著者

佐崎 祥子 廣川 俊二

出版者

バイオメカニズム学会

雑誌

バイオメカニズム学会誌 (ISSN:02850885)

巻号頁・発行日

vol.29, no.4, pp.227-234, 2005 (Released:2007-10-23)

参考文献数

9

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工業用複合材料が主要強度材である繊維と母材の中間的強度を示すのに対し,生体複合材である腱・靭帯では主要強度材である線維束よりも靭帯複合体の力学強度が高くなり,工業材料とは逆の現象を示す.本研究では,生体軟組織の階層構造を考慮しつつ,靭帯を線維束の集合体とみなした二種類の靭帯力学モデルを構築し,上記逆転現象のメカニズムの解明を試みた.モデルには,実験結果を基に線維束の力学的不均一性や線維束・間質物質間の干渉力を表す要素を含めた.最初のモデルは線維束と靭帯の伸びだけを扱った一次元離散モデルであり,靭帯の応力-ひずみ特性に見られるつま先領域,線形領域,破断領域を区別しつつモデルを構成した.第二のモデルは超弾性体の二次元連続体モデルであり,靭帯固有の特性である有限変形,非圧縮性の条件を導入した.シミュレーション解析の結果,両モデル共に,上記逆転現象を再現し得ることを確認した.

著者

Masato Otsuka Tomoharu Mine Kentarou Ohuchi Shinji Ohmori

出版者

The Japanese Biochemical Society

雑誌

The Journal of Biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.119, no.2, pp.246-251, 1996 (Released:2008-11-18)

参考文献数

19

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The metabolism of diacetyl (2, 3-butanedione), acetoin (3-hydroxy-2-butanone), and 2, 3-butanediol, which are metabolites of acetaldehyde was quantitatively investigated using rat liver homogenate, liver perfusion, and in vivo experiments. Diacetyl and acetoin were reduced to 2, 3-butanediol in these experiments, but acetoin and 2, 3-butanediol were scarcely oxidized to diacetyl, indicating that the reduction reaction to 2, 3-butanediol from diacetyl occurs actively in rat liver. The formation of acetoin from diacetyl required either NADH or NADPH as a reductant, while the reduction of acetoin to 2, 3-butanediol required NADH. Acetoin and 2, 3-butanediol were more readily accumulated than diacetyl in brain tissue.

著者

岩屋 隆夫

出版者

Japan Society of Civil Engineers

雑誌

土木史研究 (ISSN:09167293)

巻号頁・発行日

vol.17, pp.123-134, 1997-06-05 (Released:2010-06-15)

参考文献数

102

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In order to clear the functions of the floodway in the delta area, the history of the floodway development and the branch channel closing and the actual condition of the floodway were examined based on the consideration on the topogra phy and the geology. As the results, two conditions as the floodway of the excavated channel and the kept branch channel on the delta were confirmed: 1) For small capacity with the discharge less than 100% both the mainstream and the branch channel. 2) For restricting the channel separation by the existence of the water use forms on the old main channel.

著者

佐々木 清治

出版者

一般社団法人 人文地理学会

雑誌

人文地理 (ISSN:00187216)

巻号頁・発行日

vol.5, no.5, pp.323-341,402, 1953-12-30 (Released:2009-04-28)

参考文献数

28

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Various aspects and problems of Shinden(reclaimed rice-field) on delta have been so far investigated, but materials which refer to its geographical distribution are hardly to be found. Here in this report, I am to make a comparative study on the distribution of the settlemets of Shinden on the delta of the Fuji river and that of the Oi river (both in Shizuoka Pref.).(1) There are two ways in which Shinden is formed and developed on the delta, namely, the intussusception growth and the apposition growth. The one means that Shinden is formed and covers the delta by way of thrusting itself in already established villages, and by the other is meant that Shinden is added at the circumference of old settlement. In other words, the former can be called the area-expanding growth which makes Shinden spread over the delta, and the latter the thickening growth which makes the settlement on delta thicker. As the typical examples of these two ways of development of Shinden on delta, are taken the reclaimed rice-fields on the delta of the Fuji river (the apposition growth) and that of the Oi river (the intussusception growth).(2) Irrespective of the above-mentioned area-expanding growth or the thickening growth, Shinden is divided into another two kinds, the centrifugal growth and the centripetal growth, according to the direction of its development. Shinden on the delta of the Fuji river belongs to the former. There, the original rice-field being in the center of delta, the new rice-field developed thence toward the outer side-namely, the centrifugal growth. On the contrary, the one on the delta of the Oi river was centripetally formed. developing, from the circumference toward the surface of delta.(3) If developed by the intussusception growth, the reclimed rice-field is distributed all over the surface of delta. A good example is found in the one on the delta of the Oi river, which can be called an equifacial settlement. The equifacial settlement sometimes has a naturally formed nucleus, and there are two cases of forming the nucleus. In one case, the nucleus being vague, people can only surmise the nuclear part, and in the other case, the nucleus being distinct, the reclaimed rice-field is spreading around it. I call the nucleus of the latter a hilum of Shinden on delta. Such a hilum is found just in the center of delta of the Oi river, that is, Kamishinden in Aikawavillage. Besides the case the hilum coincides with the center of delta as afore-mentioned, there may be another case the hilum keeps at a distance from the center of delta.(4) The delta is edged by the reclamed rice-field if the latter developed by the thickening growth; and the bordered distribution or ringed distribution of the reclaimed ricefield on delta comes to be observed. The one on the delta of the Fuji river is its good example, which shows distinctly the distribution of pericycle settlement. When the delta is not edged wholly, the half bordered distribution is observed as we see on the deltas of the Ota river (Hiroshima Pref.) and the Hii river (Shimane Pref.). If Shinden is scanty in the center of delta while it is distributed only around it, a central gap is made in the region of reclaimed rice-field, of which good example is given by the distribution of Shinden on the delta of the Fuji river.

著者

岩本 光雄

出版者

日本霊長類学会

雑誌

霊長類研究 (ISSN:09124047)

巻号頁・発行日

vol.4, no.2, pp.134-144, 1988 (Released:2009-09-07)

被引用文献数

4 2

著者

田中 忠夫 山本 忠利

出版者

公益社団法人 日本アイソトープ協会

雑誌

RADIOISOTOPES (ISSN:00338303)

巻号頁・発行日

vol.43, no.7, pp.389-396, 1994-07-15 (Released:2010-09-07)

参考文献数

19

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自然環境の通気層中に生じる不連続な水の流れの条件下における85Srの移行挙動を明らかにするため, 85Srで汚染させた砂質土壌層へ脱イオン水を断続的に流下するカラム移行実験を行った。流れの停止回数が増すに従って, 陽イオン性85Srの土壌層中移行速度は増大する傾向を示した。この原因は, 土壌から間隙水中へ溶出するCa2+の濃度が流れの停止期間に増加することにより, 85Srの分配係数が減少するためであるとみなされた。土壌層流出液のCa2+濃度から推定した85Srの分配係数と土壌層における85Srの移行速度から得た分配係数とは, 流れの停止回数に伴う減少傾向がよく一致した。

著者

大槻 剛巳 中野 孝司 長谷川 誠紀 岡田 守人 辻村 亨 関戸 好孝 豊國 伸哉 西本 寛 福岡 和也 田中 文啓 熊谷 直子 前田 恵 松崎 秀紀 李 順姫 西村 泰光

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.66, no.3, pp.543-552, 2011 (Released:2011-06-24)

参考文献数

73

被引用文献数

1

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The research project entitled “Comprehensive approach on asbestos-related diseases” supported by the “Special Coordination Funds for Promoting Science and Technology (H18-1-3-3-1)” began in 2006 and was completed at the end of the Japanese fiscal year of 2010. This project included four parts; (1) malignant mesothelioma (MM) cases and specimen registration, (2) development of procedures for the early diagnosis of MM, (3) commencement of clinical investigations including multimodal approaches, and (4) basic research comprising three components; (i) cellular and molecular characterization of mesothelioma cells, (ii) immunological effects of asbestos, and (iii) elucidation of asbestos-induced carcinogenesis using animal models. In this special issue of the Japanese Journal of Hygiene, we briefly introduce the achievements of our project. The second and third parts and the third component of the fourth part are described in other manuscripts written by Professors Fukuoka, Hasegawa, and Toyokuni. In this manuscript, we introduce a brief summary of the first part “MM cases and specimen registration”, the first component of the fourth part “Cellular and molecular characterization of mesothelioma cells” and the second component of the fourth part “Immunological effects of asbestos”. In addition, a previous special issue presented by the Study Group of Fibrous and Particulate Substances (SGFPS) (chaired by Professor Otsuki, Kawasaki Medical School, Japan) for the Japanese Society of Hygiene and published in Environmental Health and Preventive Medicine Volume 13, 2008, included reviews of the aforementioned first component of the fourth part of the project. Taken together, our project led medical investigations regarding asbestos and MM progress and contributed towards the care and examination of patients with asbestos-related diseases during these five years. Further investigations are required to facilitate the development of preventive measures and the cure of asbestos-related diseases, particularly in Japan, where asbestos-related diseases are predicted to increase in the next 10 to 20 years.

著者

平川 浩文

出版者

日本哺乳類学会

雑誌

哺乳類科学 (ISSN:0385437X)

巻号頁・発行日

vol.44, no.1, pp.103-105, 2004 (Released:2008-04-09)

著者

永田 秀尚

出版者

The Japan Landslide Society

雑誌

地すべり (ISSN:02852926)

巻号頁・発行日

vol.39, no.1, pp.53-61, 2002-06-25 (Released:2010-06-28)

参考文献数

45

被引用文献数

2 1

著者

谷口 直樹

出版者

一般社団法人 表面技術協会

雑誌

表面技術 (ISSN:09151869)

巻号頁・発行日

vol.54, no.12, pp.951-956, 2003 (Released:2004-12-03)

参考文献数

35

被引用文献数

1 1

著者

尾崎 美智子 稲月 明 福岡 保 浦岡 忠夫 平田 賢一 上田 重春 堀内 淳

出版者

一般財団法人 日本消化器病学会

雑誌

日本消化器病学会雑誌 (ISSN:04466586)

巻号頁・発行日

vol.93, no.7, pp.470-474, 1996-07-05 (Released:2011-06-17)

参考文献数

10

著者

能美 健彦 清水 雅富 グルーズ ピーター

出版者

日本環境変異原学会

雑誌

環境変異原研究 (ISSN:09100865)

巻号頁・発行日

vol.26, no.2, pp.159-165, 2004 (Released:2005-12-21)

参考文献数

47

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Altered oxidative metabolism is a property of many tumor cells. Oxidation of dNTP pool as well as DNA is a source of genome instability. We report here that two Y-family DNA polymerases of the archaeon Sulfolobus solfataricus strains P1 and P2 incorporate oxidized dNTPs into nascent DNA in an erroneous manner: the polymerases exclusively incorporate 8-hydroxy-dGTP opposite template A, and incorporate 2-hydroxy-dATP opposite G and T. Extension onto the incorporated analogs is only slightly reduced. Human DNA polymerase η, a member of human Y-family DNA polymerases, incorporates the oxidized dNTPs in a similar erroneous manner. These DNA polymerases are shown to bypass a variety of DNA lesions. Thus, our results suggest the Y-family DNA polymerases promote mutagenesis through the erroneous incorporation of the oxidized dNTPs during DNA synthesis in addition to facilitating translesion DNA synthesis.

著者

吉村 信吉

出版者

日本陸水学会

雑誌

陸水学雑誌 (ISSN:00215104)

巻号頁・発行日

vol.13, no.2-3, pp.55-62, 1943-09-30 (Released:2009-06-12)

参考文献数

7

被引用文献数

1 1

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1. 上富には地下水面の深さから云つて三種の地下水がある。最も淺いものは年中宙水をなし,中位のものは低水時には一時的に宙水となるが,高水時には下位の一般自由地下水と一緒にになる。下位の地下水面は柳瀬川,入る間川の水と平衡を保ち,低水時には河水面に等しい所まで低下する。2. 深井戸の多くは中位の深さの井戸の底を昭和8,9年の渇水に際し掘り拔いたものである。その結果將來中位の深さの井戸水は釜.減少するであらう。3. 上富の發生當時には現在のやうに深く且平時湛水の厚い井戸は存在せず,中位の高水時以外は湛水の少い井戸に依存したのであつた。當時としては中位の井戸を掘ることも容易でなく.元祿時代まで聚落を發生せしめなかつた原因をなしたのであつた。それ以後には地下水状態は必しも居住を決定してゐない。深井戸は最近の渇水時に掘つたものである。昭18.V,17

著者

Rui KANO Ayami SHIBAHASHI Yasuhito FUJINO Hiroki SAKAI Takashi MORI Hajime TSUJIMOTO Tokuma YANAI Atsuhiko HASEGAWA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0119, (Released:2012-08-10)

被引用文献数

13 23

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Aspergillus udagawae and A. viridinutans are members of the section Fumigati; both cause invasive aspergillosis in humans. These two Aspergillus species are discriminated from A. fumigatus by molecular methods. Herein, we report two cases of feline orbital aspergillosis, one caused by A. udagawae and the other by A. viridinutans. To our knowledge, Case 1 represents the first reported case of treatment of A. udagawae with a high dosage of itraconazole, and Case 2 represents the first reported case of A. viridinutans infection associated with sarcoma. Identification of the etiologic agents of these cases was confirmed by comparative analyses of the sequences of β-tubulin-encoding genes. With the spread of non-fumigatus aspergillosis, increasing emphasis should be placed on molecular identification of the infecting Aspergillus species and the use of in vitro drug susceptibility tests to ensure the selection of appropriate antibiotics.

著者

田中 伸治 白石 智良 小宮 粋史 花房 比佐友 林 誠司 平井 洋 桑原 雅夫

出版者

東京大学生産技術研究所

雑誌

生産研究 (ISSN:0037105X)

巻号頁・発行日

vol.64, no.2, pp.259-262, 2012 (Released:2012-04-10)

参考文献数

3

被引用文献数

1

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交通シミュレーションを利用してCO2排出量等を推計する際には, 国内外で異なるモデルが使用される可能性が高いため, モデル検証の手続きを国際的に共通化することが重要である.そこで本プロジェクトでは, 交通シミュレーションモデルおよびCO2排出量モデルの検証の枠組みを提案し, 国際ワークショップを通じた合意形成のための議論を行っている.また, この検証に利用可能な実交通データを取得するため現地観測調査を行い, 得られたデータを利用して検証の枠組みの妥当性を確認するための試行検証を実施している.

著者

Takeshi HATTA Makoto MATSUBAYASHI Takeharu MIYOSHI Md. Khyrul ISLAM M. Abdul ALIM Anisuzzaman Kayoko YAMAJI Kozo FUJISAKI Naotoshi TSUJI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0175, (Released:2012-08-10)

被引用文献数

4 14

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Most causative agents of babesiosis, Babesia parasites, are transmitted transovarially in ixodid ticks. In this study, B. gibsoni, the causative agent of canine babesiosis which has transovarial transmission, was detected in tissues of the vector tick, Haemaphysalis longicornis using a modified quantitative PCR assay. Conventional PCR results showed that the newly designed primer set, which amplifies a 143-bp fragment of rhoptry-associated protein-1 (BgRAP-1) gene in B. gibsoni, was 100 times more sensitive than primers targeting P18 gene encoding 18 kDa protein of B. gibsoni, which was recently renamed as thrombospondin related adhesive protein (BgTRAP) gene, in an artificially generated sample solution containing metagenomic DNA (B. gibsoni DNA extracted from infected dog blood mixed with tick DNA). The TaqMan probe-based quantitative PCR (qPCR) for BgRAP-1 could also detect infected RBCs (iRBCs) at levels of 3.5 × 105 to 3.5 × 101/μl, a range that is broader than that of a past SYBR Green-based qPCR method for P18/BgTRAP, which had a detection limit of 3.5 × 103 iRBCs/μl. Using this qPCR assay, we attempted to quantify the B. gibsoni burden in tick ovaries and embryonated eggs. Levels of infection were normalized to the copy number of tick’s genomic DNA fragment of ribosomal DNA internal transcribed spacer region 2 (ITS2) for the standardization. According to this, low levels of parasite burden were quantified in ovaries and eggs. This detection system is sensitive and is recommended as a tool for elucidating the biological interactions between the vector tick H. longicornis and the parasite, B. gibsoni.

著者

都築 誠二

出版者

分子シミュレーション研究会

雑誌

アンサンブル (ISSN:18846750)

巻号頁・発行日

vol.9, no.38, pp.36-39, 2007-04-30 (Released:2010-06-28)

参考文献数

6

著者

都築 誠二

出版者

分子シミュレーション研究会

雑誌

アンサンブル (ISSN:18846750)

巻号頁・発行日

vol.9, no.37, pp.6-9, 2007-01-31 (Released:2010-06-28)

参考文献数

6

著者

都築 誠二

出版者

分子シミュレーション研究会

雑誌

アンサンブル (ISSN:18846750)

巻号頁・発行日

vol.8, no.36, pp.35-38, 2006-10-31 (Released:2010-06-28)

参考文献数

11

著者

都築 誠二

出版者

分子シミュレーション研究会

雑誌

アンサンブル (ISSN:18846750)

巻号頁・発行日

vol.8, no.35, pp.40-43, 2006-07-31 (Released:2010-06-28)

参考文献数

8