著者

栄田 敏之 中村 任 奥村 勝彦 栃尾 信治 長田 俊治

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.594-598, 2002-12-10 (Released:2011-03-04)

参考文献数

7

被引用文献数

3 3

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Dissolution tests of acetaminophen filled into the gelatin capsules (SHIONOGI QUALICAPS, Japan) and hydroxypropylmethylcellulose (HPMC) capsules (SHIONOGI QUALICAPS, Japan) were performed after the cap-sules were stored under conditions of 30°C/60%RH for one year, 40°C/75%RH for 6 months, or 60°C for one week. The Japanese Pharmacopoeia 1st fluid, acetic acid buffer (pH4.0), Japanese Pharmacopoeia 2nd fluid and purified water were used as dissolution media. The dissolution profiles of the gelatin capsules changed significantly in comparison to those of the initial profiles after the capsules were stored at 40°C/75%RH for 6 months or 60°C for one week. On the other hand, no delay in dissolution was observed for the HPMC capsules.Dissolution tests were additionally conduced using three commercially available HPMC capsules (SHIONOGI QUALICAPS, Japan ; CAPSUGEL, USA ; SHOGHUN, Korea), and the dissolution profiles of the HPMC capsules of SHIONOGI QUALICAPS were thus found to be independent of the dissolution medium, while the others showed different dissolution profiles depending on the dissolution medium.

著者

小林 大介 久津間 信明 中山 惠 鵜近 篤史 鈴木 暢之 佐次田 優子 遠藤 敏成 上田 秀雄 沼尻 幸彦 駒田 富佐夫 齋藤 侑也 森本 雍憲

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.571-575, 2002-12-10 (Released:2011-03-04)

参考文献数

10

被引用文献数

2 1

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When a novel additional adverse effect is reported for a marketed medicine, the medical information leaflet has to be revised to inform physicians and pharmacists of this. Pharmacists are responsible for informing patients of early warning symptoms to avoid the subsequent appearance of severe adverse effects. However, at present, patients may suffer from severe adverse events because such symptoms may remain unrecognized until the medicine is on the market. As a result, investigations to predict and prevent novel additional adverse effects of medicines are required. In this study, we investigated a novel additional adverse effect classified as a pharmacological effect based on the drug safety update (DSU). As a result, skin disorders including toxic epidermal necrolysis and Stevens Johnson syndrome, and pseudomembranous colitis have become evident as additional adverse effects of antibiotics, with a high incidence. In addition, neuroleptic malignant syndrome and aplastic anemia have also been reported as adverse effects of central nervous system agents.Therefore, it is important to provide patients with information about the early warning symptoms related to such adverse effects, even though such adverse effects are not contained in the patient information leaflet.

著者

薄井 順子 川島 真理子 小林 幸枝 大竹 智子 小清水 美千子

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.605-609, 2002-12-10 (Released:2011-03-04)

参考文献数

1

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In February 2000, a Drug Safety Emergency Bulletin reporting that some patients taking Benzbromarone developed fulminant hepatitis as a side effect was reported on newspapers and TV. We made a counter survey regarding how patients received this news. The aim of the present study is to consider how a pharmacist should behave when a similar situation occurs in the future.We selected patients taking Benzbromarone from the medication records and checked their liver function value from their charts. We discussed with the doctor about the patients whose liver function values indicated abnormal levels.After discussions with doctors, we decided to give the information to the patients and surveyed them individually. We recorded the contents on their medication records and the records of our inquiries.Seventy-five% (43/57) of the patients noticed the report and their reactions varied. Some patients did not know about the reports or did not recognize that the medicine reported was the same as one they were taking. We also gave information positively to these patients.After giving the information, 81 % (47/58) of the patients continued to take Benzbromarone. We thought that a positive explanation given by pharmacist could minimize the anxiety of such patients, as a result, they were taking the medicine with an increased understanding.As a result of the survey, we found how the patients reacted to the side effect reports and recognized again that it was important to communicate with the patients individually in such instances.

著者

小金 一恵 二神 幸次郎 岡崎 昌利 谷口 律子 荒木 博陽 五味田 裕

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.599-604, 2002-12-10 (Released:2011-03-04)

参考文献数

6

被引用文献数

2 1

---

We have recently instituted an audit system with the goal of maintaining and improving quality in pharmaceutical management and counseling services, i.e., pharmaceutical care practices. This system was created to improve the quality of record keeping for counseling services. The audit system is composed of 5 supervising pharmacists. A meeting is held once a month, and an audit is carried out concerning the patient compliance instruction documents, medication history and practice records of 2 clinical departments. In addition, methods for improving business efficiency are also discussed. We herein report on the specific guidance given to the supervising pharmacists of each clinical department, based on a total of 12 audit conferences. As a result, four problems were identified : (1) fundamental description issues, (2) record keeping modes, (3) insurance demands, (4) pharmaceutical perspective. The following improvements were instituted after notifying the relevant pharmacists and all other pharmacy staff of these problems : a reduction in the leakage of specific items, corrections of the records explaining the pharmacological effects, establishment of a drug interaction checklist, simplification of laboratory data records, simplification of the format, utilization of a problem list field, and other issues. The role of this audit system in maintaining and improving the quality of pharmaceutical management and counseling services has become increasingly important because as the counseling services for patients continue to expand.

著者

遠藤 康夫

出版者

一般社団法人 日本物理学会

雑誌

日本物理学会誌 (ISSN:00290181)

巻号頁・発行日

vol.60, no.8, pp.655, 2005-08-05 (Released:2019-01-25)

著者

園田 潤 木本 智幸

出版者

日本地球惑星科学連合

雑誌

日本地球惑星科学連合2019年大会

巻号頁・発行日

2019-03-14

---

海水は導電率が高く一般的に電波は伝搬しないとされており,現在では海水中では主に超音波が利用されている.我々は東日本大震災の津波災害による海底の行方不明者やがれきを探索するために,数百MHz帯の地中レーダを用いた海底探査を試みている.本稿では,宮城県閖上広浦湾と山元町磯浜漁港および坂元沖における地中レーダによる海底探査実験について,TDR (Time Domain Reflectometry) による海水の複素比誘電率の周波数特性と,CTD (Conductivity Temperature Depth profiler) による深さ方向の導電率分布の測定結果とともに,実際の地中レーダ画像からの海底物体探査について述べ,350 MHzの地中レーダで深さ10 m程度の海底物体の反射波が受信できたことを明らかにする.また,GPUを用いたFDTD法による海水中の電波伝搬解析を行い,実験結果の妥当性を示す.

著者

深田 陽子 山口 泰

出版者

図学研究

雑誌

図学研究 (ISSN:03875512)

巻号頁・発行日

vol.42, no.2, pp.9-14, 2008

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本研究では, 顔画像を解析することによって, 顔の見た目年齢を推定するとともに, その見た目年齢を保存しつつ魅力度を高める顔画像の操作法の実現をはかる.顔の見た目の年齢推定には, 各年代を代表する典型的な顔をサポートベクターマシンによって学習させ, 年齢判別ベクトルを求めた.この年齢判別ベクトルに各顔の特徴ベクトルを投影し, 年齢推定の判断基準として用いた.顔の魅力操作にあたっては, 性別や年代といった要素とは独立して, 魅力的/非魅力的と感じさせる要素があるものと仮定し, 年代ごとの魅力顔について調査した.以上を踏まえた上で, 入力画像に対して見た目の年齢を保ったまま顔の魅力を増減するために, 入力画像の年代を推定し, その年代における魅力顔に近づける操作法を示す.

著者

田上 直美 高野 佐知子 本田 義輝 〓田 聡 谷崎 正典 吉原 博幸 中野 眞汎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.583-589, 2002-12-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

4 2

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Recently, pharmaceutical care is increasing in importance. Pharmacists must provide pharmaceutical counseling services that can satisfy all patients. However, there are limitations in manpower and a lot of effort has to put devoted to using such manpower as effectively as possible. With this in mind, we developed a medication consultation support system for pharmacists to achieve an improved medical quality. As a result, labor saving results were obtained in document preparation of medication histories, laboratory test histories, and medication instruction records. Furthermore, the total work need to create medication instruction daily reports, monthly reports, etc. also decreased. As a result, the time and work pressure experienced by pharmacists decreased while the overall quality of this system was maintained.

著者

小林又七 著

出版者

川流堂

巻号頁・発行日

1900

著者

尾西 恭亮

出版者

日本地球惑星科学連合

雑誌

日本地球惑星科学連合2019年大会

巻号頁・発行日

2019-03-14

---

橋梁床版は,土砂化等の発生により,急速に劣化が進行することが知られている。点検サイクル内に抜け落ちにまで発展する事例が発生し,目視点検以外の事前検知手法の開発が望まれている。地中レーダは,地下空洞探査などに広く用いられており,有効な探査手法のひとつと考えられている。しかし,地中レーダで橋梁床版の損傷域を特定するのは困難な場合が多い。この理由のひとつは,探査対象深度が浅いことにある。橋梁床版の損傷は上面から進行することが多い。橋梁床版の上面深度は舗装厚により決定される。舗装厚は5~10cm程度の範囲に入っている場合が多い。深度5~10cmという範囲は,一般的な地中レーダの記録では,空中を伝播する光速度の直接波と,地表を伝播する地盤速度の直達波が同じ走時域に混在するため,イメージングが困難となる場合が多い。そこで,橋梁床版モデルを作成し,種類の異なる地中レーダで探査を行ったので,探査記録を比較した結果を示す。床版モデルは,アスファルト舗装の着脱が容易な設計となっており,損傷域の状態を簡単に変更できる特徴を有する。この結果,損傷域の誘電特性が周囲より十分異なれば,比較的に容易に異常信号を検知できることがわかった。しかし,検知された異常信号を用いても,表面からの深さ,粒径,水分状態などの異常の状態を特定するには困難であるため,床版モデルや数値計算等の解析を進め,信号特性を把握した上で,実際の床版の記録を解釈することが重要となる。

著者

田中 慶 木浦 卓治 杉村 昌彦 二宮 正士 溝口 勝

出版者

農業情報学会

雑誌

農業情報研究 (ISSN:09169482)

巻号頁・発行日

vol.20, no.1, pp.1-12, 2011

被引用文献数

4

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水稲生育予測モデルSIMRIWを利用した水稲栽培可能性予測ツールを開発した.このツールは,SIMRIWを全球に適用して,栽培可能地域,最適移植日,最大収量を地図上に表示するWebアプリケーションである.研究者向けのモデルであったSIMRIWを,政策決定者や農家向けの意思決定支援ツールとして利用できるようにした.すでにSIMRIWは作物モデル開発フレームワークを利用して,Webアプリケーションとして実装されていた.全球を対象としたシミュレーションにおいて,条件を変えて大量にモデルの繰り返し実行を行うための,モデル実行エンジンの改良が行われた.また,モデルの気象データ取得元であるMetBrokerが全球の1度グリッドの気象データを新たに扱えるようにした.栽培可能性は水稲生育モデルの移植日を365日間すべてで計算し,収量を得られるかで判定される.同時に8品種(ジャポニカ米5品種,インディカ米3品種),気候変動に対応したCO₂濃度2パターンと気温加算値3パターンで計算を行った.モデルの計算結果はXML形式のファイルで記録され,Flash版やGoogle Earth版のデータビューワで閲覧できる.<br>

著者

水野 晃子 石坂 丞二

出版者

日本地球惑星科学連合

雑誌

日本地球惑星科学連合2019年大会

巻号頁・発行日

2019-05-17

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デジタルカメラデータのRGB表色系値を用いた、光合成生物と環境条件の調査方法は、この20年間で様々な研究がなされてきた。例えば、海域ではスマートフォンカメラを用いた水質の推定(Leeuw and Boss 2018)や、航空写真からの海草植生の検出とクロロフィルa濃度の推定(Goddijn and White 2006)などがあるが、海洋域だけでなく陸域などさまざまな地域で調査のために活用される背景には、デジタルカメラの携帯性と利便性、低価格であることがあげられる。また、観測可能性が天候によって左右されることがないため、衛星観測に対する補助的、追加的な調査としてデジタルカメラの有用性は大きいと言える。本研究では、伊勢三河湾において撮影されたデジタルカメラ写真のRGB表色系値を解析することによって、クロロフィルa濃度の推定方法の構築を試みた。伊勢三河湾ではSeaWiFSおよびMODISデータを用いたクロロフィルa濃度の推定方法がHayashiら(2015)によってなされているが、デジタルカメラデータによる方法は構築されていない。 我々は、伊勢三河湾の観測航海によってクロロフィルa濃度、海表面、18%グレー版および天空のデジタルカメラ撮影写真、連続スペクトル分光放射計(RAMSES/TriOS)による海表面輝度および天空照度のスペクトルデータを採集した。デジタルカメラ写真によるクロロフィルa推定の誤差は、海面反射、波長数の少なさ、データ圧縮やデジタル化による情報劣化など様々な要因によって生じると考えられる。本研究では海面反射について考察するため、分光放射計による海面輝度データは、海面反射の影響を最小に抑えることができるドーム法(Tanaka et al 2006)と、甲板上から撮影されたデジタルカメラデータと同条件で採集された甲板法の2種類を得、デジタルカメラデータのRGB表色系値と比較するためにCIE等色関数によってスペクトルデータをRGB値へと変換した(それぞれドーム法変換RGB値、甲板法変換RGB値とする)。デジタルカメラ写真のRGB値とは、甲板法変換RGB値の方が相関が高く、ドーム法とは関係性が低かった。また、甲板法変換RGB値によるクロロフィルa濃度推定の誤差が、デジタルカメラ写真によるクロロフィルa濃度推定の誤差量とほとんど同じ大きさであったため、デジタルカメラ写真によるクロロフィルa推定の主な誤差要因は海面反射の影響が大きいことが推察された。 L.M. Goddijn; M White, Using a digital camera for water quality measurements in Galway Bay, Estuarine, Coastal and Shelf Science (2006), 66, 429-436.M. Hayashi; J. Ishizaka; M. Toratani; T. Nakamura; Y. Nakashima; S. Yamada; Evaluation and Improvement of MODIS and SeaWIFS-derived Chlorophyll a Concentration in Ise-Mikawa Bay, Journal of The Remote Sensing Society of Japan (2015), 35, 245-259.T. Leeuw; E. Boss, The HydroColor App: Above Water Measurements of Remote Sensing Reflectance and Turbidity Using a Smartphone Camera, Sensors (2018), 18, 256-271.A. Tanaka; H. Sasaki; J. Ishizaka, Alternative measuring method for water-leaving radiance using a radiance sensor with a domed cover, Optics Express(2006), 14(8), 3099-3105

著者

佐塚 泰之 廣津 祥代 広田 貞雄 金川 麻子 森田 哲生

出版者

日本DDS学会

雑誌

Drug Delivery System (ISSN:09135006)

巻号頁・発行日

vol.13, no.6, pp.415-421, 1998-11-10 (Released:2009-01-21)

参考文献数

19

被引用文献数

1 1

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We prepared the liposomes, changed the entrapped amount of adriamycin (ADR) per the amount of liposome composing lipid, and after the addition of these liposomes with the same concentration of ADR(therefore, different dose of lipid), the tumor cell uptake of ADR was examined. The high entrapped amount of ADR demonstrated the usefulness in the tumor cell uptake of the ADR liposome in vitro. The cell uptake of the liposome depended on additional amount of ADR and liposomal lipid. Next, using ADR contained liposome and irinotecan contained liposome, its usefulness on tumor cell uptake by the polyethyleneglycol (PEG) modification of the surface on the liposome in vitro examined. In both liposome, PEG modification of the surface on the liposome facilitated the initial rate of the liposome uptake into the tumor cell. We have considered that this facilitation was attributed to the lipo-hydrophilic property of PEG and the fixed aqueous layer around the liposome. Therefore, PEG modification of the surface on the liposome, prevents the adhesion of serum opsonine and avoids reticuloendothelial system, does not inhibit tumor cell uptake rather facilitates. From the results of dextran sulfate contained liposome, it is expected that these liposome passed through the membrane of the tumor cell. Therefore, a higher entrapped amount of antitumor agents in the liposome and PEG modification have been confirmed to be beneficial in the tumor cell uptake.

著者

佐塚 泰之 廣津 祥代 宮城島 惇夫 野澤 靖夫 広田 貞雄

出版者

日本DDS学会

雑誌

Drug Delivery System (ISSN:09135006)

巻号頁・発行日

vol.12, no.3, pp.193-198, 1997-05-10 (Released:2009-01-21)

参考文献数

15

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The lipid composition, particle diameter and dose have been reported to affect the liposomal uptake in the tumor. However, effects of encapsulation amount of drugs in liposomes on the uptakes have scarecely been reported either in vitro or in vivo. In this study, we examined the uptake of liposomes containing CPT-11 by Ehrlich ascites carcinoma in vitro changing the encapsulation amount of CPT-11, and also the tissue distribution of liposomal CPT-11 in vivo with mice. After the addition of high concentration as CPT-11, the uptakes in the tumor cell by liposomes was about 1/3 of that by the solution in vitro. However, after the addition of same level as tissue distribution of CPT-11 in vivo, there is no difference on CPT-11 uptakes between liposome and solution. Thus lipid satulation in the tumor cells was observed by increasing liposomes in the medium. For a definite dose, the decrease of CPT-11 amount in the liposomes reduced the uptake in the tumor cell. Therefore, we thought that the uptake of liposomes in the tumor cell depended on lipid amount of liposomes. The increase of CPT-11 amount in the liposomes enhanced CPT-11 concentration in the serum, liver and tumor after administration of liposomal CPT-11 to the mice. An enhanced antitumor activity was expected from the result of SN-38 concentration in the tumor.

著者

MORIO Atsushi MIYAMOTO Hideaki IZUMI Hiroshi HOSODA Yasuyuki FUKUCHI Yoshinosuke

雑誌

International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology (ISSN:13419625)

巻号頁・発行日

vol.5, no.4, pp.247-252, 2000-08-01

参考文献数

29

被引用文献数

1

著者

FURUSE Kiyoyuki KAWAHARA Masaaki HASEGAWA Koichi KUDOH Shoji TAKADA Minoru SUGIURA Takahiko ICHINOSE Yukito FUKUOKA Masahiro OHASHI Yasuo NIITANI Hisanobu

雑誌

International journal of clinical oncology : official journal of the Japan Society of Clinical Oncology (ISSN:13419625)

巻号頁・発行日

vol.6, no.5, pp.236-241, 2001-10-01

参考文献数

33

被引用文献数

7

著者

Ryuta Kawashima Taisuke Matsumoto Yasunori Tanimoto

出版者

Society of Automotive Engineers of Japan, INC

雑誌

International Journal of Automotive Engineering (ISSN:21850984)

巻号頁・発行日

vol.5, no.2, pp.77-83, 2014 (Released:2016-03-25)

参考文献数

18

被引用文献数

1

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The purpose of this study was to clarify the cortical activity of the dorsolateral prefrontal cortex (DLPFC) while motorcycles were being ridden. Sixteen healthy right-handed men who use motorcycles in their daily lives were recruited. Their brain activity was measured using a prototype of wearable optical topography while they were actually riding a motorcycle. We found that their brain activation patterns, which reflect the cognitive strategies behind their riding behaviors, differed depending on whether they were users of road bikes or scooters. Also, DLPFC activity, which reflects an increase in cognitive and motor demands, was greater in riders of on-road type motorcycles than scooters.

著者

井藤 達也 高岡 和夫 竹本 功 秦 温信 井上 勝一 佐々木 健太郎 平野 剛 井関 健 菅原 満 宮崎 勝巳

出版者

The Japanese Society of Clinical Pharmacology and Therapeutics

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.33, no.2, pp.47-52, 2002-03-31 (Released:2010-06-28)

参考文献数

13

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The purpose of this study was to evaluate the distribution of CPT-11 and its active metabolite, SN-38, in pleural and pericardial fluid after intravenous administration.Two patients with lung cancer were treated with intravenous CPT-11 (60 mg/m2) on days 1, 8, and 15. The CPT-11 was detected in the pleural fluid 1.5 hr after the begining of intravenous infusion, and the level reached the maximum 24 hrs later. Similarly, the active metabolite SN-38 was detected in the pleural fluid 1.5 hr after the begining of intravenous infusion, and SN-38 concentration in the pleural fluid was almost as high as that in plasma 24 hrs later. These results suggest that intravenously administered CPT-11 may penetrate the thoracic cavity and may be metabolized to SN-38 there. The proportions of maximum concentrations of CPT-11 and SN-38 in the pleural fluid to the corresponding plasma levels were 20.4% and 28.5%, respectively. In addition, the AUCs of the lactone form SN-38 were much lower than those of the carboxyl form in the pleural fluid.CPT-11, SN-38 and SN-38 glucronide showed similar pharmacokinetics in the pericardium as that in plasma.

著者

井藤 達也

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.511-520, 2002-12-10 (Released:2011-03-04)

参考文献数

26

被引用文献数

1 2

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The purpose of this study was to evaluate the distribution of CPT-11 and its active metabolite, SN-38, in both pleural and pericardial fluid after intravenous administration.Two patients with lung cancer were intravenously treated with 60mg/m2 CPT-11 on days 1, 8, and 15. The CPT-11 was detected in the pleural fluid 1.5 hrs after the start of intravenous infusion, and its level reached a maximum 24 hrs later. Similarly, the active metabolite SN-38 was detected in the pleural fluid 1.5 hrs after the start of intravenous infusion. In addition, the SN-38 concentration in the pleural fluid was almost as high as that in the plasma 24 hrs later. These results suggest that intravenously administered CPT-11 may penetrate into the thoracic cavity and therefore be metabolized into SN-38 there. The maximum concentrations of CPT-11 and SN-38 in the pleural fluid to the corresponding plasma levels were 20. 4 % and 28. 5%, respectively. In addition, the AUCs of the lactone form of SN-38 were much lower than that of the carboxyl form in the pleural fluid.CPT-11, SN-38 and SN-38 glucronide all showed similar pharmacokinetics in the pericardium to that in plasma.

著者

岡村 裕 藤井 節郎 河内 卓 川波 寿 桑野 信彦 山村 雄一

出版者

The Japanese Cancer Association

雑誌

GANN Japanese Journal of Cancer Research (ISSN:0016450X)

巻号頁・発行日

vol.53, no.4, pp.365-370, 1962 (Released:2008-10-23)

参考文献数

18

被引用文献数

1

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A basic protein fraction having toxohormone activities, isolated from rat Rhodamine sarcoma, was subjected to enzymatic hydrolysis with trypsin, pepsin, and pronase, resulting in the splitting of 12.3%, 19.1%, and 57.4% of peptide bonds of the basic protein respectively.The effect of the hydrolysis on the toxohormone activities of the basic protein was determined by bioassay with rats or mice. Liver catalase depression was markedly diminished by hydrolysis with pronase and pepsin but not by trypsin. Plasma iron decrease was affected by none of these enzymes. Liver tryptophan pyrrolase depression was markedly diminished by hydrolysis with any one of these enzymes.These results suggest that these three different activities of toxohormone are associated with different chemical entities of the basic protein.