著者

木村 恭之 土定 建夫 塚谷 才明 作本 真 三輪 高喜 古川 仭

出版者

耳鼻咽喉科展望会

雑誌

耳鼻咽喉科展望 (ISSN:03869687)

巻号頁・発行日

vol.36, no.6, pp.709-716, 1993-12-15 (Released:2011-08-10)

参考文献数

15

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中枢性嗅覚障害で病変の局在がはっきりしている脳腫瘍10例を対象に臨床的検討を行った。自覚的に「正常」と答えた7例中, 実際に検査上正常だった症例はなかった。認知嗅力損失で左右差のあった症例が8例あり, 単鼻孔嗅検査は不可欠と考えられた。検知/認知の差が2.0以上あった解離現象を示した症例が5例あった。解離現象は第3次嗅覚中枢の障害の他に嗅覚の伝達情報量が不足した場合でも起こりうると考えられた。静脈性嗅覚検査では潜伏時間は正常で持続時間が短縮していることが特徴的であったが, この現象は病変の局在を反映するものではなかった。病変と同側性あるいは両側性に嗅覚障害が発症した例が多かったが, 必ずしも当てはまらない症例もみられた。これは頭蓋内は圧迫が他の部分に影響しやすく, 周囲には浮腫性病変も合併しやすいことと関連があると考えられた。

著者

長尾 省吾 角南 典生 筒井 巧 本間 温 門間 文行 西浦 司 西本 詮

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.24, no.6, pp.396-400, 1984 (Released:2006-09-21)

参考文献数

15

被引用文献数

3 7

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Correlations between changes in wave V of the auditory brain-stem response, intracranial pressure, and neurological signs of uncal herniation as graded by Plum and Posner were investigated in 12 patients with supratentorial mass lesion. In three of the five patients who later showed signs of uncal herniation, the latency of wave V, which presumably originated in the inferior colliculus, was already significantly prolonged. In 6 cases which progressed to the early third nerve stage of uncal herniation, the latency of wave V was prolonged in 5 cases. In 7 cases which progressed to the late third nerve stage or worse, the latency was prolonged in 6 cases and suppressed in one. In four of six attempts (three cases), lowering of the intracranial pressure by 10% glycerol solution resulted in normalization of the latency of wave V without clinical improvement. These results strongly indicate that measurement of wave V can predict the beginning of uncal herniation and can assess the effectiveness of medical or surgical decompression on brain-stem function.

著者

柳澤 信夫

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.79, no.4, pp.440-445, 1990-04-10 (Released:2008-06-12)

参考文献数

5

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意識障害患者の診断には,状態と原因それぞれの診断のための検査を必要とする。まずおこなうべき検査は病態の増悪を防ぐためのものであり, vital signをチェックし,救急処置と並行して血算,電解質,血糖,血液ガスを調べる.また原因の見当付けには年令,経過,呼吸パターンなどが有用である.さらに全身疾患か脳の一次的病変の確認のために検査をすすめるが,脳疾患の意識障害の診断には脳CT,脳波,髄液検査が重要である.

著者

秋山 孝正 井ノ口 弘昭

出版者

日本知能情報ファジィ学会

雑誌

日本知能情報ファジィ学会 ファジィ システム シンポジウム 講演論文集 第27回ファジィシステムシンポジウム

巻号頁・発行日

pp.254, 2011 (Released:2012-02-15)

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現在、わが国は大規模な災害に直面しており、従来型の経済原理を主体とする土木計画を見直す必要が生じている。本研究では都市計画の側面から、市民あるいは土木事業に従事する土木技術者の自己形成に関して検討し、精神風土を考慮した土木計画理念の形成を目指す。特にここでは、臨床心理学の方法からバウムテストを取り上げ、深層心理分析が可能な情報システムを構成する。具体的には、ファジィ推論を包含した推論システムを構成する。またバウムテストの分析結果と精神障害の関係から、多面的な個人の心理状態を表現するプロセスを導入する。これより経年的な学生集団の集合的無意識についても統計的分析が可能となる。このような手順を踏まえて、既存研究で構成されたバウムテスト評価システムを拡張して、個人のアイデンティティ形成、精神状態などの多角的な深層心理を抽出する。最終的には、深層心理の解明に関して、土木計画における意義を整理する。

著者

Tokiko KUSHIRO-BANKER Robert D. KEEGAN Michelle A. DeCOURCEY Tamara L. GRUBB Stephen A. GREENE Robert ARMSTRONG

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0062, (Released:2012-09-14)

被引用文献数

2

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The objective of this study was to evaluate glomerular filtration rate (GFR) and the cardiovascular effects of the combination of tepoxalin (TPX) and medetomidine (MED) in dogs. Six healthy dogs of either sex (5 males, 1 female), aged 2.5 ± 2.2 years and weighing 14.7 ± 4.4 kg, were studied. Each dog received four randomized treatments with a minimum of 1 week between treatments: no medication as the control group (C); MED (750 μg/m2, intravenously [IV]); TPX (10 mg/kg orally for 3 days); and MT (TPX 10 mg/kg orally for 3 days plus MED 750 μg/m2, IV). Iohexol (300 mg iodine/kg, IV) was injected in all dogs in each treatment as an indicator of GFR. Blood samples for serum iohexol clearance analysis were collected before and 1, 2, 5, 10, 15, 20, 60, 120, 240, and 360 min after the iohexol administration. Rectal temperature, heart rate, respiratory rate, and direct arterial pressure (AP) were obtained before and 5, 10, 15, 20, 60, 120, 240, and 360 min after the iohexol injection. GFR did not differ between treatments. Heart rate was significantly lower in the MED and MT groups than in C or TPX. Mean AP was significantly higher with MT than TPX, but only at 5 min after the iohexol injection. TPX, MED and the combination of these two drugs do not alter GFR. The combination has minimal effect on cardiovascular variables at these doses in healthy dogs.

著者

Katsumi ISHIOKA Yumi SUZUKI Kana TAJIMA Sumire OHTAKI Masahiro MIYABE Mariko TAKASAKI Akihiro MORI Yutaka MOMOTA Daigo AZAKAMI Toshinori SAKO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0169, (Released:2012-09-14)

被引用文献数

1 10

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Monocyte chemoattractant protein-1 (MCP-1) is a member of the C-C family chemokines, which mobilizes monocytes from bone marrow to the site of inflammation. To evaluate the clinical utility of canine MCP-1 as a blood test item, we measured serum MCP-1 concentrations in normal and ill dogs. Reference interval of canine MCP-1 was established as 115.6–176.9 pg/ml. Serum MCP-1 concentrations increased in the dogs affected with neoplastic (518.0 ± 84.8 pg/ml), inflammatory (257.0 ± 42.5 pg/ml) or other diseases (360.3 ± 45.2 pg/ml). The results showed high sensitivity of MCP-1 to detect neoplasia and inflammation. Moreover, MCP-1 increased in some cases in which C-reactive protein didn’t increase. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs.

著者

Sawane MITANI Akira YABUKI Kazuyuki TANIGUCHI Osamu YAMATO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0314, (Released:2012-09-14)

被引用文献数

9 26

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The association of renin and angiotensin II, which are potent components of the renin-angiotensin system, with the severity of chronic renal disease was investigated immunohistochemically in dogs and cats. Immunoreactivities of renin and angiotensin II were evaluated quantitatively, and their correlations with the degrees of glomerulosclerosis, glomerular hypertrophy, interstitial cell infiltration, and interstitial fibrosis were statistically analyzed. Immunoreactivities for renin were detected in afferent arteries in both dogs and cats. The score of renin-positive signals showed no correlation with plasma creatinine concentration or any of the histopathological parameters, except for the diameter of glomeruli in dogs. Immunoreactivities for angiotensin II were detected in tubules (primarily proximal tubules) and interstitial mononuclear cells in both dogs and cats. The score of tubular angiotensin II correlated with glomerulosclerosis and cell infiltration in cats but not in dogs. The score of interstitial angiotensin II correlated with plasma creatinine concentration, glomerulosclerosis, cell infiltration, and fibrosis in dogs and with glomerulosclerosis and cell infiltration in cats. In conclusion, the results of the study suggest that intrarenal renin-angiotensin system is correlated with the severity of kidney disease, with the underlying mechanism differing between dogs and cats.

著者

Shingo MAEDA Yasuhito FUJINO Chie TAMAMOTO Satoshi SUZUKI Atsushi FUJITA Masashi TAKAHASHI Koichi OHNO Kazuyuki UCHIDA Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0321, (Released:2012-09-14)

被引用文献数

1 5

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A 13-year-old, neutered male miniature dachshund was presented with a one-month history of bilateral symmetrical swelling in the pinnae and carpal, cubital, and tarsal joints, and swelling in the tail. The lesions were histopathologically characterized by multiple dilated lymphatic vessels lined by a single attenuated layer of endothelial cells. The subcutis was predominantly involved. A number of spindle-shaped cells lining the irregular vessels were observed. Morphological atypia was not evident in these cells. Immunohistochemical analyses revealed that the proliferating endothelial cells were positive for factor VIII-related antigen and CD31. Based on the clinical presentation and histopathological features, the dog was diagnosed with lymphangiomatosis. Treatment with anti-inflammatory prednisolone improved the symptoms.

著者

Hiroshi Fujii Yu Ikeuchi Yasutaka Kurata Nobuhito Ikeda Udin Bahrudin Peili Li Yuji Nakayama Ryo Endo Akira Hasegawa Kumi Morikawa Junichiro Miake Akio Yoshida Kyoko Hidaka Takayuki Morisaki Haruaki Ninomiya Yasuaki Shirayoshi Kazuhiro Yamamoto Ichiro Hisatome

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-12-0126, (Released:2012-09-04)

参考文献数

27

被引用文献数

3 2

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Background: The prion protein (PrP) has been reported to serve as a surface maker for isolation of cardiomyogenic progenitors from murine embryonic stem (ES) cells. Although PrP-positive cells exhibited automaticity, their electrophysiological characteristics remain unresolved. The aim of the present study was therefore to investigate the electrophysiological properties of PrP-positive cells in comparison with those of HCN4p-or Nkx2.5-positive cells. Methods and Results: Differentiation of AB1, HCN5p-EGFP and hcgp7 ES cells into cardiac progenitors was induced by embryoid body (EB) formation. EBs were dissociated and cells expressing PrP, HCN4-EGFP and/or Nkx2.5-GFP were collected via flow cytometry. Sorted cells were subjected to reverse transcriptase-polymerase chain reaction, immunostaining and patch-clamp experiments. PrP-positive cells expressed mRNA of undifferentiation markers, first and second heart field markers, and cardiac-specific genes and ion channels, indicating their commitment to cardiomyogenic progenitors. PrP-positive cells with automaticity showed positive and negative chronotropic responses to isoproterenol and carbamylcholine, respectively. Hyperpolarization-activated cation current (If) was barely detectable, whereas Na+ and L-type Ca2+ channel currents were frequently observed. Their spontaneous activity was slowed by inhibition of sarcoplasmic reticulum Ca2+ uptake and release but not by blocking If. The maximum diastolic potential of their spontaneous firings was more depolarized than that of Nkx2.5-GFP-positive cells. Conclusions: PrP-positive cells contained cardiac progenitors that separated from the lineage of sinoatrial node cells. PrP can be used as a marker to enrich nascent cardiac progenitors.

著者

Akihiro MORI Miyuki KURISHIMA Hitomi ODA Kaori SAEKI Toshiro ARAI Toshinori SAKO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0123, (Released:2012-09-10)

被引用文献数

2 12

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Monitoring of blood glucose concentration is important to evaluate the diabetic status of dogs. Continuous glucose monitoring systems (CGMS) have been applied in veterinary medicine for glucose monitoring in diabetic dogs. The purpose of the study was to evaluate the daily glycemic profiles obtained with CGMS and compare glucose fluctuations between day- and night-time in diabetic dogs. Five diabetic dogs were used in this study and were treated with either NPH insulin or insulin detemir. For data analyses, day-time was defined as 9:00am–9:00pm and night-time as 9:00pm–9:00am. Using glucose profiles, we determined the mean glucose concentrations (1- and 12-hr intervals), and times spent in hyperglycemia >200 mg/dl or hypoglycemia <60 mg/dl. None of the parameters differed significantly between day-time and night-time in dogs treated with NPH insulin or insulin detemir. In conclusion, this study confirmed, using CGMS, that there are no differences in glucose fluctuations between day- and night-time, in diabetic dogs on a similar feeding regimen and insulin administration.

著者

Takako MOCHIZUKI Toshiroh IWASAKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.12-0212, (Released:2012-09-10)

被引用文献数

2 3

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Narrow-band UVB (NB-UVB) is light over a very narrow band of wavelengths (around 311 nm) that is concentrated in the therapeutic range and minimally in the sunburn range. It has therefore become the phototherapy treatment of choice for skin diseases. The minimal erythema dose (MED) on canine skin for standardizing dosage schedules in NB-UVB treatment and histopathological analyses were performed in these dogs. In all 32 dogs tested, the MED ranged from 432 to 864 mJ/cm2. There were no significant differences in MED among breeds, sex and age groups. Histopathology obtained from areas irradiated by MED showed only mild vascular dilatation. These findings might be valuable for the application of NB-UVB phototherapy to canine skin diseases.

著者

今井 崇裕 北川 朋子 西部 俊哉 西部 正泰

出版者

一般社団法人 日本救急医学会

雑誌

日本救急医学会雑誌 (ISSN:0915924X)

巻号頁・発行日

vol.18, no.5, pp.196-201, 2007-05-15 (Released:2009-02-27)

参考文献数

9

被引用文献数

5 4 7

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爪楊枝誤飲による消化管穿孔はまれで, 患者が誤飲を自覚していないことが多く, 爪楊枝がX線透過性であることから術前診断は困難とされる。今回われわれは術前診断が可能であった手術症例を経験した。患者は73歳の男性, 1週間前に義歯 (上顎, 総義歯) と一緒に何かを飲み込んだと自覚。3日後, 臀部周囲の熱感, 疼痛が出現したが放置していた。39度の高熱, 臀部及び陰嚢部の腫脹が増強したため救急車で搬送された。受診時下腹部に圧痛を認めたが, 腹膜刺激症状は認めなかった。入院時の血液検査では高度の炎症所見を認めたが, 単純X線, US及びCT検査では異物様の陰影を認めなかったものの, 直腸周囲から膀胱の辺縁を介して恥骨の前面に貯留したエアー像を確認した。皮下のエアー像は左側腹部脾臓レベルまで上行していた。肛門指診したところ直腸内に異物を触れ, これを用手的に摘出したところ約6cmの爪楊枝であった。爪楊枝誤飲による直腸穿孔と考え, 同日緊急に全身麻酔下でドレナージ, 洗浄及び人工肛門造設術施行した。以後, 全身管理, 創部の洗浄及びドレナージを繰り返し, 経過は良好である。今回, 本邦では非常にまれな爪楊枝誤飲による直腸穿孔の1例を経験したので報告する。

著者

元村 拓 金森 昌彦 信清 正典

出版者

日本腰痛学会

雑誌

日本腰痛学会雑誌 (ISSN:13459074)

巻号頁・発行日

vol.7, no.1, pp.126-131, 2001 (Released:2008-07-10)

参考文献数

8

被引用文献数

1 1

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単純X線像における椎間板腔の高さ,あるいはその断面積がMRIにおける変性度を反映し得るかを検討した.対象は外来患者45人(平均年齢:49.4歳)である.MRIにおけるL3/4およびL4/5高位の椎間板変性をSchneidermanの分類で評価し,単純X線側面像における椎間板腔の測定法として,(A法)本来の椎間板の前方a,中央b,後方cの和を椎体の前後径dで割る方法.(B法)骨棘を含めた椎間板の前方a ’,中央b’,後方c’の和を骨棘を含めた椎体の前後径d’で割る方法.(C法)画像解析により椎間板の面積S1と椎体の面積S2を測定し,そのピクセル比で比較する方法の3つを使用した.その結果A法およびB法ではMRIにおける椎間板変性の程度と呼応していることが分かった.Schneiderman分類における“marked”あるいは“absent”のcut-off値は約0.6∼0.7と考えられた.

著者

小島 貢利

出版者

日本経営診断学会

雑誌

日本経営診断学会論集 (ISSN:18824544)

巻号頁・発行日

vol.8, pp.159-163, 2008 (Released:2009-06-08)

参考文献数

17

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本研究では,まず,日本経済の今後の推移について説明し,円が今後強くなる可能性は乏しいことを指摘する。さらに,外国為替証拠金取引(FX)の特徴に関して紹介し,投資家がFXにより気軽にグローバル投資を行うことができることを示す。また,株式市場とFXとの比較を行い,FXは,一年中,平日24時間取引可能であり,イベントリスクに対して,より迅速に対応可能な取引システムであることを説明する。最後に,円資産に固執することのリスクを,日本人は強く認識すべきであり,将来の円下落や国内低金利継続に対して,FXは有効な資産保護対策になりうることを主張する。

著者

君波 和雄 今岡 照喜

出版者

一般社団法人 日本地質学会

雑誌

地質学雑誌 (ISSN:00167630)

巻号頁・発行日

vol.112, no.2, pp.107-121, 2006 (Released:2006-06-01)

参考文献数

31

被引用文献数

1 3

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四国西部,幡多半島東岸地域の後期漸新世~前期中新世の清水層・在岬層の混在相は,火山礫岩や火山性砂岩,含火山岩礫泥岩などの火砕岩を含む.火砕岩は,中期始新世の石灰岩を伴うことがある.火砕岩の多くは,土石流や乱泥流などの堆積物重力流に由来する.火砕岩中の火山岩は,アルカリ岩系の火山岩であり,アルカリ玄武岩,粗面安山岩,粗面岩およびコメンダイトからなる.アルカリ玄武岩や粗面安山岩には緑泥石や方解石で充填された発泡痕を有する.アルカリ玄武岩にはカンラン石仮像が含まれる.火山岩類はかなりの程度の変質作用を被っており,ほとんどの苦鉄質鉱物は,緑泥石などの粘土鉱物やFe-Ti酸化鉱物で置換されている.変質過程での移動が少ないと考えられる元素を使ったいくつかの判別図から,火山岩は海洋島起源のプレート内アルカリ岩と推定される.後期漸新世~前期中新世のある時期に四国西部の収束域で海山の衝突があったと考えられる.

著者

阪田 総一郎 岡田 孝夫

出版者

日本エアロゾル学会

雑誌

エアロゾル研究 (ISSN:09122834)

巻号頁・発行日

vol.8, no.1, pp.37-45, 1993-03-20 (Released:2011-03-04)

参考文献数

11

被引用文献数

1

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The effect of moisture on the chemical formation of air ions produced by corona discharge in clean air, and the formation of large clusters were mainly discussed in this paper. We measured the composition of positive and negative air ions generated by corona discharge in clean air using an atmospheric pressure lonization mass spectrometer (APIMS). The positive ions were composed of H+(H2O)n (n= 1 , 2 , 3 , ……), and the negative ions of CO3-(H2O)n, O2-(H2O)n, NO3-, NO2-(H2O)n, O-, and O3-. The degree of hydration, n, in those hydrate ions increased with a moisture increase. Ultra-fine particles of nanometer size were detected in the ionized clean air with a CNC, and the number of them also increased with the moisture increase. Large hydrate ions which have high degrees of hydration, probably constitute those ultra-fine particles.

著者

Yasuhiro Morisaki Yoshiki Chujo

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.41, no.9, pp.840-846, 2012-09-05 (Released:2012-08-25)

参考文献数

67

被引用文献数

27 5

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Incorporation of a [2.2]paracyclophane skeleton into a conjugated polymer main chain affords a polymer comprising stacked π-electron systems. In this article, we describe the synthesis and optical properties of some [2.2]paracyclophane-based polymers on the basis of the results of our resent research. We discuss the role of [2.2]paracyclophane in the polymer backbone, through-space conjugation of the polymer, and the feasibility of using the titled polymers as single molecular wires that allow for unidirectional energy and charge transfer via through-space interactions.

著者

平田 康 岩本 康弘 宮本 亮三 吉増 秀實 天笠 光雄 岡田 憲彦

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.50, no.1, pp.27-30, 2004-01-20 (Released:2011-04-22)

参考文献数

17

被引用文献数

2 1

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Glandular odontogenic cyst (GOC) is a rare jawbone cyst of odontogenic origin, first described by Gardner et al. in 1988. GOC is characterized by typical histopathological features, a gradual increase in size, and a high rate of local recurrence if not adequately treated. We report a case of GOC occurring in the anterior region of the mandible. The patient was a 62-year-old woman who presented with swelling of the anterior region of the mandible. Panoramic radiography indicated a multilocular radiolucent lesion in the anterior region of the mandible. Enucleation of the cyst was performed. Postoperative healing was satisfactory, and no recurrence has been noted on long-term observation. We reviewed 41 cases of GOC that had beenreported previously. Among these cases, 35 were located in the mandible and only 6 in the maxilla. The male: female ratio was 1.28 (23: 18), and the mean age was 47.8 years. Radiographically, among a total of 37 cases, 18 were unilocular and 19 were multilocular. The overall recurrence rate was 19.5%.

著者

岩渕 博史 岩渕 絵美 内山 公男 高森 康次 永井 哲夫 田中 陽一

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.52, no.12, pp.703-707, 2006-12-20 (Released:2011-04-22)

参考文献数

21

被引用文献数

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Glandular odontogenic cyst (GOC) was first proposed by Gardner et al in 1988 as an infrequent developmental epithelial cyst occurring in jaw bones. We describe our experience with a case of GOC arising in the mandible and report the clinical course. The patient was 52-year-old woman with clearly bordered multilocular radiolucent lesions in bothsides of the mandibular premolar region. These cysts were extirpated, and the specimens were studied by routine pathological examination and immunohistochemical staining with cytokeratins. The diagnosis was established to be GOC. The cyst recurred 3.5 years after surgery, and reoperation was performed.

著者

笠原 慎太郎 瀬川 清 工藤 啓吾 泉沢 充 武田 泰典

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.47, no.11, pp.688-691, 2001-11-20 (Released:2011-07-25)

参考文献数

9

被引用文献数

1 1

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Glandular odontogenic cyst is a rare jaw bone cyst of odontogenic origin, first described in 1988 by Gardner et al.Radiologically, a well-defined unilocular cyst lesion is seen. Histologic features include a thin layer of epithelium with surface cilia and glandular or pseudoglandular structures.A case of glandular odontogenic cyst of the maxilla is reported.