著者

友添 秀則

出版者

日本スポーツ教育学会

雑誌

スポーツ教育学研究 (ISSN:09118845)

巻号頁・発行日

vol.43, no.1, pp.75-79, 2023-05-31 (Released:2023-08-31)

参考文献数

6

著者

炭原 加代

出版者

公益社団法人 日本看護科学学会

雑誌

日本看護科学会誌 (ISSN:02875330)

巻号頁・発行日

vol.17, no.1, pp.58-65, 1997-02-28 (Released:2012-10-29)

参考文献数

32

著者

外山 恵里 関 ゆかり 高橋 里佳 梅原 郁美 若山 曉美 七部 史 阿部 考助 下村 嘉一

出版者

公益社団法人 日本視能訓練士協会

雑誌

日本視能訓練士協会誌 (ISSN:03875172)

巻号頁・発行日

vol.43, pp.213-218, 2014 (Released:2015-03-19)

参考文献数

7

被引用文献数

2 2

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【目的】アトロピン硫酸塩点眼薬(以下アトロピン)による屈折検査は弱視や斜視の治療に不可欠な検査であるが、副作用の発現が報告され注意が必要である。今回アトロピンによる副作用の発現率と症状について検討した。【対象及び方法】対象は2008年4月から2011年3月の3年間に屈折検査のためアトロピンを点眼した387例とした。初めて点眼した症例は387例中326例(84.2%)、2回目以上の症例は61例(15.8%)であった。点眼薬の濃度は3歳未満が0.5%、3歳以上は1%を基準とし、1日2回7日間行った。処方時に点眼による作用と副作用、点眼時の涙嚢部圧迫の必要性を説明した。副作用については発現率、発現時期、症状、濃度や年齢、他の疾患の合併の影響について検討した。【結果】初めて点眼した症例の副作用の発現は18例(5.5%)、このうち7例が点眼を中止した。症状は発熱が最も多く、点眼開始4日以内の発現が多かった。発熱や顔面紅潮は7月と8月の発現が他の期間より有意に高かった。副作用が発現した症例に他の疾患の合併はなかった。濃度別の副作用の発現は、0.5%は212例中12例(5.7%)、1%は114例中6例(5.3%)で有意な差はなかった(p>0.05)。年齢、性別による副作用の発現も有意な差はなかった(p>0.05)。2回目以上の症例の副作用の発現は61例中1例(1.6%)であった。【結論】アトロピンによる副作用の発現率は5.5%で、症状は発熱が多く、点眼薬の濃度、年齢、性別による影響はなかった。

著者

彭 飛

出版者

京都外国語大学日本語学科研究会

雑誌

無差 = Musya (ISSN:13402277)

巻号頁・発行日

no.28, pp.37-51, 2021-03-31

著者

末次 健司 棚原 怜央

出版者

日本植物分類学会

雑誌

植物地理・分類研究 (ISSN:03886212)

巻号頁・発行日

vol.71, no.2, pp.191, 2023-11-17 (Released:2023-12-04)

著者

Masahiro Hashimoto Haruo Iwabuchi Takaya Satoh

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.12, no.1, pp.A0139, 2023-12-12 (Released:2023-12-12)

参考文献数

12

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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) is a suitable method for polymer analysis. MALDI is a soft ionization technique that can generate mainly singly charged ions. Therefore, the polymer’s molecular weight distribution is easy to analyze, facilitating the calculation of the number average molecular weight and weight average molecular weight and polydispersity. However, there are polymers that are difficult to detect by MALDI-TOFMS. For example, polyacrylic acid includes carboxylic acid in the main chain, which is difficult to measure due to its low ionization efficiency. As a solution, the ionization efficiency was improved by methylation. In this technical report, we introduce a method to utilize derivatization to determine the degree of polymerization by accurate mass spectrometry (MS). Furthermore, the structures of both ends of the polymers were estimated by tandem time-of-flight MS.

著者

Daisuke Saigusa Ritsumi Saito Komei Kawamoto Akira Uruno Kuniyuki Kano Shuichi Shimma Junken Aoki Masayuki Yamamoto Tadafumi Kawamoto

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.12, no.1, pp.A0137, 2023-12-12 (Released:2023-12-12)

参考文献数

16

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The matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) technique was used to obtain the molecular images of cryosections without labeling. Although MALDI-MSI has been widely used to detect small molecules from biological tissues, issues remain due to the technical process of cryosectioning and limited mass spectrometry parameters. The use of a conductive adhesive film is a unique method to obtain high-quality sections from cutting tissue, such as bone, muscle, adipose tissue, and whole body of mice or fish, and we have reported the utilization of the film for MALDI-MSI in previous. However, some signal of the small molecules using the conductive adhesive films was still lower than on the indium tin oxide (ITO) glass slide. Here, the sample preparation and analytical conditions for MALDI-MSI using an advanced conductive adhesive film were optimized to obtain strong signals from whole mice heads. The effects of tissue thickness and laser ionization power on signal intensity were verified using MALDI-MSI. The phospholipid signal intensity was measured for samples with three tissue thicknesses (5, 10, and 20 μm); compared to the signals from the samples on the ITO glass slides, the signals with conductive adhesive films exhibited significantly higher intensities when a laser with a higher range of power was used to ionize the small molecules. Thus, the technique using the advanced conductive adhesive film showed an improvement in MALDI-MSI analysis.

著者

Reyhaneh Nosrati Steve Lin Andrew Ramadeen Dena Monjazebi Paul Dorian Vladislav Toronov

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.81, no.6, pp.879-887, 2017-05-25 (Released:2017-05-25)

参考文献数

35

被引用文献数

11 15

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Background:Maintaining cerebral oxygen delivery and metabolism during cardiac arrest (CA) through resuscitation is essential to improve the survival rate while avoiding brain injury. The effect of CA and cardiopulmonary resuscitation (CPR) on cerebral and muscle oxygen delivery and metabolism is not clearly quantified.Methods and Results:A novel hyperspectral near-infrared spectroscopy (hNIRS) technique was developed and evaluated to measure cerebral oxygen delivery and aerobic metabolism during ventricular fibrillation (VF) CA and CPR in 14 pigs. The hNIRS parameters were measured simultaneously on the dura and skull to investigate the validity of non-invasive hNIRS measurements. In addition, we compared the hNIRS data collected simultaneously on the brain and muscle. Following VF induction, oxygenated hemoglobin (HbO2) declined with a 9.9 s delay and then cytochrome-c-oxidase (Cyt-ox) decreased on average 4.4 s later (P<0.05). CPR improved cerebral metabolism, which was reflected by an average 0.4 μmol/L increase in Cyt-ox, but had no significant effect on HbO2, deoxygenated hemoglobin (HHb) and tissue oxygen saturation (tSO2). Cyt-ox had greater correlation with HHb than HbO2. Muscle metabolism during VF and CPR was significantly different from that of the brain. The total hemoglobin concentration (in the brain only) increased after ~200 s of untreated CA, which is most likely driven by cerebral autoregulation through vasodilation.Conclusions:Overall, hNIRS showed consistent measurements of hemodynamics and metabolism during CA and CPR.

著者

水野 誠 片平 秀貴

出版者

日本マーケティング学会

雑誌

マーケティングジャーナル (ISSN:03897265)

巻号頁・発行日

vol.22, no.2, pp.4-14, 2002-09-30 (Released:2023-01-13)

参考文献数

27

被引用文献数

1

著者

藤田 秀雄 村田 正之 大原 信義 片岡 敏道

出版者

公益社団法人 日本マリンエンジニアリング学会

雑誌

日本舶用機関学会誌 (ISSN:03883051)

巻号頁・発行日

vol.32, no.1, pp.11-29, 1997-01-01 (Released:2010-05-31)

著者

土田 敏恵 荻野 待子 濵元 佳江

出版者

一般社団法人 日本環境感染学会

雑誌

日本環境感染学会誌 (ISSN:1882532X)

巻号頁・発行日

vol.30, no.2, pp.117-126, 2015 (Released:2015-06-05)

参考文献数

27

被引用文献数

1 1

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感染防止の視点からわが国で実施されている陰部洗浄の実態を明らかにし,病床機能による特徴について検討することを目的に,全国の医療施設と介護福祉施設計6,000施設に勤務する看護師・介護職者を対象に構成的質問紙調査を実施した.有効回答部数は1,930部(32.2%)で,病床機能別の回収率は,一般病床937部(48.5%),療養病床600部(31.1%),介護福祉施設393部(20.4%)であった.調査対象の70%の病棟または施設で,入院/入所者の5割以上がおむつを使用していた.実施状況は,対象者1名に対し2人が10分未満で陰部洗浄を実施しており,手袋は1~2双使用していたが,エプロンやマスクは34%が使用しないと回答した.手袋とエプロンの装着は対象者に触れる前であったが,手袋を除去するタイミングは便付着時が最多であるものの多様であった.病床機能別では,対象者1名あたりの陰部洗浄を介護福祉施設の75.8%が実施者1人で実施し,所要時間は61.3%が5分未満で,手袋の使用枚数は1双が69.7%,ディスポーザブルエプロンは62.6%が使用しないと回答した.手指衛生や陰部を洗浄する順序,周囲環境汚染防止策や感染症を疑う対象者への対策については,病床機能による違いはなかった.

著者

栗原 まな 吉橋 学 飯野 千恵子 安西 里恵 田辺 仁彦

出版者

一般社団法人 日本脳神経外傷学会

雑誌

神経外傷 (ISSN:24343900)

巻号頁・発行日

vol.46, no.2, pp.70-77, 2023-12-10 (Released:2023-12-18)

参考文献数

10

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Objective: Traumatic brain injury (TBI) resulting from a traffic accident is not so common in young children. We reviewed our experience to clarify the status for further medical care.Methods: Nineteen patients aged under 7 years with severe TBI caused by traffic accidents underwent inpatient rehabilitation in our hospital between 1993 to 2010, and were followed up until after age 18 years. We retrospectively investigated the causes of injury, treatment during the acute stage, and outcomes including physical disability, intellectual disability, higher brain dysfunction, and epilepsy, and family functioning. The patients were divided into 4 groups by outcome: group I (7 cases) were independent, group II (2 cases) participated in "employment of persons with disabilities", group III (6 cases) had employment that required support, and group IV (4 cases) required full assistance for all activities of daily life. Clinical factors were compared between the 4 groups. The change in severity for each patient at 7, 13, and 18 years of age was assessed.Results: Average age at injury was 5 years in all 4 groups. Many accidents such as jumping into the road, not wearing seat–belt, and so on seemed to be preventable by adult intervention. The outcome worsened depend­ing on the depth and extent of loss of consciousness. Contusion was most prominent type of brain injury in all groups. Focal damage was prominent and diffuse damage was not seen in group IV. No infarction was found in groups I and II. Neurosurgical treatment was prominent in groups III and IV. Limited help for higher brain dysfunction was required in group I. Some support for higher brain dysfunction and mild mental disability was necessary in group II. Individual support programs for intellectual disability and higher brain dysfunction were necessary in group III. Full support for all daily life was essential in group IV. The severity of disability was gradually im­proved in most patients, but a few in group III showed regression due to intractable epilepsy and bad family functioning.Conclusion: Nineteen young patients with severe TBI caused by traffic accident were examined. Prevention of traffic accidents is the most im­portant intervention. Moreover, good programs to support higher brain dysfunction and family care are the keys to better outcome.

著者

牧野 昭二 ルトコフスキ トマシュ 宮部 滋樹 寺澤 洋子 山田 武志

出版者

筑波大学

雑誌

基盤研究(C)

巻号頁・発行日

2011

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本プロジェクトでは、人が音の空間性を認識するときの脳活動に着目し、基礎研究を行なうとともに、このような空間性を有する音の聴取時に観察される特徴ある脳活動を利用したブレインマシンインタフェースの開発を行なった。今年度は、空間聴覚刺激に対する事象関連電位の統計的特徴に基づいた電極と潜時の選択手法を提案し、識別率を向上させた。音の出力法の試みでは、スピーカによる実音源と仮想音源でP300反応に個人差があること、視覚刺激より振幅が小さいこと、頭部伝達関数を利用した空間聴覚刺激が後頭部にP300を誘発させることを確認した。

著者

田辺 則人

出版者

四日市大学

雑誌

四日市大学論集 (ISSN:13405543)

巻号頁・発行日

vol.30, no.1, pp.191-206, 2017 (Released:2018-02-28)

参考文献数

5

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国(国土庁)は、名古屋大都市圏学術研究都市整備プロジェクト(研究学園都市整備)を1980年代に計画した。しかし、この計画は、一部において開発が実現したのみであった。研究学園都市の整備は2008年ごろには実質的に終了した。その原因は、国家プロジェクトにならなかったこと、全体の推進体制が不十分であったことなどである。今後残された課題は、開発が計画されたが実現することができなかった土採り地・跡地や、インター周辺地域の土地利用のあり方である。

著者

和田 正義 高木 昭 森 俊二

出版者

The Robotics Society of Japan

雑誌

日本ロボット学会誌 (ISSN:02891824)

巻号頁・発行日

vol.18, no.8, pp.1166-1172, 2000-11-15 (Released:2010-08-25)

参考文献数

11

被引用文献数

11 16

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In this paper, a new wheel mechanism for holonomic and omnidirectional mobile robots is presented. The caster drive technique is one of the feasible solutions to allow a vehicle to have holonomic and omnidirectional mobile capability with standard wheels. The caster drive is applied to a differential drive mechanism. A drive unit equips with two drive wheels driven by individual motors. The rotational stage, driven by the third motor, is mounted on the drive unit with its rotational center locating at the off centered position from the mid point of the two driving wheels. The translational position and velocity of a mobile base are controlled by the differential-drive mechanism executing a caster like behavior. The orientation of the mobile base is controlled by the rotational stage decoupled with the translational motion of the drive unit. The vehicle 3DOF are controlled by the three motors, hence the system includes no over constraint problem. In addition, the drive mechanism is very simple and could be implemented by using a traditional differential-drive mechanism.

著者

Yoshiro Hadano Kazuhiro Ohwaki Asuka Suyama Ayako Miura Shigeo Fujii Yoshiko Suzuki Yoshitaka Tomoda Yukikazu Awaya

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.2868-23, (Released:2023-12-18)

参考文献数

20

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Objective The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and hospitals in Japan have been forced to respond to the situation. This study evaluated the broad-spectrum antimicrobial use before and during the COVID-19 pandemic in an acute tertiary-care hospital. Methods This single-center, retrospective study was conducted between January 2019 and June 2021. Patients We reviewed patients treated with three broad-spectrum antipseudomonal agents: carbapenems, tazobactam/piperacillin, and cefepime. Monthly aggregated hospital antimicrobial consumption was measured as days of therapy (DOTs) per 1,000 patient-days, and the monthly incidences of Clostridioides difficile infection (CDI), multidrug-resistant Pseudomonas aeruginosa (MRPA), and carbapenemase-producing Enterobacteriaceae (CPE) were recorded. Results The median monthly carbapenem-DOTs during the pre-pandemic and pandemic era were 8.4 and 8.2 per 1,000 patient-days, respectively. A time-series analysis showed non-significant changes in the level between periods (coefficients: 2.08; 95% confidence interval [CI]: -2.9 to 7.0; p=0.44). No change in the trend of monthly carbapenem-DOTs was observed after intervention. No post-intervention changes in the incidence of MRPA or CPE were observed; however, the trend in the incidence of CDI per 1,000 patient-days significantly differed between the two periods (coefficient: -0.04; 95% CI: -0.07, 0.00; p=0.01), and a downward trend was observed in the monthly CDI incidence during the COVID-19 period. Conclusion The consumption of broad intravenous antimicrobial agents has not changed significantly during the pandemic. We need to maintain the quality of medical care, including antimicrobial stewardship, even in specialized resource-limited facilities during a pandemic.

著者

茂木 一司 布山 毅 廣瀬 浩二郎 伊藤 亜紗 手塚 千尋 宮本 聡 大内 進 笠原 広一 池田 吏志 山城 大督

出版者

跡見学園女子大学

雑誌

基盤研究(B)

巻号頁・発行日

2021-04-01

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視覚障害教育は粘土造形による「触る美術教育」として発展・認知されてきたが,近年対話型鑑賞などによる「触らない=言葉による鑑賞」が注目を集めはじめ,二極化もみられる。本研究は,そのような触る/触らない、もの/テキストなど視覚障害美術教育における二元論的な対立を回避し,見えない人も見える人も「ともに歩めるインクルーシブアート教育」の理念と具体的なアナログ・デジタルメディアを使った題材・教材およびカリキュラム作成をめざして,取り組む実験的な研究である。

著者

Mituhiko HISADA

出版者

International Society of Histology and Cytology

雑誌

Archives of Histology and Cytology (ISSN:09149465)

巻号頁・発行日

vol.52, no.Supplement, pp.139-146, 1989 (Released:2011-10-26)

参考文献数

26

被引用文献数

2 2

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We have found a large portion of the neurons in the abdominal ganglia of the crayfish, Procambarus clarkii (Girard) to be local nonspiking neurons. These neurons are anaxonic, have extensive arborizations of neurites and have their entire structure confined within a single ganglion. They show relatively low membrane potentials of 40-50mV and under no circumstance generate action potentials, yet their membrane potential changes can effectively modulate the activity of postsynaptic neurons which are generally motoneurons. The transmission is chemical and transmitter release in many, if not all, of them is continuous even at their “resting” level. Electron microscope examination showed an extensive intermingled distribution of both input and output synaptic structures. This synaptic distribution together with the passive electric property suggests that individual neurites of this type of neurons function rather independently, constituting numerous local circuits. Similar nonspiking communication is also found among the ordinary “spiking” motoneurons, indicating that this mode of communication is far more widely used in the crayfish central nervous system than generally believed. These findings appear to necessitate a radical revision of our understanding of how the central nervous system operates in arthropods.