著者

古田 睦広 尾崎 元昭 原田 禹雄 高橋 俊一郎 村上 元正 松本 繁雄

出版者

一般社団法人 国立医療学会

雑誌

医療 (ISSN:00211699)

巻号頁・発行日

vol.26, no.2, pp.139-144, 1972 (Released:2011-10-19)

参考文献数

14

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Histopathological examination of tuberculosis was done on 107 autopsy cases in Komyoen Leprosarium from 1962 to 1970. Seventeen cases showed pulmonary tuberculosis, including healed and calcified lesions. The average age of these cases was 66.6. Active pulmonary tuberculosis was found in 10 cases; half of them formed tuberculous cavity. Only 2 cases showed remarkable extension of the disease to the other organs. This was quite different from the formm of tuberculosis before 1900 which was predominantly accompanied with direct or miliary type extension. Gaseous pneumonia of 4 cases between 1967 and 1666 suggested possibility of reinfection on the aged. Active tuberculosis on the aged seemed to have a tendency to become caseous pneumonia. There was no correlation between the types of leprosy and tuberculosis. We deny any specific relation of tuberculosis to leprosy patients.

著者

村上 元 森元 隆文 西山 薫 池田 望

出版者

日本パーソナリティ心理学会

雑誌

パーソナリティ研究 (ISSN:13488406)

巻号頁・発行日

pp.27.1.8, (Released:2018-05-18)

参考文献数

36

被引用文献数

1

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本研究は,被害妄想的観念の頻度,確信度,苦痛度の3側面に対して影響を与える要因を検証することを目的とした。被害妄想的観念への影響要因としては原因帰属,不安,抑うつを想定した。原因帰属は,内在性,安定性,全般性の3次元とし,内在性についてはさらに内的帰属,外的–状況的帰属,外的–人的帰属の3次元に細分化した。研究には統合失調症患者48名が参加した。階層的重回帰分析の結果,被害妄想的観念の頻度には抑うつと全般性が,確信度には抑うつ,外的–人的帰属,および全般性が,苦痛度には抑うつと不安が影響を与えていた。以上のことから,被害妄想的観念の3側面それぞれは,影響をおよぼされる要因が異なることが示された。したがって,被害妄想的観念への介入に際しては,各側面ごとに,感情の統制,もしくは原因帰属の把握が必要であることが示唆された。

著者

村上 元彦

出版者

日本高圧力学会

雑誌

高圧力の科学と技術 (ISSN:0917639X)

巻号頁・発行日

vol.18, no.1, pp.21-30, 2008-02-20 (Released:2008-03-18)

参考文献数

36

被引用文献数

1 1

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Brillouin scattering measurements of the aggregate shear wave velocities in MgSiO3 perovskite and post-perovskite phase were conducted at high-pressure conditions relevant to the Earth’s lowermost mantle. Infrared laser annealing of samples in a diamond anvil cell enabled to obtain high quality Brillouin spectra and to extend the upper limit of pressure of Brillouin measurements. The large pressure range over which acoustic measurements of MgSiO3 perovskite and post-perovskite phase were performed has thereby allowed us to put tighter constraints on compositional models of the Earth’s lower mantle and enigmatic seismic observations in the lowermost mantle.

著者

錦織 圭史 村上 元良 内田 清 尾留川 正博 宮武 範夫

出版者

公益社団法人日本磁気学会

雑誌

日本応用磁気学会誌 (ISSN:18804004)

巻号頁・発行日

vol.21, no.4, pp.321-324, 1997-04-15

被引用文献数

1

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The potential advantages of magnetically induced super-resolution (MSR) for high-density recording in magneto-optical disks have spurred the study of various related technology. MSR systems can read signals from a smaller area than the laser spot area by using magnetic films with different temperature characteristics. Most MSR systems require an external magnetic field in the readout. We have developed a new type of MSR (S-RAD) that does not require an external magnetic field. The front masking area of the S-RAD is formed by shrinking the recording mark in the readout layer. This paper describes the readout principle and readout characteristics of S-RAD. A C/N of 49 dB was obtained at the 0.5μm recording mark. A crosstalk level of less than -40 dB was obtained at a track pitch of 0.8 μm.We believe that S-RAD has sufficient potential to allow practical use of high-density magneto-optical recording.

著者

蔵本 築 桑子 賢司 松下 哲 三船 順一郎 坂井 誠 岩崎 勤 賀来 俊 峰 雅宣 村上 元孝

出版者

一般社団法人 日本老年医学会

雑誌

日本老年医学会雑誌 (ISSN:03009173)

巻号頁・発行日

vol.15, no.3, pp.267-273, 1978-05-30 (Released:2009-11-24)

参考文献数

16

被引用文献数

5

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脳出血, 脳梗塞に伴う心電図変化の成因を検討する目的で, 発作前1カ月内及び発作後の心電図, 臨床検査成績が得られ, 剖検上確認された老年者脳出血18例, 脳梗塞29例について, 発作前後の心電図, 臨床検査成績, 血圧の変化, 剖検による冠狭窄度, 脳病変の部位, 大きさ等を対比検討した.発作前後の心電図変化は脳出血88.9%, 脳梗塞89.7%に認められST, T変化がそれぞれ61.1%, 69.0%と高頻度に見られ, 高度な虚血性変化は脳梗塞で多く見られた. 不整脈は脳出血55.6%, 脳梗塞41.4%に見られ, 発作時の心房細動出現は脳梗塞にのみ10.3%に見られた. 期外収縮は脳出血に多く上室性22.1%, 心室性11.1%, 脳梗塞ではそれぞれ10.3%, 3.4%であった.脳卒中発作前後のヘマトクリット上昇は脳梗塞で大きい傾向があり, 虚血性ST, T変化を示した群では脳出血2.44±0.57, 脳梗塞6.04±1.74の上昇を示し, 著明なヘマトクリットの上昇による冠微小循環の障害が虚血性ST, T変化を斉すことを示唆した.脳卒中発作時の収縮期血圧上昇は脳出血では52.5±8.9mmHgで心電図変化の程度に拘らず200mmHg以上の高値を示したが脳梗塞では8.7±10.4とその変動は僅かで血圧上昇が心電図変化の原因とはいえなかった.冠動脈狭窄の程度は脳出血, 脳梗塞共各心電図変化群の間に狭窄指数の差が見られず, 虚血性心電図変化が太い冠動脈の狭窄によるものではないことを示した. 一方心筋梗塞の合併は脳出血5.6%に比し脳梗塞で50.0%と有意に高頻度であった.脳病変の部位, 大きさでは外側型脳出血に虚血性ST, T変化の多い傾向が見られたが, 脳梗塞では中大脳動脈領域の梗塞に於ても心電図変化に一定の傾向はなく, 部位による特徴は認められなかった. また両群共病巣の大きさと心電図変化には一定の傾向は見られなかった.脳出血, 脳梗塞の虚血性心電図変化は病巣の部位, 大きさ, 冠硬化, 血圧上昇等とは関連が認められず, ヘマトクリット上昇による冠微小循環の障害がその一因と考えられた.

著者

村上 元 森元 隆文 西山 薫 池田 望

出版者

札幌医科大学保健医療学部

雑誌

札幌保健科学雑誌 = Sapporo Medical University Sapporo Journal of Health Sciences

巻号頁・発行日

no.7, pp.25-30, 2018-03

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妄想的観念はその主題に基づいて分けることができる.負の感情価の主題を持つ観念は被害妄想的観念となり,正の感情価の主題を持つ観念は誇大妄想的観念となる.妄想的観念は主題の相違によりその発生メカニズムが異なると想定されている.そこで,本研究では,被害妄想的観念は「疎外」「被害」の主題を持つ観念で,誇大妄想的観念は「被好意」「庇護」「他者操作」「自己肯定」の主題を持つ観念で構成されると想定し,各6つの主題に対する感情と原因帰属の影響を検討した.対象は統合失調症患者48名であり,全ての対象に妄想的観念チェックリスト,原因帰属尺度,気分調査票短縮版による測定を実施した.その結果,正あるいは負の感情価の主題を持つ妄想的観念ごとに抑うつや怒りなど共通する影響要因が存在した一方で,各6つの主題ごとに異なる影響要因も存在した.以上のことから,妄想的観念の主題に応じた介入を展開することが望ましいと言える.

著者

村上元三 著

出版者

朝日新聞社

巻号頁・発行日

vol.第1巻, 1952

著者

船曳 康子 北 徹 石井 賢二 日下 茂 袴田 康弘 若月 芳雄 村上 元庸 横出 正之 久米 典昭 堀内 久徳

出版者

一般社団法人 日本老年医学会

雑誌

日本老年医学会雑誌 (ISSN:03009173)

巻号頁・発行日

vol.36, no.4, pp.274-278, 1999

被引用文献数

10

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症例は83歳男性. 1996年12月末より徐々に喀痰, 咳嗽, 全身倦怠感, 食欲低下みられ当院受診. 肺炎と診断され1997年1月7日入院となった. 入院時血圧70/48mmHg, PaO2 55.5mmHg, CRP20mg/dl, ラ音聴取, 黄色膿性痰みられ, 抗生剤を開始した, 血清抗体価の上昇より (入院時4倍→2週後128倍), インフルエンザA感染症の合併と診断した. 発熱, 呼吸困難は抗生剤治療に抵抗性であった. 血中よりアスペルギルス抗原を検出し (2+), 抗真菌剤治療により抗原は (1+) と改善したが, 2月20日, 喀血をきたし永眠された, アスペルギルス症は免疫不全患者が罹るとされているが, 本例では入院後数日間白血球数が低下しており, インフルエンザによる一時的免疫力低下がアスペルギルス症の発症に関与したと考えられた. また高齢者のインフルエンザ感染症の合併症の重篤さが示唆された.

著者

岩崎 勤 松下 哲 折茂 肇 白木 正孝 萬木 信人 加藤 洋一 高橋 龍太郎 蔵本 築 村上 元孝 野間 昭夫 岡部 紘明

出版者

一般社団法人 日本動脈硬化学会

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.9, no.1, pp.87-91, 1981-04-01 (Released:2011-09-21)

参考文献数

13

被引用文献数

1

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Effects of γ-oryzanol on the serum HDL, LDL and total cholesterol (ch) and Triglyceride were studied in 17 cases whose age was 47 years old to 82 years old (mean age was 71.2 years old). Three hundred mg/day of γ-oryzanol was given for 4 months.Serum HDL-ch was 50.0±2.3 (m±SE) mg/dl before γ-oryzanol and 53.7mg/dl 3 months later but HDL-ch which was below 50mg/dl before treatment increased significantly (p<0.01) from 43.3mg/dl to 50.4mg/dl 2 months later. HDL-ch below 45mg/dl increased significantly (p<0.01) from 41.3mg/dl (mean) to 50.0mg/dl (mean) 2 months later. LDL-ch decreased significantly (p<0.01) from 158.8mg/dl to 134.8mg/dl after γ-oryzanol. HDL-ch×10/LDL-ch showed significant changes (p<0.01) (from 3.26 to 4.14) 2 months later. Total-ch did not change and between 203mg/dl and 208mg/dl. Triglyceride did not show significant changes.It is suggested that γ-oryzanol alters the metabolism of HDL-ch and LDL-ch and increases serum low HDL-ch.

著者

三田 修三 長倉 弘幸 勝見 則和 堀田 滋 川合 清行 村上 元一

出版者

公益社団法人 自動車技術会

雑誌

自動車技術会論文集 (ISSN:02878321)

巻号頁・発行日

vol.45, no.5, pp.799-804, 2014 (Released:2018-01-25)

参考文献数

8

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シリンダボアのクロスハッチ形状を考慮した潤滑モデルを開発し,ピストンリング列-シリンダボア間の摩擦特性予測に適用した.クロスハッチ角の縮小(30°→10°)に伴い,油膜形成が促進されて摩擦平均有効圧が1kPa 以上低減できることを予測し,実部品を用いたラボ計測および浮動ライナ法での実動時測定により効果を確認した.

著者

竹越 国夫 山之内 博 東儀 英夫 村上 元孝 亀山 正邦

出版者

一般社団法人 日本老年医学会

雑誌

日本老年医学会雑誌 (ISSN:03009173)

巻号頁・発行日

vol.13, no.6, pp.371-377, 1976-11-30 (Released:2009-11-24)

参考文献数

15

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老年者の新鮮脳血管障害66例 (脳硬塞38例, 脳出血28例) 中, 41例にステロイドを使用し, 25例は対照群として, ステロイドの有効性を, 意識レベルの改善と生存を指標として検討した. 対象の年齢は, 平均76.2歳であった. 47剖検例については, 病巣部位, 病巣の大きさを確認した. ステロイドの使用方法について, 薬剤はプレドニゾロンが22例, デキサメサゾンが14例, その他5例であった. 薬剤の使用総量は, デキサメサゾン換算量で平均40.4mgであり, 一日最大使用量は, 平均10.0mgであった. ステロイドは, 発症後平均1.7日以内に使用開始し, 平均7.2日間使用した.結果は, 1) 脳硬塞において, 意識レベルの改善は, ステロイド使用群では23例中9例 (39%) にみられたのに対し, 対照群では15例中5例 (33%) にみられ, 両群間に有意の差は認められなかった. 4週生存率は, ステロイド使用群では70%であったのに対し, 対照群では80%であり, 両群間に有意の差は認められなかった. 入院時意識レベル別に検討した場合, 意識レベルの改善率と生存率において, ステロイド使用群と対照群の両群間に有意差は認められなかった.2) 脳出血において, 意識レベルの改善は, ステロイド使用群で18例中5例(27%)にみられたのに対し, 対照群では10例中1例 (10%) にみられ, 両群間に有意差は認められなかった. 4週生存率は, ステロイド使用群で56%であったのに対し, 対照群では10%であった. しかし, ステロイド使用群と対照群の間に, 意識レベルの条件が一致せず, 厳密に比較検討することはできなかった.3) ステロイドの副作用について, 消化管出血が, ステロイド使用群に3例, 対照群に1例みられ, 非ケトン性糖尿病性昏睡が, ステロイド使用群に1例みられた.

著者

松田 保 小河原 緑 平林 直子 関 俊子 横内 正利 村上 元孝 島田 馨 三船 順一郎

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.9, no.2, pp.208-212, 1978

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Recently, growing interests had been devoted largely to disseminated intravascular coagulation (DIC), because of its frequency and clinical importance. It has been known that shock is a frequent complication of DIC, although it has not been elucidated whether shock is a cause of DIC rather than a result. This study was made to clarify relationship between DIC and shock in 699 consecutive autopsied cases, almost all of whom was over age sixty, in Tokyo Metropolitan Geriatric Hospital.<br>The diagnosis of DIC was established when coagulation analysis revealed presence of consumption coagulopathy. Among these cases, 106 had evidences of DIC and 30 had clinical and pathological findings highly suggestive of DIC although the coagulation findings were not specific. Shock was complicated in 38 of the former and 10 of the latter.<br>Eight of these 48 patients with DIC complicated with shock revealed consumption coagulopathy simultaneously with the development of shock. 24 cases had not clea r-cut evidences of DIC immediately after the development of shock in coagulation findings, although they showed marked coagulation abnormalities indicating DIC after the shock developed. 44% of conditions associated with the shock in these patients was gram-negative septicaemia. The other underlying pathologic conditons in these cases consisted of cancer, peptic ulcer, acute myocardial infarction and pneumonia.<br>Onset of shock was observed in 16 cases in whom diagnosis of DIC had been already established by coagulation analysis. 11 cases of these had cancer with metastases, primary organs of which were stomach, colon or biliary tracts. 70% of these patients were febrile.<br>Acute renal failure, purpura, petechiae, melena, coma, epileptic seizure, systemic peripheral gangrene and/or red cell fragmentation in peripheral blood smear were main symptoms in DIC with shock. Four cases, excluding two cases in whom DIC developed following development of acute myocardial infarction, showed ECG findings indicating development of acute myocardial infartion, although myocardial infarction was evident in only one cases by postmortem examination.<br>Presence of fibrin thrombi was confirmed in 36 cases out of the 48 autopsied cases with DIC accompained with shock. Terminal hemorrhagic necrotizing enteropathy was observed in 15 of those cases. Hemorrhage from adrenal was observed in 4 cases.<br>From these results, it is concluded that shock does frequently cause DIC and that shock in gram-negative septicaemia is especially important because of its high incidence to result DIC.

著者

村上 元孝 上田 好雄 松田 保 梅田 俊彦

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.3, no.3, pp.212-217, 1962

著者

小竹 要 大江 国広 長谷田 恭子 吉野 公明 万見 新太郎 黒田 満彦 松田 保 竹田 亮祐 村上 元孝

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.15, no.5, pp.487-494, 1974

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Studies on platelet functions of 21 patients with renal insufficiency have been preformed. Platelet counts were significantly decreased in uremic patients, although severe thrombocytopenia less than 100&times;10³ platelets/mm³ was detected only in two patients. Platelet adhesiveness to glass was remarkably decreased in uremic patients. Platelet factor-3 availability was impaired in some of these patients, while platelet factor-3 activity was not decreased. Clot retraction was slightly defective in few patients. The significant correlation was not found between platelet adhesiveness and BUN, creatinine, uric acid or inorganic phosphate level in the serum of these patients. The abnormalities of platelet functions were partially corrected after dialysis.<br>In vitro, urea at high concentration showed an inhibitory effect on platelet aggregation. Guanidinosuccinic acid had less inhibitory effect on platelet aggregation, and creatinine had no inhibitory effect.

著者

村上 元孝 松田 保 西野 哲夫 平丸 三樹 万見 新太郎 高瀬 雅子

出版者

Japan Heart Foundation

雑誌

心臓 (ISSN:05864488)

巻号頁・発行日

vol.1, no.11, pp.1131-1140, 1969

著者

山崎 義亀与 松田 保 黒田 満彦 内田 健三 嶋田 千恵子 大谷 逸子 村上 元孝 北川 正信

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.14, no.1, pp.81-87, 1973

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A 25-year-old male was admitted because of dark-red urine, jaundice and purpura. 5 days prior to admission, the patient noticed that the urine color became dark red, and purpuric rash and jaundice were noted by his wife.<br>Examination revealed scleral icterus, pallor, numerous petechiae and an ecchymosis. The sensorium was clear. The neurologic examination was normal.<br>The patient had hemolytic anemia, thrombocytopenic purpura, fever and proteinuria. Shortly after admission, fluctuating neurologic symptoms developed, and the patient was diagnosed as thrombotic thrombocytopenic purpura.<br>He was treated with prednisolone and heparin without benefits, and expired on the 14 th hospital day.<br>Hyaline thromboses of the vessels of liver and kidney were demonstrated by the examination of the specimens obtained by post mortem needle puncture.<br>Coagulation studies disclosed that partial thromboplastin time and prothrombin time were slightly prolonged, however, factor V activity and fibrinogen titre were not low. Fibrinogen degradation products determined by tanned red cell hemagglutination inhibition immunoassay were markedly increased, although euglobulin lysis time was not shortened.<br>Immunological analysis of serum proteins showed the increase of acute phase reactants, the decrease of &beta;₁-AC and haptoglobin, and the appearance of fibrinogen degradation products.<br>These results were discussed in relation to the pathogenesis of the disease.

著者

村上 元孝 松田 保

出版者

大道学館出版部

雑誌

臨牀と研究 (ISSN:00214965)

巻号頁・発行日

vol.54, no.11, pp.p3506-3511, 1977-11

著者

村上 元孝 上田 好雄 松田 保 梅田 俊彦 太田 五六

出版者

一般社団法人 日本血液学会

雑誌

臨床血液 (ISSN:04851439)

巻号頁・発行日

vol.3, no.1, pp.52-59, 1962

著者

松田 保 児玉 直子 秀野 啓子 小河原 緑 松崎 俊久 村上 元孝 山之内 博

出版者

一般社団法人 日本血栓止血学会

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.7, no.2, pp.146-150, 1976

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Apparent blood viscosity was measured on freshly shed blood from 127 healthy subjects, ages 21 to 88, and patients hospitalized in Tokyo Metropolitan Yoikuin Geriatrics Hospital, over age 60. Determination of blood viscosity was performed at 37&deg;C using rotational viscometer at shear rates between 0.07 and 4.6sec^-1.<br>Mean blood viscosity in 43 healthy older subjects over age 60 (mean age: 74&plusmn;6) was 45&plusmn;25cp at 0.07sec^-1 and 8&plusmn;2cp at 4.6sec^-1, respectively. Yield stress was calculated from Casson plot at very low shear rates (between 0.44 and 0.07sec^-1) by the method of least squares. Mean value of yield stress in the healthy older subjects was 0.011 dynes/cm². Blood viscosity in the healthy subjects was significantly correlated with hematocrit values. Yield stress in these subjects was also correlated with hematocrit values and blood viscosity at very low shear rates. In these healthy subjects, blood viscosity, yield stress and hematocrit values were highest in the group at age 30-39. Blood viscosity and yield stress showed a slight decline with age in the healthy older subjects.<br>In the hospitalized patients, blood viscosity was higher than 70cp at 0.07sec^-1, and/or higher than 11cp at 4.6sec^-1 in 107 measurements (86 cases) out of 1443 determinations from December 1973 to October 1974. These patients with blood high viscosity included 12 cases of cancer (one of them was accompanied with disseminated intravascular coagulation (DIC); three of them developed DIC thereafter), 5 cases of acute myocardial infarction, 4 cases of acute cerebral infarction, 5 cases of angina pectoris, 6 cases of old myocardial infarction, 18 cases of old cerebrovascular diseases, 11 cases of diabetes mellitus, and 5 cases of stress polycythemia or polycythemia vera. In these cases, viscosity at 4.6sec^-1 was significantly correlated with hematocrit values, whereas viscosity at 0.07sec^-1 was not. All patients with blood high viscosity and relatively low hematocrit values suffered from cancer. In 6 cases of acute myocardial, cerebral of renal infarction, in whom changes in blood viscosity, yield stress and hematocrits were investigated before and after the development of infarction, changes in blood viscosity and yield stress were parallel with hematocrits.<br>From these results, it was concluded that high hematocrits caused blood high viscosity and were regarded as one of the risk factors in the pathogenesis of thrombosis, although the other factors than hematocrits might also influence blood viscosity at very low shear rates.

著者

松田 保 村上 元孝

出版者

Japan Atherosclerosis Society

雑誌

動脈硬化 (ISSN:03862682)

巻号頁・発行日

vol.3, no.4, pp.447-455, 1976

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Coagulability of blood was measured in 80 cases of acute myocardial infarction, 98 cases of acute cerebral infarction and 33 cases of acute cerebral hemorrhage. Platelet counts, activated partial thromboplastin times, prothrombin times, plasma fibrinogen content, levels of plasma antithrombin III, α₂-macroglobulin and fibrin degradation products (FDP) determined within 1 month before the attack of myocardial infarction or stroke, and those measured within 48 hours or 3 to 7 days following the onset of these diseases were compared with data obtained from 370 healthy subjects over age sixty.<br>Concentrations of plasma antithrombin III were apparently decreased before and after the development of myocardial infarction. In ten autopsied patients with acute myocardial infarction, three cases with extremely low levels of plasma antithrombin III (less than 2 mg/d<i>l</i>) were complicated with disseminated intravascular coagulation (DIC), acute cerebral infarction and/or thromboembolism of lower extremities, while no thromboembolic episodes following myocardial infarction were observed in the other seven cases in whom plasma antithrombin III concentrations were more than 20mg/d<i>l</i>. Levels of the other thrombin inhibitor in plasma than antithrombin III, i. e. α₂-macroglobulin, were increased immediately after the occurrence of cerebral hemorrhage. Plasma fibrinogen content was markedly increased after the development of myocardial infarction or cerebrovascular diseases. Activated partial thromboplastin times, prothrombin times and FDP did not significantly change before and after the development of these diseases. These data suggest that there may be a relation between development of myocardial infarction and the low levels of plasma antithrombin III. Increased levels of plasma fibrinogen, as a result of myocardial infarction or stroke, may not accelerate coagulation mechanism but act disadvantageously by elevating blood viscosity.<br>Relationship between activated partial thromboplastin times, prothrombin times, plasma fibrinogen content, levels of plasma antithrombin III, α₂-niacroglobulin or FDP, determined within 1 month before death, and grade of atherosclerosis of aorta, cerebral, coronary or femoral artery, classified grossly with the naked eye, was investigated in 186 autopsied cases without cancer or DIC, retrospectively. There were no correlations between these parameters and the grade of atherosclerosis, except that levels of FDP were significantly increased in cases with severe atherosclerosis of femoral artery. From these results, direct evidences supporting thrombogenic hypothesis of atherosclerosis suggested by Duguid were not obtained. However, atherosclerotic lesion of peripheral artery may activate clotting processes and increase FDP.