著者

Masayuki UCHIDA Orie KOBAYASHI

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

pp.130319, (Released:2013-09-07)

被引用文献数

15

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We have reported an inhibitory effect of Lactobacillus gasseri OLL2809 (OLL2809) on the growth of mouse endometrial tissue in the abdominal cavity. The present study aimed to investigate the efficacy of Lactobacillus gasseri OLL2809 (OLL2809) on pre-existing endometriosis implanted on the abdominal wall in diestrus Wistar-Imamichi female rats. One week after implantation, the volume of the endometrial tissue was measured after laparotomy. OLL2809 and dienogest were administered for 4 weeks. OLL2809 significantly enhanced the decrease in the volume (p<0.01) as compared with control. Complete healing was observed in two of nine rats, but in none of the control group. Dienogest did not show significant efficacy. These findings suggest that OLL2809 is useful not only in therapy of pre-existing endometriosis but also in the prevention of the growth of endometrial tissue.

著者

Naoto FUJINAMI Taeko KOGA Hiroshige MORISHIMA Farideh ZAKERI Seiichi NAKAMURA Kanji TORIZUKA Tsutomu SUGAHARA

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.46, no.1, pp.66-69, 2011 (Released:2012-01-25)

参考文献数

11

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Individual external doses of inhabitants were examined in high levels of natural radiation areas (HLNRAs) in Ramsar. Each of 15 inhabitants in HLNRAs and 10 inhabitants in a control area carried an electronic personal dosimeter (EPD) for one day in April and in December 2005. In addition, their individual doses were estimated from indoor and outdoor radiation dose rates determined with a NaI (Tl) survey meter. A good correlation existed between the dose rate values obtained through estimation and personal measurement, and estimated annual doses ranged from 0.5 to 32 mGy/y. Each of the dosimetric subjects carried also an optically stimulated luminescence dosimeter (OSLD) for about one month in September 2005, but a few values obtained by these measurements deviated widely from those obtained by one-day measurements with EPDs and those estimated by environmental dosimetry. This deviation might have been due to the fact that these OSLDs were left behind somewhere in houses. Hence, the observed dose values depended heavily on the place where dosimeters had been left, because of the non-uniform distribution of Ra-226 contained in building materials as well as the structure of the house and the existence of shields.

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.122, no.3, pp.Cover01_1-Cover01_3, 2013

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(表面)太平洋プレート上部境界面から10km上方の曲面(地表面からほぼ40–120kmの深さ範囲)に沿うS波速度の分布(Nakajima and Hasegawa, 2010).S波速度をカラースケールで示す.太平洋プレートとフィリピン海プレートの接触域を2本の太い黒破線で囲んで示す.赤星印は1885年以降に南関東で発生した5つのM7級地震.ビーチボールは1921年竜ヶ崎地震(M7.0)(2通りの解を示す)と1987年千葉県東方沖地震(M6.7)のメカニズム解.黒丸は1987年千葉県東方沖地震の余震.(裏面)フィリピン海プレート東端部の蛇紋岩化域(茶色の領域).ピンク色の太い破線は蛇紋岩化域の西縁.フィリピン海プレート上面の深さ分布を灰色破線のコンターで示す.緑色の四角と丸は太平洋プレート上部境界面で発生した地震,灰色の点はフィリピン海プレートマントル内の地震.1921年竜ヶ崎地震と1987年千葉県東方沖地震に加え,フィリピン海プレートのマントル内の4つの地震のメカニズム解もビーチボールで示す.紫色の丸は1923年関東地震の約30時間後に発生したM7.1の余震.フィリピン海プレートはピンク色の太い破線を境にして2つに裂け,東側の蛇紋岩化域は西側の本体部分からとり残され,より遅い速度で沈み込んでいる.ピンク色の細い破線で囲んだ楕円はOkada and Kasahara(1990)が指摘した地震の空白域.(長谷川 昭)

著者

鈴木 博雄

出版者

一般社団法人 日本教育学会

雑誌

教育学研究 (ISSN:03873161)

巻号頁・発行日

vol.38, no.4, pp.273-281, 1971-12-30 (Released:2009-01-13)

参考文献数

31

著者

栗本 蕗 堀 里子 佐藤 宏樹 三木 晶子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.9, pp.1023-1034, 2013 (Released:2013-09-01)

参考文献数

22

被引用文献数

1

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For drug fostering and evolution, it is important to collect information directly from patients on the efficacy and safety of drugs as well as patient needs. At present, however, information gathered by healthcare professionals, pharmaceutical companies, or governments is not sufficient. There is concern that patients may fail to recognize the importance of providing information voluntarily. The present study was conducted to provide drug information to patients/consumers, to enlighten them on the importance of providing drug information by themselves, and to develop an Internet website, called “Minkusu,” for collecting drug information from patients. This website is based on a registration system (free of charge). It is designed to provide information on proper drug use, and to collect opinions about drugs. As of May 31, 2012, a total of 1149 people had been registered. The male/female ratio of registered members was approximately 1:1, and patients/consumers accounted for 23%. According to the results of a questionnaire survey, several patient/consumer members appreciated the usefulness of the information service, and they took an opportunity to know of the concepts of drug development and evolution (Ikuyaku, in Japanese) through the information services provided by this site. In conclusion, the developed information system would contribute to the proper use of drugs by patients/consumers and to the promotion of drug development and evolution.

著者

井岡 聖一郎 岩月 輝希 酒井 利彰 石島 洋二

出版者

日本水文科学会

雑誌

日本水文科学会誌 (ISSN:13429612)

巻号頁・発行日

vol.37, no.4, pp.287-293, 2007-11-30 (Released:2009-03-27)

参考文献数

33

被引用文献数

1 2

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Redox potential (Eh) is one of the most important physico-chemical properties of groundwater. Groundwater Eh have been studied in terms of safety of high-level radioactive waste disposals, water resource management and so on. As the results, it is getting clear that redox potential of deep groundwater in sedimentary and crystalline rocks have a remarkable variability. For example, some reported Eh values of deep groundwater decrease with increasing depth, i.e. with residence time. However, there are few reports showing data measured in situ. Only some Eh values of deep groundwater measured from research borehole drilled at crystalline rocks in Japan and Sweden have been reported. Between 200 and 1000m depth, the Eh values of the deep groundwater range from about 0 to -400mV.This essay first briefly summarizes methodology for Eh measurement and reports Eh values of deep groundwater. Then, it discusses the remaining issues of Eh measurement that are to develop of measurement technology applicable for various geological environments and to understand the redox evolution process through the groundwater flow system.

著者

Kentaro Asayama Hiroshi Yamadera Takao Ito Hideaki Suzuki Yoshihisa Kudo Shunkichi Endo

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.70, no.4, pp.334-341, 2003 (Released:2003-08-29)

参考文献数

29

被引用文献数

73 173

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Previously, we reported that morning bright light therapy improved sleep time and cognitive function in Alzheimer type of dementia. We conducted a double blind study to examine the effects of melatonin on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type of dementia. The subjects were 9 persons given a placebo (PLA), and 11 given melatonin (3 mg)(MLT). The mean age was 79.2±6.4 (17 females and 3 males). The drugs were given at 20: 30 each day for 4 weeks. We checked sleep time and activity by Actigraph through one week before and the 4th week after drug administration. Cognitive and non-cognitive functions were evaluated with the clinical dementia rating scale (CDR), and Mini Mental State Examination (MMSE), and the Alzheimer's Disease Assessment Scale (ADAS). We successfully recorded Actigraph data from 18 patients (PLA8, MLT10). The mean sleep time change ratio and SD of the administration of PLA in the night was-0.2±13.7%, and MLT was 33.2±37.6%. The mean activity counts and SD of the administration of PLA in the night was 29.8±77.0%; in MLT it was-44.9±21.9%. Melatonin significantly prolonged the sleep time (p=0.017) and decreased activity (p=0.014) in the night (21: 00∼6: 00) in the MLT group, although no significant difference in sleep time or activity in the daytime (6: 00∼21: 00) was recognized between the two groups. In comparison with ADAS cognition score changes, the mean change and SD in the PLA was 0.3±3.7; in MLT it was-4.3±3.6 points. In comparison with ADAS non-cognition score, the mean change and SD in the PLA group was-0.8±1.0, in the MLT group it was-4.1±2.2 points. There were also significant differences between the PLA and the MLT groups in the comparison with the score improvement of ADAS cognition (p=0.017) and non-cognition (p=0.002), otherwise there was no significant difference in improvement of MMSE between both groups.Melatonin administration had effect to improve sleep time and night activity, but no significant effect to improve daytime naps and activity. Although melatonin administration might has less strong effect on circadian rhythm than morning bright light therapy we previously reported, cognitive and non-cognitive functions were improved. Melatonin seemed to be useful for care of the Alzheimer type of dementia patients.

著者

Miroslaw JANIK Shinji TOKONAMI

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.44, no.1, pp.116-121, 2009 (Released:2010-10-08)

参考文献数

34

被引用文献数

7

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In Poland there are some special regions in which the natural background radiation is obviously higher than in neighboring areas. This paper presents a review of recent radiation measurements taken in the Polish environment. Natural sources including radon, potassium, uranium and thorium as well as artificial sources such as cesium are characterized. Their contribution to the annual radioactivity dose rate is described.

著者

古賀 佑彦

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.24, no.1, pp.39-42, 1989 (Released:2010-02-25)

参考文献数

8

著者

吉澤 隆志 松永 秀俊 藤沢 しげ子

出版者

理学療法科学学会

雑誌

理学療法科学 (ISSN:13411667)

巻号頁・発行日

vol.25, no.1, pp.13-17, 2010 (Released:2010-03-26)

参考文献数

12

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〔目的〕積極的に映像を流す形式(映像授業)と従来授業における授業意識の比較と,学習意欲との関係を検討した。〔対象〕某A専門学校理学療法学科学生(91名)とした。〔方法〕映像授業と従来授業とを実施し,映像授業における授業意識アンケート結果について因子分析を行い,両授業の下位尺度得点を比較した。また,映像授業における下位尺度得点と学習意欲アンケート結果との相関を調べた。〔結果〕映像授業における因子分析結果のうち第1因子(授業や将来に対する意欲)は,従来授業よりも下位尺度得点が高かった。また,第1因子は学習意欲の中でも特に内発的動機づけと学院への適応度との相関が見られた。〔結語〕映像授業は,従来授業よりも内発的動機づけや学院への適応度を高めることのできる授業形式であると考えられた。

著者

平山 匡彦 田中 秀和 鈴木 慎太郎 井上 広平 永富 亜紀 作元 誠司 北原 敏弘 宮﨑 長一郎 吉谷 清光 佐藤 宏樹 堀 里子 三木 晶子 澤田 康文

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.8, pp.913-922, 2013 (Released:2013-08-01)

参考文献数

2

被引用文献数

1

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This study was conducted among 252 inhabitants aged 16 years or older of small remote islands in Gotoh. The survey was conducted in a direct interview format based on a questionnaire. In the interview, the respondents were asked about the statuses of their Internet usage, purchase/use/storage of nonprescription drugs, acquisition of information regarding nonprescription drugs, as well as regulations pertaining to the sale of nonprescription drugs, including the use of postal services. Among the respondents, 7.5% were Internet users, whereas people who had past experiences in purchasing nonprescription drugs through Internet accounted for as few as 0.8% of the total number of respondents; 63.9% of the inhabitants of small remote islands did not use nonprescription drugs, additionally, most inhabitants of small remote islands did not express any need for nonprescription drugs sold through Internet. Further, the findings suggested that a large number of people felt the need for the presence of pharmacists and experts to provide them with explanations and information regarding nonprescription drugs. However, because a large number of these people were unaware of the existence of pharmacists, it is important that in the future, pharmacists should conduct “consultation meetings and briefings regarding medications.” These meeting may be held in a continuous manner in these small remote islands, such that the inhabitants recognize the difference in a pharmacists' profession. It is essential that “family pharmacies/pharmacists” play a central role in promoting the supply, management, and proper use of pharmaceutical products.

著者

檜作 進

出版者

日本応用糖質科学会

雑誌

Journal of Applied Glycoscience (ISSN:13447882)

巻号頁・発行日

vol.46, no.2, pp.159-165, 1999-06-30 (Released:2010-06-28)

参考文献数

35

被引用文献数

5 13

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L-Arabinose is a common component in a plant cell wall and is widely distributed in the plant kingdom. It is a main component of cereal hemicellulose, such as corn, wheat, rye, and rice, pectic substances of beet and apple pulps, and some plant gums. The sugar occurs in the free state in the heartwood of coniferous trees, but its small amounts have been found also in several foods and beverages made from cereals and other plant sources such as bread, miso, beer and tea. L-Arabinose is produced by the mild acid hydrolysis of some plant gums, corn fiber, and beet pulps. The taste of L-arabinose is quite similar to sucrose, but approximately half the sweetness . Naturally occurring arabinose is an L-form, and it is not metabolized in animals; thus it is a noncaloric sugar . Furthermore, it strongly inhibits intestinal sucrase uncompetitively and consequently inhibits the absorption of sucrose from the small intestine. The addition of 2-3% of L-arabinose to sucrose causes about a 60% reduction of the digestion of sucrose in the small intestine. The nondigested sucrose and L-arabinose, possibly metabolized by intestinal microbes, produce short-chain fatty acids and thus function similar to dietary fiber. L-Arabinose, by this function, reduces the increase of the levels of blood sugar, insulin, triglycerides, and cholesterol by the ingestion of sucrose . Therefore it has great merits as a sweetener and a food additive to improve the obesity and to maintain good health .

著者

麻生 誠

出版者

日本教育社会学会

雑誌

教育社会学研究 (ISSN:03873145)

巻号頁・発行日

vol.34, pp.64-78,en206, 1979-09-30 (Released:2011-03-18)

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From a viewpoint of the post-war trends of high school education, I intend to review some of the main sociological studies on high school. The following criteria are adopted for the evaluation of studies;(1) problem setting, (2) research methods and techniques, (3) contribution to fact-finding and theory-building, and (4) contribution to solving practical problems. Since 1950, the number of studies on high school has increased five times as large as that at the begining, and also studies have risen to a higher academic level, especially by adopting the method of multivariate analysis. Now, senior high school has become one of the research fields in which Merton's middle range researches and theories are especially dominant.

著者

羽鳥 徳太郎

出版者

公益社団法人 日本地震学会

雑誌

地震 第2輯 (ISSN:00371114)

巻号頁・発行日

vol.27, no.4, pp.321-337, 1974-12-30 (Released:2010-03-11)

参考文献数

51

被引用文献数

6

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Source areas of the tsunamis generated in northeast Japan since 1896 are compiled on a bathymetric chart (Newly estimated: 14; Reanalyses: 14). Sources of large tsunamis lie on the steep continental slope off the Sanriku coast. Most of small tsunami sources are located in the sea shallower than the depth of 2000m. Source dimensions are closely related with earthquake magnitude; the Utsu formula for the relation between the earthquake magnitude and aftershock area can be applied well for the tsunami source area. Generally speaking, the magnitudes of tsunami correspond to earthquake magnitude. However, a few tsunamis generated in the vicinities of the west Aomori and Miyagi regions are especially small in comparison with those at other regions.Judging from the initial motion on tsunami records, most of tsunamis off the Sanriku coast seem to be generated by the reverse fault type earthquake. The sense, up or down, of the initial motion of the 1896 Sanriku tsunami is opposite to that of the 1933 tsunami which is caused by a normal fault earthquake. This suggests that the 1896 tsunami was generated by the reverse fault earthquake. Source dimension of the 1933 tsunami is newly revised and found to be about 300km. This area is smaller than the former estimations, because arrival times at the tide stations of Hokkaido were read too early by misunderstanding a noise as the first motion.

著者

大島 正滿

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:00167444)

巻号頁・発行日

vol.6, no.7, pp.1186-1208_2, 1930-07-01 (Released:2008-12-24)

著者

平田 秋彦 陳 明偉

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.53, no.5, pp.326-331, 2011-10-31 (Released:2011-11-20)

参考文献数

24

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Local structural order in a metallic glass was investigated by Angstrom beam electron diffraction using an aberration corrected scanning transmission electron microscope. The coherent electron probe with a diameter of 0.3 - 0.4 nm was successfully obtained by using Ronchigram method. The fine electron probe enables us to pick up Angstrom-scale local structure information which cannot be obtained by conventional diffraction methods and thereby provide a direct evidence of short- to medium-range order in metallic glasses with the help of ab-initio molecular dynamics simulation.

著者

Hidenori Arai Akira Yamamoto Yuji Matsuzawa Yasushi Saito Nobuhiro Yamada Shinichi Oikawa Hiroshi Mabuchi Tamio Teramoto Jun Sasaki Noriaki Nakaya Hiroshige Itakura Yuichi Ishikawa Yasuyoshi Ouchi Hiroshi Horibe Nobuo Shirahashi Toru Kita

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.13, no.4, pp.202-208, 2006 (Released:2006-08-15)

参考文献数

15

被引用文献数

87 126

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To determine the prevalence of metabolic syndrome in the Japanese general population, we analyzed data from a nationwide survey conducted in 2000. According to the Japanese new diagnostic criteria for metabolic syndrome in 2005, we analyzed 3,264 people aged from 20 to 79 (men, 1,917; women, 1,347) from the total participants. The incidence of metabolic syndrome was 7.8%. Men had a higher incidence (12.1%) than women (1.7%). Most of the women satisfying the criteria were 50 years old or over, while the incidence in men started to rise from their 30s. When we applied the criteria of Adult Treatment Panel III, the incidence was about 3-fold higher. In this population visceral obesity was associated with metabolic abnormalities, such as higher LDL-cholesterol, triglyceride, glucose, and blood pressure and lower HDL-cholesterol. Thus we determined the incidence of metabolic syndrome and each metabolic abnormality in the Japanese general population in 2000 and found an association of visceral obesity with metabolic abnormalities. Intervention to reduce the incidence of metabolic syndrome in Japan is necessary to reduce the risk of cardiovascular disease.

著者

Yusuke Unno Takuro Shinano

出版者

日本微生物生態学会 / 日本土壌微生物学会 / Taiwan Society of Microbial Ecology / 植物微生物研究会

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

pp.ME12181, (Released:2012-12-19)

被引用文献数

10 48

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While phytic acid is a major form of organic phosphate in many soils, plant utilization of phytic acid is normally limited; however, culture trials of Lotus japonicus using experimental field soil that had been managed without phosphate fertilizer for over 90 years showed significant usage of phytic acid applied to soil for growth and flowering and differences in the degree of growth, even in the same culture pot. To understand the key metabolic processes involved in soil phytic acid utilization, we analyzed rhizosphere soil microbial communities using molecular ecological approaches. Although molecular fingerprint analysis revealed changes in the rhizosphere soil microbial communities from bulk soil microbial community, no clear relationship between the microbiome composition and flowering status that might be related to phytic acid utilization of L. japonicus could be determined. However, metagenomic analysis revealed changes in the relative abundance of the classes Bacteroidetes, Betaproteobacteria, Chlorobi, Dehalococcoidetes and Methanobacteria, which include strains that potentially promote plant growth and phytic acid utilization, and some gene clusters relating to phytic acid utilization, such as alkaline phosphatase and citrate synthase, with the phytic acid utilization status of the plant. This study highlights phylogenetic and metabolic features of the microbial community of the L. japonicus rhizosphere and provides a basic understanding of how rhizosphere microbial communities affect the phytic acid status in soil.

著者

浅見 裕 百鬼 史訓 横山 直也 大矢 稔 田中 幸夫 山神 眞一 田中 秀幸

出版者

日本武道学会

雑誌

武道学研究 (ISSN:02879700)

巻号頁・発行日

vol.26, no.Supplement, pp.34-34, 1993 (Released:2012-11-27)

著者

Carl Bereiter

出版者

日本認知科学会

雑誌

認知科学 (ISSN:13417924)

巻号頁・発行日

vol.9, no.3, pp.321-327, 2002-09-01 (Released:2008-10-03)

参考文献数

12

被引用文献数

1

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Although there is innovation in education it tends to be sporadic and discontinuous, with the result that innovative practices seldom win out against those with a long evolutionary history. Factors contributing to this condition include the difficulty of envisioning the human consequences of innovations and the predominance of research models that do not contribute to innovation. Design research is an emerging effort to bring what Whitehead called “disciplined progress” into education, but it has not yet taken on a clear form or purpose. Design research is not defined by its methods but by the goals of those who pursue it. Design research is constituted within communities of practice that have certain characteristics of innovativeness, responsiveness to evidence, connectivity to basic science, and dedication to continual improvement.