著者

加藤咄堂 著

出版者

大東出版社

巻号頁・発行日

1938

著者

山田 國晶 番匠 千津 三木 隆寛

出版者

特定非営利活動法人 日本顎咬合学会

雑誌

日本顎咬合学会誌 咬み合わせの科学 (ISSN:13468111)

巻号頁・発行日

vol.29, no.1-2, pp.108-114, 2009-04-24 (Released:2015-01-30)

著者

森 順子

出版者

人間環境大学

雑誌

こころとことば = Mind and language (ISSN:13472895)

巻号頁・発行日

no.1, pp.51-63, 2002-03-31

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作家、宇野千代の九十九年間の人生は、絶対的権力者としての父親の存在を抜きにしては語ることが出来ない。それは恐怖心として、彼女の精神の髄まで刻み込まれる。父親の言葉によって植え付けられた自信喪失に懊悩し続ける中で、宇野千代がいかにして生涯、自分自身であることを希求して生き抜いたかを探る。Chiyo UNO was a Japanese novelist and essayist who lived for 99 years. She suffered from loss of self-confidence throughout most of her life under the emotionally abusive influence of her father. He was an absolute patriarch and continuously spoke ill of her dark complexioned face. He was a terror to her. The present writer would like to focus upon this emotional abuse and its effect upon her and to speculate upon how she overcame difficulties and tried to be mentally independent, striking out a path of her own in life.

著者

岩崎 寛

出版者

におい・かおり環境協会

雑誌

におい・かおり環境学会誌 = Journal of Japan Association on Odor Environment (ISSN:13482904)

巻号頁・発行日

vol.39, no.4, pp.231-238, 2008-07-25

参考文献数

11

被引用文献数

1

著者

十龜 盛次

出版者

神戸大学

雑誌

國民經濟雜誌 (ISSN:03873129)

巻号頁・発行日

vol.71, no.6, pp.69-93, 1941-12

著者

福島, 隣春

出版者

写

巻号頁・発行日

vol.巻9,

著者

吉田 忠正

出版者

The Japanese Circulation Society

雑誌

JAPANESE CIRCULATION JOURNAL (ISSN:00471828)

巻号頁・発行日

vol.28, no.9, pp.704-711, 1964

被引用文献数

1

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Recently, the hepatic circulation in hemorrhagic shock has been investigated by HEINEMANN, BRADLEY, SELKURT, FRANK and others. However, the opinions among the authors have not yet been in agreement but rather controversial, par icularly, as to the relationship between hepatic blood flow and cardiac output. HEINEMANN reported that hepatic blood flow fell sharply following hemorrhage and then returned spontaneously the control level in absence of the restoration of blood pressure. While, the others reported that hepatic blood flow did not recovered and remained in decreased level, having the same trend in blood pressure change. It seems likely that such a controversy will be partly due to the difference of the methods employed in measuring hepatic blood flow and partly to the confusion in recognizing the stage of shock, because the sequence of respective hemodynamic phenomenon is considerably different at the period of observation in this condition. The purpose of the present paper is to classify the relationship of hepatic blood flow and cardiac output throughout the entire course of hemorrhagic shock and its bearing on the irreversibility of shock. Oxygen utilization in the splanchnic viscera was also studied. The Relationship between Hepatic Blood Flow and Cardiac Output 1) Methods : Hepatic blood flow was measured by modified Frank's method. Twenty-two dogs ranging in weight from 8 to 20 kg were used and anesthetized with intravenous pentobarbital sodium of 25 mg/kg. A polyethylene catheter was passed through a right external jugular vein into the hepatic vein and then wedged into one of hepatic lobar veins. The outer end of the catheter in the hepatic vein was fixed at the level of the vena cava and allowed to drain continuously. The rate of hepatic outflow was measured by a graduated cylinder and stop watch. The blood collected was returned by transfer to an elevated burette draining into a left external jugular vein. Heparin (3-5 mg/kg) was given intravenously during the experiments. Cardiac output was calculated from indicator dilution curves according to the STEWART-HAMILTON principle. Two different procedures were used. In one method <SUP>32</SUP>P labelled red cells were used as an indicator and injected intravenously. Blood samples were collected successively from the femoral artery. In another cases, radio-iodinated serum albumin (RISA) was injected as an indicator. Cardiac output was calculated from radio-cardiograms by using a scintillation detector at the heart region and a rate-meter. 2) Results : We could distinguish the following two stages in hemorrhagic shock in relation to hepatic blood flow and cardiac output. a) The first stage : In the early stage of shock, hepatic blood flow decreases in parallel with the changes in cardiac output. b) The second stage : After same delay from the initial bleeding, hepatic blood flow decreases progressively without marked reduction in cardiac output. Consequently, a difference or "gap" appears in percentile changes of hepatic blood flow and cardiac output. c) Effects of transfusion : Complete recovery of arterial pressure, cardiac output and hepatic blood flow can be obtained by a transfusion performed in the first stage. Whereas, the transfusion made in the second stage give rise only transient recovery of arterial pressure and cardiac output.

著者

呉羽 好三 田川 憲夫

出版者

関東東山病害虫研究会

雑誌

関東東山病害虫研究会年報 (ISSN:03888258)

巻号頁・発行日

vol.1967, no.14, pp.103-103, 1967 (Released:2010-03-16)

著者

MIHOKO YAMAMOTO TOKUJI IKENAKA

出版者

The Japanese Biochemical Society

雑誌

The Journal of Biochemistry (ISSN:0021924X)

巻号頁・発行日

vol.62, no.2, pp.141-149, 1967-08-25 (Released:2011-01-25)

参考文献数

23

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1. A simple method was developed for the preparative purification of large amounts of two soybean trypsin inhibitors, namely the Kunitzand the 1.9S-inhibitors.2. These two trypsin inhibitors were characterized in terms of their major chemical and physicochemical properties, and these results were compared with those of soybean trypsin inhibitors isolated by other investigators.The Kunitz-inhibitor was shown to be identical to that isolated by Kunitz and the 1.9S-inhibitor appears to be a new innibitor. Molecular weight of the 1.9S-inhibitor was determined to be 16, 400 and this protein contains more than 19 per cent of cystine and lacks cysteine and glycine.3. The inhibiting activites of the two inhibitors against several proteinases were investigated.

著者

小栗 勝也

出版者

慶應義塾大学法学研究会

雑誌

法学研究 (ISSN:03890538)

巻号頁・発行日

vol.68, no.1, pp.p509-537, 1995-01

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中村勝範教授退職記念号一 問題の所在二 政府の法案提出理由と反対論者三 代表的反対論者の主張四 中間的反対論の特徴五 革命肯定論者の反対論六 結語

著者

大蔵省印刷局 [編]

出版者

日本マイクロ写真

巻号頁・発行日

vol.1948年12月31日, 1948-12-31

著者

岩本 功

出版者

長崎大学熱帯医学研究所

雑誌

熱帯医学 (ISSN:03855643)

巻号頁・発行日

vol.14, no.3, pp.124-137, 1972-09

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For explanation of the mechanism of microfilarial periodicity, it is a basic problem to know the survival time of microfilaria in the host. Therefore, there have been reported several papers concerning the experimental investigations on it. Viewing these papers reported in the past, however, there is found a great difference in the survival times obtained by each investigator. This disagreement may due to the irrationality of procedual method employed in these studies. In the present study, the author attempts to discuss the longevity and viability of microfilaria in various conditions from the results obtained by using a new method originated by us. When the heparinized blood containing microfilaria is maintained in a test-tube, living microfilariae swarm together near the boundary area between the blood plasma and the blood cell sediment. Microfilariae were isolated from there by pippett, removed to the various kind of media in the watch-glass and then incubated in the glass capillaries. Under microscope, the activity of each microfilaria was checked until all microfilariae died and the numbers were counted every 8 hours. When the commulative mortality was drawn on logarithmic scale. a straight regression line could be obtained. The theoretical mean survival time can be represented by the 50 per cent value of mortality on this regression line. For this observation, microfilaria of Dirofilaria immitis and Wuchereria bancrofti were used and the total numbers in each group of the experiment were approximately 1,000-3,000. First of all, the viability was tested at various temperatures and in various media such as distilled water, physiological saline solution, and the blood plasma of animals and human beings. When one compares the mortality curves given by different temperatures from 5℃ to 37℃, it becomes clear that the survival time in vitro of microfilaria depends much on the temperature. Generally speaking, the survival time was longer in refrigerator at 5℃ than at room temperature of 20℃, while it was signifcantly short at 37℃. In physiological saline solution, the mean survival time of D. immitis microfilaria expressed by 50 per cent value was 216 hours at 5℃, 61 hours at 21℃, 9 hours at 37℃ respectively, but in each group, the last microfilaria was remained alive for 426 hours, 352 hours and 48 hours after all others died out. The survival time was also influenced by the kind of media in which microfilariae were incubated, for example, the mean survival time of D. immitis microfilaria at room temperature was approximately 74 hours in distilled water, 61 hours in physiological saline solution and 216 hours in the rabbit blood plasma, and it was longest in the blood plasma of non-infected dogs as long as 254 hours. It was of interest to note that the blood plasma of infected dog tend to reduce the survival time of D. immitis microfilaria. The survival time of bancroftian type microfilaria in vitro as compared to that of dog heart worm was relatively short in any conditions, especially the viability was found markedly inhibited in the blood plasma of animals other than human being. This finding suggest that bancroftian filarial worm has the high specificity in adaptation to the host. In order to see the longevity of microfilaria in vivo, the living microfilariae were transfused intraveneously into fresh animals. In the dogs received intraveneous transfusion of the blood containing about 950,000-5,700,000 microfilariae of D. immitis, the microfilaria continued the emigration into the peripheral circulation for a long time at least more than 50 days, showing a nocturnal sub-periodic fluctuation in the number. However, the microfilariae transfused into rabbits disappeared from the peripheral blood within 21 days, during which the periodicity was rather indistinct. On the other hand, it was noticed that W. bancrofti microfilaria could not be demonstrated in the blood streams of recipient dog and rabbit, even if a large number of the larvae were given. However, of the animals which were autopsied immediately after tte transfusion, a moderate number of the living larva was usually recovered in the various organs such as the lung, liver and kidney.1)体外での仔虫の死亡経過は時間の対数と関係があり,50%値(MfMD_<50>)を求め,その仔虫群の平均生存時間とすることが出来る.2)仔虫の生存時間は5℃で最も長く,37℃になると早く死亡する.3)夫々対応宿主の血漿内で最も長く生存するが,感染宿主血漿は抑制的に働く.4)いかなる条件のもとでもバンクロフト仔虫は犬糸状虫のそれより生存時間が短く,人以外の動物血漿では早く死亡する.5)犬糸状虫仔虫は犬に移注されると長期にわたり末梢血中に出現し,夜間出現性を最後まで維持する.家兎の場合はにれより速やかに消失し,早期より夜間出現性の乱れがみられる.6)バンクロフト糸状虫仔虫は犬,家兎に移注を行っても末梢血内に出現せず,一部内臓や大血管に集積される.本論文要旨の一部は第21,22回日本寄生虫学会南日本支部大会(1968,1969)及び第38回日本寄生虫学会総会において報告した.稿を終るに当り,終始御指導,御校閲頂いた恩師片峰大助教授に深甚の謝意を表します.

著者

小野田 尚佳 神森 眞 岡本 高宏 中島 範昭 伊藤 研一 宮崎 眞和 吉田 明

出版者

日本内分泌外科学会・日本甲状腺外科学会

雑誌

日本内分泌・甲状腺外科学会雑誌 (ISSN:21869545)

巻号頁・発行日

vol.33, no.2, pp.110-114, 2016 (Released:2016-07-28)

参考文献数

9

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甲状腺乳頭癌(PTC)に対する放射性ヨウ素内用療法の現状を把握し,意義を見出すため,多施設共同の後ろ向き研究を行った。ʼ03~ʼ12年に初発のPTCに対し全摘術を受けた患者1,324例のデータを7施設から集積した。全摘,内用療法施行とも増加傾向にありʼ12年には全初発PTC手術例の60%,25%を越えた。内用療法は480例に施行され全摘例の36%に相当,M1,Stage ⅣB,ⅣC症例の2/3に施行されていた。疾患特異的生存率は内用療法施行群で有意に不良であった。予後リスクによって層別化すると内用療法施行により生命予後に差は認めなかったが,中間リスクの施行例は非施行例に比し術後診断の進行度が有意に高かった。本研究により内用療法の現状が明らかとなり,中間リスク患者での効果が示唆されたが,適応や治療法の問題点も確認され,内用療法の意義を見出すためにはさらなる症例集積研究が必要と考えられた。

著者

山﨑 むつみ 岩澤 まり子

出版者

情報メディア学会

雑誌

情報メディア研究 (ISSN:13485857)

巻号頁・発行日

vol.14, no.1, pp.1-10, 2015-05-27 (Released:2015-05-27)

参考文献数

13

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本研究では,リンクリゾルバによる学術文献のナビゲートの精度の向上のための方法を検討した.リンクリゾルバでナビゲートできなかった学術文献のうち,WEB上から入手できた文献を対象として,これらの入手方法と入手源を調査した.その結果,出版元や著者所属機関のページ,ソーシャル・ネットワーキング・サービス等において無料公開された学術文献にナビゲートできない状況が認められた.無料公開されたオープンアクセス文献のナビゲートを確実にするためには,ナビゲートシステムの改善だけではなく,文献がナビゲートされやすいように公開者による対応が必要であることがわかった.当面のナビゲートの問題を解消するためには,サーチエンジンの補完的使用が有効であったが,その時々に応じた利用者支援も必要である.

著者

早野 慎吾 松井 洋子 小田原 恵美子 宮田 好恵 佐藤 和之 田中 利砂子

出版者

宮崎大学

雑誌

宮崎大学教育文化学部紀要. 人文科学 (ISSN:13454005)

巻号頁・発行日

vol.19, pp.39-50, 2008-09-30

出版者

日経BP社

雑誌

日経メディカル (ISSN:03851699)

巻号頁・発行日

vol.44, no.3, pp.62-65, 2015-03

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まず教育。特に医学生への教育の負担が高まっている。私立大学教授のA氏が指摘するのは、「『医学生への教育』が教授の評価項目になった」ということだ。A氏の大学では、講義を医学生が評価する「授業評価」を導入している。

著者

山際 虎二

出版者

The Ornithological Society of Japan

雑誌

鳥 (ISSN:00409480)

巻号頁・発行日

vol.14, no.66, pp.14-23_1, 1955

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First, the history of the lake as waterfowl resort (less than 20 acres) and later artificial interferance are mentioned. After the war, eight swans (<i>C. c. cygnus</i>) were first noticed on January 28, 1950, by Mr. J. Yoshikawa, by whose painstaking effort not to alarm them, and by effective help of Mr. K. Nitta, the swan increased to 42 on February 17 (46 birds in March). The maximum of 27 birds in 1951, 39 in 1952, 33 in 1953 and 32 in 1954 have been recorded. Yoshikawa's effort to tame the swans was such that he or his asistants must watch the boys and dogs day and night, as the lake froze to allow them reach the swans. Then, after great offort, the stream water was poured into the lake to keep it free from freezing, and the swans were fed with grains. In the third year of feeding, his effort was proved fruitful as the swans became so tame as to come to him at his calling voice to eat grains a few meters from him. They were however watchful to the voice of the other persons. As the lake is in the village, there are still occasional annoyance, for example, the fireworks.

著者

柏木如亭

出版者

澤宗次郎

巻号頁・発行日

1860

著者

大藪 泰

出版者

一般社団法人 色材協会

雑誌

色材協会誌 (ISSN:0010180X)

巻号頁・発行日

vol.70, no.6, pp.404-413, 1997-06-20 (Released:2012-11-20)

参考文献数

67

著者

林 邦夫

出版者

鹿児島大学

雑誌

鹿児島大学教育学部研究紀要 人文社会科学編 (ISSN:03896684)

巻号頁・発行日

no.35, pp.p21-48, 1983