著者
中野 茉莉恵 有馬 正貴 長田 洋資 桜井 研三 升森 智香子 水野 将徳 都築 慶光 小野 裕國 後藤 建次郎 近田 正英 麻生 健太郎
出版者
特定非営利活動法人 日本小児循環器学会
雑誌
第51回日本小児循環器学会総会・学術集会
巻号頁・発行日
2015-04-21

【緒言】単心室症例のFontan術後にhepatic factorの偏在が側副血行路を生むことが報告され、長期予後への影響が示唆されている。肝静脈血を左右の肺動脈に灌流させる必要があるが、Fontan手術施行例では肝静脈と肺動脈を繋ぐルートの作成に苦慮する場合も多い。今回、Total cavopulmonary shunt (TCPS)術後に肝静脈-肺動脈ルート作成に難渋した心房内臓錯位症例に対して肝静脈-半奇静脈吻合を行い、良好なFontan循環を確立した症例を経験したので報告する。【症例】2歳10ヶ月女児。在胎39週5日、2896gで出生。胎児期より心房内臓錯位を指摘されており、出生後、左側相同、両大血管右室起始、肺動脈狭窄、卵円孔開存、下大静脈欠損半奇静脈結合と診断した。心房は左心房が右前方、右心房が左後方の関係にあり、肝静脈は椎体の左側を走行し右心房に開口していた。生後7ヶ月時に肺動脈絞扼術、心房中隔作成術を施行した。1歳1ヶ月時にTCPSを施行、左上大静脈と左肺動脈を吻合した。2歳4か月時、Total cavopulmonary connection(TCPC)の方針となり、心外導管のルーティングについて検討した。肝静脈が椎体の左側にあるため、導管を右側に通して作成すると椎骨や心室によりルートが圧迫される可能性が考えられた。一方で、左側に作成すると、ルートが長く屈曲することやTCPS吻合部近辺の肺動脈形成が必要となると予想され、どちらの術式を選択しても導管狭窄やhepatic factorの分布に偏りが生じる可能性があったため、肝静脈-半奇静脈吻合を選択した。術後1ヶ月時に施行した心臓カテーテル検査では、肝静脈圧 11 mmHg, 半奇静脈圧 9 mmHg, 肺動脈圧 8 mmHgで、肺動静脈瘻の発生はなく良好なFontan循環を維持していた。【結語】下大静脈欠損を伴う左側相同に対して肝静脈-半奇静脈吻合を行い、その後も良好なFontan循環を確認した。肝静脈-半奇静脈吻合は、下大静脈欠損の症例に対する右心バイパスの有効な吻合方法である。
著者
亀井 敬泰 森下 真莉子
出版者
日本DDS学会
雑誌
Drug Delivery System (ISSN:09135006)
巻号頁・発行日
vol.25, no.4, pp.392-402, 2010 (Released:2010-11-05)
参考文献数
23

蛋白質やペプチドなどのバイオ薬物は,消化管粘膜における透過性の低さや不安定性の問題から注射剤による投与方法に制限されている.そこで筆者らは,cell-penetrating peptides(CPPs)と総称される細胞膜透過ペプチドを利用し,これらバイオ薬物の経口製剤化の実現に向けた研究を行っている.本稿では,まずCPPsを利用した近年のDDS研究動向をアップデートし,その後,蛋白質・ペプチドの消化管吸収改善におけるCPPsの応用性について筆者らの検討結果を紹介する.さらに,鼻粘膜吸収への応用性や吸収改善メカニズムについて展開し,バイオ薬物の非侵襲的投与経路におけるバイオアベイラビリティ改善ツールとしてのCPPsの有用性について示したい.
著者
金森 史枝 蛭田 秀一 KANAMORI Nobue HIRUTA Shuichi
出版者
名古屋大学総合保健体育科学センター
雑誌
総合保健体育科学 (ISSN:02895412)
巻号頁・発行日
vol.43, no.1, pp.9-23, 2020-05-29

The purpose of the study was to clarify what kind of impacts athletic club activities in university days have on job hunting and early stage career development around the 3rd year of employment through qualitative analysis, laying the concept of proactive as an analysis framework. The study interviewed Mr. A in the 3rd year of employment who belonged to an athletic club in his university days and started working after graduating from the first stage of the doctoral program. The interview revealed that Mr. A first found significance in having aspiration from his successful experience of getting into the college he had wanted to go after preparing for the entrance examination after failure in his first trial. So, he joined a triathlon club, which is one of athletic clubs, and proactively addressed organizational reform of the club and formed an organization which had not been established yet. Next, he worked on job hunting at his own responsibility and selected and joined a company in which he can utilize his specialized knowledge. After joining the company, he was assigned to the desired department where his strengths such as aggressiveness and leadership were highly evaluated in character evaluation. Furthermore, he is participating in corporate sports activities, deepening friendship with colleagues, and is positively involved in social contribution activities of the company. In this way, he is now living a fulfilling working life in the 3rd year of employment. As mentioned above, Mr. A has been selecting his behavior without shifting his principle “proactively behaving” and has been able to concretely demonstrate “proactive behavior”, that is, behavior by an individual of being actively engaged with an organization. Therefore, the hypothesis “students who are proactively participating in athletic club activities in university days enrich their university lives and aggressively conduct proactive behavior after starting working” has been validated. In addition, this study has proposed that the value of extracurricular activities in universities such as athletic clubs does not lie in belonging to an organization and instead it is necessary for a student to establish a self-sustained individual who has withdrawn from a “hierarchical system” in their voluntary activities. Studies of the impact of studying and other lives in universities on proactive behavior after starting working are meaningful, since almost no concrete or individual verification has been made on the theme because the theme began to gather attention recent years and few studies have been accumulated. However, this study is just one example, and a remaining future challenge is to proceed with the study focusing on various types of students. While various reforms have been promoted on university education, nothing is more important than proactive practices by students in formal curriculums and extracurricular activities in universities.
著者
芋生 憲司 森嶋 博 瀬尾 康久 澤田 達也
出版者
The Japanese Society of Agricultural Machinery and Food Engineers
雑誌
農業機械学会誌 (ISSN:02852543)
巻号頁・発行日
vol.55, no.1, pp.67-74, 1993 (Released:2010-04-30)
参考文献数
10

果実の品質を非破壊で迅速に評価する方法の一つとして, 果実を平板上に落下させた際に受ける衝撃荷重に関する研究を行った。果実の質量, 速度および力学的物性が衝撃荷重に及ぼす影響を理論的に示し, 果実硬度を示すパラメータの計算方法を提案した。この値は衝撃荷重と果実の質量から計算され, 衝突速度を特定する必要はない。実験は加様々な熟度のキウイフルーツを用いて行い, 衝撃荷重を測定, 解析すると同時に非破壊果実硬度, 糖度および酸度を測定し, 衝撃荷重から求めた硬さ指数とこれらの測定値の関係を示した。
著者
平子 紘平 森崎 裕磨 藤生 慎 高山 純一 柳原 清子 西野 辰哉 寒河江 雅彦
出版者
公益社団法人 土木学会
雑誌
土木学会論文集F6(安全問題) (ISSN:21856621)
巻号頁・発行日
vol.74, no.2, pp.I_41-I_51, 2018 (Released:2019-02-19)
参考文献数
18

東北地方太平洋沖地震において,高齢者や障がい者の被害も甚大であったことから,避難行動要支援者の名簿作成が各自治体に義務付けられた.一方,熊本地震において,庁舎の被災等により,名簿が活用できない事例が発生し,平時より避難行動要支援者の精緻な支援計画策定が重要視されている.本研究ではArc GISのNetwork Analystツールの到達圏解析を用い,道路ネットワークを考慮し,避難行動要支援者の避難施設へ到達可能性の検証を行った.本研究では,我が国における超高齢化に伴い,人数が莫大に増加している後期高齢者に着目し,中でも特に避難にケアを必要とする自宅に居住する要介護認定者を分析対象者とした.到達圏解析の結果,要介護認定者の避難時の実態と何人の要支援者が避難所まで到達できない可能性を持つのか,詳細な把握を行うことが可能となった.
著者
角森 唯子 東中 竜一郎 高橋 哲朗 稲葉 通将
出版者
一般社団法人 人工知能学会
雑誌
人工知能学会論文誌 (ISSN:13460714)
巻号頁・発行日
vol.35, no.1, pp.DSI-G_1-10, 2020-01-01 (Released:2020-01-01)
参考文献数
26
被引用文献数
1

The task of detecting dialogue breakdown, the aim of which is to detect whether a system utterance causes dialogue breakdown in a given dialogue context, has been actively researched in recent years. However, currently, it is not clear which evaluation metrics should be used to evaluate dialogue breakdown detectors, hindering progress in dialogue breakdown detection. In this paper, we propose finding appropriate metrics for evaluating the detectors in dialogue breakdown detection challenge 3. In our approach, we first enumerate possible evaluation metrics and then rank them on the basis of system ranking stability and discriminative power. By using the submitted runs (results of dialogue breakdown detection of participants) of dialogue breakdown detection challenge 3, we experimentally found that RSNOD(NB,PB,B) is an appropriate metric for dialogue breakdown detection in dialogue breakdown detection challenge 3 for English and Japanese, although NMD(NB,PB,B) and MSE(NB,PB,B) were found appropriate specifically for English and Japanese, respectively.
著者
森 秀雄
出版者
大阪教育大学附属高等学校池田校舎
雑誌
研究紀要
巻号頁・発行日
no.44, pp.39-45, 2011-11-18

忘れられた橋田邦彦という一生理学者・政治家・教育者の著書『行の科学』を読み解くことにより、道元の主著『正法眼蔵』が、橋田の科学思想にどのように影響を与えたかを解明した。結論としては、橋田は『正法眼蔵』の一部に、歪めたとはいえないとしても極めて独創的な解釈を施し、それに独自の価値観を付与して、自らの科学思想に取り込み消化したと言えよう。
著者
森 みどり 中易 秀敏 三好 哲也
出版者
一般社団法人 日本機械学会
雑誌
日本機械学会論文集C編 (ISSN:18848354)
巻号頁・発行日
vol.79, no.803, pp.2408-2423, 2013 (Released:2013-07-25)
参考文献数
21
被引用文献数
1 1

In order to keep a highly safe and reliable system of car driving, it is important that the system would be considered as a man-machine system including not only the feature of vehicle movement but also human perception, cognition, and motion of a driver. In this paper, it is examined to clarify the relation between feature of eye movements and driving behavior in conventional and unconventional situation by the experiments using the driving simulator and the eye tracking system. The measurements of time histories of eye movements were performed in the situation of different traffic regulation by the simulator. It is recognized in both turns that typical patterns of eye movements in horizontal axis appeared between the start and end of the turns. It is found from the time histories of eye movements by synchronizing that of vehicle data that the appearances of fixations were distributed uniformly on the trajectories of vehicle by trained drivers from the start of turning to the end, while the appearance of fixation by untrained drivers are concentrated in the beginning of turning or the end. These facts mean that the untrained driver did not receive visual information during the operation of turning, therefore the trajectories of vehicle by untrained driver showed the overshooting in the right turn and undershooting in the left turn.
著者
梅干野 成央 土本 俊和 小森 裕介
出版者
日本建築学会
雑誌
日本建築学会計画系論文集 (ISSN:13404210)
巻号頁・発行日
vol.76, no.659, pp.211-220, 2011-01-30 (Released:2011-03-07)
参考文献数
28
被引用文献数
4 4

This paper traces some links of the development process of mountain huts through the example of the mountain huts scattered along Weston's trail on Mt. Yari in the Japan Alps. By the analysis of the mountain huts and the land on which they were built, the development process of the mountain huts was classified into four types. And the mountain huts were built by using the sites and the huts of the occupants (i.e. woodsmen and huntsmen, etc.) and by taking advantage of their knowledge and expertise of both the sites and huts.
著者
丸井 淳己 則 のぞみ 榊 剛史 1 森純 一郎 Marui 1 Junki Nori 2 Nozomi Sakaki 1 3 Takeshi Mori 1 Junichiro
雑誌
SIG-KBS = SIG-KBS
巻号頁・発行日
vol.B4, no.01, pp.51-56, 2014-07-24

It is now common to have a conversation with others on social media. Many research have been taken to see the community structure on social media, but there are few studies that apply link-based community (link community) detection on a large social network. Link community detection allows users to belong to more than one community. We improve the method of existing link community detection of Ahn et al., which extracts many small communities. We evaluate existing and proposing methods by network indexes, and we characterize link communities from users' biographies. We found that link communities sharing users have similar characteristics from biographies.