著者

小松重之 編

出版者

国書刊行会

巻号頁・発行日

1980

著者

松本 和浩 加藤 正浩 竹村 圭弘 田辺 賢二 田村 文男

出版者

一般社団法人 園芸学会

雑誌

園芸学研究 (ISSN:13472658)

巻号頁・発行日

vol.9, no.3, pp.339-344, 2010 (Released:2010-07-28)

参考文献数

21

被引用文献数

6 8

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秋季の窒素施肥量の違いがニホンナシ‘二十世紀’と‘豊水’の耐寒性と脂質含量に及ぼす影響を調査した.‘豊水’は‘二十世紀’に比べ,多肥による影響を受けやすく,施肥後,樹体内窒素の増加が著しく,耐寒性の上昇が抑制され,春季の生長も阻害された.脂質およびPC含量は‘二十世紀’に比べ‘豊水’で少なかった.両品種とも多肥処理により,脂質およびPC含量の増加が抑制され,脂質の不飽和度の上昇も抑制された.このように,窒素多肥による脂質含量や脂質不飽和度の低下が,耐寒性の低下に影響を及ぼしていると考えられた.

著者

村田 和久

出版者

社団法人 繊維学会

雑誌

繊維学会誌 (ISSN:00379875)

巻号頁・発行日

vol.66, no.5, pp.P_154-P_158, 2010-05-10 (Released:2010-06-10)

著者

清水 孝

出版者

早稲田商学同攻会

雑誌

早稲田商學 (ISSN:03873404)

巻号頁・発行日

vol.462, pp.1-47, 2022-03-15

著者

長野 哲雄

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.47, no.9, pp.843-854, 1989-09-01 (Released:2010-01-22)

参考文献数

88

被引用文献数

6 9

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The review describes about the compounds which can enhance the generation of superoxide (O2-) and hydrogen peroxide (H2O2) in the biological systems and about the novel metal complexes which can have superoxide dismutase activity in vivo. Some compounds are readily reduced by one or two electron (s) to produce their reduced forms. When these reduced forms can react with dioxygen, the compounds often have the potential to increase the production (s) of O2- and/or H2O2 in living cells. The review shows that hypervalent heteropentalenes, 3, 4-diaza-1, 6, 6 a-trithiapentalenes (TTP) and 1, 6-dioxa-6 a-thia-2, 5-diazapentalenes (HEP), are capable of this in studies with electrochemical reactions and Escherichia coli, respectively The hypervalent structures may be essential for enhancement of O2- and/or H2O2 generation in living cells. The review also shows that novel metal complexes, Fe (II) -tetrakis N, N, N'- (2-pyridylmethyl) ethylenediamine (Fe-TPEN) and Fe (III) -tris [N- (2-pyridylmethyl) -2-aminoethyl] amine (Fe-TPAA) act as potent superoxide dismutase mimics in vivo. The iron complexes appear to have the possibility of being applied therapeutically.

著者

中世城郭研究会

出版者

中世城郭研究会

巻号頁・発行日

1987

著者

伊藤 友美

出版者

Japan Society for Southeast Asian Studies

雑誌

東南アジア -歴史と文化- (ISSN:03869040)

巻号頁・発行日

vol.1997, no.26, pp.113-136, 1997-06-01 (Released:2010-02-25)

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This essay examines the religious significance of Buddhadasa Bhikkhu's (1906-1993) thoughts in contemporary Thai Buddhism. He advocated the understanding and practice of “Dhamma”, instead of the unconscious, routine practices of conventional Buddhism, to annihilate the internal sufferings. His teachings marked an epoch in Thai society.Buddhadasa's trials had historical precedings in the last century. The Thammayut Movement headed by Prince Mongkut had been critical of the ‘superstitious’ beliefs and the lack of knowledge about Buddhist philosophy since the early nineteenth century. His son and successor, Prince Patriarch Wachirayan Warorot continued this movement to promote scriptural knowledge. The authorized understandings of Buddhist doctrine had been diffused through the educational hierarchy of the centralized national sangha by the beginning of this century.Along with this expansion of Buddhist education, questions on the unnatural religious discourses like heaven and hell in the next life were often discussed with suspicion among intellectuals in 1930s. All of three viewpoints on the next life, either positive, negative or neutral, agreed that the moral order of social life in this world would suffer if the actual existence of the next world is denied. It was Buddhadasa who made a break-through on the question of morality and mysterious religious discourses by teaching “Dhamma”: the essence of Buddhism.Buddhadasa started to search for the “Dhamma” of Buddhism, instead of conventional “practical religion” of Thai Buddhism, in Thailand's national Buddhist education which had been prepared by Wachirayan. First, Buddhadasa tried to learn essential Buddhism in scriptural orthodoxy, but he came to its dead end. He found his way out in the “practice” of Dhamma through meditation practice and Zen style of everyday life. He revived meditation practice in the modern world as a means of capturing the insight necessary to extinguish internal sufferings; rather than a means of cultivating magical power as traditional meditation monks had practiced. Also, he taught to look within oneself by introducing Zen Buddhism to the Theravada Buddhists who were more concerned with merit-making practice to achieve better rebirth. Now his teachings play an active role in the mission of Buddhism to the born Buddhists of Thailand, rather than to the non-Buddhists of foreign countries.In Buddhadasa's thoughts, the “Dhamma” of Buddhism which is Buddhism for extinguishing one's internal sufferings, was essential. On the perceptual level, Buddhadasa denied earthly expectations of religious practice, such as a wish for heaven and a fear for hell, which prevented one's awareness of internal sufferings. He preached that the unnatural religious discourses about subjects like hell, the hungry ghost and even the nibbana, were all psychological phenomena within the self of individuals living in this world, whose existence was the only tangible reality for the modern intellectuals. On the practical level, he invited people to achieve emptiness of mind by staying away from attachment, either through meditation practice or in conscious everyday life. He believed that it was the practice of internal emptiness that sustained the moral order in this world, instead of behavior based on the religious reward.Buddhadasa's disciples and followers remarked that they have been attracted to Buddhadasa's teaching on practice of Dhamma, rather than his rational, demythologized interpretations of unscientific religious discourses. This suggests that the Buddhadasa's efforts to bring the internal practice of “Dhamma” to people's attention, was significant for the contemporary Thai Buddhists.

著者

原渕 保明

出版者

一般社団法人 日本耳鼻咽喉科頭頸部外科学会

雑誌

日本耳鼻咽喉科学会会報 (ISSN:00306622)

巻号頁・発行日

vol.115, no.1, pp.48-49, 2012 (Released:2012-02-14)

参考文献数

8

被引用文献数

2 2

著者

君塚 康一郎 畑 幸彦 小林 博一

出版者

中部日本整形外科災害外科学会

雑誌

中部日本整形外科災害外科学会学術集会 抄録集 第109回中部日本整形外科災害外科学会

巻号頁・発行日

pp.362, 2008 (Released:2008-10-08)

著者

福田,久美子

出版者

東京動物學會

雑誌

動物学雑誌

巻号頁・発行日

vol.91, no.4, 1982-02-25

出版者

函館財界問題研究所

巻号頁・発行日

vol.22(12), no.283, 1990-09

著者

神田辰之助 著

出版者

朝日新聞社

巻号頁・発行日

1938

著者

板垣 翔大 岡本 恭介 佐藤 和紀 三井 一希 泰山 裕 安藤 明伸 堀田 龍也

出版者

一般社団法人 日本教育工学会

雑誌

日本教育工学会論文誌 (ISSN:13498290)

巻号頁・発行日

pp.S46030, (Released:2022-07-11)

参考文献数

8

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本研究では,授業中の教育実習生に参観者が助言や励ましを送信可能なシステムを開発し,教育実習生の授業で実践利用した.授業者と指導教員へのインタビュー調査からシステムを評価した結果,授業中の助言により,その場で授業を改善するきっかけを与えられることや,送られる励ましによって安心感や心強さが生じること,また,授業中に助言等を受け取るツールとしてスマートグラスが妥当であることなどが示唆された.

著者

岡田 ゆみ

出版者

一般社団法人 日本看護研究学会

雑誌

日本看護研究学会雑誌 (ISSN:21883599)

巻号頁・発行日

vol.29, no.2, pp.2_73-2_79, 2006-06-01 (Released:2016-03-31)

参考文献数

24

被引用文献数

1

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本研究は,断酒会に通う長期断酒中のアルコール依存症者が,どのように断酒への意識を築いているのかを明らかにすることを目的とした。対象は,5年以上断酒している6人とし,参加観察と面接調査を行い質的帰納的に分析した。 分析の結果,長期断酒体験で築かれた断酒への意識には,10のサブカテゴリーを含む3つのカテゴリー『定めた決まりで酒を断つ』『断酒を絶えず誓う』『断酒によって生まれる新たな意識』が抽出された。3つのカテゴリーは,仲間や家族など周囲の存在が背景にある中で,それぞれが相互に影響し合いながら繰り返される意識であった。また,長期断酒者が『定めた決まりで酒を断つ』意識の中で,必ずしも飲酒の危機に結び付いていない不安定な感情にも,あらかめじ定めておいた行動を早くとりながら断酒生活を維持していた事については,看護職者がアルコール依存症者の断酒を理解し,必要な支援を検討する上で示唆を得たといえる。

著者

下司 晶 須川 公央 安道 健太郎 宮澤 康人 櫻井 歓 後藤 悠帆

出版者

教育思想史学会

雑誌

近代教育フォーラム (ISSN:09196560)

巻号頁・発行日

vol.29, pp.139-146, 2020 (Released:2021-09-11)

著者

Ryo Ichikawa Sosuke Masuda Junta Nakahara Mio Kobayashi Risako Yamashita Suzuka Uomoto Ohshima Kanami Erika Hara Yuko Ito Makoto Shibutani Toshinori Yoshida

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.47, no.7, pp.289-300, 2022 (Released:2022-07-01)

参考文献数

43

被引用文献数

1

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To study the effects of autophagy inducer carbamazepine (CBZ) in a high-fat diet (HFD)/streptozotocin (STZ)-related early hepatocarcinogenesis model, we determined autophagic flux by immunohistochemical analysis of autophagy marker expression in preneoplastic liver foci and compared that with the expression of the NADPH oxidase subunit. Male F344 rats were fed a basal diet or HFD and subjected to two-stage hepatocarcinogenesis; diabetes mellitus was induced via STZ administration. Several STZ-treated, HFD-fed rats were administered CBZ (a total of five doses every one or two days) at week 7 and 8. STZ-treated, HFD-fed rats decreased β cells in the islet of Langerhans and increased adipophilin-positive lipid droplets in the liver; moreover, they had a larger area of glutathione S-transferase placental form-immunopositive preneoplastic liver foci, which was associated with inhibition of autophagy and induction of the NADPH oxidase subunit, as demonstrated by increased immunohistochemical expression of an autophagosome receptor marker microtubule-associated protein light chain 3 (LC3)-binding protein p62, and of an NADPH oxidase subunit p22phox in the preneoplastic foci. An increased trend of an autophagy phagophore marker LC3 in preneoplastic foci was also detected. CBZ administration could induce autophagy and impair p22phox expression, as shown by altered expression of autophagy regulators (Atg5, Atg6, Lamp1, Lamp2, and Lc3), NADPH oxidase subunits (P22phox and P67phox), and antioxidant enzymes Gpx1 and Gpx2. These results suggest that inhibition of autophagy and induction of p22phox might contribute to HFD/STZ-related early hepatocarcinogenesis in rats; however, the effects of CBZ administration on the STZ/HFD-increased preneoplastic foci were marginal in this study.

著者

Toshinori Yoshida Mio Kobayashi Suzuka Uomoto Kanami Ohshima Emika Hara Yoshitaka Katoh Naofumi Takahashi Takanori Harada Tatsuya Usui Mohamed Elbadawy Makoto Shibutani

出版者

JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

vol.35, no.3, pp.225-235, 2022 (Released:2022-07-02)

参考文献数

66

被引用文献数

4

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The development of in vitro toxicity assessment methods using cultured cells has gained popularity for promoting animal welfare in animal experiments. Herein, we briefly discuss the current status of hepatoxicity assessment using human- and rat-derived hepatocytes; we focus on the liver organoid method, which has been extensively studied in recent years, and discuss how toxicologic pathologists can use their knowledge and experience to contribute to the development of in vitro chemical hepatotoxicity assessment methods for drugs, pesticides, and chemicals. We also propose how toxicological pathologists should assess toxicity regarding the putative distribution of undifferentiated and differentiated cells in the organoid when liver organoids are observed in hematoxylin and eosin–stained specimens. This was done while considering the usefulness and limitations of in vitro studies for toxicologic pathology assessment.

著者

Satoru Kawauchi Koichi Chida Takashi Moritake Yusuke Hamada Shogo Yoda Hideyuki Sakuma Wataro Tsuruta Yuji Matsumaru

出版者

The Japanese Society for Neuroendovascular Therapy

雑誌

Journal of Neuroendovascular Therapy (ISSN:18824072)

巻号頁・発行日

pp.oa.2022-0024, (Released:2022-07-14)

参考文献数

30

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Objective: In interventional neuroradiology (INR), the evaluation of the peak skin dose (PSD) and lens dose is important because the patient radiation dose increases in cases in which the procedure is more difficult and complex. This study evaluated the radiation doses during INR procedures using a direct measurement system.Methods: Radiation dose measurements during INR were performed in 332 patients with unruptured aneurysm (URAN), dural arteriovenous fistula (DAVF), and arteriovenous malformation (AVM). The PSD and bilateral lens doses were analyzed for each disease. The Pearson correlation test was used to determine whether the PSD and lens doses were linearly related to the reference air kerma (Ka,r).Results: In all cases, the PSD and right and left lens doses were 2.36 ± 1.28 Gy, 114.2 ± 54.6 mGy, and 189.8 ± 160.3 mGy, respectively. The PSD and lens doses of the DAVF and AVM cases were significantly higher than those of the URAN case. The Pearson correlation test revealed statistically significant positive correlations between Ka,r and PSD, Ka,r and right lens dose, and Ka,r and left lens dose.Conclusion: The characteristics of radiation dose in INR were clarified. Owing to the concern of increased radiation doses exceeding the threshold values in DAVF and AVM cases, protection from radiation is required. Simple regression analysis revealed the possibility of precisely predicting PSD using Ka,r.

著者

石井妙子著

出版者

KADOKAWA

巻号頁・発行日

2019

著者

和泉 京子 阿曽 洋子 山本 美輪

出版者

日本老年社会科学会

雑誌

老年社会科学 (ISSN:03882446)

巻号頁・発行日

vol.33, no.4, pp.538-554, 2012-01-20 (Released:2020-02-10)

参考文献数

52

被引用文献数

1

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本研究の目的は,在宅の軽度要介護認定高齢者の要介護度の推移の状況とその要因を明らかにし,介護予防対策の示唆を得ることである.2004年度に要支援と認定された939人と要介護1と認定された659人の計1,598人について分析を行った.基本属性,身体・心理・社会的項目について単変量の解析より,5年後の要介護度と有意であった項目について,多重ロジスティック回帰分析を行った.要支援者および要介護1者共に,悪化の抑制には老研式活動能力指標得点の1点あがる毎が関連し,悪化の促進には後期高齢者,排泄の失敗ありが共通して関連していた.要支援者では,主観的健康感の非健康,趣味なし,要介護1者では,過去1年間の転倒経験ありも悪化の促進に関連していた. 軽度要介護認定高齢者に対しては,排泄の失敗の予防・支援,要支援者へは,趣味をもち活動することへの支援,要介護1者へは転倒予防の支援が介護予防につながると考えられる.