著者

Yuki Ishikawa-Ishiwata Yuichi Nosaka Toshinori Usui Hiroshi Sasaki

出版者

The Plankton Society of Japan, The Japanese Association of Benthology

雑誌

Plankton and Benthos Research (ISSN:18808247)

巻号頁・発行日

vol.18, no.2, pp.74-83, 2023-05-31 (Released:2023-05-30)

参考文献数

58

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We investigated the growth, thermotolerance, and fatty acid composition of the green alga Desmodesmus sp., which was isolated from a freshwater puddle in Ibaraki, Japan. Incubation experiments on the isolated strain were performed at a range of temperatures (20–40°C) with continuous illumination (110 µmol photons m−2 s−1) and nutrient-replete medium. High specific growth rates of 1.14–1.62 day−1 were observed at 20–35°C, but growth rates declined to 0.59 day−1 at 40°C. Lipid contents were 13.2%–14.4% (% dry weight) at 20–35°C and increased to 21.3% at 40°C. Some microalgae are known to regulate membrane fluidity by changing their fatty acid compositions in response to changes in ambient temperature. We found that the major polyunsaturated fatty acid (PUFA; C18:3 ω3) of Desmodesmus sp. was negatively correlated with water temperature. By contrast, no significant relationship was identified between temperature and the ratio of saturated to unsaturated fatty acids. The negative relationship between ω3 PUFA composition and temperature was stronger among thermotolerant as opposed to non-thermotolerant microalgae. This suggests that thermotolerant Desmodesmus sp. can grow at high temperatures by altering its fatty acid composition to affect membrane fluidity.

著者

Hiroshi Kadowaki Hiroshi Akazawa Akito Shindo Tomomi Ueda Junichi Ishida Issei Komuro

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0838, (Released:2023-12-12)

参考文献数

82

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Epidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via secreted factors, so-called cardiokines, and epigenetic remodeling of bone marrow cells into an immunosuppressive phenotype. Reciprocally, cancer promotes HF via cachexia-related wasting and metabolic remodeling in the heart, and possibly via cancer-derived extracellular vesicles influencing myocardial structure and function. The novel concept of the “heart-cancer axis” will help in our understanding of the shared and reciprocal relationships between HF and cancer, and provide innovative diagnostic and therapeutic approaches for both diseases.

著者

Hiroshi Ikawa Shigetaka Okamoto Naoki Shinohara Saya Ozaki Toshiaki Kusuhara

出版者

The Japanese Society for Neuroendovascular Therapy

雑誌

Journal of Neuroendovascular Therapy (ISSN:18824072)

巻号頁・発行日

pp.tn.2023-0031, (Released:2023-08-08)

参考文献数

13

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Objective: This is a report on the usefulness of 3D fusion imaging with susceptibility-weighted imaging (SWI) as preoperative imaging for mechanical thrombectomy (MT) for acute ischemic stroke (AIS).Case Presentations: Among 17 cases of patients who underwent MT in AIS between March 2021 and April 2022, 14 patients who underwent MRI with SWI (shortened SWI for stroke) and 3D T2-weighted sampling perfection with application-optimized contrasts using different flip angle evolution were targeted in the study. Three cases with motion artifacts due to body movement were excluded from the images. After imaging, 3D fusion images were constructed to visualize thrombi and occluded vessels. SWI for stroke obtained thrombus information in 11 of the 14 cases (78.5%) and 3D images of the thrombi could be created in all 11 cases. 3D fusion images could be created in nine of the 14 cases (64.2%).Conclusion: 3D fusion images, using SWI for stroke, can visualize thrombi and occluded vessels and may be effectively used as preoperative images for MT.

著者

Akihiro Shiroshita Norio Yamamoto Natsumi Saka Hiroshi Shiba Shinji Toki Mari Yamamoto Eisuke Doi Yuki Kataoka

出版者

Society for Clinical Epidemiology

雑誌

Annals of Clinical Epidemiology (ISSN:24344338)

巻号頁・発行日

pp.24005, (Released:2023-06-10)

著者

Hirotoshi Watanabe Takeshi Morimoto Ko Yamamoto Yuki Obayashi Masahiro Natsuaki Kyohei Yamaji Manabu Ogita Satoru Suwa Tsuyoshi Isawa Takenori Domei Kenji Ando Shojiro Tatsushima Hiroki Watanabe Masanobu Oya Kazushige Kadota Hideo Tokuyama Tomohisa Tada Hiroki Sakamoto Hiroyoshi Mori Hiroshi Suzuki Tenjin Nishikura Kohei Wakabayashi Takeshi Kimura for the STOPDAPT-2 ACS Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.87, no.5, pp.657-668, 2023-04-25 (Released:2023-04-25)

参考文献数

28

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Background: The REAL-CAD trial, reported in 2017, demonstrated a significant reduction in cardiovascular events with high-intensity statins in patients with chronic coronary syndrome. However, data are scarce on the use of high-intensity statins in Japanese patients with acute coronary syndrome (ACS).Methods and Results: In STOPDAPT-2 ACS, which exclusively enrolled ACS patients between March 2018 and June 2020, 1,321 (44.2%) patients received high-intensity statins at discharge, whereas of the remaining 1,667 patients, 96.0% were treated with low-dose statins. High-intensity statins were defined as the maximum approved doses of strong statins in Japan. The incidence of the cardiovascular composite endpoint (cardiovascular death, myocardial infarction, definite stent thrombosis, stroke) was significantly lower in patients with than without high-intensity statins (1.44% vs. 2.69% [log-rank P=0.025]; adjusted hazard ratio [aHR] 0.48, 95% confidence interval [CI] 0.24–0.94, P=0.03) and the effect was evident beyond 60 days after the index percutaneous coronary intervention (log-rank P=0.01; aHR 0.38, 95% CI 0.17–0.86, P=0.02). As for the bleeding endpoint, there was no significant difference between the 2 groups (0.99% vs. 0.73% [log-rank P=0.43]; aHR 0.96, 95% CI 0.35–2.60, P=0.93).Conclusions: The prevalence of high-intensity statins has increased substantially in Japan. The use of the higher doses of statins in ACS patients recommended in the guidelines was associated with a significantly lower risk of the primary cardiovascular composite endpoint compared with lower-dose statins.

著者

Yuji Okura Kazuyuki Ozaki Hiroshi Tanaka Tatsuya Takenouchi Nobuaki Sato Tohru Minamino

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0426, (Released:2019-09-18)

参考文献数

98

被引用文献数

10 10

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Onco-cardiology, a new academic field, aims to improve the quality of life and prognosis of cancer patients and survivors with cardiovascular diseases (CVD). With the aging of the population, an epidemic of cancer with CVD is emerging in developed countries. Cancer and CVD share risk factors, pathophysiology, treatments, and preventive and rehabilitative measures. A multidisciplinary team-based approach is needed to support cancer treatment to maximize its effectiveness and minimize its cardiotoxic potential. Basic and clinical onco-cardiology are already being practiced harmoniously. However, systematization in academia and clinical practice and accumulation of evidence have just started. In this review, we present the epidemiology, common risk factors between cancer and CVD, future epidemic of CVD in patients with cancer, and the necessity for an onco-cardiological approach to managing the burden of CVD in cancer patients and survivors.

著者

Nobuyuki Ohte Tomoko Ishizu Chisato Izumi Hiroshi Itoh Shiro Iwanaga Hiroyuki Okura Yutaka Otsuji Yasushi Sakata Toshihiko Shibata Toshiro Shinke Yoshihiro Seo Masao Daimon Masaaki Takeuchi Kazuaki Tanabe Satoshi Nakatani Masaki Nii Kazuhiro Nishigami Takeshi Hozumi Satoshi Yasukochi Hirotsugu Yamada Kazuhiro Yamamoto Masaki Izumo Katsuji Inoue Hiroyuki Iwano Atsushi Okada Akihisa Kataoka Shuichiro Kaji Kenya Kusunose Akiko Goda Yasuharu Takeda Hidekazu Tanaka Kaoru Dohi Hirotoshi Hamaguchi Hidekatsu Fukuta Satoshi Yamada Nozomi Watanabe Makoto Akaishi Takashi Akasaka Takeshi Kimura Masami Kosuge Tohru Masuyama on behalf of the Japanese Circulation Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.86, no.12, pp.2045-2119, 2022-11-25 (Released:2022-11-25)

参考文献数

460

被引用文献数

16

著者

Kentaro YOSHII Keita MOTTATE Yuki OMORI-URABE Yumiko CHIBA Takahiro SETO Takahiro SANADA Junko MAEDA Mayumi OBARA Shuji ANDO Naoto ITO Makoto SUGIYAMA Hiroshi SATO Hiroshi FUKUSHIMA Hiroaki KARIWA Ikuo TAKASHIMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1010260371, (Released:2010-11-02)

被引用文献数

22 25

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Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis in humans. Rodent species which are potential hosts for TBEV are widely distributed in various regions in Japan. In this study, we carried out large-scale epizootiological surveys in rodents from various areas of Japan. A total of 931 rodent and insectivore sera were collected from field surveys. Seropositive rodents against TBEV were found in Shimane Prefecture in Honshu, and in several areas of Hokkaido Prefecture. These results emphasize the need for further epizootiological and epidemiological research of TBEV and preventive measures for emerging tick-borne encephalitis in Japan.

著者

佐久間 敬 Hiroshi SAKUMA

出版者

創価女子短期大学紀要委員会

雑誌

創価女子短期大学紀要

巻号頁・発行日

no.21, pp.3-12, 1997-06-01

著者

Hiroshi Koga Atsushi Yamagishi Atsushi Takayanagi Kohji Maeda Takashi Matsukubo

出版者

Tokyo Dental College, Japan

雑誌

The Bulletin of Tokyo Dental College (ISSN:00408891)

巻号頁・発行日

vol.48, no.3, pp.119-128, 2007 (Released:2007-12-05)

参考文献数

16

被引用文献数

7 9

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Fluoride dentifrice has been accepted widely for use in caries prevention and its effectiveness has been confirmed. In order to enable the use of fluoride dentifrice effectively in daily brushing, the present study was performed to examine the relationship between fluoride uptake and the amount of fluoride dentifrice used and brushing time for adults. We examined the relationship between fluoride uptake into the surface layer (4-6 μm)of enamel and the active fluoride concentration in vitro and the relationship between the amount of fluoride dentifrice (1,000ppmF) used and the fluoride concentration in oral fluid in vivo. It became clear that fluoride uptake into the enamel was increased at the concentrations of 300ppmF or more. Fluoride uptake at 300ppmF was increased for 2min and became saturated thereafter. The results of the relationship between the fluoride concentration in the oral fluid and the amount of fluoride dentifrice used indicated that the amount of dentifrice that could maintain the mean fluoride concentration at 300ppm or more for 2min was 1.0g or more. From these results, the recommended amount of fluoride dentifrice (1,000ppmF) is 1.0g or more for adults.

著者

Susumu Ohtsuka Kazuhiko Koike Dhugal Lindsay Jun Nishikawa Hiroshi Miyake Masato Kawahara Nova Mujiono Juro Hiromi Hironori Komatsu

出版者

The Plankton Society of Japan, The Japanese Association of Benthology

雑誌

Plankton and Benthos Research (ISSN:18808247)

巻号頁・発行日

vol.4, no.1, pp.1-13, 2009-02-25 (Released:2009-04-20)

参考文献数

91

被引用文献数

45 53

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Since marine medusae and ctenophores harbor a wide variety of symbionts, from protists to fish, they constitute a unique community in pelagic ecosystems. Their symbiotic relationships broadly range from simple, facultative phoresy through parasitisim to complex mutualism, although it is sometimes difficult to define these associations strictly. Phoresy and/or commensalism are found in symbionts such as pycnogonids, decapod larvae and fish juveniles. Parasitism and/or parasitoidism are common in the following symbionts: dinoflagellates, ciliates, anthozoan larvae, pedunculate barnacles, anuropid isopods, and hyperiid amphipods. Mutualism is established between ctenophores and gymnamoebae, and between rhizostome medusae and endosymbiotic dinoflagellates. More information on symbiotic apostome ciliates, anthozoan larvae and hyperiid amphipods is definitely needed for further studies in consideration of their high prevalence and serious damage they can inflict on their hosts. The present paper briefly reviews previously published data on symbionts on these gelatinous predators and introduces new information in the form of our unpublished data.

著者

Shoko Tomooka Emi Oishi Masako Asada Satoko Sakata Jun Hata Sanmei Chen Takanori Honda Kosuke Suzuki Hiroshi Watanabe Norihito Murayama Naohisa Wada Takanari Kitazono Toshiharu Ninomiya

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20220232, (Released:2022-12-24)

参考文献数

37

被引用文献数

1

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Background: The association between chronic lipopolysaccharide exposure and the development of metabolic syndrome (MetS) is unclear. In this study we examined the association between serum lipopolysaccharide-binding protein (LBP) levels, an indicator of lipopolysaccharide exposure, and the development of MetS in a general Japanese population.Methods: 1,869 community-dwelling Japanese individuals aged ≥40 years without MetS at baseline examination in 2002–2003 were followed up by repeated examination in 2007–2008. MetS was defined according to the Japanese criteria. Serum LBP levels were classified into quartiles (quartiles 1–4: 2.20–9.56, 9.57–10.78, 10.79–12.18, and 12.19–24.34 μg/mL, respectively). Odds ratios (ORs) for developing MetS were calculated using a logistic regression model.Results: At the follow-up survey, 159 participants had developed MetS. Higher serum LBP levels were associated with greater risk of developing MetS after multivariable adjustment for age, sex, smoking, drinking, and exercise habits (OR [95% confidence interval] for quartiles 1–4: 1.00 [reference], 2.92 [1.59–5.37], 3.48 [1.91–6.35], and 3.86 [2.12–7.03], respectively; P for trend <0.001). After additional adjustment for homeostasis model assessment of insulin resistance, this association was attenuated but remained significant (P for trend=0.007). On the other hand, no significant association was observed after additional adjustment for serum high-sensitivity C-reactive protein (P for trend=0.07).Conclusions: In the general Japanese population, our findings suggest that higher serum LBP levels are associated with elevated risk of developing MetS. Low-grade endotoxemia could play a role in the development of MetS through systemic chronic inflammation and insulin resistance.

著者

LUNDYSHEVA Olga TURANSKAYA Anna UMEMURA Hiroshi ZIEME Peter KOROSTELEVA Kristina

出版者

Toyo Bunko

巻号頁・発行日

2021

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Compiled by Olga Lundysheva, Anna Turanskaya, Hiroshi UmemuraEdited by Peter ZiemeManuscripts conservation by Kristina KorostelevaСоставители: О.В. Лундышева, А.А. Туранская, Х. УмэмураНаучный редактор: П. ЦимеРеставрация рукописей: К.В. Коростелева

著者

Masahiko Umei Hiroshi Akazawa Akiko Saga-Kamo Hiroki Yagi Qing Liu Ryo Matsuoka Hiroshi Kadowaki Akito Shindo Ayaka Nakashima Kosuke Yasuda Kengo Suzuki Issei Komuro

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.2, pp.83-91, 2022-02-10 (Released:2022-02-10)

参考文献数

40

被引用文献数

1

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Background:Patients with heart failure (HF) often experience gastrointestinal problems such as constipation, diarrhea, and disturbances to drug absorption. In HF, hypoperfusion and congestion cause structural and functional changes in the gut, which, in turn, lead to impaired cardiac function.Euglena gracilisZ (hereafter “Euglena”), calledMidorimushiin Japanese, is a microalga that is used as a food or nutritional supplement. It is unclear whether Euglena is beneficial for bowel habitus and cardiac function in subjects with HF.Methods and Results:We injected C57BL/6 male mice subcutaneously with isoproterenol (ISO) (20 mg/kg/day) for 7 days to examine bowel movement in HF. Euglena was orally administered to mice on anad libitum-feeding to a normal chow containing 2% dietary mixture. ISO induced a decrease in bowel movement and an increase in fecal retention in the cecum, as well as a decrease in left ventricular (LV) contraction. Euglena accelerated intestinal transit, relieved fecal retention, and prevented the alterations in gut pathology in ISO-treated mice. Euglena also suppressed ISO-induced decreases in LV contraction, although it had no significant effect on LV hypertrophy.Conclusions:The results suggested that oral administration of Euglena alleviated constipation and cardiac dysfunction in a mouse model of ISO-induced HF, and highlight the potential clinical benefit of Euglena in patients with HF in preventing constipation and contractile deterioration.

著者

Yukie Moroda Kazuhisa Tsuboki Shinsuke Satoh Katsuhiro Nakagawa Tomoo Ushio Hiroshi Kikuchi

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2022-018, (Released:2022-04-15)

被引用文献数

1

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A rapid rise of the lightning activity center in the upper part of a cloud is called a lightning bubble (LB). It remains unclear how LBs occur in thunderstorm clouds. Recently, high-spatiotemporal resolution data obtained by a phased array weather radar enabled observation of temporal changes in the three-dimensional structure of precipitation cores in a precipitation cell. To understand the mechanism by which LBs occur, we examined the relationship between the time-evolution of precipitation cores and the flash initiation points.After a precipitation core developed in an isolated thundercloud, the top height of the core reached its highest altitude and then started to descend. Meanwhile, the echo tops above the core continued to rise, which is termed an upward reflectivity pulse (URP). Over an hour, nine URPs were successively observed in the thundercloud. The average tracking period of the URPs was 3.9 minutes. Flash initiation points appeared near the highest points of the URPs and continued to rise with time. These observational results suggest that URPs cause LBs by enhancing the electric field, via the separation of graupel and ice crystals near the highest points of ascending URPs.

著者

TOCHIMOTO Eigo YOKOTA Sho NIINO Hiroshi YANASE Wataru

出版者

Meteorological Society of Japan

雑誌

気象集誌. 第2輯 (ISSN:00261165)

巻号頁・発行日

pp.2022-007, (Released:2021-10-06)

被引用文献数

1

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Ensemble forecasts with 101 members (including one ensemble mean) using ensemble Kalman filter analysis were performed to understand the atmospheric conditions favorable for the development of a meso-β-scale vortex (MBV) that caused shipwrecks as a result of sudden gusty winds in the southwestern part of the Sea of Japan on 1 September 2015. A composite analysis was performed to reveal differences in the structure of the MBV and atmospheric conditions around the MBV between the strongest eight (STRG) and weakest ten (WEAK) ensemble members, where two of the strongest ten members that developed the MBV much earlier than the other members were excluded from the analysis. The analysis shows that near-surface cyclonic horizontal shear to the northeast and the south of the MBV was stronger for STRG than for WEAK. In addition, larger low-level water vapor and its horizontal flux for STRG contribute to greater convective available potential energy to the southeast of the MBV, resulting in stronger convection around the MBV. The results of the composite analysis are also statistically supported by an ensemble-based sensitivity analysis. Differences in near-surface horizontal shear were closely related to the structure of the extratropical cyclone in which the MBV was embedded. Although the strength of the extratropical cyclone for STRG was comparable with that for WEAK, the cyclonic horizontal shear of winds in the northeastern quadrant of the extratropical cyclone was greater for STRG than for WEAK.

著者

Hiroyuki Tsutsui Shin-ichi Momomura Akira Yamashina Hiroaki Shimokawa Yasuki Kihara Yoshihiko Saito Nobuhisa Hagiwara Hiroshi Ito Masafumi Yano Kazuhiro Yamamoto Junya Ako Takayuki Inomata Yasushi Sakata Takashi Tanaka Yasushi Kawasaki on behalf of the J-SHIFT Study Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-19-0227, (Released:2019-08-08)

参考文献数

18

被引用文献数

24 49

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Background:Increased heart rate (HR) is an independent risk factor for cardiovascular outcomes in chronic heart failure (HF). Ivabradine, anIfinhibitor, improved outcomes in patients with HF and reduced ejection fraction (HFrEF) in the SHIFT study. We evaluated its efficacy and safety in Japanese HFrEF patients in a randomized, double-blind, placebo-controlled phase III study: the J-SHIFT study. The main objective was to confirm a hazard ratio of <1 in the primary composite endpoint of cardiovascular death or hospital admission for worsening HF.Methods and Results:Patients with NYHA functional class II–IV, left ventricular EF ≤35%, and resting HR ≥75 beats/min in sinus rhythm under optimal medical therapy received ivabradine (n=127) or placebo (n=127). Mean reduction in resting HR was significantly greater in the ivabradine group (15.2 vs. 6.1 beats/min, P<0.0001). However, symptomatic bradycardia did not occur. A total of 26 (20.5%) patients in the ivabradine group and 37 (29.1%) patients in the placebo group had the primary endpoint event (hazard ratio 0.67, 95% CI 0.40–1.11, P=0.1179) during median follow-up of 589 days. Mild phosphenes were reported in 8 (6.3%) patients in the ivabradine group and 4 (3.1%) patients in the placebo group (P=0.3760).Conclusions:The J-SHIFT study supported the efficacy and safety of ivabradine for Japanese HFrEF patients, in accord with the SHIFT study.

著者

Hiroshi Baba Kazumi Matsuoka 馬場 博史 松岡 和美

出版者

国立民族学博物館

雑誌

Senri Ethnological Studies = Senri Ethnological Studies (ISSN:03876004)

巻号頁・発行日

vol.101, pp.29-42, 2019-06-21

著者

Hiroaki Watanabe Hiroaki Kise Takako Toda Yosuke Kono Yohei Hasebe Masashi Yoshizawa Yuto Sunaga Tatsuya Shimizu Shigeaki Kaga Masahiro Hamasaki Satoshi Funayama Hiroyuki Morisaka Utaroh Motosugi Hiroshi Onishi

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0199, (Released:2021-05-19)

参考文献数

1

著者

Moeri Araki Kazutoshi Uehara Hiroshi Senou Hiroyuki Motomura

出版者

The Japanese Society of Systematic Zoology

雑誌

Species Diversity (ISSN:13421670)

巻号頁・発行日

vol.25, no.2, pp.163-169, 2020-08-07 (Released:2020-08-07)

参考文献数

19

被引用文献数

1

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Five specimens (41.2–47.0 mm standard length) of the Indo-Pacific species Bulbonaricus davaoensis (Herald, 1953), previously recorded from Kenya, Taiwan, the Philippines, Indonesia, Papua New Guinea, Australia, and Fiji, were collected from Okinoerabu Island, Amami Islands, Ryukyu Islands and Chichi Island, Ogasawara Islands. The specimens represent the first Japanese and northernmost (Okinoerabu Island) records of the species. A detailed description is given for the specimens and the new standard Japanese name “Shuuyajiri-chin’yojiuo” is proposed for the species. Photographs of fresh metamorphosed adult specimens, a fresh larval specimen, and live individuals of B. davaoensis are provided.