著者

銅谷 賢治

出版者

The Japanese Society for Artificial Intelligence

雑誌

人工知能学会全国大会論文集

巻号頁・発行日

pp.90, 2002 (Released:2003-07-10)

著者

Eun-Sun Choi Taeho Chung Jun-Sung Kim Hakmo Lee Ki Han Kwon Nam-Pyo Cho Sung-Dae Cho

出版者

日本酸化ストレス学会

雑誌

Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)

巻号頁・発行日

vol.53, no.2, pp.89-93, 2013 (Released:2013-08-31)

参考文献数

40

被引用文献数

3 12

---

Mithramycin A (Mith) is an aureolic acid-type polyketide produced by various soil bacteria of the genus Streptomyces. Mith inhibits myeloid cell leukemia-1 (Mcl-1) to induce apoptosis in prostate cancer, but the molecular mechanism underlying this process has not been fully elucidated. The aim of this study was therefore to investigate the detailed molecular mechanism related to Mith-induced apoptosis in prostate cancer cells. Mith decreased the phosphorylation of mammalian target of rapamycin (mTOR) in both cell lines overexpressing phospho-mTOR compared to RWPE-1 human normal prostate epithelial cells. Mith significantly induced truncated Bid (tBid) and siRNA-mediated knock-down of Mcl-1 increased tBid protein levels. Moreover, Mith also inhibited the phosphorylation of mTOR on serine 2448 and Mcl-1, and increased tBid protein in prostate tumors in athymic nude mice bearing DU145 cells as xenografts. Thus, Mith acts as an effective tumor growth inhibitor in prostate cancer cells through the mTOR/Mcl-1/tBid signaling pathway.

著者

Toshio Tanaka Takehiko Oka Yasuhito Shimada Noriko Umemoto Junya Kuroyanagi Chikara Sakamoto Liqing Zang Zhipeng Wang Yuhei Nishimura

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.107, no.1, pp.8-14, 2008 (Released:2008-05-20)

参考文献数

9

被引用文献数

11 21

---

The most important strategies in pharmacogenomics are gene expression profiling and the network analysis of human disease models. We have previously discovered novel drug target candidates in cardiovascular diseases through investigations of these pharmacogenomics. The significant induction of S100C mRNA and protein expression was detected in the rat pulmonary hypertension and myocardial infarction model. We also found increased taurine in hypoxia, a calcium-associated cytoprotective compound, to suppress the hypoxia-induced S100C gene expression and vascular remodeling. These results suggest that S100C may be one of the potential novel drug targets in hypoxic or ischemic diseases. Delayed cerebral vasospasm after aneurysmal subarachnoid hemorrhage causes cerebral ischemia and infarction. Using a DNA microarray, a prominant upregulation of heme oxygenase-1 (HO-1) and heat shock protein (HSP) 72 mRNAs were observed in the basilar artery of a murine vasospasm model. Antisense HO-1 and HSP 72 oligodeoxynucleotide inhibited HO-1 and HSP 72 induction, respectively, and significantly aggravated cerebral vasospasm. Moreover, we have also developed a unique heart failure model in zebrafish and identified several candidate genes as novel drug targets. These results suggest that pharmacogenomic network analysis has the potential to bridge the gap between in vitro and in vivo studies and could define strategies for identifying novel drug targets in various cardiovascular diseases.

著者

Tetsuya KAWAKITA Fuminori KAWABATA Tomoko TSUJI Motoko KAWASHIMA Shigeto SHIMMURA Kazuo TSUBOTA

出版者

バイオメディカルリサーチプレス

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.34, no.5, pp.215-220, 2013 (Released:2013-11-02)

参考文献数

19

被引用文献数

2 36

---

The purpose of this study was to evaluate the efficacy of fish oil supplementation added to usual dry eye treatment in dry eye subjects in a randomized controlled trial. Twenty-seven typical dry eye subjects were selected from 43 candidates by the diagnostic criterion for dry eye in this study. They were assigned to the randomized fish oil group (n = 15) or the placebo group (n = 12). Fish oil group ingested fish oil capsules containing eicosapentaenoic acid (EPA, 1245 mg/day) and docosahexaenoic acid (DHA, 540 mg/day) for 12 weeks. Placebo group ingested placebo capsules without EPA or DHA. A visual analog scale test estimating subjective symptoms, the Schirmer I test, tear film break-up time (BUT) measurement, fluorescein staining, and rose bengal staining were performed every 4 weeks during the 12-week supplementation period and 4-week washout period. The subjective symptom of “eye pain”, BUT, and changes in rose bengal staining score of the fish oil group were significantly improved after 8-12 weeks of supplementation and/or 4 weeks of washout, compared to those of the placebo group. These results suggest that fish oil supplementation added to usual care may be effective in the treatment of dry eye.

著者

尾内 能夫

出版者

公益社団法人 日本アイソトープ協会

雑誌

RADIOISOTOPES (ISSN:00338303)

巻号頁・発行日

vol.28, no.6, pp.403-411, 1979-06-15 (Released:2010-07-21)

参考文献数

11

被引用文献数

1 1

著者

長橋 良隆 吉川 周作 宮川 ちひろ 内山 高 里口 保文

出版者

日本第四紀学会

雑誌

第四紀研究 (ISSN:04182642)

巻号頁・発行日

vol.43, no.5, pp.345-352, 2004-10-01 (Released:2009-08-21)

参考文献数

28

被引用文献数

2 7

---

火山ガラスの屈折率は,その主要成分化学組成に依存している.そのことを火山ガラスの主要成分含有量と屈折率(n)から,各成分ごとに屈折度(n-1)を算出することにより例示した.また,近畿地方および八ヶ岳山麓に産するテフラ(102試料)のEDS分析結果を用いて,主成分元素の酸化物含有量と屈折率との関係について検討した.SiO2はその含有量が多いことから,屈折率に寄与する割合が大きい.またSiO2量が増加すると,屈折率は低下する.SiO2と負の相関にある成分(TiO2・Al2O3・FeO*・MgO・CaO)は,含有量が増加するにつれて屈折率が高くなる.SiO2と相関のないNa2Oは,含有量と屈折率に相関がない.K2Oは,SiO2-K2O図でK2Oレベルの異なる複数のトレンドがあるが,含有量と屈折率には一続きの相関はない.火山ガラスの屈折率はテフラ同定・対比の際の重要な指標であるが,屈折率が近似する火山ガラスでも,主要成分化学組成は異なる場合がある.

著者

渡辺 偉夫

出版者

公益社団法人 日本地震学会

雑誌

地震 第2輯 (ISSN:00371114)

巻号頁・発行日

vol.36, no.1, pp.83-107, 1983-03-25 (Released:2010-03-11)

参考文献数

63

被引用文献数

2

著者

Taku Shoji Akifumi Maruyama Mitsuhisa Maruyama Shunji Ito Tetsuo Okujima Junya Higashi Kozo Toyota Noboru Morita

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

pp.20130275, (Released:2013-11-08)

被引用文献数

15

---

6-Methoxy- and 6-dimethylaminoazulenes with methylthio groups at the 1- or 1,3-positions have been prepared by electrophilic substitution of the corresponding azulenes with DMSO in the presence of acid anhydride, followed by treatment with Et3N. The products, 1-methylthioazulenes, reacted with Tf2O to afford the corresponding 1,1’-biazulene derivatives in moderate yields. The redox behavior of these azulene and 1,1’-biazulene derivatives was examined by cyclic voltammetry (CV), which revealed reversible electron transfers under electrochemical oxidation conditions. 6-Dimethylamino-1,3-bis(methylthio)azulenes with a heteroaryl group at the 2-position were also prepared by the reaction of 6-dimethylamino-1,3-bis(methylthio)azulene with triflates of N-containing heterocycles, i.e., pyridine, quinoline, isoquinoline, acridine, and 1,10-phenanthroline, followed by treatment with KOH in alcohols.

著者

山下 泰央 上瀧 弘晃 高橋 大志

出版者

公益社団法人 計測自動制御学会

雑誌

計測自動制御学会論文集 (ISSN:04534654)

巻号頁・発行日

vol.48, no.11, pp.773-780, 2012 (Released:2012-11-29)

参考文献数

17

---

This research analyzed the relationship between headline news and bond market in Japan through text mining technology. As a result of intensive analyses, we found the significant relationship between interest rate changes and the negative (or positive) news classified by keywords. At the same time, we also found that a measure of constructing keyword list has a significant impact on performance of classification.

著者

山崎 高弘 常盤 欣一朗

出版者

一般社団法人 電気学会

雑誌

電気学会論文誌C(電子・情報・システム部門誌) (ISSN:03854221)

巻号頁・発行日

vol.132, no.9, pp.1524-1532, 2012-09-01 (Released:2012-09-01)

参考文献数

10

---

This paper describes a method of readability assessment for web documents. Readability is the ease in which text can be read and understood. We hypothesize that the readability is determined whether a reader can easily grasp text structures. The impression and the complexity of text are significant factors. We extract the features about impression and complexity from a plain text and additional data such as HTML tags.In order to compare effect of extracting features, we are assessing readability rank by machine learning. We conduct 5-fold cross validation for each domain, and calculate the root mean squared error between the actual rank and the estimated rank. The cross validation experiments confirm that the performance of our method is high measured. It shows effectiveness of extracting features about the impression and the complexity for readability assessment.

著者

上野 大樹 樋口 文人 安村 通晃

出版者

公益財団法人 情報通信学会

雑誌

情報通信学会誌 (ISSN:02894513)

巻号頁・発行日

vol.30, no.2, pp.2_57-2_65, 2012 (Released:2012-12-25)

参考文献数

17

---

近年、Webのソーシャル化に伴い、一部のWeb情報が急激に流行る傾向がでてきた。例えば、Twitterやソーシャルブックマークサービスなどの影響により、情報が一気に伝搬して流行ることが多くなってきた。こういった情報の中には、流行りが過ぎてしまうと、あまり有用ではなくなるものも多く、賞味期限の短い情報もどんどん増加してきている。そのため、筆者らはその情報がどれだけ長期間利用されているかの指標、いわば情報の長期度のような指標が重要になってきたのではないかと考える。そこで、本研究では長期度の計算手法を提案し、長期間利用され続けている情報を取得するためのシステムを提案する。そして、検索キーワードがどれだけ長期間に渡って、検索され続けているかという時系列情報を利用して、Web上で長期間利用される検索キーワード一覧を取得するシステムを開発した。

著者

清水 幾太郎

出版者

日本社会学会

雑誌

社会学評論 (ISSN:00215414)

巻号頁・発行日

vol.2, no.2, pp.2-8, 1951-08-30 (Released:2009-11-11)

著者

栗原 藤三郎 菊地 正雄

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.95, no.11, pp.1283-1285, 1975-11-25 (Released:2008-05-30)

参考文献数

6

被引用文献数

3 22

---

A new isoflavone glycoside, kakkalide, was isolated from the methanol extract of fresh flower of Pueraria thunbergiana BENTH., and its chemical structure was determined as irisolidone-7-β-D-xylopyranosyl-6-O-β-D-glucopyranoside

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.110, no.8, pp.604-611, 1990-08-25 (Released:2008-05-30)

参考文献数

33

被引用文献数

8 19

---

The present study was designed to examine the effects of methanolic extract (PE-ME), isoflavonoid fraction (PF-IF), triterpenoid saponin fraction (PF-SP) and N-acyl-N1-glucosyl-tryptophan (PF-P) isolated from puerariae flos on alcohol-induced unusual metabolism (as for glucose (BG), triglyceride (TG), and urea nitrogen (BUN) level in blood) and experimental liver injury (model : CCl4-and high fatty food induced) in mice. These alcohol-induced increasing responses were inhibited by the extracted and refined substances from puerariae flos. In short, PF-ME (4500 mg/kg) and PF-P (400 mg/kg) inhibited an increase in BG level induced by alcohol, whereas PF-IF (1000 mg/kg) and PF-SP (1000 mg/kg) did not. Similary, PF-ME and PF-SP inhibited an increase in TG induced by alcohol, whereas PF-IF did not. In addition, PF-IF and PF-SP inhibited increasing BUN level. Still more, PF-IF and PF-SP significantly inhibited an increase in gulutamate oxalacetate transaminase or gulutamate pyruvate transaminase level induced by high-fatty food and CCl4 in control animals. Especially PF-IF (250 mg/kg) administration showed a remarkable effect (inhibition : 76.3%) in control animals. These results suggested that puerariae flos or its combination drugs may be a useful drug as a traditional medicinal system for counteraction to drinking.

著者

新甫 勇次郎 山崎 律 中島 嘉次郎 伊東 宏 竹下 尚 金城 順英 野原 稔弘

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.109, no.6, pp.424-431, 1989-06-25 (Released:2008-05-30)

参考文献数

26

被引用文献数

7 31

---

In the general rule, Puerariae Flos or it's combination drugs are used in traditional medicinal system for counteraction to drinking among Japanese and Chinese therapy. One of such drugs is Kakkakaiseito. Here we report the results of investigation on some pharmacological actions including alcoholic metabolism. The experiments were carried out to confirm its actual effect on alcohol, acetaldehyde and ketone body metabolism in the blood and the alteration of behaviour pattern of mice. Drugs used in this study were methanolic extract (PF-ME), isoflavonoid fraction (PF-IF) and triterpenoid saponin fraction (PF-SP) isolated from Puerariae Flos. Each drug was orally administrated to mice. These results were shown as follows : the concentrations of blood alcohol and acetaldehyde decreased more after the treatment with PF-IF (800 mg/kg) than those of the control group. This fact was evidenced remarkable effects with area under the blood concentration-time curve, mean residence time, and variance residence time and values on the moment analysis. However, a reduction effect was not recognized by the treatment with PF-SP (1000 mg/kg). Moreover, PF-ME and PF-IF suppressed the increment of spontaneous movement induced by alcohol administration, whereas PF-SP did not prevent the decrease in the increment caused by alcohol administration. These results support the basis that Puerariae Flos or its combination drugs is used in a traditional medicinal system for counteraction to drinking. However, further investigation is necessary.

著者

小川 知彦

出版者

日本細菌学会

雑誌

日本細菌学雑誌 (ISSN:00214930)

巻号頁・発行日

vol.61, no.4, pp.391-404, 2006-11-25 (Released:2011-06-17)

参考文献数

85

---

1933年Boivinらは初めてネズミチフス菌から内毒素を抽出して以来, 内毒素の化学的, 生物学的な研究が多方面にわたり進められた. 1952年Westphalらの温フェノールー水により抽出された内毒素性リボ多糖 (LPS) の構造学的, 機能学的性状が明らかにされるとともに, 今日, これらグラム陰性菌の感染防御機構に関する研究が国内外で盛んに行われ大きな進歩がみられる. これまでのPS研究のなかで, 1960年代からBacteroides類縁菌LPSの特徴的な化学構造やその生物活性に注目が集まりこれまでの長い研究の歴史がある. また, 口腔内に棲息する歯周病の原因菌として注目される菌種もかつてはバクテロイデス属に分類されていたものが多くみられ, なかでも黒色色素産生性偏性嫌気性菌であるPorphyromonas gingivalis (旧Bacteroides gingivalis) LPSについてもビルレンス因子としての可能性が探究されてきた. これらBacteroides類縁菌LPSの活性中心であるリピドA分子は, その特徴的な化学構造の故に内毒素作用や種々の生物活性が弱く, しばしばLPSのアンタゴニストとして作用することが知られている. 他方, これらしPSは, LPSに不応答であるC3H/HeJマウスの細胞を活性化することが多数報告されている. 我々はP.gingivalisリピドAの化学構造を最初に明らかにしたが, 当初, P.gingivalisLPSやリピドAがC3H/HeJマウスに作用することを多くの研究者と同様に報告した. その後近年のToll-likereceptor研究の隆盛に応じて, P.gingivalisLPSやリピドAがTLR2に作用するリガンドであるとの知見が多くみられた. 我々は, P.gingivalisリピドA種の不均質性ならびに生物学的に活性な成分の混入などの問題点を解決するためにリピドAの化学合成対応物を作出し, TLR4アゴニストであるとの結果を得ている. さらにP.gingivalisLPSやリピドAがTLR2リガンドであるとの通説を払拭するためにP.gingivalisLPS画分に混入するTLR2アゴニストを分離・精製し, その化学構造が3残基の脂肪酸からなるリポタンパク質であることを明らかにし, 長年のBacteroides類縁菌LPSにまつわる問題を解決した. 歯科領域ばかりでなく, 自然免疫分野では今なお, “TLR2活性LPS1リピドA”との誤認に基づく研究が跡を絶たない. これまでの歴史的経緯を踏まえて, 腸内細菌科由来LPSやリピドAと同様に, TLR4に作用するリガンドであるBactem/des類縁菌PSについて, P.gingivalisLPSやリピドAに関する研究を中心に概説した.

著者

Masaaki KATAYAMA Yoshiki KAWAKAMI Rieko KATAYAMA Shunsuke SHIMAMURA Yasuhiko OKAMURA Yuji UZUKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0209, (Released:2013-11-05)

被引用文献数

3

---

Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) trough level in human and feline organ transplant patients. However, the interaction of CLM with CsA has not been reported in dogs. In this study, the effects of multiple dosing of CLM on the pharmacokinetics of CsA in three healthy beagles were investigated. The treatments included CsA 10 mg/kg alone and CsA 10 mg/kg + multiple-dose of CLM 10 mg/kg. Co-administration of CLM with CsA resulted in significant increases of oral bioavailability of CsA. The results of our study suggest that administration of multiple therapeutic doses of CLM may decrease the required CsA dosage in CsA-based immunosuppressive therapy in renal transplanted dogs.

著者

Zongli HAN Yanli DU Hui QI Wei YIN

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.53, no.9, pp.630-634, 2013 (Released:2013-09-25)

参考文献数

22

被引用文献数

1 10

---

To add a further contribution to the literature supporting the relationship between previous head trauma and the development of glioma. We present the first case of pregnancy-related post-traumatic malignant glioma in a 29-year-old female who was admitted because of left sided hemiplegia and epilepsy due to a malignant glial tumor. She had been operated for a right frontal hematoma caused by a motorbike accident 9 years before. Neuroimaging showed a large neoplasia in the right frontal region beneath the material used for cranialplasty, and postoperative pathological revealed a glioblastoma multiforme (GBM) in continuity with the scar resulting from the trauma. While epidemiologic studies may not be conclusive, a pathologic basis has been suggested which show that trauma act as a cocarcinogen in the presence of an initiating carcinogen. Our case fulfilled the widely established criteria for brain tumors of traumatic origin. We believe that in specific cases it is reasonable to acknowledge an etiological association between head trauma and glioma. And additional factors such as pregnancy may promote the manifestation of the clinical symptoms.

著者

宇谷 明秀 西元 雅明 山本 尚生

出版者

日本知能情報ファジィ学会

雑誌

知能と情報 (ISSN:13477986)

巻号頁・発行日

vol.24, no.3, pp.791-802, 2012-06-15 (Released:2012-06-26)

参考文献数

21

被引用文献数

1

---

本論文では高次元連続型多峰性関数の最適化問題に対する解探索性能に優れた Artificial Bee Colony アルゴリズムに着目し,高次元(数百次元)の最適化問題に対して,一つの大域的最適解ではなく,複数の許容解を求めることができるように拡張発展させた実用手法を提案する.数値実験では多峰性を有する代表的な3つのベンチマ-ク関数(Rastrigin関数/ Schwefel関数/ Griewank関数)を用いてその解探索性能を評価した.数値実験の結果は既往の複数解探索手法に対する提案手法の優位性を示している.

著者

矢上 一夫 村上 薫 正泉寺 秀人 山田 仁穂

出版者

繊維学会

雑誌

繊維学会誌 (ISSN:00379875)

巻号頁・発行日

vol.47, no.9, pp.487-491, 1991-09-10 (Released:2008-11-28)

参考文献数

9

---

Acid dyes of anthraquinone type, C. I. Acid Green 25, Acid Green 27 and Acid Blue 40, on wool and silk were irradiated to investigate the interaction with a fluorescent agent of pyrazoline type, C. I. FBA 54 (FWG), using a low pressure mercury lamp, a high pressure mercury lamp and a xenon lamp equipped with a Pyrex filter. The dyed fabrics showed a decrease and then an increase in reflectances at the initial stage of the reaction followed by a monotonous decay in color. The fading of the dyes were depressed by FWG. The fluorescence of FWG increased at the initial stage of the reaction and then decreased. The degradation of FWG was depressed in the presence of dyes.