著者

弥久保 宏 Hiroshi YAKUBO 駒沢女子大学人文学部国際文化学科

出版者

駒沢女子大学

雑誌

駒沢女子大学研究紀要 (ISSN:13408631)

巻号頁・発行日

vol.17, pp.309-323, 2010-12-24

著者

Junichiro Irie Emi Inagaki Masataka Fujita Hideaki Nakaya Masanori Mitsuishi Shintaro Yamaguchi Kazuya Yamashita Shuhei Shigaki Takashi Ono Hideo Yukioka Hideyuki Okano Yo-ichi Nabeshima Shin-ichiro Imai Masato Yasui Kazuo Tsubota Hiroshi Itoh

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.67, no.2, pp.153-160, 2020 (Released:2020-02-28)

参考文献数

21

被引用文献数

22 114

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Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide (NAD+) levels causes aging-related disorders and therapeutic approaches increasing cellular NAD+ prevent these disorders in animal models. The administration of nicotinamide mononucleotide (NMN) has been shown to mitigate aging-related dysfunctions. However, the safety of NMN in humans have remained unclear. We, therefore, conducted a clinical trial to investigate the safety of single NMN administration in 10 healthy men. A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN. Clinical findings and parameters, and the pharmacokinetics of NMN metabolites were investigated for 5 h after each intervention. Ophthalmic examination and sleep quality assessment were also conducted before and after the intervention. The single oral administrations of NMN did not cause any significant clinical symptoms or changes in heart rate, blood pressure, oxygen saturation, and body temperature. Laboratory analysis results did not show significant changes, except for increases in serum bilirubin levels and decreases in serum creatinine, chloride, and blood glucose levels within the normal ranges, independent of the dose of NMN. Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention. Plasma concentrations of N-methyl-2-pyridone-5-carboxamide and N-methyl-4-pyridone-5-carboxamide were significantly increased dose-dependently by NMN administration. The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects. Thus, the oral administration of NMN was found to be feasible, implicating a potential therapeutic strategy to mitigate aging-related disorders in humans.

著者

Itoh Hiroshi Nishida Shuhei

出版者

日本プランクトン学会、日本ベントス学会

雑誌

Plankton & benthos research (ISSN:18808247)

巻号頁・発行日

vol.2, no.3, pp.134-146, 2007-08-01

参考文献数

48

被引用文献数

3 14

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A 17-month field survey and laboratory experiments were conducted to investigate the life cycle, seasonal population fluctuations, and salinity tolerance in the poecilostomatoid copepod Hemicyclops gomsoensis associated with the burrows of the mud shrimp Upogebia major and the ocypodid crab Macrophthalmus japonicus in the mud-flats of the Tama-River estuary, central Japan. On the basis of sample collections in the water column and from the burrows, it was revealed that H. gomsoensis is planktonic during the naupliar stages and settles on the bottom during the first copepodid stage to inhabit the burrows of U. major and, to a lesser extent, those of M. japonicus. While females carrying egg-sacs were present throughout the year, the copepods' reproduction took place mainly during early summer to autumn with a successive decrease from autumn to winter. Occasionally the copepod populations in the burrows suffered from severe flushes of river water that led to salinity decreases in the burrow water to fatal levels, but usually the salinity in the burrow was within optimal levels and permitted recovery and maintenance of the populations.

著者

Yoshihiro Kawahara Tomoko Endo Mitsuo Omura Yumiko Teramoto Takeshi Itoh Hiroshi Fujii Takehiko Shimada

出版者

Japanese Society of Breeding

雑誌

Breeding Science (ISSN:13447610)

巻号頁・発行日

pp.19097, (Released:2020-03-05)

被引用文献数

10

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Citrus species are some of the most valuable and widely consumed fruits globally. The genome sequences of representative citrus (e.g., Citrus clementina, C. sinensis, C. grandis) species have been released but the research base for mandarin molecular breeding is still poor. We assembled the genomes of Citrus unshiu and Poncirus trifoliata, two important species for citrus industry in Japan, using hybrid de novo assembly of Illumina and PacBio sequence data, and developed the Mikan Genome Database (MiGD). The assembled genome sizes of C. unshiu and P. trifoliata are 346 and 292 Mb, respectively, similar to those of citrus species in public databases; they are predicted to possess 41,489 and 34,333 protein-coding genes in their draft genome sequences, with 9,642 and 8,377 specific genes when compared to C. clementina, respectively. MiGD is an integrated database of genome annotation, genetic diversity, and Cleaved Amplified Polymorphic Sequence (CAPS) marker information, with these contents being mutually linked by genes. MiGD facilitates access to genome sequences of interest from previously reported linkage maps through CAPS markers and obtains polymorphism information through the multiple genome browser TASUKE. The genomic resources in MiGD (https://mikan.dna.affrc.go.jp) could provide valuable information for mandarin molecular breeding in Japan.

著者

Tetsuro Miyazaki Kazunori Shimada Yoshitaka Iwama Atsumi Kume Katsuhiko Sumiyoshi Yayoi Sato Hirotoshi Ohmura Yoshiro Watanabe Hiroshi Mokuno Hiroyuki Daida

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.15, no.1, pp.6-12, 2008 (Released:2008-03-04)

参考文献数

36

被引用文献数

9 10

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Aim: The critical role of hyperinsulinemia, independent of hyperglycemia, in the pathogenesis of atherosclerosis has not been fully determined. We investigated the association between secretion patterns of insulin after oral glucose load and the severity of coronary artery disease (CAD) in patients with normal glucose tolerance (NGT).Methods: We enrolled 116 subjects with NGT from 243 patients who had undergone coronary angiography and a standard 75-g oral glucose tolerance test. The patients were divided into 0-vessel, single-vessel and multi-vessel disease groups on the basis of the severity of CAD.Results: The 2-h insulin levels in the multi-vessel disease group (p=0.005) and the single-vessel disease group (p<0.05) were significantly higher than those in the 0-vessel disease group. Multivariate analysis revealed that the levels of 2-h insulin were an independent variable for the presence of CAD (p=0.02) after adjustment for gender and the presence of each criterion of metabolic syndrome using the definition of the International Diabetes Federation.Conclusion: A slight but significant increase in prolonged insulin secretion, which is associated with the early stage of insulin resistance, in subjects with NGT, may play an important role in the pathogenesis of atherosclerosis.

著者

Takefumi Hiraki Shogo Fukushima Hiroshi Watase Takeshi Naemura

出版者

The Institute of Image Information and Television Engineers

雑誌

ITE Transactions on Media Technology and Applications (ISSN:21867364)

巻号頁・発行日

vol.7, no.4, pp.160-168, 2019 (Released:2019-10-01)

参考文献数

18

被引用文献数

5

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We previously studied methods leveraging pixel-level visible light communication (PVLC) that embeds imperceptible information for human eyes in each pixel of an image. The PC computation load and amount of data transferred between the PC and projector in previous PVLC systems were excessive because the PC executed both the video and data encoding processes. As a result, it was impossible to achieve both high-dynamic-range images and dynamic updates of the images and data. In this paper, we propose a dynamic PVLC system that offers high video quality and interactively updates the PVLC information through hardware encoding processing. Our system can project a 24-bit gradation color PVLC video that contains 64-bit data at 120 fps by synchronously controlling the ON/OFF states of the DMD and LED light sources at the given performance limit of the projector.

著者

Yuki Oya Hiroshi Kajihara

出版者

The Japanese Society of Systematic Zoology

雑誌

Species Diversity (ISSN:13421670)

巻号頁・発行日

vol.24, no.1, pp.1-6, 2019-05-25 (Released:2019-01-25)

参考文献数

28

被引用文献数

6

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We describe a new species of polyclad flatworm, Phaenoplana kopepe sp. nov., from Chichijima island in the Ogasawara Islands, Japan. This is the first report of Phaenoplana from Japan. Phaenoplana kopepe sp. nov. is characterized by i) a vagina that curves anteriorly, ii) gonopores well-separated from each other, and iii) a Lang’s duct that is shorter than the vagina. We provide a partial sequence (610 bp) from the mitochondrial cytochrome c oxidase subunit I gene as a DNA barcode for the species.

著者

藤田 貴子 井上 貴仁 中村 紀子 井原 由紀子 友納 優子 二之宮 信也 井手口 博 安元 佐和 廣瀬 伸一 Fujita Takako Inoue Takahito Nakamura Noriko Ihara Yukiko Tomonoh Yuko Ninomiya Shinya Ideguchi Hiroshi Yasumoto Sawa Hirose Shinichi

出版者

福岡大学研究推進部

雑誌

福岡大学医学紀要 = Medical Bulletin of Fukuoka University (ISSN:03859347)

巻号頁・発行日

vol.36, no.4, pp.231-234, 2009-12

著者

Haruka Ishizaki Hiroshi Matsuyama

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.14, pp.192-196, 2018 (Released:2018-12-14)

参考文献数

23

被引用文献数

11

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Radar/Raingauge-Analyzed Precipitation (RA) represents 1 km-grid precipitation after 2006 created by combining radar precipitation and ground precipitation, i.e., Automated Meteorological Data Acquisition System (AMeDAS) of Japan Meteorological Agency along with ground data observed by other organizations. Although RA is slightly greater than ground precipitation, no earlier studies investigated the spatial distribution of this accuracy across Japan using 1 km grid data, as clarified in this study. We selected hourly data of RA and AMeDAS located closest each other, for which miss rates were less than 10% in 2006-2010. We then investigated the distribution of the annual precipitation ratio (RA/AMeDAS). The ratio diverged in the smaller annual precipitation, but converged to ca. 1.2 for larger annual precipitation. By setting the observational area of 46 radars across Japan using Thiessen method, we investigated the relation between the annual precipitation ratio and the distance from the radar to AMeDAS station. We found only negative relation was statistically significant. As a possible reason for this relation, we considered that RA far from the radar is affected by the attenuating and shadowing effect of heavy rainfall near the radar.

著者

Tetsushi HIRANO Shogo YANAI Takuya OMOTEHARA Rie HASHIMOTO Yuria UMEMURA Naoto KUBOTA Kiichi MINAMI Daichi NAGAHARA Eiko MATSUO Yoshiko AIHARA Ryota SHINOHARA Tomoyuki FURUYASHIKI Youhei MANTANI Toshifumi YOKOYAMA Hiroshi KITAGAWA Nobuhiko HOSHI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.77, no.10, pp.1207-1215, 2015 (Released:2015-11-05)

参考文献数

42

被引用文献数

7 61

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Neonicotinoids, some of the most widely used pesticides in the world, act as agonists to the nicotinic acetylcholine receptors (nAChRs) of insects, resulting in death from abnormal excitability. Neonicotinoids unexpectedly became a major topic as a compelling cause of honeybee colony collapse disorder, which is damaging crop production that requires pollination worldwide. Mammal nAChRs appear to have a certain affinity for neonicotinoids with lower levels than those of insects; there is thus rising concern about unpredictable adverse effects of neonicotinoids on vertebrates. We hypothesized that the effects of neonicotinoids would be enhanced under a chronic stressed condition, which is known to alter the expression of targets of neonicotinoids, i.e., neuronal nAChRs. We performed immunohistochemical and behavioral analyses in male mice actively administered a neonicotinoid, clothianidin (CTD; 0, 10, 50 and 250 mg/kg/day), for 4 weeks under an unpredictable chronic stress procedure. Vacuolated seminiferous epithelia and a decrease in the immunoreactivity of the antioxidant enzyme glutathione peroxidase 4 were observed in the testes of the CTD+stress mice. In an open field test, although the locomotor activities were not affected, the anxiety-like behaviors of the mice were elevated by both CTD and stress. The present study demonstrates that the behavioral and reproductive effects of CTD become more serious in combination with environmental stress, which may reflect our actual situation of multiple exposure.

著者

蔭山 宏 Hiroshi Kageyama

出版者

甲南大学法学会

雑誌

甲南法学 = Konan Hogaku : Konan Law Review (ISSN:04524179)

巻号頁・発行日

vol.57, no.3・4, pp.1-54, 2017-03-30

著者

Hiroshi Yatsuya Hiroyasu Iso Yuanying Li Kazumasa Yamagishi Yoshihiro Kokubo Isao Saito Norie Sawada Manami Inoue Shoichiro Tsugane

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-0081, (Released:2016-04-15)

参考文献数

41

被引用文献数

4 36

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Background:Global risk assessment for the prevention of atherosclerotic cardiovascular diseases helps guide the intensity of behavioral and pharmacological interventions.Methods and Results:The Japan Public Health Center-based prospective (JPHC) Study Cohort II (age range: 40–69 years at baseline in 1993–1994, n=15,672) was used to derive the risk equations for coronary artery disease (CAD) and ischemic stroke incidence via hazard regression. The model discrimination was evaluated by the area under the receiver-operating curve (AUC), and model goodness-of-fit by the Grønnesby-Borgan chi-squared statistic. During a mean of 16.4 years of follow up, 192 incident CAD cases and 552 ischemic stroke cases occurred. Variables selected for the CAD equation were age, sex, current smoking, systolic blood pressure, antihypertensive medication use, diabetes, and high-density lipoprotein cholesterol (HDLC) and non-HDLC. The same variables, except non-HDLC, were selected for the ischemic stroke equation. The equations discriminated incidence reasonably well (AUC: 0.81 for CAD, 0.78 for ischemic stroke). The AUC of the equation applied externally to Cohort I (n=11,598) was also good: 0.77 and 0.76 for CAD and ischemic stroke, respectively. Risk calculator application and color charts to visualize estimated risk according to the combinations of risk factors were prepared.Conclusions:Risk equations were developed to estimate the 10-year probability of CAD and ischemic stroke in Japanese people, using variables that are routinely obtained.

著者

Tsutomu Shimura Ichiro Yamaguchi Hiroshi Terada Toshihiko Yunokawa Erik Robert Svendsen Naoki Kunugita

出版者

内閣府食品安全委員会

雑誌

Food Safety (ISSN:21878404)

巻号頁・発行日

vol.3, no.3, pp.84-91, 2015 (Released:2015-09-29)

参考文献数

21

被引用文献数

2

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Herein we analyzed food monitoring data regarding the Fukushima accident. The Japanese government ordered local governments to implement food monitoring after the Fukushima nuclear accident. This protective action for food safety contributed to the reduction of internal radiation exposure derived from the Fukushima accident. According to the food monitoring data collected from March 2011 to March 2015, more than 70% of the samples were beef. One hundred fifty four samples from a total of 776,310 beef samples that were above provisional regulation values or new standard limits were restricted from market distribution. Most of the beef samples were below the detection limits by regulation of consumption of contaminated rice straw. Two hundred forty one from a total of 251,510 beef samples were above the detection limit during fiscal year 2014. The mean committed effective dose due to annual beef consumption was estimated to be 1 µSv. The 99.9 percentile committed effective dose was 20 µSv. Thus, internal exposure due to beef consumption is limited. However, local governments continue regular monitoring for beef in response to social concerns. It should be noted that continuous staff effort and high costs are required to maintain this food surveillance program. A formal evaluation may help to assist in the development of a more effective and efficient food monitoring system.

著者

Hiroyuki Tsutsui Shin-ichi Momomura Yoshihiko Saito Hiroshi Ito Kazuhiro Yamamoto Yasushi Sakata Tomomi Ohishi Takayuki Iimori Toshihito Kitamura on behalf of the PARALLEL-HF Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0349, (Released:2023-11-21)

参考文献数

18

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Background: Lower systolic blood pressure (SBP) is known to be associated with poor prognosis in heart failure (HF). We evaluated the efficacy and safety of sacubitril/valsartan according to baseline SBP tertiles in Japanese patients from the PARALLEL-HF study.Methods and Results: In all, 223 patients were stratified into tertiles according to baseline SBP (≤114 mmHg: n=75; >114 and ≤130 mmHg: n=76; and >130 mmHg: n=72). Patients with lower SBP (≤114 mmHg) had the highest median N-terminal pro B-type natriuretic peptide (NT-proBNP) concentrations at baseline (P=0.0184). No significant difference was observed between sacubitril/valsartan and enalapril for the composite outcome of cardiovascular death and HF hospitalization across SBP tertiles (P-interaction=0.2682). Although the P-interaction value was not significant (0.2106), a greater reduction in NT-proBNP with sacubitril/valsartan compared with enalapril was observed in patients with SBP >130 mmHg (P=0.0076). The incidence of hypotension-related events and reduction or discontinuation of treatment due to hypotension-related events was higher in the lower SBP subgroup, and these events were more frequent in the sacubitril/valsartan than enalapril group.Conclusions: The efficacy of sacubitril/valsartan compared with enalapril was consistent across baseline SBP tertiles in Japanese patients from the PARALLEL-HF study. Hypotension-related events were more common in patients treated with sacubitril/valsartan with lower SBP.

著者

Makoto Eriguchi Kotaro Iida Shuhei Ikeda Manabu Osoegawa Kenya Nishioka Nobutaka Hattori Hiroshi Nagayama Hideo Hara

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.58, no.13, pp.1935-1938, 2019-07-01 (Released:2019-07-01)

参考文献数

17

被引用文献数

17 29

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We herein report the case of a 38-year-old man who developed parkinsonism 4 years after ingesting glyphosate. The patient presented with right-sided bradykinesia and cogwheel rigidity without autonomic symptoms. Magnetic resonance imaging of the brain and [123I]-metaiodobenzylguanidine myocardial scintigraphy were normal. A drastic response to levodopa and the presence of levodopa-induced dyskinesia without strong non-motor symptoms were seen in this patient. We considered that young-onset atypical parkinsonism was associated with a history of sublethal glyphosate ingestion. Epidemiologic investigations have shown that exposure to pesticides is a risk factor for Parkinson's disease (PD). Our findings support the notion that glyphosate exposure might be related to the onset of PD.

著者

Keiichi Kojima Hiroshi C. Watanabe Satoko Doi Natsuki Miyoshi Misaki Kato Hiroshi Ishikita Yuki Sudo

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

vol.15, pp.179-188, 2018 (Released:2018-09-07)

参考文献数

42

被引用文献数

7 9

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Anion channelrhodopsin-2 (ACR2), a light-gated channel recently identified from the cryptophyte alga Guillardia theta, exhibits anion channel activity with exclusive selectivity. In addition to its novel function, ACR2 has become a focus of interest as a powerful tool for optogenetics. Here we combined experimental and computational approaches to investigate the roles of conserved carboxylates on the anion transport activity of ACR2 in Escherichia coli membrane. First, we replaced six conserved carboxylates with a neutral residue (i.e. E9Q, E56Q, E64Q, E159Q, E219Q and D230N), and measured anion transport activity using E. coli expression system. E159Q and D230N exhibited significantly lower anion transport activity compared with wild-type ACR2 (1/12~1/3.4), which suggests that E159 and D230 play important roles in the anion transport. Second, to explain its molecular aspects, we constructed a homology model of ACR2 based on the crystal structure of a cation channelrhodopsin (ChR). The model structure showed a cavity formed by four transmembrane helices (TM1, TM2, TM3 and TM7) similar to ChRs, as a putative anion conducting pathway. Although E159 is not located in the putative pathway, the model structure showed hydrogen bonds between E159 and R129 with a water molecule. D230 is located in the pathway near the protonated Schiff base (PSB) of the chromophore retinal, which suggests that there is an interaction between D230 and the PSB. Thus, we demonstrated the functional importance and the hypothetical roles of two conserved carboxylates, E159 and D230, in the anion transport activity of ACR2 in E. coli membrane.

著者

Takahiro Nishihara Toru Miyoshi Noriaki Akagi Mitsutaka Nakashima Kazufumi Nakamura Hiroshi Ito

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-23-0034, (Released:2023-05-18)

参考文献数

1

著者

山川 宏 前田 行雄 石井 信明 小川 博之 野中 聡 山本 高行 津田 雄一 川口 淳一郎 周東 三和子 感応寺 治城 Yamakawa Hiroshi Maeda Yukio Ishii Nobuaki Ogawa Hiroyuki Nonaka Satoshi Yamamoto Takayuki Tsuda Yuichi Kawaguchi Junichiro Shuto Miwako Kannoji Harushiro

出版者

宇宙航空研究開発機構

雑誌

宇宙航空研究開発機構特別資料: M-V型ロケット:5号機から8号機まで = JAXA Special Publication: The M-V Rockets: From the Fifth to the Eighth Vehicle (ISSN:1349113X)

巻号頁・発行日

vol.JAXA-SP-07-023, pp.477-525, 2008-02-29

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資料番号: AA0064112030

著者

Rie Hayashi Hiroyasu Iso Kazumasa Yamagishi Hiroshi Yatsuya Isao Saito Yoshihiro Kokubo Ehab S. Eshak Norie Sawada Shoichiro Tsugane for the Japan Public Health Center-Based (JPHC) Prospective Study Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.5, pp.1072-1079, 2019-04-25 (Released:2019-04-25)

参考文献数

43

被引用文献数

24 27

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Background: Evidence from prospective cohort studies regarding the relationship between working hours and risk of cardiovascular disease is limited Methods and Results: The Japan Public Health Center-Based Prospective Study Cohort II involved 15,277 men aged 40–59 years at the baseline survey in 1993. Respondents were followed up until 2012. During the median 20 years of follow up (257,229 person-years), we observed 212 cases of acute myocardial infarction and 745 stroke events. Cox proportional hazards models adjusted for sociodemographic factors, cardiovascular risk factors, and occupation showed that multivariable-adjusted hazard ratios (HRs) associated with overtime work of ≥11h/day were: 1.63 (95% confidence interval [CI] 1.01–2.63) for acute myocardial infarction and 0.83 (95% CI 0.60–1.13) for total stroke, as compared with the reference group (working 7 to <9 h/day). In the multivariable model, increased risk of acute myocardial infarction associated with overtime work of ≥11 h/day was more evident among salaried employees (HR 2.11, 95% CI 1.03–4.35) and men aged 50–59 years (HR 2.60, 95% CI 1.42–4.77). Conclusions: Among middle-aged Japanese men, working overtime is associated with a higher risk of acute myocardial infarction.

著者

Matsumoto Yu Kajihara Hiroshi Kakui Keiichi

出版者

Sociedade Brasileira de Carcinologia

雑誌

Nauplius (ISSN:23582936)

巻号頁・発行日

vol.31, pp.e2023005, 2023

被引用文献数

1

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A new podocerid amphipod, Leipsuropus seisuiae sp. nov., from 338-340 m depth in the Kumano Sea, Japan, Northwestern Pacific, is described. This is the deepest record of any Leipsuropus species. Leipsuropus seisuiae sp. nov. is distinguished from four other congeneric species in having: i) pereonites 2-5 each with five narrow spiniform projections on tergal plate, ii) one dorsal tubercle on the telson, and iii) one small, proximal, denticulate projection on gnathopod-2 palmar margin. A key to males of the species of Leipsuropus is provided.