著者

Lori B. Daniels Jane C. Burns

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.79, no.11, pp.2299-2305, 2015-10-23 (Released:2015-10-23)

参考文献数

81

被引用文献数

2 3

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Acute Kawasaki disease (KD) is diagnosed and treated by pediatricians, but decades later, these individuals are presenting to adult cardiologists with a variety of cardiovascular sequelae, including myocardial ischemia and infarction, congestive heart failure secondary to myocardial fibrosis, and claudication because of vascular insufficiency from thrombosed peripheral arteries. There are no clinical trials to guide management, interventions, and medical therapy in this patient population. This review summarizes the emerging information regarding evaluation of the cardiovascular status of adults decades after childhood KD. (Circ J 2015; 79: 2299–2305)

著者

雷被害対策の接地システムに関する調査研究委員会(自主研究)

出版者

一般社団法人 電気設備学会

雑誌

電気設備学会誌 (ISSN:09100350)

巻号頁・発行日

vol.33, no.11, pp.825-826, 2013-11-10 (Released:2014-09-09)

参考文献数

4

著者

Takashi Yokota Yasuo Kunii Shin Teshima Yasuo Yamada Toshihiro Saito Shu Kikuchi Hidemi Yamauchi

出版者

東北ジャーナル刊行会

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.186, no.2, pp.121-130, 1998 (Released:2005-10-14)

参考文献数

16

被引用文献数

30 63

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A retrospective analysis was carried out on 93 patients with signet ring cell carcinoma of the stomach operated on between 1985 and 1995, to review the clinicopathologic characteristics from the database of gastric cancer at Sendai National Hospital. The results were compared with those for 590 patients with other types of gastric carcinoma. Women were afflicted as commonly as men in the signet ring cell carcinoma group. These patients tended to be younger and to have larger tumors. The histological type was commonly scirrhous and infiltrative. The survival of patients with signet ring cell carcinoma was worse than that of patients with other types of gastric cancer but the difference was not statistically significant. Patients with early signet ring cell carcinoma had a good prognosis, similar to that of the other groups. However, prognosis of patients with advanced signet ring cell carcinoma was poor compared with patients with other types of this disease. In multivariate analysis, the statistical significant prognostic factors were vascular microinvasion and tumor location. These findings suggest that signet ring cell carcinoma of the stomach should be regarded as a distinct type of gastric cancer.

著者

Michihito TAGAWA Eiichi KANAI Genya SHINBOU Mikiya KANO Hideki KAYANUMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.15-0456, (Released:2015-11-21)

被引用文献数

9

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Depth to width ratio (D/W) is the only quantitative item in the criteria recommended by the Japanese Ultrasound Society for the evaluation of breast tumors in humans. However, the usefulness of the D/W has not been evaluated in dogs. Eighty-six mammary masses in 34 female dogs underwent ultrasonographic examination to determine the D/W and other characteristics. Results of ultrasonographic and histopathologic examinations were compared. The D/W of malignant tumors was significantly greater than that of benign tumors, and it had a sensitivity of 56.3% and a specificity of 92.9% for the diagnosis of malignancy when the threshold of D/W was 0.7. In addition, irregular margin, polymorphous shape and heterogeneous internal echographic characteristics were correlated with malignancy.

著者

大木 秀一

出版者

日本行動医学会

雑誌

行動医学研究 (ISSN:13416790)

巻号頁・発行日

vol.8, no.1, pp.31-37, 2002 (Released:2014-07-03)

参考文献数

18

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目的は包括的な健康習慣に対してどの程度遺伝要因が関与しているかを数量的に評価する事である。対象は東京大学教育学部附属中等教育学校を卒業した成人双生児である。2000年前半に、卒業生双生児に対して「生活習慣等についての質問紙調査」を実施した。ペアで回答を得ることが出来た同性双生児 (一卵性双生児145組、二卵性双生児14組) を分析対象とした。包括的な健康習慣を表わす指標として以下の基準を採用した。「7~8時間の睡眠時間」「週に1度以上の運動をする」「自覚的なストレスが中等度以下である」「毎日飲酒でない (過度の飲酒をしない)」「喫煙をしない (喫煙習慣なしまたはやめた)」「朝食を毎日食べる」「栄養のバランスを考えている」の7項目を良い生活習慣とみなした。良い生活習慣を取っている個数の合計は0点から7点に分布し、高得点の方が包括的な生活習慣がよいと考えた。全ての質問項目の回答を得た141組に対して双生児研究法の原理に共分散構造分析を応用し、健康習慣の背後に仮定した遺伝要因・環境要因の関与の程度を推定した。潜在変数としては2種類の遺伝要因 (相加的遺伝要因 (A)・優性遺伝要因 (D)) と2種類の環境要因 (共有環境要因 (C)・非共有環境要因 (E)) および年齢要因を仮定した。最適のモデルはAESモデル (年齢要因を考慮したAEモデル) であった。相加的遺伝要因の寄与は27%、非共有環境要因の寄与は72%であった。我が国ではこれまで、生活習慣は環境面からのみ検討される事が多かったが、一部で遺伝的に規定されている事が確認された。量的遺伝学の概念は集団を対象に定義されており個人に対するものではない。また、生活習慣に対する遺伝規定性と言った場合には、単一の遺伝子や生物学的な問題を想定しているわけではない。広く、ある種の行動パターンを選択したり、嗜好するような心理的要因・性格傾向の遺伝規定性をも念頭に置いている。ただし、健康習慣を全体として見れば70%以上が非共有環境要因により説明されており、個人に特異的な環境要因の影響が強い。それゆえ、環境要因を改善することで生活習慣の是正を図る事は行動遺伝学的な見地からも妥当なものである。生活習慣の評価や改善を論じる上でも遺伝要因の影響を無視し得ないと結論できる。

著者

鈴木 寿志

出版者

The Geological Society of Japan

雑誌

日本地質学会学術大会講演要旨 (ISSN:13483935)

巻号頁・発行日

pp.629, 2013 (Released:2014-04-01)

著者

杉村 薫 石原 秀至

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.55, no.4, pp.210-211, 2015 (Released:2015-07-31)

参考文献数

7

著者

桜井 良 上田 剛平

出版者

農村計画学会

雑誌

農村計画学会誌 (ISSN:09129731)

巻号頁・発行日

vol.33, no.Special_Issue, pp.329-334, 2014-11-20 (Released:2015-11-21)

参考文献数

19

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Mail survey is the most well used method for understanding public perceptions of certain topics. However, low response rate has been pointed out as the disadvantage of this method. We compared perceptions and socio-demographics of early respondents and late respondents to predict characteristics of non-respondents as well as to reveal issues that mail survey method entails. We used data of the mail survey conducted to retired hunters of all over Japan in 2012. Multiple regression analysis revealed that respondents who were interested in re-acquiring hunting license tended to be late in responding to survey (p<0.05).

著者

Yosuke Sasaki Satoru Manda Takahiro Sato Tadashi Maeda Taito Miyazaki Kazushige Nakanishi Yoshihisa Urita

出版者

日本プライマリ・ケア連合学会

雑誌

Journal of General and Family Medicine (ISSN:21896577)

巻号頁・発行日

vol.16, no.3, pp.204-207, 2015-09-20 (Released:2015-10-30)

参考文献数

15

被引用文献数

3

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Chikungunya virus infection (CVI) typically manifests via a “two-phase” presentation: most patients develop acute fever and some patients subsequently develop arthralgia that can persist for years. Many patients visit clinics during the second phase, for relief of the arthralgia, but not during the acute febrile phase. We report a 25-year-old Japanese man infected with CVI in Jamaica who presented with chronic disabling peripheral-dominant symmetric polyarthralgia without fever, which affected the neck, knees, elbows, wrists, and fingers. Given the recent emergence of dengue fever in Japan, clinicians should consider CVI as a differential diagnosis of dengue fever when examining travelers complaining of persistent arthralgia, regardless of their countries of origin.

著者

奥 恒行 中村 禎子

出版者

Japanese Association for Dietary Fiber Research

雑誌

日本食物繊維研究会誌 (ISSN:13431994)

巻号頁・発行日

vol.5, no.1, pp.11-22, 2001-06-30 (Released:2010-06-28)

参考文献数

21

被引用文献数

1 7

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The effects of dietary fiber rich cereal-based breakfast on the increment of fecal wet weight, defecation rate and condition of evacuation were investigated in normal subjects (n=36) and the data of 29 subjects selected from 36 subjects were used for the evaluation. The study design was crossover experiment for continuous 1 weeks, and the subjects consumed 2 different test cereal flakes (cereal A, B) in random order in their breakfast. Total dietary fiber contents of the test cereals for three trials were 6.4g for cereal A 40g, 9.6g for cereal A 60g and 5.Og for cereal B 60g, respectively. The cookie as the control does not contain dietary fiber. The results obtained were as follows ;1) The fecal wet weight significantly increased with cereal A 40g, A60g and also cereal B60g and the increment was dependent on the total dietary fiber contents of the test cereals, comparing to the control . 2) The defecation rate of days and times per week were significantly increased with cereal A40g, A60g and cereal B60g, comparing of the control, respectively. 3) The condition of evacuation such as fecal form, color and smell were significantly improved in cereal A 40g and cereal A60g ingestions. 4) The wet weight of feces which makes feel defecation every day was approximately 150g. We concluded that dietary fiber rich cereal-based breakfast has a fecal bulking effect and the improvement of condition of the evacuation in the additional ingestion of 5.0-6.4g of dietary fiber in a day.

著者

金井 昌宏

出版者

特定非営利活動法人 産学連携学会

雑誌

産学連携学 (ISSN:13496913)

巻号頁・発行日

vol.11, no.2, pp.2_41-2_50, 2015 (Released:2015-07-01)

参考文献数

30

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平成18年改正に係る教育基本法において,社会貢献が教育及び研究に次ぐ我が国の大学の第三の使命として明記され,今日では共同研究や知的財産権ライセンス等の産学連携が,我が国でも活性化している.大学にとっても,産学連携は,ライセンス対価や研究費等の外部資金を導入できるメリットがある. しかし,大学の基本的機能である教育及び研究は,依然として大学の本質的価値を根拠付ける活動である.産学連携がこれらに悪影響を与えることがあってはならない. 本稿では,特に共同研究契約を対象として,産学連携終了後に,大学が自由な研究活動を継続するために,考慮すべき契約条件の検討を行った.

著者

西田 昌利

出版者

一般社団法人 資源・素材学会

雑誌

日本鉱業会誌 (ISSN:03694194)

巻号頁・発行日

vol.99, no.1146, pp.667-671, 1983-08-25 (Released:2011-07-13)

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Sunagawa Colliery has managed to solve many difficult problems since 1914 and the technical innovation took place in 1964 when the colliery employed hydraulic mining. Subsequently, the hydraulic mining has been steadily improved widening the range of its application. The colliery is now working steeply inclined seams at the depth of 900 to 1000 meters below surface. The author intends to introduce parts of the results successfully practiced in the deep mining at Sunagawa Colliery.

著者

梶原 豊 後藤 和文 徳丸 元幸 木庭 正光 中西 喜彦 小川 清彦

出版者

日本繁殖生物学会

雑誌

家畜繁殖学雑誌 (ISSN:03859932)

巻号頁・発行日

vol.34, no.3, pp.191-198, 1988 (Released:2008-05-15)

参考文献数

27

被引用文献数

8 8 3

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牛卵胞卵子を体外成熟,体外受精後,体外培養することにより得た胚(胚盤胞~脱出胚盤胞)について割球数を算定し,染色体を詳細に分析して,染色体数の異常を調べるとともに性染色体分析による性判別も試みた。体外受精後8~12日目に得た胚盤胞~脱出胚盤胞を供試胚とし,0.04μg/mlのコルセミドと5%仔牛血清を含むTCM 199(25 mM HEPES緩衝)中で90~180分培養した。ついで0.5%クエン酸ナトリウム溶液で低調処理後,メタノール:酢酸:水=3••2••1で一次固定,スライドガラス上で酢酸を滴下することにより二次固定を行い,ギムザ染色後,割球数と染色体解析を行った。主なる結果は次の通りであった。1.胚盤胞,拡張胚盤胞および脱出胚盤胞にみられる平均割球数は,それぞれ68.2±34.7,100.1±51.5,128.1±56.8個と変異は大きいが,ステージが進むにつれ,平均割球数は有意に増加した。2.中期核板出現率は81%前後でステージによる変化はなく,中期核板数は胚盤胞期で平均4.3個,拡張胚盤胞期で5.7個,脱出途中~胚盤胞脱出胚盤胞期で5.1個であった。3.雌雄判別率は胚盤胞,拡張胚盤胞,脱出胚盤胞とステージが進むにつれ53.7,65.1,82.4%と有意に増加した。判別可能であった全胚のうち雌は35個,雄は29個であった。4.染色体数の異常胚率は発生ステージが進むにつれて,やや増加する傾向を示した。また雌胚の方が雄胚にくらべて染色体異常が多い傾向がみられた。

著者

吉村 康夫

出版者

信州医学会

雑誌

信州医学雑誌 (ISSN:00373826)

巻号頁・発行日

vol.60, no.2, pp.67-77, 2012 (Released:2012-04-18)

参考文献数

50

被引用文献数

2 4

著者

山口 創 趙 松楠 中塚 雅也 山下 良平

出版者

地域農林経済学会

雑誌

農林業問題研究 (ISSN:03888525)

巻号頁・発行日

vol.50, no.2, pp.107-112, 2014 (Released:2015-10-17)

参考文献数

5

被引用文献数

1

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In order to identify problems in rural areas, this study analyzed reports on community support activities in Hyogo Prefecture by using text mining methods.We collected 320 reports on community support activities conducted between 2007 and 2011 in the areas of Tanba, Tajima, and Awaji. After classifying the reports according to their sphere of activity (e.g., a village, several villages, a town), we used text mining methods to identify local problems specific to each level.The main findings were as follows:(1) All three levels shared problems related to children, the elderly, exchanges among local residents, and tourism.(2) At the village level, the management of living environments and farming were the problems.(3) The problem unique to the several-village level was with regard to the elementary schools.(4) At the town level, food and welfare were the local problems.

著者

金 相賢 大和 裕幸

出版者

The Japan Society of Naval Architects and Ocean Engineers

雑誌

日本造船学会論文集 (ISSN:05148499)

巻号頁・発行日

vol.2000, no.188, pp.211-223, 2000 (Released:2009-09-16)

参考文献数

12

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In this paper, the longitudinal control system for full-submerged hydrofoil based on wave prediction was proposed to exclude human operation and to improve the performance of contouring waves. The proposed control system consists of optimal preview servo system, Kalman filter and generation of future reference input and future wave disturbance.In the proposed control system, the wave disturbance and the wave elevation were filtered and predicted by using sensor signals, Kalman filter, 30th linear prediction model and the augmented system. Then the future reference input and the future wave disturbance were generated by using predicted wave disturbance and wave elevation, and were used to calculate the feedforward control input in the optimal preview servo system. And also the future reference was modified based on the significant wave height for ship height control.The simulation results show that the proposed control system has good performance of contouring waves in the follow sea and the hydrofoil regulates heave and pitch motion in low significant wave height and contours the waves in high significant wave height without human operation. And also the experiment was performed to confirm the algorithm of filtering of wave disturbance and hydrofoil motion, and calculation of wave elevation.

出版者

一般社団法人 日本農村医学会

雑誌

日本農村医学会雑誌 (ISSN:04682513)

巻号頁・発行日

vol.61, no.6, pp.878-879, 2013 (Released:2013-07-23)

著者

Inna Martha Rumainum Kanjana Worarad Yoshikazu Yamaki Kenji Yamane

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.MI-077, (Released:2015-11-21)

被引用文献数

7

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A red-fleshed peach (Prunus persica L. Batsch ‘Tenshin Suimitsuto’; ‘Tianjinshuimi’ in Chinese) was used to study the mechanisms of skin and flesh pigmentation. Anthocyanin accumulation was detected at the pre-endocarp-hardening and maturation stages in skin, while it appeared from maturation stage in flesh. The flesh at harvest stage contained approximately 1.1 mg·g−1 FW of anthocyanin. In contrast, flavonoid and phenolic compounds were found in all stages. The final phenolics concentration was 1.6 mg·g−1 FW. To study the effects of light, fruits were on-tree bagged in double-layered paper bags. The total anthocyanin content in the skin was significantly lowered by bagging, but not in the flesh. This suggested that flesh tissue pigmentation was less sensitive to light intensity than that of skin tissue, and thus, anthocyanin accumulation in flesh occurred even under low light conditions. Dark treatments, such as triple-layered paper bagging, significantly reduced anthocyanin and phenolic concentrations in the skin and flesh. A combined treatment of darkness and an auxin polar transport inhibitor, 2,3,5-triiodobenzoic acid (TIBA), had no effect on anthocyanin concentration in skin and flesh. However, total flavonoids in the skin was increased by TIBA treatments under darkness. Factors affecting anthocyanin accumulation in the flesh tissue are discussed.

著者

Jing-Dong Guo Takahiro Sasamori Yutaro Yamamoto Hiroshi Matsubara Shigeru Nagase Hideki Yorimitsu

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

pp.20150343, (Released:2015-11-16)

被引用文献数

4

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The previously reported palladium-catalyzed silylation of aryl chlorides with silylsilatranes were theoretically reinvestigated by DFT calculations with a focus on the effect of the transannular Si–N coordination on silyl transfer. The Si–N coordination proved to be not so influential as to accelerate the silyl transfer. However, it should be of benefit to use silylsilatranes as silylating agents because of their easy handling and facile preparation.

著者

Naoki Aratani Atsuhiro Osuka

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.88, no.1, pp.1-27, 2015-01-15 (Released:2015-01-15)

参考文献数

241

被引用文献数

35 1

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Directly linked linear porphyrin arrays were synthesized and their photophysical properties depending on the length of the arrays were investigated. Ag(I)-promoted oxidative coupling of 5,15-diaryl Zn(II) porphyrins has proven to be effective for preparations of very long meso–meso-linked Zn(II) porphyrin arrays (Zn). A stepwise doubling strategy with strict purification at each doubling step allowed for preparation of gigantic but discrete linear arrays in an unprecedented manner. Large cyclic porphyrin wheels were also synthesized by final meso–meso coupling intramolecular cyclization. Crucial to this success are high reactivity and high regioselectivity of the Ag(I)-promoted oxidative coupling. Equally important are high solubilities of Zn despite their large molecular weights, which arise from their perpendicularly linked structures. Another advantage of this doubling strategy is a large difference in the molecular weights among reactants and products that increases as the reactant array becomes larger, allowing separation of coupling products by preparative GPC-HPLC. As an alternative protocol, Pd-catalyzed Suzuki–Miyaura cross-coupling has been extensively used for synthesis of cyclic porphyrin arrays. This strategy gave novel linear and cyclic porphyrin arrays from β-borylated porphyrins that were prepared by Ir-catalyzed borylation of meso-free porphyrins. As an interesting example, a porphyrin nanotube consisting of four porphyrins doubly bridged by 2,6-pyridinylene spacers was synthesized and revealed to possess a C60-encapsulation capability. Exciton coupling, effective energy hopping, coherent length, and excitation energy transfer of meso–meso-linked linear and cyclic porphyrin arrays are discussed. STM and AFM detections of the large porphyrin arrays are also presented. We believe that these studies expand the range of organic molecules we can manipulate and open a door to a new area of nanoscaled and sub-microscaled functional porphyrin materials.