial pattern. However, the prognosis of such patients has been reported to generally be benign. Due to difficulties in performing bacterial identification and the wide-spectrum clinical pictures associated with this bacteremia, no comprehensive understanding of the clinical features of each Actinomyces species has yet been established.

著者

中村 泉 三浦 悌二

出版者

日本生気象学会

雑誌

日本生気象学会雑誌 (ISSN:03891313)

巻号頁・発行日

vol.29, no.3, pp.172-172, 1992-10-12 (Released:2010-10-13)

著者

古川 昭栄

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.135, no.11, pp.1213-1226, 2015 (Released:2015-11-01)

参考文献数

71

被引用文献数

1 3

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The author has studied nerve growth factor (NGF) and its family of neurotrophic factors (neurotrophins) for over 40 years. During the first 20 years, my laboratory established a highly sensitive enzyme immunoassay for NGF and analyzed the regulatory mechanism of NGF synthesis in cultured primary cells. Fibroblast cells cultured from peripheral organs such as the heart and astrocytes from the brain produced a substantial amount of NGF in a growth-dependent manner. Furthermore, synthesis of NGF in these cells could be upregulated by catechol compounds including catecholamines. This observation might explain a physiological relation between the level of NGF mRNA and the density of innervation in the peripheral sympathetic nervous systems. Over the subsequent 20 years, my laboratory investigated the physiological functions of neurotrophic factors, including neurotrophins, during development or post-injury and found that brain-derived neurotrophic factor (BDNF) plays a role in the formation of the laminar structure of the cerebral cortex. In addition, my laboratory discovered that endogenous glial cell line-derived neurotrophic factor (GDNF) contributes to the amelioration of motor activity after spinal cord injury. Therefore we aimed to develop low-molecular weight compounds that generate neurotrophic factor-like intracellular signals to protect or ameliorate neurological/psychiatric diseases. 2-Decenoic acid derivatives and other similar molecules could protect or ameliorate in animal models of mood disorders such as depression and enhance recovery from spinal cord injury-induced motor paralysis. Compounds that can generate neurotrophin-like signals in neurons are expected to be developed as therapeutic drugs for certain neurological or psychiatric disorders.