著者

廣長軒元閑 編

出版者

和泉屋次郎右衛門

巻号頁・発行日

vol.[5], 1694

著者

米原 弘 高橋 信孝 大岳 望

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.5, no.1, pp.37-44, 1967-01-25 (Released:2009-05-25)

参考文献数

3

著者

歌代 慎吉 岩淵 義郎

出版者

Tokyo Geographical Society

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.80, no.2, pp.77-88, 1971-04-25 (Released:2009-11-12)

参考文献数

8

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Sagami Bay is structurally active area through the geological history, and also the epicenter of the Great Kanto Earthquake (1923) was here. To make clear the features of the topography and geological structure of the active area, it seems to be fundamental step for the earthquake predication today.In April to May 1968, the surveying ship Meiyo of the Japanese Hydrographic Office carried out the sea bottom surveys of Sagami Bay with echo-sounder, seismic profiler and proton-geomagnetometer, including the dredge and coring operation, and took the data from about 3000 kilometers of her traverses.The ship's position was mainly determined by an auto-tape system with the estimated accuracy of ±2 meters. The simultaneous measurement of magnetic intensity, bathymetry and submarine geological structure by air-gun system allows direct comparison of the measurements. Figure 1 is the track chart of the Meiyo and figures 2 and 3 are some profiles based on the collected data.From the analyses of the collected data mentioned above, the topography and geological structure and magnetic anomaly of Sagami Bay can be summarized as follows.1. TopographyFigure 4 shows the bathymetric chart of Sagami Bay. In the eastern part of the bay, many banks and small basins range from NW to SE. Many submarine canyons cross the topography mentioned above and incise deeply, so that especially small basins do not keep their complete shape.The central part of the bay is called Sagami Trough, which is deeper than 1 kilometer. The floor of the trough generally shows low relief with the exception of the eastern part of the trough, which submarine canyons flow into, and gentle slope with the trend of NS at the central part, facing east and reflecting the fault topographically.In the western part of the bay, continental shelf and slope are monotonous, comparing with its eastern part. There are several conical banks between the Izu Peninsula and O Shima Island.2. Geological structureGeological structure based on the seismic profiler is shown in Figure 5. The area surrounded Sagami Bay is relatively uplifted zone in contrast with the trough showing the relative subsidence. Acoustic basement rock outcrops on the uplifted zone and may probably be composed of the Hayama group (Lower Miocene) and partly the lower part of the Miura group (Middle Miocene).The large part of the thinly layered sediment at the upper part of sediment body in Sagami Trough is younger than the age of uplifted zone mentioned above. The layered sediment is wholly tilted to the axis of the trough, and is found the folding in the margin of the trough and also the active fault near surface. Its maximum thickness is found at the northern part of the trough, and is over about 1 second in the reflection time approximately.The area along the Izu Peninsula and around O Shima Island is extensively covered with the volcanic products. Small banks between the Izu Peninsula and O Shima Island are volcanic cones of the effusive body which pierced through the layers probably composed of the Shirahama group (Middle to Upper Miocene).3. GeomagnetismThe resultant magnetic chart, contoured at intervals of 100 gammas, was in Figure 6. The results of the magnetic surveys revealed that there were many magnetic anomalies of about 500 to 800 gammas off shore along the Izu Peninsula in Sagami Bay and a pair of remarkable positive and negative magnetic anomalies of about 1800 gammas in the sea area along the west side of O Shima Island.On the other hand, it was found that there was no remarkable magnetic anomaly in the central part and eastern part of Sagami Bay.From the results of magnetic surveys and submarine geological structure, it can be concluded that the sea area off shore along the Izu Peninsula and around O Shima Island are composed of volcanic rocks of higher magnetic susceptibility, such as basalt or andesite.

著者

湯川 健 立川 敬子 宗像 源博 塩田 真 春日井 昇平

出版者

公益社団法人 日本口腔インプラント学会

雑誌

日本口腔インプラント学会誌 (ISSN:09146695)

巻号頁・発行日

vol.27, no.2, pp.175-180, 2014-06-30 (Released:2014-07-25)

参考文献数

15

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A questionnaire survey was conducted to determine the information required by patients prior to providing informed consent for dental implant surgery. Questionnaires were distributed to 1,585 patients who visited the Tokyo Medical and Dental University Hospital for oral implants between January 2012 and December 2012, of which 1,159 (73%) valid questionnaires were collected. The results showed that preservation of an adjacent tooth was the reason that 32% of participants chose implant therapy. Over 70% of participants indicated that their main concerns regarding implant therapy were aftereffects of surgery, the number of years the implants would be in place, and treatment cost. Regarding knowledge about implant therapy, patients' most frequent reply was“ I do not know” when asked about postoperative pain, peri-implantitis, the importance of implant maintenance, and the relationship between general health and implant therapy. Fifty-nine percent of the patients recognized smoking as a risk factor for periodontal disease, of which 23% recognized smoking as a risk factor for implant therapy. Sixty-one percent of patients replied“ more than 20 years” when asked about the number of years that they believed the implants would be in place. This research identified the information required by patients in order to provide informed consent. Comprehensive information is required before informed consent is sought, as the majority of patients did not possess sufficient knowledge regarding implant therapy.

著者

三浦 巌 高橋 正典 青木 聡之 安芸 晋冶

出版者

日本結晶成長学会

雑誌

日本結晶成長学会誌 (ISSN:03856275)

巻号頁・発行日

vol.31, no.3, 2004

参考文献数

1

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The usefulness of low-power P MR in the study of polymorphous and molecular dynamics was examined. The milling, high temperature and humidification effect on amino acids crystal were studied by PMR. The results of these experiments were demonstrated that the normal liquid PMR system can be used as a powerful analytical tool of the solid materials.

著者

田中 洋和 中原 邦夫 畑中 洋 稲村 典昭 黒田 昭雄

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.117, no.8, pp.542-554, 1997-08-25 (Released:2008-05-30)

参考文献数

17

被引用文献数

7 19

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Tacrolimus hydrate (FK506), a novel 23-membered macrolide, is an immunosuppressant isolated from Streptomyces tsukubaensis using extensive screening of fermentation products to identify a compound inhibiting the mixed lymphocyte reaction (MLR). The in vitro and in vivo immunosuppressive activities of FK506 were found to be more potent than those of cyclosporine (CyA). The superior immunosuppression with FK506 treatment was also confirmed in the skin allograft model in rats and liver transplantation in dogs. Clinical studies were initiated by Prof. Starzl at the University of Pittsburgh in 1989, and he demonstrated that FK506 surpassed CyA in the incidence of graft survival and the frequency of graft rejection. Multicenter randomized clinical studies, comparing FK506 to CyA corroborated the efficacy of FK506 on the survival of patients and of grafts, and especially on the appearance of severe refractory graft rejection. FK506 was marketed in 1993 in Japan, and was followed in 1994 in the U.S.A., U.K, and Germany. The mechanism of action of this compound was clarified by the endeavors of Prof. Schreiber, who demonstrated the existence of a binding protein for FK506 called FKBP, similar to cyclophilin for CyA. The FK506/FKBP complex binds with calcineurin, a serine/threonine phosphatase to inhibit the translocation of NFAT into the nucleus, resulting in inhibition of transcription of IL-2 mRNA. FK506 displays potent immunosuppressant activity, and contributes not only to the progress of transplantation therapy for clinical studies, but also to the clarification of signal transduction in T cell activation for basic science.

著者

TOM S. CHEN BYRON H. ARISON LINDA S. WICKER EDWARD S. INAMINE RICHARD L. MONAGHAN

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.45, no.1, pp.118-123, 1992-01-25 (Released:2006-04-19)

参考文献数

7

被引用文献数

15 17

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The immimosuppressants FK506 and FR 900520 were desmethylated by Actinoplanes sp. ATCC 53771 to yield various O-desmethylated products. The products were isolated and purified by solvent extraction and HPLC chromatography, and identified by NMR and MS spectroscopy.

著者

西川隆

雑誌

薬事日報

巻号頁・発行日

vol.11, 1998

被引用文献数

1

著者

森永 太 伊東 隆利 阿部 成善 添島 義樹 土屋 直行 松井 孝道 飯島 俊一 川口 和子

出版者

公益社団法人 日本口腔インプラント学会

雑誌

日本口腔インプラント学会誌 (ISSN:09146695)

巻号頁・発行日

vol.31, no.2, pp.170-179, 2018-06-30 (Released:2018-07-25)

参考文献数

15

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長期症例のインプラントに対して,しばしばインプラントの残存率が一つの成功基準として使用される.しかし,患者の実態を知るにはそれだけでは十分といえない.この研究の目的はインプラント治療を受けた患者の長期経過の実態を知ることである.我々は,インプラント治療後20年以上経過した患者に対しアンケート調査を行った.患者は九州インプラント研究会に所属する歯科医師によって治療された.アンケートは1,168名に送付し509名からの回答を得た(回答率44%).回答者の内,78%がインプラントに何も問題ないと答えた.また,歯の経過については68%が何もないと回答した.食事については84%が何でもよく噛めると回答した.また93%がインプラント治療に満足していると回答した.

著者

栄留 里美

出版者

大阪市立大学

雑誌

人権問題研究 (ISSN:1346454X)

巻号頁・発行日

vol.8, pp.93-110, 2008-03

著者

間瀬 俊明

出版者

帝京大学

巻号頁・発行日

1987

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博士論文

著者

山下 道雄

出版者

慶應義塾大学

巻号頁・発行日

1985

---

博士論文

著者

久米 悠太 平松 健司 長嶋 光樹 松村 剛毅 山崎 健二

出版者

特定非営利活動法人 日本心臓血管外科学会

雑誌

日本心臓血管外科学会雑誌 (ISSN:02851474)

巻号頁・発行日

vol.45, no.4, pp.154-160, 2016-07-15 (Released:2016-08-19)

参考文献数

23

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[背景]小児期の人工弁置換術には術後の脳関連合併症や血栓弁,成長に伴うサイズミスマッチなどの懸念があり可及的に弁形成術を行うことが望ましいが,やむを得ず弁置換術となる症例が存在する.15歳以下の孤立性僧帽弁疾患(孤立性僧帽弁閉鎖不全症,孤立性僧帽弁狭窄症)に対する僧帽弁形成術,僧帽弁置換術の遠隔期成績を検討した.[対象]1981年1月から2010年12月までに当院で僧帽弁形成術を行った30例(P群:男児21例,平均年齢4.6±4.6歳,平均体重13.4±8.9 kg),および機械弁による僧帽弁置換術を行った26例(R群:男児9例,6.2±4.6歳,平均体重16.4±11.2 kg)の計56例を対象とした.平均追跡期間9.3±7.8年,最長27.7年であった.また,孤立性僧帽弁閉鎖不全症(iMR)群と孤立性僧帽弁狭窄症(iMS)群とに分けて追加検討を行った.[結果]P群,R群ともに周術期死亡例はなく,遠隔期にR群で4例を失った.再手術はP群で6例,R群で5例に認めた.脳関連合併症は両群とも遠隔期に1例ずつ認めたのみで,人工弁感染は認めなかった.10年時および20年時での生存率はP群100%,100%,R群88.0%,80.0%であり有意差が見られた(p=0.043).10年時および20年時での再手術回避率はP群77.6%,77.6%,R群77.0%,70.0%,10年時における脳関連合併症回避率はともに100%であり有意差は見られなかった.iMR群とiMS群の10年時における生存率は100%と53.3%であり有意差がみられた(p=0.001).iMR群とiMS群の10年時における再手術回避率は77.1%と64.3%,20年時では72.0%と64.3%であり有意差は見られなかった.[結語]15歳以下の孤立性僧帽弁疾患に対する僧帽弁形成術,僧帽弁置換術の遠隔期成績は,懸念していた機械弁置換術後の脳関連合併症回避率や再手術回避率も僧帽弁形成術と有意差なく,小児期の僧帽弁手術として許容されるものであった.特に孤立性僧帽弁閉鎖不全症に対する僧帽弁手術の遠隔期成績は良好であった.孤立性僧帽弁狭窄症においては孤立性僧帽弁閉鎖不全症に劣らない再手術回避率であったが生存率には懸念が残る結果となった.

著者

遠西 昭寿 久保田 英慈

出版者

一般社団法人 日本科学教育学会

雑誌

日本科学教育学会研究会研究報告

巻号頁・発行日

vol.18, no.5, pp.37-42, 2004

参考文献数

7

被引用文献数

8

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概念変換をめざす理科の授業において、個々の生徒の心的変容をリアルタイムでフィードバックするためのツールとして「運勢ライン法」を改良し、使用した。概念変換は概念切り替えとコミットメントの変化によって測定した。この結果、授業者の授業設計の意図にもかかわらず、多様な学びのパターンが存在することがわかった。また、概念変容は実験によってより、むしろ討論など相互作用の中に生じることが明らかになった。さらに、授業における教師の「まとめ」が科学理論習得にとって重要な役割を演じていることも明らかになった。運勢ライン法は授業の流れにほとんど影響を与えずに、個々の生徒の心的変容をリアルタイムで測定でき、その解釈も直感的に可能であり、教育の臨床研究のツールとして有用である。

著者

新井 健一郎

出版者

Center for Southeast Asian Studies, Kyoto University

雑誌

Southeast Asian Studies (ISSN:21867275)

巻号頁・発行日

vol.4, no.3, pp.445-486, 2015-12-31 (Released:2017-03-30)

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This paper is an attempt to explore the features of Indonesia's post-New Order regime in terms of the reorganization of the spatial, economic, and socio-political order in the Jabodetabek region. Although buoyant property investments in the last seven to eight years significantly changed the skyline of the metropolis, this paper reveals that the basic pattern did not alter after the regime change, with major developers taking control of vast areas of suburban land and creating an oligopolistic order. This paper argues that this continuity was due greatly to the developers' ability to organize and protect their collective interests through business associations and strong ties with political parties and the administration. The paper concludes that the emerging new regime comprises privatized urban governance in satellite cities, a dual government arrangement, and widening socio-spatial cleavages. So far, the tension inherent in this arrangement has been contained by measures such as the privatization of security and the political mobilization of Islam.

著者

鎌田 七男 大瀧 慈 田代 聡

出版者

長崎大学

雑誌

長崎醫學會雜誌 : Nagasaki Igakkai zasshi (ISSN:03693228)

巻号頁・発行日

vol.89, pp.272-275, 2014-09-25

出版者

吉田四郎右衛門尉

巻号頁・発行日

vol.[14], 1647

著者

山下 道雄 松田 充功 大畑 暢敬 神田 宗和 檜垣 知臣

出版者

日本生物工学会

雑誌

生物工学会誌 : seibutsu-kogaku kaishi (ISSN:09193758)

巻号頁・発行日

vol.83, no.3, pp.123-131, 2005-03-25

参考文献数

3

被引用文献数

1

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In 1989, in the course of our screening for new antifungal antibiotics with cell wall synthesis inhibition activity, FR901379 (WF11899A) was discovered in the culture broth of Coleophoma empetri F-11899. The strain was isolated from a soil sample collected in Iwaki city, Fukushima-prefecture, Japan. Because FR901379 had hemolytic activity, we decided to screen for semi-synthesis derivatives with low toxicity and high antifungal activity and evaluated many derivatives with substituted side chains. We started by using Actinoplanes utahensis to replace the palmitoyl group of FR901379 with other organic acids. After synthesizing several hundred organic acids and making repeated derivatives, we discovered FR131535, which had similar antifungal activity to FR901379 in vitro and in vivo and low hemolytic activity. It was not however selected as a development candidate because of insufficient antifungal activity. In the search for a more potent compound, we hypothesized that a compound with a similar molecular structure to FR131535 might produce a good antifungal drug. We therefore began the screening of Fujisawa's original acylase using a specially devised and effective screening system. After discovering "FR901379 Acylase" produced by Streptomyces sp. No. 6907, we continued with our evaluation of derivatives. We finally selected FK463 as a candidate compound for commercial drug development. In 1990, to establish an industrial manufacturing method for Micafungin (FK463), our laboratories (Fermentation Development Laboratories) commenced the following development research : (1) strain improvement of Coleophoma, (2) screening of "FR901379 Acylase"-producing strains, (3) studies to increase the scale of fermentation of FR901379 and "FR901379 Acylase", (4) determination of effective purification procedures for FR901379, a key intermediate of FR179642 and FK463, and (5) development of a HPLC assay system to measure the amount of objective compounds and impurities. Micafungin (general name, Trade mark : Funguard, Development No. : FK463) was launched in Japan on December 6, 2002. Approval in the USA and EU is pending and expected shortly.

著者

Kinji Ishikawa Ken Kanamasa Iwao Ogawa Toshihiko Takenaka Takeo Naito Noriaki Kamata Tadahiko Yamamoto Shoji Nakai Junkichi Hama Miki Oyaizu Akio Kimura Kentaro Yamamoto Naoko Aso Miyuki Arai Hiroshi Yabushita Ryo Katori on behalf of the Secondary Prevention Group

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.60, no.10, pp.779-788, 1996 (Released:2001-12-25)

参考文献数

27

被引用文献数

50 63

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Background Nitrates dilate coronary arteries, ameliorate myocardial ischemia, minimize left ventricular remodeling, and reduce mortality in patients with acute myocardial infarction. However, the effects of long-term treatment with nitrates on cardiac events in patients with healed myocardial infarction are not known. Methods and Results A total of 1,002 patients with healed myocardial infarction (789 male and 213 female) were randomly divided into 2 groups: treatment with nitrates or nontreatment. The mean observation period was 18.0 ±19.9 months. Primary end points were nonfatal and fatal recurrent myocardial infarction, death from congestive heart failure, and sudden death. Baseline characteristics of the 2 groups were also compared to determine any effects on outcome. Among the 621 cases treated with nitrates, 41 cases (6.6%) experienced cardiac events during the observation period, whereas only 12 of the 381 cases that were not treated with nitrates (3.1%) had cardiac events. This difference was statistically significant (p<0.05; odds ratio 2.17; 95% confidence interval 1.13-4.19). There were no differences in the incidence of noncardiac death or being lost to follow-up between the 2 groups. Although the precise mechanism of this increase in the occurrence of cardiac events by long-term treatment with nitrates is not clear, nitrate tolerance with possible rebound and neurohormonal effects may be involved. Conclusion Long-term treatment with nitrates increased cardiac events in patients with healed myocardial infarction. (Jpn Circ J 1996; 60: 779 - 788)

著者

三浦 景祐 松井 正宏 真栄城 玄一

出版者

一般社団法人 日本風工学会

雑誌

風工学シンポジウム論文集

巻号頁・発行日

vol.24, pp.337-342, 2016

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台風のような自然現象の観測データを用いた風速予測には不確定性が存在するため、その影響も考慮する必要がある。一つは極めて稀に起こりうる事象に起因する現象論的不確定性、もう一つは知識やデータの不足に起因する認識論的不確定性である。前者は事象の偶然性に関わるものであるため、新たな観測データが蓄積したとしても低減させることができない。一方、後者は経験や知識を蓄積することで低減させることができるものである。本研究では、確率分布パラメータの推定方法が台風気圧場に及ぼす影響を検討するとともに台風観測記録のデータ数や分布パラメータの推定方法が風速評価に与える影響についても検討を行い、不確定性の低減を図る。