著者

稲田 伊史 J.A.F. Garrick

出版者

日本魚類学会

雑誌

魚類学雑誌 (ISSN:00215090)

巻号頁・発行日

vol.25, no.4, pp.235-243, 1979-02-15 (Released:2010-06-28)

参考文献数

23

---

Rhinochimaera pacifica previously known only from Japan and Peru is reported and described from 23 New Zealand specimens taken on the Chatham Rise, Challenger Plateau and east of Stewart Island in depths of 750-1110 m. Comparison with R.atlantica, the other nominal species, shows that R.pacifica differs only in its higher number of denticulations on the upper caudal margin of males (34-69 in New Zealand and Japanese specimens, 25-30 in R.atlantica).

著者

Marie Kurihara Vera Thiel Hirona Takahashi Keiichi Kojima David M. Ward Donald A. Bryant Makoto Sakai Susumu Yoshizawa Yuki Sudo

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.71, no.2, pp.154-164, 2023-02-01 (Released:2023-02-01)

参考文献数

45

被引用文献数

1

---

Rhodopsins are transmembrane proteins with retinal chromophores that are involved in photo-energy conversion and photo-signal transduction in diverse organisms. In this study, we newly identified and characterized a rhodopsin from a thermophilic bacterium, Bellilinea sp. Recombinant Escherichia coli cells expressing the rhodopsin showed light-induced alkalization of the medium only in the presence of sodium ions (Na+), and the alkalization signal was enhanced by addition of a protonophore, indicating an outward Na+ pump function across the cellular membrane. Thus, we named the protein Bellilinea Na+-pumping rhodopsin, BeNaR. Of note, its Na+-pumping activity is significantly greater than that of the known Na+-pumping rhodopsin, KR2. We further characterized its photochemical properties as follows: (i) Visible spectroscopy and HPLC revealed that BeNaR has an absorption maximum at 524 nm with predominantly (>96%) the all-trans retinal conformer. (ii) Time-dependent thermal denaturation experiments revealed that BeNaR showed high thermal stability. (iii) The time-resolved flash-photolysis in the nanosecond to millisecond time domains revealed the presence of four kinetically distinctive photointermediates, K, L, M and O. (iv) Mutational analysis revealed that Asp101, which acts as a counterion, and Asp230 around the retinal were essential for the Na+-pumping activity. From the results, we propose a model for the outward Na+-pumping mechanism of BeNaR. The efficient Na+-pumping activity of BeNaR and its high stability make it a useful model both for ion transporters and optogenetics tools.

著者

A.B. Katende Ann Birnie and Bo Tengnäs

出版者

Sida's Regional Land Management Unit

巻号頁・発行日

2000

著者

Keiko Ikeda Mitsunori Nishide Kazuko Tsujimoto Sayuri Nagashima Tomomi Kuwahara Takahiko Mitani A. Hajime Koyama

出版者

National Institute of Infectious Diseases

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.73, no.1, pp.8-13, 2020 (Released:2020-01-23)

参考文献数

20

被引用文献数

4 6

---

In this study, umesu phenolics were purified from the salt extracts of Japanese apricot (Nanko-mume cultivar of Prunus mume Sieb. et Zucc.). Characterization of umesu phenolics revealed that, when added to the culture media of the infected cells, they inhibited the multiplication of influenza and many other RNA and DNA viruses. In addition to these antiviral activities, the phenolics significantly decreased the plating efficiency of influenza virus, if present in the virus inoculum. More drastic effects were observed in terms of virucidal activity; the infectivity of several strains of influenza viruses decreased less than 0.001 when they were incubated with 4 mg/ml phenolics at 30 ℃ for 5 min. The virucidal activity of phenolics was found to be more remarkable in acidic conditions; however, the activity was not merely a result of the acidity of the phenolics. These results clearly support the antiviral and virucidal activities of the umesu phenolics against influenza viruses and suggest their potential pharmacological usefulness as disinfectants or preventive medicine against superficial infections, such as the respiratory infections.

著者

Mahmoud M. Ramadan Essam M. Mahfouz Gamal F. Gomaa Tarek A. El-Diasty Louie Alldawi Taruna Ikrar Ding Limin Makoto Kodama Yoshifusa Aizawa

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.72, no.5, pp.778-785, 2008 (Released:2008-04-25)

参考文献数

40

被引用文献数

25 31

---

Background Coronary calcification has been correlated with the presence and extent of coronary artery disease (CAD), so in the present study the associations between coronary artery calcification score (CACS) and endothelial dysfunction, as well as the important inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and oxidized low-density lipoprotein (OxLDL), were studied in asymptomatic individuals at intermediate risk for CAD. Methods and Results The study group comprised 177 subjects (103 males) aged 50.6±5.9 years. CACS was measured by multidetector computed tomography using the Agatston method. Endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent nitroglycerin-mediated dilatation (NMD) were measured by high-resolution external brachial ultrasound. Coronary artery calcification (CAC) was detected in 82 subjects (52 males), and the median CACS was 143 [31-311.25] units. After adjusting for gender and body mass index, log (CACS +1) correlated positively with age (r=0.401, p<0.001) and IL-6 levels (r=0.442, p<0.001), and negatively with FMD (r=-0.511, p<0.001). The correlations of log (CACS +1) with CRP and OxLDL levels, and with NMD, were non-significant. In a multivariate-adjusted logistic regression model, age (odds ratio (OR) =1.083 [1.014-1.156]), serum IL-6 level (OR=3.837 [2.166-6.798]) and FMD (OR=0.851 [0.793-0.913]) were significantly and independently associated with CAC. Conclusions Peripheral endothelial function inversely correlated with CACS, whereas IL-6 level was associated with CACS. Testing for endothelial function and IL-6 level may improve cardiovascular risk assessment and help target the therapeutic strategies in asymptomatic patients at intermediate CAD risk. (Circ J 2008; 72: 778 - 785)

著者

A.K.

出版者

公益社団法人日本船舶海洋工学会

雑誌

造船協会雑纂 (ISSN:03861597)

巻号頁・発行日

no.101, pp.4-6, 1930-08

著者

Mohammed A. ALSHEHRI Jagan Kumar BASKARADOSS Amrita GEEVARGHESE Ravikumar RAMAKRISHNAIAH Dimitris N. TATAKIS

出版者

日本歯科理工学会

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2013-317, (Released:2015-01-19)

参考文献数

62

被引用文献数

2 8

---

The present in vitro study sought to determine the effects of myrrh-containing solutions on common suture materials used in periodontal surgery. Three commonly used suture materials (silk, polyglactin 910, polytetrafluoroethylene) were immersed in four thermostatically controlled experimental media to simulate daily oral rinsing activity, namely —artificial saliva, normal saline solution with 0.2% Commiphora myrrh, full-concentration (100%) Commiphora myrrh oil, and a myrrh-containing commercial mouthwash. Tensile strength was measured at the end of each day using an Instron tensile testing machine. Silk sutures were susceptible to tensile strength loss when exposed to 0.2% myrrh solution once daily for 5 days. Myrrh-containing commercial mouthwash had no effect on tensile strength, but all three suture materials lost tensile strength when exposed to 100% myrrh oil. For patients that routinely use myrrh mouthwashes postoperatively, findings of this study suggested that silk sutures might not be the optimal material choice.

著者

A. Pusztai S. Bardocz 荒田 洋一郎

出版者

FCCA(Forum: Carbohydrates Coming of Age)

雑誌

Trends in Glycoscience and Glycotechnology (ISSN:09157352)

巻号頁・発行日

vol.8, no.41, pp.149-165, 1996-05-02 (Released:2010-01-05)

参考文献数

40

被引用文献数

43 90

---

食物に含まれるレクチンは、生理活性を持つ成分として重要であり、強力な外来性のシグナルとなる。食物中のレクチンの含量は大きく異なるが、消化管全体に劇的な影響を与え、消化管内の細菌の数、体の代謝、健康にも大きく影響する。レクチンの強い効果は、腸におけるタンパク質分解に対する抵抗性、腸の上皮細胞表面 (高等動物から下等生物に至るまで) に発現している内在性受容体に対する特異的、かつ高い化学反応性に由来する。経口であれ、非経口的であれ、取り込まれたレクチンは強力な免疫原となり、その生理作用が複雑にからみあって免疫機能に干渉することもある。しかし、レクチンの初期効果やバイオシグナルとしての能力は、糖鎖との特異的な化学反応の直接の結果である。こういった反応を想定すれば、レクチンを臨床医学的に、病原体、免疫系刺激物質、ホルモン調節因子、代謝活性化物質の阻害剤として利用したり、トランスジェニック植物における内在性の殺虫剤として利用するといったことが将来的に見込める。

著者

by Ōta Gyūichi translated and edited by J.S.A. Elisonas and J.P. Lamers

出版者

Brill

巻号頁・発行日

2011

著者

Jane Tapsubei Creider and Chet A. Creider

出版者

R. Köppe

巻号頁・発行日

2001

著者

Yağız Anıl Çiçek David C. Luther Jessica A. Kretzmann Vincent M. Rotello

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.42, no.3, pp.304-311, 2019-03-01 (Released:2019-03-01)

参考文献数

83

被引用文献数

4

---

Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) technology has revolutionized therapeutic gene editing by providing researchers with a new method to study and cure diseases previously considered untreatable. While the full range and power of CRISPR technology for therapeutics is being elucidated through in vitro studies, translation to in vivo studies is slow. To date there is no totally effective delivery strategy to carry CRISPR components to the target site in vivo. The complexity of in vivo delivery is furthered by the number of potential delivery methods, the different forms in which CRISPR can be delivered as a therapeutic, and the disease target and tissue type in question. There are major challenges and limitations to delivery strategies, and it is imperative that future directions are guided by well-conducted studies that consider the full effect these variables have on the eventual outcome. In this review we will discuss the advances of the latest in vivo CRISPR/Cas9 delivery strategies and highlight the challenges yet to be overcome.

著者

Tetiana I. Bogdanova Vladimir A. Saenko Mitsuyoshi Hirokawa Masahiro Ito Liudmyla Yu. Zurnadzhy Toshitetsu Hayashi Tatiana I. Rogounovitch Akira Miyauchi Mykola D. Tronko Shunichi Yamashita

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ17-0134, (Released:2017-08-10)

被引用文献数

9

---

This study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrainian) PTCs from patients without radiation history were analyzed initially as a combined pediatric group and then subdivided into childhood (aged ≤14 years) and adolescent (aged from 15 to ≤18 years) age series. On multivariate comparison, the Japanese pediatric PTC was characterized by a higher sex ratio (p=1.504E-4), and a higher frequency of microcarcinoma (p=0.039), papillary dominant growth pattern (p=0.024), focal oxyphilic cell metaplasia (p=7.644E-6), intrathyroid spread (p=0.010), lymphatic/vascular invasion (p=0.01) and regional lymph node metastases (p=3.540E-6). In the Ukrainian group, multifocal (p=0.004) and non-encapsulated tumors with the solid-trabecular growth pattern (p=0.05) were more frequent. Childhood Japanese PTCs differed from Ukrainian PTCs by more pronounced invasive properties such as lymphatic/vascular invasion and nodal disease, but did not differ by the dominant growth pattern. In adolescents, the differences were detected not only for lymph node metastases, but also for a higher frequency of the papillary dominant pattern in Japanese PTC. Overall, significantly higher frequencies of oxyphilic cell metaplasia and more pronounced invasive features observed in the Japanese PTC in both age-matched series represent the major differences between the tumors from two geographical areas.

著者

Jung-A Boo Sang-Hyun Moon Sun-Min Lee Jung-Hyun Choi Si-Eun Park

出版者

理学療法科学学会

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.28, no.2, pp.558-562, 2016 (Released:2016-02-29)

参考文献数

30

被引用文献数

7

---

[Purpose] The purpose of this study was to determine the effect of whole-body vibration exercise in a sitting position prior to therapy in stroke patients. [Subjects and Methods] Fourteen chronic stroke patients were included in this study. Prior to occupational therapy, whole-body exercise was performed for 10 minutes, 5 times per week, for a total of 8 weeks. Muscle tone and upper extremity function were measured. The Modified Ashworth Scale (MAS) was used to measure muscle tone, and the Manual Function Test (MFT) and Fugl-Meyer Assessment scale (FugM) were used to measure upper extremity function. [Results] MAS score was significantly decreased, and MFT and FugM were significantly increased. [Conclusion] These results indicate that whole-body vibration exercise in a sitting position prior to therapy had a positive effect on muscle tone, and upper extremity function in stroke patients.

著者

K.A.

出版者

公益社団法人日本船舶海洋工学会

雑誌

造船協会雑纂 (ISSN:03861597)

巻号頁・発行日

no.110, pp.2-3, 1931-05

著者

Iara Katrynne F OLIVEIRA Vanessa C CARVALHO Gabriela S SANTOS Nayara V N MONTEIRO Margarete A F AZEVEDO Carlos Henrique R LIMA Emídio M M NETO Maria do Carmo C MARTINS Liania A LUZIA Patrícia H C RONDÓ Adriana A PAIVA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.69, no.6, pp.395-401, 2023-12-31 (Released:2023-12-31)

参考文献数

33

---

The role of vitamin A in the pathophysiological context of coronavirus disease 2019 (COVID-19) represents a current challenge, given the major impact of COVID-19 on morbidity and mortality and the importance of retinol in pulmonary and immunomodulatory functions. The aim of this review is to assess the relationship between vitamin A nutritional status and clinical outcomes in people with COVID-19. The PubMed, Web of Science, Scopus and ScienceDirect databases were used to search for observational studies that assessed retinol levels in hospitalized individuals with COVID-19, following the PRISMA recommendations. A total of 1,912 articles were identified and seven met the inclusion criteria. Four studies showed borderline or deficient retinol blood levels (retinol <0.20 mg/L or <0.70 mol/L) in people with COVID-19, associated with worsened clinical outcomes. In the other three studies lower mean values of this vitamin were identified in COVID-19 symptomatic groups compared to asymptomatic or convalescent groups that showed worse clinical outcomes. The results suggest a possible association between retinol and COVID-19 outcomes. However, there is a clear need to develop clinical trials to elucidate the role of vitamin A in the pathophysiological process of COVID-19.

著者

Mayank Goyal Leon A. Rinkel Johanna M. Ospel

出版者

The Japanese Society for Neuroendovascular Therapy

雑誌

Journal of Neuroendovascular Therapy (ISSN:18824072)

巻号頁・発行日

pp.ra.2023-0035, (Released:2023-07-12)

参考文献数

54

被引用文献数

1

---

Endovascular treatment (EVT) has revolutionized the management of acute ischemic stroke (AIS), but almost half of patients undergoing EVT do not achieve a good outcome. Adjunctive therapies have been proposed to improve the outcomes of EVT in AIS. This review aims to summarize the current evidence on the use of adjunctive therapies in EVT for AIS, including antithrombotic agents, intra-arterial thrombolytics, cerebroprotective agents, normobaric oxygen, and hypothermia. Several adjunctive therapies have shown promise in improving the outcomes of EVT in AIS, but phase 3 clinical trials are needed to establish clinical efficacy. We summarize the advantages and disadvantages of adjunctive EVT treatments and outline the challenges that each of these therapies will face before being adopted in clinical practice.

著者

竹村 英二 伊東 貴之 江藤 裕之 Kornicki Peter Francis Elman Benjamin A. Tortarolo Edoardo Domanska Ewa Guthenke Constanze Grafton Anthony Pollock Sheldon Collcutt Martin C. Tankha Brij Mohan 佐藤 正幸 大川 真 尾崎 順一郎

出版者

国士舘大学

雑誌

基盤研究(C)

巻号頁・発行日

2013-04-01

---

本科研研究では、(1) 18~19世紀日本の儒学世界において発展した実証主義的学問の解明、(2) その清代考証学との比較検討と日中間の学問特性の相違点の考察、(3) 日本考証学と西欧のフィロロギーとの比較研究が目指され、これらを、分野の異なる研究者との共同研究、海外の研究者との国際研究連携をもってすすめ、下記「研究成果」に列挙したごとくの成果が産出された。またその過程では、ヨーロッパ日本研究協会(EAJS、欧州最大の日本研究学会)を含めた主要な国際学会での研究発表、英ケンブリッジ大学に於ける国際研究集会の開催も実施され、これらを通じ、高い水準の日本思想史研究の海外への発信にも寄与した。

著者

ルナーAサイエンスチーム

出版者

北海道大学大学院理学研究科地球惑星科学専攻(地球物理学)

雑誌

北海道大学地球物理学研究報告 (ISSN:04393503)

巻号頁・発行日

vol.61, pp.141-166, 1998-03-20

著者

スピルマン クリストファー・W・A

出版者

九州産業大学

雑誌

九州産業大学国際文化学部紀要 (ISSN:13409425)

巻号頁・発行日

vol.31, pp.A1-A8, 2005-09-30

著者

小畑 弘己 丑野 毅 高瀬 克範 山本 悦世 高宮 広土 宮ノ下 明大 百原 新 那須 浩郎 宇田津 徹朗 中沢 道彦 中山 誠二 川添 和暁 山崎 純男 安 承模 田中 聡一 VOSTETSOV YU. E. SERGUSHEVA E. A. 佐々木 由香 山田 悟郎 椿坂 恭代

出版者

熊本大学

雑誌

基盤研究(A)

巻号頁・発行日

2008

---

日本の考古学において、縄文時代の農耕の存否問題は古くから議論され、今でも論争中の課題である。この混乱の根底には、確実な栽培植物が存在しなかったという研究上の制約があった。我々は、この問題を解決するために、土器中に残る植物種子や昆虫の痕跡(土器圧痕)を検出することで解決しようと考えた。研究期間内に、日本列島の縄文時代~弥生時代171遺跡、海外の新石器時代9遺跡において圧痕調査(約400, 000点の土器)を実施し、多種・多様な栽培植物種子や貯蔵食物害虫(総数552点)を検出した。また、圧痕法の学問的定立のための方法論的整備を行った。その結果、まだ問題点は残るものの、縄文時代の栽培植物の実態と問題点を明らかにすることができた。