著者

Hiroaki Nakagawa Hiroshi Wada Takashi Hajiro Taishi Nagao Emiko Ogawa Atsushi Hatamochi Toshihiro Tanaka Yasutaka Nakano

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.24, pp.3181-3184, 2015 (Released:2015-12-15)

参考文献数

15

被引用文献数

16

---

A 17-year-old teen was hospitalized with bilateral pneumothorax. After the bilateral lungs were expanded using catheter tubes, he fully recovered and he was discharged from our hospital. He had a history of colon perforation. Ehlers-Danlos syndrome (EDS) was suspected due to the combination of colon perforation and pneumothorax, and EDS type IV was confirmed after a genetic study identified a c.1511g>a mutation in the COL3A1 gene. This is the first report of bilateral pneumothorax caused by EDS type IV. Clinicians should consider EDS type IV in the differential diagnosis for bilateral pneumothorax in conjunction with distinct previous histories and radiological findings.

著者

Hiroshi Yakushiji Atsu Yamasaki Shozo Kobayashi Junko Kaneyoshi Akifumi Azuma Hiroyoshi Sugiura Akihiko Sato

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.MI-080, (Released:2015-12-29)

被引用文献数

4

---

‘Hasshu’, a dwarf budsport that originated from the leading persimmon cultivar ‘Hiratanenashi’ (Diospyros kaki Thunb.), was discovered in Japan in 2005. Although ‘Hiratanenashi’ is seedless because of anisoploidy (2n = 135 = 9x), ‘Hasshu’ produces some small normal seeds. In this study, we investigated differences in the morphological characteristics of the vegetative organs and fruits and in the ploidy level between ‘Hasshu’ and ‘Hiratanenashi’. The shoot length, internode length, and leaf size of ‘Hasshu’ were smaller than those of ‘Hiratanenashi’. ‘Hasshu’ bore smaller flowers than those of ‘Hiratanenashi’ in late May, and had consistently smaller fruit than ‘Hiratanenashi’ at all fruit development stages. ‘Hasshu’ ripened in late October, similar to ‘Hiratanenashi’. Both ‘Hiratanenashi’ and ‘Hasshu’ are pollination-variant astringent (PVA) cultivars. Except for the deletion of one allele at ssrdk10, no differences were detected between the two cultivars at four simple sequence repeat (SSR) marker loci. By flow cytometric analysis and chromosome observation, we confirmed that ‘Hasshu’ was octoploid (2n = 120 = 8x), indicating that it was both a dwarf and a ploidy-reduction mutation. These results suggest that recovery of the ability to produce some normal seeds by ‘Hasshu’ may have been caused by the change in ploidy from anisoploid to isoploid.

著者

Shinya TAKAMAEDA-YAMAZAKI Hiroshi NAKATSUKA Yuichiro TANAKA Kenji KISE

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E98-D, no.12, pp.2150-2158, 2015-12-01

---

Soft processors are widely used in FPGA-based embedded computing systems. For such purposes, efficiency in resource utilization is as important as high performance. This paper proposes Ultrasmall, a new soft processor architecture for FPGAs. Ultrasmall supports a subset of the MIPS-I instruction set architecture and employs an area efficient microarchitecture to reduce the use of FPGA resources. While supporting the original 32-bit ISA, Ultrasmall uses a 2-bit serial ALU for all of its operations. This approach significantly reduces the resource utilization instead of increasing the performance overheads. In addition to these device-independent optimizations, we applied several device-dependent optimizations for Xilinx Spartan-3E FPGAs using 4-input lookup tables (LUTs). Optimizations using specific primitives aggressively reduce the number of occupied slices. Our evaluation result shows that Ultrasmall occupies only 84% of the previous small soft processor. In addition to the utilized resource reduction, Ultrasmall achieves 2.9 times higher performance than the previous approach.

著者

Hiroshi Ureshino Toshihiko Ando Kensuke Kojima Hidekazu Itamura Shunichi Jinnai Kazuko Doi Koichi Ohshima Kazuya Kurogi Masaharu Miyahara Shinya Kimura

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.24, pp.3205-3208, 2015 (Released:2015-12-15)

参考文献数

25

被引用文献数

1 12

---

Rituximab treatment may cause or exacerbate Kaposi's sarcoma (KS) in patients with human immunodeficiency virus (HIV)-associated multicentric Castleman's disease. Despite the widespread use of rituximab, rituximab-induced KS has not yet been reported in HIV-negative patients with diffuse large B cell lymphoma (DLBCL). We herein report a case of KS that developed after undergoing rituximab-containing chemotherapy in an HIV-negative patient with DLBCL. An 84-year-old man who received rituximab-containing chemotherapy for the treatment of DLBCL developed severe infection, and subsequently KS. Our observations indicate that serious infections under rituximab treatment may trigger KS. KS should therefore be considered when skin tumors appear in lymphoma patients receiving rituximab-containing chemotherapy.

著者

瀧田 浩 タキタ ヒロシ Hiroshi Takita

雑誌

二松學舍大學論集

巻号頁・発行日

vol.50, pp.95-117, 2007

著者

若松 寛 Hiroshi Wakamatsu

出版者

京都府立大学学術報告委員会

雑誌

京都府立大学学術報告 人文 (ISSN:00757381)

巻号頁・発行日

no.32, pp.p1-17, 1980

著者

Jing-Dong Guo Takahiro Sasamori Yutaro Yamamoto Hiroshi Matsubara Shigeru Nagase Hideki Yorimitsu

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

pp.20150343, (Released:2015-11-16)

被引用文献数

4

---

The previously reported palladium-catalyzed silylation of aryl chlorides with silylsilatranes were theoretically reinvestigated by DFT calculations with a focus on the effect of the transannular Si–N coordination on silyl transfer. The Si–N coordination proved to be not so influential as to accelerate the silyl transfer. However, it should be of benefit to use silylsilatranes as silylating agents because of their easy handling and facile preparation.

著者

Sukehiro Nayu Kida Nori Umezawa Masahiro Murakami Takayuki Arai Naoko Jinnai Tsunesada Inagaki Shunichi Tsuchiya Hidetoshi Maruyama Hiroshi Tsuda Yoshio

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.66, no.3, pp.189-194, 2013

被引用文献数

41

---

The invasion of the yellow fever mosquito <i>Aedes aegypti</i> at Narita International Airport, Japan was detected for the first time. During the course of routine vector surveillance at Narita International Airport, 27 <i>Ae. aegypti</i> adults emerged from larvae and pupae collected from a single larvitrap placed near No. 88 spot at passenger terminal 2 on August 8, 2012. After the appearance of <i>Ae. aegypti</i> in the larvitrap, we defined a 400-m buffer zone and started an intensive vector survey using an additional 34 larvitraps and 15 CO₂ traps. International aircraft and passenger terminal 2 were also inspected, and one <i>Ae. aegypti</i> male was collected from the cargo space of an international aircraft from Darwin via Manila on August 28, 2012. Larvicide treatment with 1.5% fenitrothion was conducted in 64 catch basins and one ditch in the 400-m buffer zone. Twenty-four large water tanks were also treated at least once with 0.5% pyriproxyfen, an insect growth regulator. No <i>Ae. aegypti</i> eggs or adults were found during the 1-month intensive vector survey after finding larvae and pupae in the larvitrap. We concluded that <i>Ae. aegypti</i> had failed to establish a population at Narita International Airport.

著者

岡林 洋 オカバヤシ ヒロシ Okabayashi Hiroshi

出版者

大阪大学大学院文学研究科

雑誌

待兼山論叢. 美学篇 (ISSN:03874818)

巻号頁・発行日

vol.14, pp.13-34, 1980

著者

Akihiko Kitamura Hiroshi Naito Takahiko Kimura Kazumitsu Shinohara Takashi Sasaki Haruhiko Okumura

出版者

一般社団法人 映像情報メディア学会

雑誌

映像情報メディア学会誌 (ISSN:13426907)

巻号頁・発行日

vol.69, no.10, pp.J292-J297, 2015 (Released:2015-09-25)

参考文献数

12

被引用文献数

6

---

To establish the superiority of monocular presentation in augmented reality (AR) over binocular presentation, we report two experiments involving a tracing task with an AR image covering a visual field observed in both the monocular and binocular conditions. In Experiment 1, the subjective visibility of the AR image and the accuracy of the tracing task were measured. In Experiment 2, participants identified a character in the AR image while tracing. The AR image was less visible in the monocular condition than in the binocular condition. Hence, participants could observe the real world more easily in the monocular condition, and the resulting performance on the tracing task was better in the monocular condition. Information acquisition from the AR image in the monocular condition was equivalent to that in the binocular condition. These results exhibit the superiority of monocular AR presentation for the performance of manual tasks.

著者

Siddiquee Salah Uddin Fujita Masao Nakamura Hiroshi

出版者

日本環境動物昆虫学会

雑誌

環動昆

巻号頁・発行日

vol.16, no.1, pp.39-47, 2005-04-30

---

To clarify whether the species composition of carabid beetles can be used to evaluate the field environments of 3 different husbandry practices(fertilizer(F), tillage(T) and green manure(Gr)), pitfall trappings were taken between June and October 2003 in Nagano Prefecture, Japan. The surveyed field was divided into 8 plots(7.5m X 14m) growing the same kinds of vegetables, and combinations of the 3 husbandry practices were decided using an experimental design based on 3 factors and 2 levels. ANOVA based on a table of orthogonal arrays of the L⁸(2⁷) type was used for the numbers of carabid beetles, species richness and species diversity. A total of 821 carabid beetles of 6 subfamilies representing 31 species were captured during the survey period. The three dominant species were Dolichus halensis, Pterostichus microcephalus and Harpalus tridens. Through cluster analysis using an a index, the 8 plots were classified into a green manure group and a non-green manure group, except for 1 plot. The numbers of captured beetles of Pterostichinae, especially D. halensis, were significantly more abundant in chemical fertilizer plots and non-green manure plots. For Zabrinae and Harpalinae, more individuals were captured in tillage plots and green manure plots. In the tillage plots and green manure plots, the values of the species diversity index(1/λ and H') were significantly higher. These results suggest that carabid assemblages may be used as a bio-indicator for evaluating the field environments of different husbandry practices.ゴミムシ群集を指標種として栽培されている植物は全く同じであるが, 異なった耕作法が実施された圃場環境の評価の可能性を検討するため, 有機肥料と化学肥料, 耕起と不耕起, 緑肥ありと緑肥なしという3要因2水準の実験計画法に沿った8区画を長野県波田町に設け, ゴミムシ群集の調査を2003年の6月から10月まで行った. 結果の解析は, L₈(2⁷)型直交配列表に従った分散分析を用いた. ゴミムシは合計で31種821個体捕獲され, 優占種は多い順にセアカヒラタゴミムシ, コガシラナガゴミムシ, コゴモクムシであった. 類似度指数αをもとにしたクラスター分析では, 8区画は緑肥ありグループとなしグループに分かれた. 分散分析の結果, ナガゴミムシ亜科, 特にセアカヒラタゴミムシでは化学肥料区と緑肥なし区で個体数が多く, 反対にマルガタゴミムシ亜科とゴモクムシ亜科では耕起区と緑肥あり区で個体数が多かった. また耕起区と緑肥あり区では多様度指数(1/λとH')が有意に高くなった. 以上の結果から, ゴミムシ群集を指標種として耕作法が異なった圃場環境を評価できる可能性が示唆された.

著者

Hiroshi Sugimoto

出版者

Sonnabend Sundell Editions

巻号頁・発行日

2000

著者

矢後 文子 白坂 龍曠 小幡 裕 藤原 純江 小林 誠一郎 黒川 きみえ YAGO Ayako SHIRASAKA Ryukoh OBATA Hiroshi KUROKAWA Kimie FUJIWARA Sumie KOBAYASHI Seiichiro

出版者

東京女子医科大学学会

雑誌

東京女子医科大学雑誌 (ISSN:00409022)

巻号頁・発行日

vol.47, no.5, pp.566-565, 1977-05-25

著者

Hiroshi Kumagai Asako Zempo-Miyaki Toru Yoshikawa Takehiko Tsujimoto Kiyoji Tanaka Seiji Maeda

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ14-0555, (Released:2015-03-01)

被引用文献数

3 44

---

Obesity has reached global epidemic proportions and is associated with multiple comorbidities, including cardiovascular disease. A novel predictor of cardiovascular disease is elevated central systolic blood pressure. In fact, lifestyle modifications have been shown to decrease the central systolic blood pressure in overweight and obese men. The mechanism underlying these changes has yet to be fully elucidated. Interestingly, testosterone has been found to have cardioprotective effects. Moreover, serum testosterone levels are lower in obese men than in normal weight men. However, it is still unclear whether testosterone participates in the decrease of central blood pressure in overweight and obese men following lifestyle modifications. So, the purpose of the present study was to investigate the effect of testosterone on central systolic blood pressure in overweight and obese men before and after the 12-week lifestyle modification program. Forty-four overweight and obese men completed a 12-week lifestyle modification program (aerobic exercise training and dietary modifications). For all participants, central systolic blood pressure and serum testosterone levels were measured before and after the program. After the program, central systolic blood pressure was significantly decreased while serum total testosterone levels were significantly increased in overweight and obese men. Moreover, we also found a significant negative relationship between the change in serum testosterone levels and that in central systolic blood pressure. The present study suggests that increased serum testosterone levels likely contribute to a decrease in central blood pressure in overweight and obese men.

著者

Mohammed ABDEL-HAKIEM Ayuko YAMASHITA Ayman ATIBA Yasuhiko OKAMURA Masaaki KATAYAMA Haroun YOUSSEF Hiroshi ISOMURA Yuji UZUKA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.14-0233, (Released:2015-08-21)

被引用文献数

1

---

The pathogenesis of intervertebral disc (IVD) degeneration is not fully understood. The biomolecular signaling pathways involved in the IVD degeneration require further investigation. The aim of this study was to investigate the expression of NG2 proteoglycan in the degenerated IVD. IVD samples were obtained from 16 Dachshunds that were confirmed to have IVD herniation and subsequently underwent hemilaminectomy. The samples were subjected to histological and immunohistochemical (IHC) examination. IHC revealed positive results for the expression of NG2 proteoglycan in all examined samples. The results showed the expression of NG2 proteoglycan by the degenerated IVDs.

著者

Masanori YOSHINO Toki SAITO Taichi KIN Daichi NAKAGAWA Hirofumi NAKATOMI Hiroshi OYAMA Nobuhito SAITO

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.tn.2014-0278, (Released:2015-07-28)

参考文献数

28

被引用文献数

9

---

Three-dimensional (3D) computer graphics (CG) are useful for preoperative planning of neurosurgical operations. However, application of 3D CG to intraoperative navigation is not widespread because existing commercial operative navigation systems do not show 3D CG in sufficient detail. We have developed a microscopic optically tracking navigation system that uses high-resolution 3D CG. This article presents the technical details of our microscopic optically tracking navigation system. Our navigation system consists of three components: the operative microscope, registration, and the image display system. An optical tracker was attached to the microscope to monitor the position and attitude of the microscope in real time; point-pair registration was used to register the operation room coordinate system, and the image coordinate system; and the image display system showed the 3D CG image in the field-of-view of the microscope. Ten neurosurgeons (seven males, two females; mean age 32.9 years) participated in an experiment to assess the accuracy of this system using a phantom model. Accuracy of our system was compared with the commercial system. The 3D CG provided by the navigation system coincided well with the operative scene under the microscope. Target registration error for our system was 2.9 ± 1.9 mm. Our navigation system provides a clear image of the operation position and the surrounding structures. Systems like this may reduce intraoperative complications.

著者

Keiko Yamada Nagisa Mori Mina Kashiwabara Sakiko Yasuda Rumi Horie Hiroshi Yamato Loic Garçon Francisco Armada

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.25, no.7, pp.496-504, 2015-07-05 (Released:2015-07-05)

参考文献数

39

被引用文献数

7

---

Background: Despite being a signatory since 2004, Japan has not yet fully implemented Article 8 of the World Health Organization’s Framework Convention on Tobacco Control regarding 100% protection against exposure to second-hand smoke (SHS). The Japanese government still recognizes designated smoking rooms (DSRs) in public space as a valid control measure. Furthermore, subnational initiatives for tobacco control in Japan are of limited effectiveness. Through an analysis of the Hyogo initiative in 2012, we identified key barriers to the achievement of a smoke-free environment.Methods: Using a descriptive case-study approach, we analyzed the smoke-free policy development process. The information was obtained from meeting minutes and other gray literature, such as public records, well as key informant interviews.Results: Hyogo Prefecture established a committee to propose measures against SHS, and most committee members agreed with establishing completely smoke-free environments. However, the hospitality sector representatives opposed regulation, and tobacco companies were allowed to make a presentation to the committee. Further, political power shifted against completely smoke-free environments in the context of upcoming local elections, which was an obvious barrier to effective regulation. Throughout the approving process, advocacy by civil society for stronger regulation was weak. Eventually, the ordinance approved by the Prefectural Assembly was even weaker than the committee proposal and included wide exemptions.Conclusions: The analysis of Hyogo’s SHS control initiative shed light on three factors that present challenges to implementing tobacco control regulations in Japan, from which other countries can also draw lessons: incomplete national legislation, the weakness of advocacy by the civil society, and the interference of the tobacco industry.

著者

Tomonobu Ishigaki Tomoya Ishida Mina Samukawa Hiroshi Saito Yuya Ezawa Motoki Hirokawa Takumi Kato Makoto Sugawara Harukazu Tohyama Masanori Yamanaka

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.27, no.5, pp.1299-1302, 2015 (Released:2015-05-26)

参考文献数

19

被引用文献数

1 14

---

[Purpose] Glenohumeral posterior capsule tightness possibly relates to posterior capsule thickness (PCT). The purpose of the current study was to analyze the relationships between PCT and glenohumeral range of motion (ROM) in horizontal adduction (HAdd) and internal rotation (IR). [Subjects and Methods] This study recruited 39 healthy collegiate baseball players. We measured PCT by using ultrasonography and ROM of the glenohumeral joint of the throwing shoulder by using a digital inclinometer. Pearson’s correlation coefficients were calculated between PCT and HAdd or IR ROM. [Results] There was no correlation between PCT and HAdd ROM, but PCT was significantly correlated with IR ROM. [Conclusion] This result indicates that posterior shoulder capsule tightness only relates to IR ROM, and that restricted HAdd ROM might reflect tightness of other tissue, such as the posterior deltoid.

著者

Hiroshi Fukasawa Madoka Nakagomi Naoko Yamagata Hiroshi Katsuki Kohichi Kawahara Kazuyoshi Kitaoka Takami Miki Koichi Shudo

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.35, no.8, pp.1206-1212, 2012-08-01 (Released:2012-08-01)

参考文献数

69

被引用文献数

17 75

---

Tamibarotene (Am80), a synthetic retinoid approved in Japan for treatment of acute promyelocytic leukemia (APL), is a retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. Am80 is considered to be a promising candidate drug for treatment of Alzheimer’s disease (AD) because of its transcriptional controls of multiple target genes involved in etiology and pathology of AD. In APP23 AD model mice, administration of Am80 decreased the deposition of insoluble amyloid-β(42). In senescence-accelerated mice (SAMP8), Am80 ameliorated the decrease of cortical acetylcholine, as well as reducing anxiety in behavioral tests and improving the sleep deficit. Am80 also effected a significant improvement of memory in the rat scopolamine-induced memory deficit model. Like other retinoids, Am80 also has an immunomodulatory effect and reduces secretion of proinflammatory cytokines and chemokines by astrocytes and microglia surrounding amyloid-β plaques. In a rat experimental autoimmune encephalomyelitis model, Am80 reduced inflammatory cytokines and showed significant efficacy. Retinoids also promote differentiation of neural stem cells, and Am80 improved the recovery of spinal cord-injured rats. Am80 may also improve vascular factors involved in onset and/or progression of AD. Am80 has been in clinical use for treatment of APL in Japan since 2005, and has been reported to have fewer side effects than other retinoids. We have recently started a clinical study to evaluate the efficacy and safety of Am80 for the treatment of Alzheimer’s disease.

著者

Shingo ISHIKAWA Hiroshi TAKEMITSU Makoto HABARA Nobuko MORI Ichiro YAMAMOTO Toshiro ARAI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0245, (Released:2015-07-13)

被引用文献数

4

---

Nuclear factor κB (NF-κB) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-κB. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-κB in cat fibroblast cells. The up-regulation of NF-κB transcriptional activity and pro-inflammatory cytokine mRNA expression by p65 subunit of NF-κB and lipopolysaccharide was suppressed by cSIRT1 in cat fibroblast cells. Our findings show that cSIRT1 is involved in the suppression of inflammation in cat fibroblast cells.