著者
Yo Kunii Takashi Uruno Koji Mukasa Kenichi Sekiya Kenji Iwaku Akifumi Suzuki Kiminori Sugino Jaeduk Yoshimura Noh Koichi Ito
出版者
(社)日本内分泌学会
雑誌
Endocrine Journal (ISSN:09188959)
巻号頁・発行日
vol.63, no.1, pp.21-27, 2016 (Released:2016-01-31)
参考文献数
20
被引用文献数
1 5

In the event of a nuclear power plant accident, prophylactic administration of potassium iodide (KI) is recommended to prevent thyroid damage due to uptake of radioiodine. To assess the inhibitory effect of low-dose inorganic iodine on thyroidal radioactive iodine uptake (RAIU) in healthy adults without dietary iodine restriction, single or repeated doses of 10 mg inorganic iodine solution were given to 22 Japanese volunteers, 18 men and 4 women with the mean age of 35.7 years, between 2011 and 2013. Changes in urinary iodine excretion, thyroid function and 24-hour RAIU were also evaluated. The median 24-hour RAIU without iodine restriction was 13 % (range, 5-26 %). A single-dose of 10 mg inorganic iodine suppressed the median 24-hour RAIU measured one hour after iodine administration to 3 % (range, 1-7 %) and, in 90.9% of 22 participants their 24-hour RAIU was < 5 %. For seven participants given 10 mg of inorganic iodine daily for 14 days, the median 24-hour RAIU measured at 24 hours after the last administration of iodine was 6 % (range, 2-12 %), although the inhibitory effect was diminished in two participants. Serum thyroid stimulating hormone concentration was slightly elevated in three participants without decreased serum FT3 and FT4 levels. We conclude that a single-dose of 10 mg inorganic iodine is sufficient to inhibit RAIU in adults, although the inhibitory effect of repeated-dose on RAIU is diminished when KI is given once daily. The dose, duration or interval of iodine administration should be evaluated in iodine-sufficient regions in a future.
著者
小幡 彌太郎 佐々 三郎 谷口 利廣
出版者
公益社団法人 日本水産学会
雑誌
日本水産学会誌 (ISSN:00215392)
巻号頁・発行日
vol.14, no.6, pp.289-291, 1949-04-25 (Released:2008-02-29)
参考文献数
3

The crystalline lenses of Theragra chalcogramma Pallas (I) and Ommastrephes sloani pacificus Steenstrup (II) were tested as for their value as a sticking matter for ply-wood. The results obtained are as following: The sticking power for the 4 m.m. Max. Min. Average Ply-wood I 28, 0kg/cm2 24, 3kg/cm2 26, 3kg/cm2 II 26, 6 24, 6 25, 6
著者
小幡 彌太郎 佐々 三郎 谷口 利廣
出版者
公益社団法人 日本水産学会
雑誌
日本水産学会誌 (ISSN:00215392)
巻号頁・発行日
vol.14, no.5, pp.251-253, 1949-03-25 (Released:2008-02-29)
参考文献数
1

The sticking power of fish-meat for ply-wood was tested with the meat of the following five species of fish: Fresh meat of Squalas sucklegi (Girard) I, Dinogunellus grigorjewi (II), and of Atheresthes evermanni Jordan & Starkes (III), and dry meat of Raiia isotrachys (IV) and of Theragra chalcogramma Pallas (V). The results obtained are as follows: Meat The Sticking Power for the 4 m.m. Ply-wood (Birch tree) max. min. average I 23.6kg/cm2 19.3kg/cm2 21.3kg/cm2 II 26, 6 25.8 26, 2 III 25, 3 25.3 25, 5 IV - - 15.0 V - -22.0
著者
溝口 環 飯島 節 江藤 文夫 石塚 彰映 折茂 肇
出版者
一般社団法人 日本老年医学会
雑誌
日本老年医学会雑誌 (ISSN:03009173)
巻号頁・発行日
vol.30, no.10, pp.835-840, 1993-10-25 (Released:2009-11-24)
参考文献数
14
被引用文献数
17 31 17

痴呆に伴う各種の行動異常は介護者にとって大きな負担となるが, 行動異常を定量的に評価する方法はまだ確立されていない. そこで, Baumgarten らの Dementia Behavior Disturbance Scale (DBDスケール) を用いて, 痴呆患者の行動異常の評価を試み, 評価法の信頼性と妥当性ならびに介護者の有する負担感との関連について検討した.痴呆群27例 (アルツハイマー型21例, 脳血管性6例, 男性9例, 女性18例, 平均年齢77.7歳) および神経疾患を有するが痴呆のない非痴呆群17例 (男性2例, 女性15例, 平均年齢76.8歳) の外来通院患者と施設入所痴呆患者10例 (アルツハイマー型9例, 脳血管性1例, 男性2例, 女性8例, 平均年齢82.3歳) を対象とした. DBDスケールは, 28項目の質問からなり, 異常行動の出現頻度を5段階に分けて介護者が評価した.DBDスケールの信頼性については, 再テスト法の相関係数0.96, Cronbach のα係数0.95, 評価者間信頼性は Intraclass Correlation Coefficient (ICC) 平均0.71と何れも高い値を示した. 妥当性については, DBDスケール得点と簡易知能質問紙法 (SPMSQ) 誤答数との相関係数0.54と知的機能との相関は良好であった. DBD得点とアンケートで評価した介護者の負担感との間に有意の相関を認め (r=0.53), 介護の負担度を反映し得る指標としての有用性も示唆された.DBDスケールは, 痴呆に伴う行動異常の客観的評価や経過観察の方法として信頼性が高く, 介護負担も反映しうる有用な評価法である.
著者
廣瀬 悠人 舟橋 弘晃
出版者
日本繁殖生物学会
雑誌
日本繁殖生物学会 講演要旨集 第105回日本繁殖生物学会大会
巻号頁・発行日
pp.1140, 2012 (Released:2012-09-04)

【目的】本研究は,ブタ精液の凍結保存液への細胞膜非透過性トレハロース(T)の添加または凍結保護物質のグリセリン(G)との置換の可能性について検討した。【方法】15℃で一晩静置した大ヨークシャー種雄ブタ射出濃厚部精液を使用した。希釈液(20%(v/v)卵黄含有8.8%ラクトース液)中に精子を再浮遊(1×109 cells/ml)後,5℃まで2時間で冷却した。その後,OEP(1%(v/v)および異なる組み合わせの糖類含有希釈液を同量添加し(最終濃度2%(v/v) G,100 mM T,0.5%(v/v) G + 50 mM T), 0.5-mlストローに充填・封入した。そのストローを液体窒素の液面上方4.5 cmで15分間静置後,液体窒素中に投入した。その後,39℃温湯に30秒間浸漬したストローから精液を回収し,修正モデナ液中で遠心洗浄し,凍結前後の精子の運動精子率および生存精子率,融解後の先体反応精子率および活性酸素種量を調べた。【結果】すべての区で凍結の前後で運動精子率および生存率が有意に低下した。2% G添加区および0.5% G + 50 mM T添加区の融解後の運動精子率(それぞれ20.31±1.52%および16.12±2.35%)は,100 mM T添加区のそれ(5.56±0.62%)より高かった(P0.05)。 以上の結果から,GのTでの置換は精子の運動性を低下させるが,50 mM T + 0.5% G存在下では,2% G添加対照区と比較して,凍結融解後のブタ精子の運動性を低下させないことが示された。
著者
Go SUGAHARA Junichi KAMIIE Ryosuke KOBAYASHI Takayuki MINESHIGE Kinji SHIROTA
出版者
公益社団法人 日本獣医学会
雑誌
Journal of Veterinary Medical Science (ISSN:09167250)
巻号頁・発行日
pp.15-0722, (Released:2016-02-06)
被引用文献数
3

Phospholipase A2 receptor (PLA2R) expressed in human podocytes has been highlighted as a causative autoantigen of human idiopathic membranous nephropathy. However, its expression was found to be minimal or absent in murine and rat podocytes. In this study, immunofluorescence revealed the expression of PLA2R in the glomerular podocytes in the kidney tissue sections of dogs. We then attempted to culture canine podocytes and investigate the expression of PLA2R in these cells. Glomeruli were isolated from dog kidneys and cultured to obtain podocytes using nylon mesh-based isolation method as followed for isolating rat podocytes. The cultured cells expressed PLA2R mRNA and protein in addition to other podocyte markers (synaptopodin, podocin and nephrin). These results indicate that the canine podocytes express PLA2R.
著者
辻澤 隆彦 日野 裕也
出版者
自動制御連合講演会
雑誌
自動制御連合講演会講演論文集 第47回自動制御連合講演会
巻号頁・発行日
pp.83, 2004 (Released:2005-01-11)

本論文は、定在波を用いて測定距離を算出するレーダについて、データを微分処理することによる簡便な計測手法を提案するものである。微分処理により定在波データの位相は変化するが、定在波の節間の距離は定常状態において一定となることを利用することで、定常状態における節間距離を計測することが本手法の特徴である。
著者
天野 達雄 佐藤 允之 寺西 裕 堀川 弘吏 太田 貴裕 松丸 祐司
出版者
特定非営利活動法人 日本脳神経血管内治療学会
雑誌
Journal of Neuroendovascular Therapy (ISSN:18824072)
巻号頁・発行日
vol.9, no.5, pp.238-244, 2015 (Released:2015-11-30)
参考文献数
15
被引用文献数
1

要旨: 【目的】急性期脳梗塞症例に対する血栓回収療法において,血管内治療医が移動し血栓回収療法を行うMobile Endovascular-therapy Team(MET)という形態で病院間連携を行った.MET,患者転送症例における画像診断から治療までの時間を検討した.【方法】2012 年7 月から2015 年6 月までに,発症8 時間以内に血栓回収療法を開始したMET 症例(MET 群),転送症例(Transfer 群)を対象とした.治療開始をガイディングカテーテル(GC)留置時刻とし,初期画像撮影(画像)から治療開始までの時間推移を比較した.【結果】MET 群は55 例,Transfer 群は9 例だった.画像から穿刺時間(MET 群 vs. Transfer 群:54 分 vs. 128 分,p<0.0001),画像から治療開始時間(105 分 vs. 168分,p=0.0003),MET or 転送要請から治療開始時間(80 分 vs. 125 分,p<0.0001)はいずれもMET 群で有意に短かった.【結論】MET により血栓回収療法を遅延なく開始することが可能であり病院間連携の1 つとして有用な手段であると考えられる.
著者
Mitsumasa Umesawa Hiroyasu Iso Yoshihisa Fujino Shogo Kikuchi Akiko Tamakoshi
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.26, no.2, pp.92-97, 2016-02-05 (Released:2016-02-05)
参考文献数
18
被引用文献数
1 26

Background: High sodium intake is a potential risk factor of gastric cancer. However, limited information is available on the relationship between salty food preference or intake and risk of gastric cancer. The aim of the present study was to determine the association between these variables among the Japanese population.Methods: Between 1988 and 1990, 15 732 men and 24 997 women aged 40–79 years old with no history of cancer or cardiovascular disease completed a lifestyle questionnaire that included information about food intake. The subjects were enrolled in the Japan Collaborative Cohort (JACC) Study for Evaluation of Cancer Risk Sponsored by Monbusho. After a median follow-up of 14.3 years, 787 incident gastric cancers were documented. We examined the associations between salty food preference and intake and gastric cancer incidence using the Cox proportional hazard model.Results: The risk of gastric cancer among subjects with a strong preference for salty food was approximately 30% higher than among those who preferred normal-level salty food (hazard ratio [HR] 1.31; 95% confidence interval [CI], 1.02–1.67). The risk of gastric cancer in subjects who consumed 3 and ≥4 bowls/day of miso soup was approximately 60% higher than in those who consumed less miso soup (HR 1.67; 95% CI, 1.16–2.39 and HR 1.64; 95% CI, 1.11–2.42, respectively). Sodium intake correlated positively and linearly with risk of gastric cancer (P for trend = 0.002).Conclusions: The present study showed that salty food preference, consumption of large quantities of miso soup, and high sodium intake were associated with increased risk of gastric cancer among Japanese people.
著者
Tsuyako Sakamaki Motohiko Hara Kazunori Kayaba Kazuhiko Kotani Shizukiyo Ishikawa
出版者
日本疫学会
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
vol.26, no.2, pp.71-75, 2016-02-05 (Released:2016-02-05)
参考文献数
23
被引用文献数
5

Background: Previous studies on the association between coffee consumption and subarachnoid hemorrhage (SAH) have provided inconsistent results. We examine the risk of SAH from coffee consumption in a Japanese population.Methods: Our analyses were based on the Jichi Medical School Cohort Study, a large-scale population-based prospective cohort study. A total of 9941 participants (3868 men and 6073 women; mean age 55 years) with no history of cardiovascular disease or carcinoma were examined. Participants were asked to choose one of five options to indicate their daily coffee consumption: none, less than 1 cup a day, 1–2 cups a day, 3–4 cups a day, or 5 or more cups a day. The incidence of SAH was assessed independently by a diagnostic committee. Cox proportional hazards models were used to calculate hazard ratios (HRs) and their 95% confidence intervals (CI) after adjustment for age and sex (HR1) and for additional potential confounders (HR2).Results: During 10.7 years of follow-up, SAH occurred in 47 participants. When compared with the participants who consumed less than 1 cup of coffee a day, the HR of SAH was significantly higher in the group who consumed 5 or more cups a day in both models (HR1 4.49; 95% CI, 1.44–14.00; HR2 3.79; 95% CI, 1.19–12.05).Conclusions: The present community-based cohort study showed that heavy coffee consumption was associated with an increased incidence of SAH after adjusting for age, sex, and multiple potential cardiovascular confounders.
著者
戸田山 和久
出版者
人間環境学研究会
雑誌
人間環境学研究 (ISSN:13485253)
巻号頁・発行日
vol.1, no.1, pp.1_5-1_10, 2003 (Released:2009-06-22)
参考文献数
21

Philosophical naturalism is made up of two basic claims as follows. (1) Ontological claim (physicalism); Only 'physical entities and phenomena' and what supervene upon them really exist. (2) Epistemological claim; There is no 'first philosophy', that is, every method of investigation including philosophy itself must consist of the methods which are regarded as legitimate in empirical sciences. One consequence of the latter claim is called 'naturalization of philosophy of science' which has grown to be a powerful alternative to the traditional philosophy of science such as logical positivism or Bayesianism. The main concern of this paper resides in the question whether a philosophical naturalist could believe in these two claims at the same time. For, if naturalized philosophy of science found, in empirical data from the real history of science, the fact that the ultimate aim of scientific investigation is not to reach the literally true description of the world but to attain some other epistemic values (e.g. to control the nature or to make better predictions), it might undermine the realistic reading of the ontological claim of philosophical naturalism. This possibility is overlooked by virtually all the naturalists, but might pose a serious difficulty on their philosophic research program. In the last section of this paper, I tired to propose a way-out from this predicament for a philosophical naturalist like myself. The proposal consists of these two measures. (1) to adopt a Hackingean operationist criterion concerning what exists and what not, (2) to reinterpret scientific theories not as sets of theoreteical sentences but as semantic models.
著者
Peter J. Waddell Hirohisa Kishino Rissa Ota
出版者
日本バイオインフォマティクス学会
雑誌
Genome Informatics (ISSN:09199454)
巻号頁・発行日
vol.12, pp.141-154, 2001 (Released:2011-07-11)
参考文献数
28
被引用文献数
252

A major effort is being undertaken to sequence an array of mammalian genomes. Coincidentally, the evolutionary relationships of the 18 presently recognized orders of placental mammals are only just being resolved. In this work we construct and analyse the largest alignments of amino acid sequence data to date. Our findings allow us to set up a series of superordinal groups (clades) to act as prior hypotheses for further testing. Important findings include strong evidence for a clade of Euarchonta+Glires (=Supraprimates) comprised of primates, flying lemurs, tree shrews, lagomorphs and rodents. In addition, there is good evidence for a clade of all placental mammals except Xenarthra and Afrotheria (=Boreotheria) and for the previously recognised clades Laurasiatheria, Scrotifera, Fereuungulata, Ferae, Afrotheria, Euarchonta, Glires, and Eulipotyphla. Accordingly, a revised classification of the placental mammals is put forward. Using this and molecular divergence-time methods, the ages of the superordinal splits are estimated. While results are strongly consistent with the earliest superordinal divergences all being gt; 65 mybp (Cretaceous period), they suffer from greater uncertainty than presently appreciated. The early primate split of tarsiers from the anthropoid lineage at '55 mybp is seen to be an especially informative fossil calibration point. A statistical framework for testing clades using SINE data is presented and reveals significant support for the tarsier/anthropoid clade, as well as the clades Cetruminantia and Whippomorpha. Results also underline our thesis that while sequence analysis can help set up hypothesised clades, SINEs obtainable from sequencing 1-2 MB regions of placental genomes are essential to testing them. In contrast, derivations suggest that empirical Bayesian methods for sequence data may not be robust estimators of clades. Our findings, including the study of genes such as TP53, make a good case for the tree shrew as a closer relative of primates than rodents, while also showing a slower rate of evolution in key cell cycle genes. Tree shrews are consequently high value experimental animals and a strong candidate for a genome sequencing initiative.
著者
Takaaki DEGUCHI Yoshiaki TANIGUCHI Go HASEGAWA Yutaka NAKAMURA Norimichi UKITA Kazuhiro MATSUDA Morito MATSUOKA
出版者
一般社団法人 電子情報通信学会
雑誌
IEICE Transactions on Communications (ISSN:09168516)
巻号頁・発行日
vol.E99.B, no.2, pp.347-355, 2016-02-01 (Released:2016-02-01)
参考文献数
17
被引用文献数
1 1

In this paper, we propose a workload assignment policy for reducing power consumption by air conditioners in data centers. In the proposed policy, to reduce the air conditioner power consumption by raising the temperature set points of the air conditioners, the temperatures of all server back-planes are equalized by moving workload from the servers with the highest temperatures to the servers with the lowest temperatures. To evaluate the proposed policy, we use a computational fluid dynamics simulator for obtaining airflow and air temperature in data centers, and an air conditioner model based on experimental results from actual data center. Through evaluation, we show that the air conditioners' power consumption is reduced by 10.4% in a conventional data center. In addition, in a tandem data center proposed in our research group, the air conditioners' power consumption is reduced by 53%, and the total power consumption of the whole data center is exhibited to be reduced by 23% by reusing the exhaust heat from the servers.
著者
梶原 葉子 山田 真知子
出版者
公益社団法人 日本水環境学会
雑誌
水環境学会誌 (ISSN:09168958)
巻号頁・発行日
vol.20, no.3, pp.185-192, 1997-01-10 (Released:2008-01-22)
参考文献数
30
被引用文献数
1 4 9

Quantitative sampling of sessile animals and monitoring of water quality in Dokai Bay, northern Kyushu, Japan, were carried out from 1991 to '92 for four times to evaluate the water condition in the bay, Kitakyushu heavy and chemical industry area.In this study, seventy four species of sessile animals ware collected, which include Mytilus galloprovincialis, Limnoperna fortunei, Crassostrea gigas, Mytilopsis sallei, Balanus amphitrite, Balanus trigonus, Balanus eburneus, Ciona intestinalis, and Styela plicata. These nine reprentative species in the bay showed characteristic distribution and seasonal occurrence patterns. We noted eight immigrated species of sessile animals including an ascidian Polyandrocarpa zorritensis recorded first in Japanese coastal water.Eutrophic level of water in Dokai Bay was classified according to the occurrence of the sessile animals in the bay. Water conditions of the inner most and central parts of the bay were classified as hyper eutrophic level, and those of the bay mouth were at intemediate one between hyper eutrophic and eutrophic levels. We suggest that six dominant species, including a mussel M. galloprovincialis, are useful as biological indicator organisms of hyper eutrophic level of coastal water.
著者
中野 和弘 荒木 肇 福山 利範 濱田 智和
出版者
農業情報学会
雑誌
農業情報研究 (ISSN:09169482)
巻号頁・発行日
vol.12, no.2, pp.105-112, 2003 (Released:2013-03-31)
参考文献数
15
被引用文献数
1 1 4

ムギ類のリビングマルチによる雑草抑制の可能性を調査した.コムギとオオムギの茎葉による地表面での遮光率と被覆率を測定した.リビングマルチとして販売されている緑肥用コムギ(マルチムギ)の7月播種では,播種密度3.2kg/10a以上で播種当初から分げつ数と草丈が大きくなり,遮光率も50%以上の高い値を示した.播種密度3.2kg/10aで5月に播種されたオオムギの分げつ数と草丈は品種間で大きく異なった.マルチムギの遮光率が播種後28日で37.5%であったのに対し,オオムギではそれより大きい品種が多数存在し,特にK027は遮光率74.2%を示した.供試したムギ類をビデオ撮影し,それを画像処理することで地表面被覆率を算出した.マルチムギの地表面被覆率が34.5%であったのに対し,オオムギのそれは25~60%と品種により大きく異なった.地表面被覆率は,分げつ数,草丈,地上部乾物重の地上部生長量を示す形質との間で相関が認められた.遮光率は地表面被覆率との間に高い相関関係(r=0.833)があるものの,地上部乾物重との相関は認められなかった.本研究によりK001, K069およびK027がリビングマルチの資材として有望であると考えられた.
著者
菅野 泰子
出版者
国立研究開発法人 科学技術振興機構
雑誌
情報管理 (ISSN:00217298)
巻号頁・発行日
vol.48, no.6, pp.320-332, 2005 (Released:2005-09-01)
参考文献数
44

情報システムと情報通信網が重要な社会インフラとなり,政治,経済,社会,生活を支えている現在,情報セキュリティ対策は必要不可欠である。企業や情報システムの抱える脆(ぜい)弱性(情報セキュリティにおける弱点)が,最悪の場合,企業の存続を脅かすほど巨大になる可能性は現実のものとして存在しており,経営者は,自社の情報セキュリティにおける脅威と脆弱性とリスクを見極め,適切なリスクマネジメントを行うことが不可欠である。そして,導入され,運用されている対策が有効であるかどうかは評価される必要がある。評価無くして,対策の実効性は担保できない。セキュリティ対策における評価には,「ISMS適合性評価制度による認証」「情報セキュリティ監査」「脆弱性検査(または脆弱性診断,脆弱性監査)」「セキュリティ対策ベンチマーキング」などが挙げられる。また,セキュリティ製品やシステムを評価・認証する制度として「ITセキュリティ評価及び認証制度」がある。このそれぞれについては,膨大な規格群と研究報告書,解説が公表されている。これらのキーワードに示される「情報セキュリティ評価」の全体像を,各評価の違いを明らかにしつつ,ベースとなる標準や規格等も紹介しながら,その概要を提示する。