著者

木宮 直仁 平川 博 Naohito Kimiya Hiroshi Hirakawa

出版者

東京海洋大学

雑誌

東京海洋大学研究報告 (ISSN:21890951)

巻号頁・発行日

vol.9, pp.21-37, 2013-02-28

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本稿では、これまで編著した「あ~し」の続編として、「す~」で始まる用語について、対訳語が複数あるものを取り上げ、類義語との異同に関する注釈を付け、用例は実例を調査して、できるだけ多く提示することを試みた。法律用語の中には、請求金額のように、ビジネス用語や日常語と法律用語とが異なるものがあり、このような場合は訳語の使い分けができるように工夫することを心掛けた。また、あらぬ誤訳が生じることが懸念される場合は、特殊な法律専門用語よりも、対訳語として一般的に用いられる表現を優先的に取り上げるように配慮した。 著者らは商事法和英辞典の作成途上にあり、本稿には不十分なところも多々あると考えている。お気づきの点があれはご教示願いたい。

著者

Naoko Kosaka Yusuke Umemiya Naoto Endou Tsuneko Kura Hiroshi Matsubara Masaki Hisada Akinori Murata Satoshi Mitarai

出版者

公益社団法人 日本気象学会

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2023-016, (Released:2023-05-22)

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This paper presents experimental observations to improve typhoon prediction accuracy and to understand interactions between atmosphere and ocean directly under typhoons. Two unmanned surface vehicles (Wave Gliders (WGs)) equipped with interchangeable sensors were sailed toward the path of an approaching Category 5 typhoon (Hinnamnor), which began on 29 August 2022 and subsided on 6 September, reaching a minimum pressure of 920 hPa and a maximum wind speed of 55 m/s (105 knots). Sensors on WGs measured atmospheric pressure, wind speed, atmospheric and seawater temperature, wave height, currents, salinity, and chlorophyll-a concentrations in different parts of the typhoon. These observations made it possible to clarify changes in various phenomena as the typhoon approached and to compare differences in storm characteristics measured by the two WGs. Sea surface pressure in the core of a typhoon is useful as an initial predictor of its intensity. Data assimilation into numerical models and other observations are expected to improve prediction accuracy of typhoon phenomena. Furthermore, simultaneous observations of atmosphere and ocean will also be useful for modeling interactions.

著者

Migaku Kikuchi Yoshio Tahara Junichi Yamaguchi Takahiro Nakashima Osamu Nomura Akihito Tanaka Sunao Kojima Katsutaka Hashiba Naoki Nakayama Hiroyuki Hanada Toshiaki Mano Takeshi Yamamoto Kunihiro Matsuo Ichiro Takeuchi Tetsuya Matoba Hiroshi Nonogi for the Japan Resuscitation Council (JRC) Acute Coronary Syndrome (ACS) Task Force and the Guideline Editorial Committee on behalf of the Japanese Circulation Society (JCS) Emergency and Critical Care Committee

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0096, (Released:2023-04-20)

参考文献数

23

被引用文献数

4

著者

Daisuke FURUSHIMA Ibuki SUGIYAMA Yuzuki NOMURA Keiko UNNO Hiroshi YAMADA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.6, pp.540-546, 2022-12-31 (Released:2022-12-31)

参考文献数

30

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l-Theanine, the most abundant amino acid component in green tea, has anti-stress effects and refreshes the mental state. A recent study demonstrated that l-arginine, the second most abundant amino acid in green tea, might enhance the anti-stress effects of l-theanine. The aim of this study was to evaluated the effects of combined ingestion of l-theanine and l-arginine on psychological stress in humans. A randomized placebo-controlled trial was conducted including 120 healthy young adults (mean age 22.4 y, 63.3% female). Subjects were randomly assigned to theanine (200 mg l-theanine), combined theanine/arginine (200 mg l-theanine, 50 mg l-arginine), or placebo groups. After consuming a test beverage, we administered a stress-loading test (Uchida-Kraepelin performance test) and performed salivary alpha-amylase activity (sAA) measurements to assess the physiological stress response at 0 min (immediately after), 5 min, and 15 min. The changes in sAA at 15 min after the stress-loading test were −2.75 (11.2) kIU/L in the theanine/arginine group, −0.40 (11.5) kIU/L in the theanine group, and 6.95 (18.6) kIU/L in the placebo group. The values in the theanine/arginine (p=0.007) and theanine (p=0.02) groups differed significantly from those in the placebo group. However, the difference between theanine/arginine and theanine groups, was not statistically significant (p=0.74). From this study, no clear conclusion could be drawn regarding the potentiating effect of theanine and arginine combined ingestion on anti-stress effects in human.

著者

Shunsuke Ogata Yoshito Ishii Keiichiro Asano Erena Kobayashi Shun Kubota Keita Takahashi Yosuke Miyaji Yuichi Higashiyama Hideto Joki Hiroshi Doi Michiaki Koga Hideyuki Takeuchi Fumiaki Tanaka

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.11, pp.1757-1760, 2022-06-01 (Released:2022-06-01)

参考文献数

9

被引用文献数

10

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Guillain-Barré syndrome (GBS) has occasionally occurred in people who have received coronavirus disease 2019 (COVID-19) vaccines. Dysgeusia is rare symptom of GBS. We herein report a rare case of sensory ataxic GBS with dysgeusia just after the second dose of the Pfizer-BioNTech COVID-19 vaccine. Although autoantibodies against glycolipids were not detected, immunotherapy with intravenous immunoglobulin and methylprednisolone pulse therapy effectively ameliorated the symptoms. Our report suggests that the COVID-19 vaccine may induce various clinical subtypes of GBS, including a rare variant with sensory ataxia and dysgeusia.

著者

Shunsuke Yamada Kanako Yamada Hiroshi Nishida

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.19, pp.2995, 2022-10-01 (Released:2022-10-01)

参考文献数

4

被引用文献数

5

著者

Hirotoshi Watanabe Takeshi Morimoto Ko Yamamoto Yuki Obayashi Masahiro Natsuaki Kyohei Yamaji Manabu Ogita Satoru Suwa Tsuyoshi Isawa Takenori Domei Kenji Ando Shojiro Tatsushima Hiroki Watanabe Masanobu Oya Kazushige Kadota Hideo Tokuyama Tomohisa Tada Hiroki Sakamoto Hiroyoshi Mori Hiroshi Suzuki Tenjin Nishikura Kohei Wakabayashi Takeshi Kimura for the STOPDAPT-2 ACS Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-22-0650, (Released:2022-12-08)

参考文献数

28

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Background: The REAL-CAD trial, reported in 2017, demonstrated a significant reduction in cardiovascular events with high-intensity statins in patients with chronic coronary syndrome. However, data are scarce on the use of high-intensity statins in Japanese patients with acute coronary syndrome (ACS).Methods and Results: In STOPDAPT-2 ACS, which exclusively enrolled ACS patients between March 2018 and June 2020, 1,321 (44.2%) patients received high-intensity statins at discharge, whereas of the remaining 1,667 patients, 96.0% were treated with low-dose statins. High-intensity statins were defined as the maximum approved doses of strong statins in Japan. The incidence of the cardiovascular composite endpoint (cardiovascular death, myocardial infarction, definite stent thrombosis, stroke) was significantly lower in patients with than without high-intensity statins (1.44% vs. 2.69% [log-rank P=0.025]; adjusted hazard ratio [aHR] 0.48, 95% confidence interval [CI] 0.24–0.94, P=0.03) and the effect was evident beyond 60 days after the index percutaneous coronary intervention (log-rank P=0.01; aHR 0.38, 95% CI 0.17–0.86, P=0.02). As for the bleeding endpoint, there was no significant difference between the 2 groups (0.99% vs. 0.73% [log-rank P=0.43]; aHR 0.96, 95% CI 0.35–2.60, P=0.93).Conclusions: The prevalence of high-intensity statins has increased substantially in Japan. The use of the higher doses of statins in ACS patients recommended in the guidelines was associated with a significantly lower risk of the primary cardiovascular composite endpoint compared with lower-dose statins.

著者

小野 寛 Hiroshi Ono

出版者

学習院女子短期大学国語国文学会

雑誌

国語国文論集 (ISSN:02896753)

巻号頁・発行日

no.20, pp.20-34, 1991-03-20

著者

Yu Mizutani Shinichiro Kawamoto Michiko Takahashi Hisayo Doi Kumiko Wakida Satoko Tabuchi Masaaki Tanda Akihiro Soga Ruri Chijiki Hidetomo Takakura Koji Kawaguchi Ako Higashime Marika Watanabe Hiroya Ichikawa Sakuya Matsumoto Rina Sakai Hideaki Goto Keiji Kurata Seiji Kakiuchi Yoshiharu Miyata Kiyoaki Uryu Yumiko Inui Akihito Kitao Kimikazu Yakushijin Hiroshi Matsuoka Hironobu Minami

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.1314-22, (Released:2023-02-15)

参考文献数

41

被引用文献数

1

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Objective High-dose chemotherapy with autologous hematopoietic stem cell transplantation (auto-HSCT) is an effective treatment option for relapsed and refractory aggressive malignant lymphoma. However, patients frequently experience treatment-induced gastrointestinal symptoms. Synbiotics, including live microorganisms and nondigestible food ingredients, reportedly ameliorate chemotherapy-induced mucosal damage. In this study, we assessed the efficacy and safety of synbiotics in patients undergoing auto-HSCT. Methods This randomized, double-blinded study included patients with malignant lymphoma eligible for auto-HSCT. The patients were randomly assigned to either a synbiotic group receiving Bifidobacterium longum (BB536) and guar gum or a placebo group receiving a placebo containing dextrin. The supplements were administered twice daily from the start of conditioning chemotherapy up to 28 days after auto-HSCT. The primary endpoint was the duration of total parenteral nutrition (TPN). Results In total, 12 patients were included and randomized. The median duration of TPN was 15 (range, 12-33) days in the synbiotic group and 17.5 (range, 0-32) days in the placebo group. The median duration of grade ≥3 diarrhea was shorter in the synbiotic group than in then placebo group (2.5 vs. 6.5 days), as was the duration of hospital stay (31.5 vs. 43 days). The oral intake and quality of life regarding diarrhea and anorexia improved in the synbiotic group after engraftment. Synbiotic infections, including bacteremia, were not observed. Conclusion Synbiotics may reduce gastrointestinal toxicity, thereby reducing nutritional problems and improving the quality of life of patients undergoing auto-HSCT, without severe adverse events.

著者

宮崎 寛 Hiroshi MIYAZAKI 京都産業大学世界問題研究所

出版者

京都産業大学世界問題研究所

雑誌

京都産業大学世界問題研究所紀要 = The bulletin of the Institute for World Affairs, Kyoto Sangyo University (ISSN:03885410)

巻号頁・発行日

vol.28, pp.269-283, 2013-02

著者

Hiroshi Takasaki Takahiro Ueno

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.35, no.1, pp.31-39, 2023 (Released:2023-01-01)

参考文献数

21

被引用文献数

1

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[Purpose] We aimed to identify possible solutions to enhance evidence-based practice (EBP) in rehabilitation professionals in Japan. [Participants and Methods] A three-round Delphi method was undertaken among a cohort of clinical therapists (328 physical therapists, 55 occupational therapists, and 6 speech therapists). In the first round, the participants listed possible solutions for promoting EBP, other than 12 solutions presented in a previous study; subsequently, a new list was created. In the second round, a newly-created list of solutions was presented, and the participants responded on a 5-point Likert scale on how much they agreed with the solutions promoting EBP in Japanese rehabilitation professionals. In the third round, the distribution of responses obtained in the second round was presented, and participant’s agreement was again assessed on a 5-point Likert scale. [Results] Across the three rounds, data were collected from 33.7% to 47.0% of all eligible participants. After the first round, 17 possible solutions were developed, and a list of 29 solutions was used in the second round. After the third round, 10 solutions reached the predetermined criteria for consensus. [Conclusion] In this study, ten possible solutions to promote EBP were proposed by the Japanese rehabilitation professionals.

著者

Yoshitaka Wada Satoshi Hirano Ayaka Kumagai Kaori Takeuchi Ryosuke Inagaki Hiroshi Hosokawa Hirofumi Maeda Seiko Shibata Yohei Otaka

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.7, pp.20220052, 2022 (Released:2022-09-24)

参考文献数

13

被引用文献数

1

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Background: Coronavirus disease 2019 (COVID-19) is associated with an increased risk of thrombotic complications. Nonetheless, there is a paucity of clinical knowledge regarding rehabilitation of patients with COVID-19 after lower-limb amputation.Case: A 74-year-old woman with COVID-19 was admitted to a university hospital. During hospitalization, she underwent right transfemoral amputation due to acute limb ischemia. Three months after admission, the patient was transferred to a convalescent rehabilitation ward in the same hospital. A femoral prosthesis was prescribed 2 weeks after her transfer to the rehabilitation ward. It featured ischial-ramal containment with a soft liner and belt suspension, 668-g multiple linkage-type safety knee joint (Imasen Engineering; M0781 SwanS), and a solid-ankle cushioned-heel foot. The total rehabilitation time during the patient’s stay in the acute-care and rehabilitation wards was 65.5 h (0.99 h/day, 66 days) and 275.0 h (3.02 h/day, 91 days), respectively. In the rehabilitation ward, the patient underwent 54.4 h (19.8%) of muscle strength training, 48.1 h (17.5%) of comprehensive assessments, and 47.1 h (17.1%) of gait training. The patient was discharged home 6 months after admission, with a total Functional Independence Measure score of 120. The patient could walk slowly [44.2 s (0.23 m/s) in the 10 m-walk test] with a femoral prosthesis and a quad cane but exhibited limited endurance (75.0 m in the 6-min walk test).Discussion: Following appropriate rehabilitation, a patient was able to walk independently after lower-limb amputation despite the complication of COVID-19, although her walking ability was limited.

著者

Hiroshi Habu Soshi Takao Ryohei Fujimoto Hiromichi Naito Atsunori Nakao Takashi Yorifuji

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20210066, (Released:2021-06-26)

参考文献数

44

被引用文献数

13

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Background: Hardships associated with the ongoing coronavirus disease 2019 (COVID-19) pandemic can affect mental health, potentially leading to increased risk of suicide. We examined the relationship between the COVID-19 outbreak and suicide attempts in Okayama, Japan using information from emergency dispatches.Methods: This was a descriptive epidemiological study. We collected information on emergency dispatches in Okayama City and Kibichuo from March to August in 2018, 2019 and 2020 (n = 47,770 cases). We compared emergency dispatches and their demographic characteristics, especially focusing on suicide attempts, during these 3 years.Results: The number of emergency dispatches in 2020 decreased compared with the previous 2 years, while the number and proportion of emergency dispatches related to suicide attempts increased. This increase was more pronounced among women and those aged 25–49 years. Among women aged 25–49 years, there was a cumulative total of 43 suicide attempts in 2018 and 2019 and 73 suicide attempts in 2020.Conclusions: The number and proportion of emergency dispatches related to suicide attempts increased in 2020 compared with the previous 2 years, especially among women and those aged 25–49 years. This increase may be partly explained by hardships such as economic losses or reduced social ties during the COVID-19 outbreak.

著者

Taisei Tanaka Yoshinobu Konishi Hiroshi Ichise Shinya Tsukiji Michiyuki Matsuda Kenta Terai

出版者

Japan Society for Cell Biology

雑誌

Cell Structure and Function (ISSN:03867196)

巻号頁・発行日

pp.21052, (Released:2021-11-06)

被引用文献数

1

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IFN-γ secreted from immune cells exerts pleiotropic effects on tumor cells, including induction of immune checkpoint and antigen presentation, growth inhibition, and apoptosis induction. We combined a dual promoter system with an IFN-γ signaling responsive promoter to generate a reporter named the interferon sensing probe (ISP), which quantitates the response to IFN-γ by means of fluorescence and bioluminescence. The integration site effect of the transgene is compensated for by the PGK promoter-driven expression of a fluorescent protein. Among five potential IFN-γ-responsive elements, we found that the interferon γ-activated sequence (GAS) exhibited the best performance. When ISP-GAS was introduced into four cell lines and subjected to IFN-γ stimulation, dose-dependency was observed with an EC50 ranging from 0.2 to 0.9 ng/mL, indicating that ISP-GAS can be generally used as a sensitive biosensor of IFN-γ response. In a syngeneic transplantation model, the ISP-GAS-expressing cancer cells exhibited bioluminescence and fluorescence signals in an IFN-γ receptor-dependent manner. Thus, ISP-GAS could be used to quantitatively monitor the IFN-γ response both in vitro and in vivo.Key words: in vivo imaging, tumor microenvironment, interferon-gamma, dual promoter system

著者

Shohei Nagata Tomoki Nakaya Yu Adachi Toru Inamori Kazuto Nakamura Dai Arima Hiroshi Nishiura

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.31, no.6, pp.387-391, 2021-06-05 (Released:2021-06-05)

参考文献数

14

被引用文献数

56

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Background: As the COVID-19 pandemic spread, the Japanese government declared a state of emergency on April 7, 2020 for seven prefectures, and on April 16, 2020 for all prefectures. The Japanese Prime Minister and governors requested people to adopt self-restraint behaviors, including working from home and refraining from visiting nightlife spots. However, the effectiveness of the mobility change due to such requests in reducing the spread of COVID-19 has been little investigated. The present study examined the association of the mobility change in working, nightlife, and residential places and the COVID-19 outbreaks in Tokyo, Osaka, and Nagoya metropolitan areas in Japan.Methods: First, we calculated the daily mobility change in working, nightlife, and residential places compared to the mobility before the outbreak using mobile device data. Second, we estimated the sensitivity of mobility changes to the reproduction number by generalized least squares.Results: Mobility change had already started in March, 2020. However, mobility reduction in nightlife places was particularly significant due to the state of emergency declaration. Although the mobility in each place type was associated with the COVID-19 outbreak, the mobility changes in nightlife places were more significantly associated with the outbreak than those in the other place types. There were regional differences in intensity of sensitivity among each metropolitan area.Conclusions: Our findings indicated the effectiveness of the mobility changes, particularly in nightlife places, in reducing the outbreak of COVID-19.

著者

仲内 悠祐 前田 孝雄 佐伯 和人 吉光 徹雄 大竹 真紀子 大槻 真嗣 長岡 央 佐藤 広幸 白石 浩章 本田 親寿 吉川 健人 山中 千博 石原 吉明 國井 康晴 NAKAUCHI Yusuke MAEDA Takao SAIKI Kazuto YOSHIMITSU Tetsuo OHTAKE Makiko OTSUKI Masatsugu NAGAOKA Hiroshi SATO Hiroyuki SHIRAISHI Hiroaki HONDA Chikatoshi YOSHIKAWA Kento YAMANAKA Chihiro ISHIHARA Yoshiaki KUNII Yasuharu

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

第21回宇宙科学シンポジウム 講演集 = Proceedings of the 21st Space Science Symposium

巻号頁・発行日

2021-01

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第21回宇宙科学シンポジウム (2021年1月6日-7日. オンライン開催)

著者

Hiroyuki Yamamoto Tomofumi Takaya Nobuyuki Takahashi Hiroshi Tsunamoto Hirohisa Murakami Hiroya Kawai

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.7, pp.333-334, 2022-07-08 (Released:2022-07-08)

著者

ISLAM Md. Rezuanul SATOH Masaki TAKAGI Hiroshi

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2022-024, (Released:2022-02-03)

被引用文献数

6

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This study investigated tidal records and landfall tropical cyclone (TC) best tracks from 1980 to 2019 to determine changes in storm surge heights in coastal regions of Central Japan, including Tokyo. The results indicate that annual mean storm surge heights have increased in the last 20 years (2000-2019) compared to those in 1980-1999, and that these changes are noteworthy, particularly in Tokyo Bay. TC wind intensity and size during landfall time frame have become stronger and larger, respectively, corresponding to increasing storm surge magnitudes from 1980 to 2019. The increased occurrence frequency of TCs with more northeastward tracks is another factor that may have contributed to the increased surge hazards around Tokyo. Additionally, a positive correlation between surge heights and a hazard index supports these statistical findings. Japan central coast will likely experience increasing numbers of extreme storm surge events in the future, if, the current increasing tendency continues.

著者

杉原 アフマッド清志 松下 将典 森 治 松本 純 中条 俊大 佐伯 孝尚 津田 雄一 川口 淳一郎 奥泉 信克 宮崎 康行 古谷 寛 坂本 啓 松永 三郎 谷 義隆 清水 裕介 岡田 達明 岩田 隆浩 川崎 繁男 西山 和孝 月崎 竜童 神田 大樹 細田 聡史 高尾 勇輝 久保 勇貴 柏岡 秀哉 名田 悠一郎 豊田 裕之 佐藤 泰貴 田中 孝治 中村 徹哉 柴田 優一 中尾 達郎 森 一之 後藤 亜紀 藤井 さなえ 渡邊 秋人 酒井 良次 伊藤 裕明 SUGIHARA Ahmed Kiyoshi MATSUSHITA Masanori MORI Osamu MATSUMOTO Jun CHUJO Toshihiro SAIKI Takanao TSUDA Yuichi KAWAGUCHI Jun'ichiro OKUIZUMI Nobukatsu MIYAZAKI Yasuyuki FURUYA Hiroshi SAKAMOTO Hiraku MATUNAGA Saburo TANI Yoshitaka SHIMIZU Yusuke OKADA Tatsuaki IWATA Takahiro KAWASAKI Shigeo NISHIYAMA Kazutaka TSUKIZAKI Ryudo KODA Daiki HOSODA Satoshi TAKAO Yuki KUBO Yuki KASHIOKA Shuya NADA Yuichiro TOYOTA Hiroyuki SATO Yasutaka TANAKA Koji AKAMURA Tetsuya SHIBATA Yuichi NAKAO Tatsuro MORI Kazuyuki GOTO Aki FUJII Sanae WATANABE Akihito SAKAI Ryoji ITOH Hiroaki

出版者

宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)

雑誌

第20回宇宙科学シンポジウム 講演集 = Proceedings of the 20th Space Science Symposium

巻号頁・発行日

2020-01

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第20回宇宙科学シンポジウム (2020年1月8日-9日. 宇宙航空研究開発機構宇宙科学研究所(JAXA)(ISAS)相模原キャンパス), 相模原市, 神奈川県

著者

Yukiko Onishi Tomonori Oura Hiroshi Nishiyama Sumika Ohyama Masakazu Takeuchi Noriyuki Iwamoto

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.63, no.3, pp.263-273, 2016 (Released:2016-03-31)

参考文献数

21

被引用文献数

17 20

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The efficacy and tolerability of once weekly dulaglutide 0.75 mg in Japanese patients with type 2 diabetes (T2D) were evaluated by subgroups defined by key demographic characteristics. This post hoc analysis included data from patients who received dulaglutide 0.75 mg for up to 26 weeks in three phase 3 trials (one open-label, randomized; one double-blind and open-label, randomized; one open-label, nonrandomized). Patients were classified into subgroups on the basis of sex (male, female), age (<65, ≥65 years), body weight (<70, ≥70 kg), body mass index (BMI; <25, ≥25 kg/m2), duration of diabetes (<7, ≥7 years), HbA1c (≤8.5, >8.5%), use of concomitant sulfonylurea (yes, no), and use of concomitant biguanide (yes, no). Efficacy measures analyzed were changes from baseline in HbA1c and body weight and percentages of patients achieving HbA1c <7.0%. Safety measures analyzed were incidence of hypoglycemia and nausea and change from baseline in seated pulse rate. A total of 855 patients were analyzed. Once weekly dulaglutide 0.75 mg improved blood glucose control as measured by HbA1c regardless of patient characteristics; patients with higher baseline HbA1c values had greater improvements compared to patients with lower baseline values. Weight loss was greater in patients with lower baseline HbA1c and in patients taking concomitant biguanides. Concomitant use of sulfonylureas had the greatest effect on the incidence of hypoglycemia. Treatment of T2D with once weekly dulaglutide 0.75 mg for 26 weeks was associated with significant improvement in glycemic control irrespective of age, sex, duration of diabetes, body weight, BMI, or concomitant medication.