著者

Fumio Terasaki Arata Azuma Toshihisa Anzai Nobukazu Ishizaka Yoshio Ishida Mitsuaki Isobe Takayuki Inomata Hatsue Ishibashi-Ueda Yoshinobu Eishi Masafumi Kitakaze Kengo Kusano Yasushi Sakata Noriharu Shijubo Akihito Tsuchida Hiroyuki Tsutsui Takatomo Nakajima Satoshi Nakatani Taiko Horii Yoshikazu Yazaki Etsuro Yamaguchi Tetsuo Yamaguchi Tomomi Ide Hideo Okamura Yasuchika Kato Masahiko Goya Mamoru Sakakibara Kyoko Soejima Toshiyuki Nagai Hiroshi Nakamura Takashi Noda Takuya Hasegawa Hideaki Morita Tohru Ohe Yasuki Kihara Yoshihiko Saito Yukihiko Sugiyama Shin-ichiro Morimoto Akira Yamashina on behalf of the Japanese Circulation Society Joint Working Group

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.11, pp.2329-2388, 2019-10-25 (Released:2019-10-25)

参考文献数

355

被引用文献数

95 243

著者

Kwang Whoi Kim Soon-Yeong Chung Dohan Kim

出版者

Research Institute forMathematical Sciences

雑誌

Publications of the Research Institute for Mathematical Sciences (ISSN:00345318)

巻号頁・発行日

vol.29, no.2, pp.289-300, 1993 (Released:2009-01-22)

参考文献数

18

被引用文献数

34

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We show that if a C∞-solution u(x, t) of heat equation in R+n+1 does not increase faster than exp[ε(\frac{1}{t}+|x|)] then its boundary value determines a unique Fourier hyperfunction. Also, we prove the decomposition theorem for the Fourier hyper functions. These results generalize the theorems of T. Kawai and T. Matsuzawa for Fourier hyperfunctions and solve a question given by A. Kaneko.

著者

Makoto Watanabe Kazutaka Aonuma Toyoaki Murohara Yasuo Okumura Takeshi Morimoto Sadanori Okada Sunao Nakamura Shiro Uemura Koichiro Kuwahara Tadateru Takayama Naofumi Doi Tamio Nakajima Manabu Horii Kenichi Ishigami Kazumiki Nomoto Daisuke Abe Koji Oiwa Kentaro Tanaka Terumasa Koyama Akira Sato Tomoya Ueda Tsunenari Soeda Yoshihiko Saito PREVENT CINC-J Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0869, (Released:2022-04-22)

参考文献数

37

被引用文献数

2

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Background: Previous studies have reported that high-dose strong statin therapy reduces the incidence of contrast-induced nephropathy (CIN) in statin naïve patients; however, the efficacy of high-dose strong statins for preventing CIN in real-world clinical practice remains unclear. The aim of this study was to evaluate the efficacy of strong statin therapy in addition to fluid hydration for preventing CIN after cardiovascular catheterization.Methods and Results: This prospective, multicenter, randomized controlled trial included 420 patients with chronic kidney disease who underwent cardiovascular catheterization. They were assigned to receive high-dose pitavastatin (4 mg/day × 4 days) on the day before and of the procedure and 2 days after the procedure (Statin group, n=213) or no pitavastatin (Control group, n=207). Isotonic saline hydration combined with a single bolus of sodium bicarbonate (20 mEq) was scheduled for administration to all patients. In the control group, statin therapy was continued at the same dose as that before randomization. CIN was defined as a ≥0.5 mg/dL increase in serum creatinine or ≥25% above baseline at 48 h after contrast exposure. Before randomization, 83% of study participants were receiving statin treatment. The statin group had a higher incidence of CIN than the control group (3.0% vs. 0%, P=0.01). The 12-month rate of major adverse cardiovascular events was similar between the 2 groups.Conclusions: High-dose pitavastatin increases the incidence of CIN in this study population.

著者

Miho Nishitani-Yokoyama Katsumi Miyauchi Kazunori Shimada Takayuki Yokoyama Shohei Ouchi Tatsuro Aikawa Mitsuhiro Kunimoto Miki Yamada Akio Honzawa Shinya Okazaki Hiroyuki Daida

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.83, no.1, pp.101-109, 2018-12-25 (Released:2018-12-25)

参考文献数

23

被引用文献数

1 13

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Background:Cardiac rehabilitation (CR) is an established multidisciplinary secondary preventive program. We investigated the effects of CR involving intensive physical activity (PA) on coronary plaque volume and components in patients with acute coronary syndrome (ACS).Methods and Results:We enrolled 32 consecutive patients with ACS in early phase II CR and randomly assigned them to an intensive CR group (n=18; CR participation ≥twice/week, daily PA ≥9,000 steps) or a standard CR group (n=14; CR participation ≥once/2weeks, daily PA ≥6,000 steps). Serial integrated backscatter intravascular ultrasound was performed for non-culprit lesions at baseline and after 8 months. Baseline clinical data were identical between the 2 groups. Unexpectedly, CR participation and PA did not differ significantly between the 2 groups, and there was no significant difference in plaque volume (PV) or components between the 2 groups. Subsequently, we classified the patients into 2 groups according to median PA (7,000 steps). There were significant differences in percent change of PV and of lipid volume between these 2 groups. In addition, these changes were negatively and independently correlated with PA.Conclusions:No significant difference was observed in PV or components between the intensive CR and the standard CR groups. Intensive PA, however, may retard coronary PV and ameliorate lipid component in patients with ACS participating in late phase II CR.

著者

In-Ho Choi 山下 雅道

出版者

一般社団法人 日本航空宇宙学会

雑誌

日本航空宇宙学会誌 (ISSN:00214663)

巻号頁・発行日

vol.47, no.551, pp.287-294, 1999-12-05 (Released:2019-04-09)

参考文献数

37

被引用文献数

1

著者

Yasuaki Takeji Tomohiko Taniguchi Takeshi Morimoto Shinichi Shirai Takeshi Kitai Hiroyuki Tabata Kazuki Kitano Nobuhisa Ono Ryosuke Murai Kohei Osakada Koichiro Murata Masanao Nakai Hiroshi Tsuneyoshi Tomohisa Tada Masashi Amano Hiroki Shiomi Hirotoshi Watanabe Yusuke Yoshikawa Ko Yamamoto Mamoru Toyofuku Shojiro Tatsushima Norino Kanamori Makoto Miyake Hiroyuki Nakayama Kazuya Nagao Masayasu Izuhara Kenji Nakatsuma Moriaki Inoko Takanari Fujita Masahiro Kimura Mitsuru Ishii Shunsuke Usami Kenichiro Sawada Fumiko Nakazeki Marie Okabayashi Manabu Shirotani Yasutaka Inuzuka Tatsuhiko Komiya Kenji Minatoya Takeshi Kimura on behalf of the CURRENT AS Registry-2 Investigators

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-1062, (Released:2022-04-19)

参考文献数

29

被引用文献数

2

---

Background: There is scarce data evaluating the current practice pattern and clinical outcomes for patients with severe aortic stenosis (AS), including both those who underwent surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) and those who were managed conservatively in the TAVI era.Methods and Results: The Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis (CURRENT AS) Registry-2 is a prospective, physician-initiated, multicenter registry enrolling consecutive patients who were diagnosed with severe AS between April 2018 and December 2020 among 21 centers in Japan. The rationale for the prospective enrollment was to standardize the assessment of symptomatic status, echocardiographic evaluation, and other recommended diagnostic examinations such as computed tomography and measurement of B-type natriuretic peptide. Moreover, the schedule of clinical and echocardiographic follow up was prospectively defined and strongly recommended for patients who were managed conservatively. The entire study population consisted of 3,394 patients (mean age: 81.6 years and women: 60%). Etiology of AS was degenerative in 90% of patients. AS-related symptoms were present in 60% of patients; these were most often heart failure symptoms. The prevalence of high- and low-gradient AS was 58% and 42%, respectively, with classical and paradoxical low-flow low-gradient AS in 4.5% and 6.7%, respectively.Conclusions: The CURRENT AS Registry-2 might be large and meticulous enough to determine the appropriate timing of intervention for patients with severe AS in contemporary clinical practice.

著者

Hans-Joachim Kornadt

出版者

公益社団法人 日本心理学会

雑誌

心理学研究 (ISSN:00215236)

巻号頁・発行日

vol.56, no.1, pp.52-56, 1985-04-30 (Released:2010-07-16)

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In this survey of the development of German psychology, the following topics are addressed: (1) the historical development of psychology in West Germany (the pre-World War II period, emigration of a number of prominent German psychologists during the 1930's, the academic vacuum following World War II, re-establishment in the 1960's), (2) contemporary German psychology (the university system, expansion of departments of psychology, increase in the number of students majoring in psychology, establishment of extrauniversity institutes for psychological research), (3) the contributions of contemporary German psychologists (increasing responsibilities to diverse areas of German society, contacts and cooperation at the international level). The article concludes by outlining plans for a cross-cultural study of “aggression”. Hope is expressed for a continuing dialogue between West German and Japanese psychologists.

著者

ダニエル-ディフォー 著

出版者

刊

巻号頁・発行日

1857

著者

Chih-Chien Chang Shu-Chih Yang Stephen G. Penny

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.18, pp.33-40, 2022 (Released:2022-03-18)

参考文献数

32

被引用文献数

2

---

A regional hybrid gain data assimilation (HGDA) system is newly developed using Weather Research and Forecasting model (WRF). The WRF-HGDA augments an ensemble-based Kalman filter (WRF-LETKF) with information from the variational analysis system (WRF-3DVAR) by combining their gain matrices. The performance of WRF-HGDA is evaluated by assimilating the GNSS radio occultation (RO) observations from the FORMOSAT-3/COSMIC (FS3/C) and the FORMOSAT-7/COSMIC2 (FS7/C2) under an Observing System Simulation Experiment (OSSE) framework. The results demonstrate that the variational correction improves the WRF-LETKF, with the equal-weighted WRF-HGDA outperforming its component DA systems in the moisture and wind fields when only conventional observations are assimilated. Assimilating additional RO data from FS7/C2 further improves the WRF-LETKF and WRF-HGDA systems. Although the variational correction for the mid-level temperature causes degradation in the WRF-HGDA analysis, this can be alleviated by adjusting the combination weight to include more flow-dependent information in WRF-HGDA at these levels. Further tuning of the static background error covariance used in WRF-3DVAR also brings some improvement in the WRF-HGDA wind analysis. Our results imply that a well-tuned variational system is critical for the accuracy of the regional HGDA analysis.

著者

Ju-Young Shin Kyu Rang Kim Yong Hee Lee

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

vol.18, pp.41-46, 2022 (Released:2022-03-18)

参考文献数

28

---

Determining the thresholds for risk assessment is critical for the successful implementation of thermal health warning systems. A risk assessment methodology with multiple thresholds must be developed to provide detailed warning information to the public and decision makers. This study developed a new methodology to identify multiple thresholds for different risk levels for heat or cold wave events by considering simultaneously impact on public health. A new objective function was designed to optimize segmented Poisson regression, which relates public health to temperature indicators. Thresholds were identified based on the values of the objective functions for all threshold candidates. A case study in identifying thresholds for cold and heat wave events in Seoul, South Korea, from 2014 to 2018, was conducted to evaluate the appropriateness of the proposed methodology. Daily minimum or maximum air temperature, mortality, and morbidity data were used for threshold identification and evaluation. The proposed methodology can successfully identify multiple thresholds to simultaneously represent different risk levels. These thresholds show comparable performance to those using the relative frequency approach.

著者

Kana Watanabe-Toma Jin Murata Tetsuo Ohi-Toma

出版者

The Japanese Society for Plant Systematics

雑誌

Acta Phytotaxonomica et Geobotanica (ISSN:13467565)

巻号頁・発行日

vol.72, no.3, pp.281-287, 2021-10-31 (Released:2021-11-27)

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A new variety, Aristolochia kaempferi Willd. var. laevipes Watan.-Toma & Ohi-Toma (Aristolochiaceae), is described. The variety is distinguished from var. kaempferi by having glabrous pedicels. This new variety is disjunctly distributed in the Ise-Shima region of the Kii Peninsula and the northeastern part of the Owari region of central Honshu, Japan. Moreover, we newly confirmed the presence of A. kaempferi var. kaempferi in the central part of the Kii Peninsula and the Owari region based on flowering individuals in natural populations and in cultivation. Aristolochia kaempferi var. kaempferi and A. tanzawana were in proximity with A. kaempferi var. laevipes in the Owari region.

著者

Yuya Matsuda Shunsaku Nakagawa Ikuko Yano Satohiro Masuda Satoshi Imai Atsushi Yonezawa Takashi Yamamoto Mitsuhiro Sugimoto Masahiro Tsuda Tetsunori Tsuzuki Tomohiro Omura Takayuki Nakagawa Toyofumi Fengshi Chen-Yoshikawa Miki Nagao Hiroshi Date Kazuo Matsubara

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.4, pp.397-402, 2022-04-01 (Released:2022-04-01)

参考文献数

24

被引用文献数

3

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Invasive Aspergillus infection is a major factor for poor prognosis in patients receiving lung transplantation (LT). An antifungal agent, itraconazole (ITCZ), that has antimicrobial activity against Aspergillus species, is used as a prophylactic agent against Aspergillus infection after LT. ITCZ and its metabolite, hydroxyitraconazole (OH-ITCZ), potently inhibit CYP3A and P-glycoprotein that metabolize or excrete calcineurin inhibitors (CNIs), which are the first-line immunosuppressants used after LT; thus, concomitant use of ITCZ and CNIs could induce an increase in the blood concentration of CNIs. However, no criteria for dose reduction of CNIs upon concomitant use with ITCZ in LT recipients have been defined. In this study, the effect of ITCZ and OH-ITCZ on the blood concentrations of two CNIs, tacrolimus and cyclosporine, after LT were retrospectively evaluated. A total of 39 patients who received LT were evaluated. Effects of ITCZ and OH-ITCZ on the concentration/dosage (C/D) ratio of tacrolimus and cyclosporine were analyzed using linear mixed-effects models. The plasma concentrations of OH-ITCZ were about 2.5-fold higher than those of ITCZ. Moreover, there was a significant correlation between the plasma concentrations of ITCZ and OH-ITCZ. Based on parameters obtained in the linear regression analysis, the C/D ratios of cyclosporine and tacrolimus increase by an average of 2.25- and 2.70-fold, respectively, when the total plasma concentration of ITCZ plus OH-ITCZ is 1000 ng/mL. In conclusion, the plasma levels of ITCZ and OH-ITCZ could be key factors in drawing up the criterion for dose reduction of CNIs.

著者

edited by Reuven Amitai-Preiss and David O. Morgan

出版者

Brill

巻号頁・発行日

1999

著者

Toru SATO Koichi OHNO Takashi TAMAMOTO Mariko OISHI Hideyuki KANEMOTO Kenjiro FUKUSHIMA Yuko GOTO-KOSHINO Masashi TAKAHASHI Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.1, pp.35-40, 2017 (Released:2017-01-20)

参考文献数

21

被引用文献数

26 37

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Canine pancreatitis is a relatively common disorder, and its mortality rate remains high. However, prognostic factors for pancreatitis based on evidence are limited. Moreover, the relationship between changes in C-reactive protein (CRP) concentration—an important prognostic factor for human patients with acute pancreatitis—and the prognosis of dogs with pancreatitis has not been widely studied. Therefore, we examined prognostic factors for canine pancreatitis during the first medical examination and evaluated the usefulness of serial CRP measurements during hospitalization. Sixty-five dogs met the inclusion criteria, including 22 that were hospitalized and treated. In Study 1, a multivariate analysis revealed that three factors— decreased platelet count and a marked (greater than 1,000 µg/l) elevation of specific canine pancreatic lipase (Spec cPL) concentration at the first medical examination, as well as elevated blood urea nitrogen (BUN) and/or creatinine (CRE) level—were significantly different between the survivors and nonsurvivors. Moreover, CRP concentrations on the third and fourth days were significantly different between the two groups in Study 2. An evaluation of the decreased platelet count, remarkable elevation of Spec cPL concentration at the first medical examination, elevation of BUN and/or CRE as well as serial CRP concentration measurements may be useful for predicting the prognosis of canine pancreatitis.

著者

蔡 雅芸 Ya-Yun TSAI

出版者

東北大学文学部日本語学科

雑誌

東北大学文学部日本語学科論集 (ISSN:09174036)

巻号頁・発行日

no.6, pp.35-46, 1996-09-30

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「これ、面白くない?」という疑問文を文末上昇の音調で発話すると、発話時の場面によっては、話者自身の持っている意見に対して聞き手に同意を求める同意要求的疑問文になる。本来なら、このような同意要求的疑問文の音調は、アクセント核を保ちつつ文末のみが上昇する音調であるが、最近は新種の音調の出現も指摘されている。本稿はこの音調について、東京の若者の発話のピッチ曲線によるパターンの確認と分類を行い、更にその機能の考察を試みたものである。

著者

柏木 信一 カシワギ シンイチ Shin-ichi Kashiwagi

出版者

広島修道大学ひろしま未来共創センター

雑誌

修道商学 = Papers of the Research Society of Commerce and Economics (ISSN:03875083)

巻号頁・発行日

vol.55, no.2, pp.175-198, 2015-02

著者

Ya-Ping Li Jie-Wen Cai Li-Juan Liao Han Ding Xun-Jie Cao Guo-Dong Zhu Xu-Guang Guo

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2021.406, (Released:2021-11-30)

参考文献数

21

被引用文献数

4

---

Based on previous studies, we found that Bacillus Calmette–Guérin(BCG) vaccination may have a role in preventing SARS-CoV-2 infection. Thus, we conducted this meta-analysis to investigate this protective effect. We searched in Embase, PubMed, Web of Science, Cochrane Library, BioRxiv, and MedRxiv databases for studies that evaluated the relationship between BCG vaccination and SARS-CoV-2 infection or COVID-19 disease. The quality of all included studies was assessed through the Risk of Bias in Non-randomized Studies - of Interventions and the Agency for Healthcare Research and Quality. Review Manager (Version 5.3) was used for conducting all data analyses. A total of 8 studies were ultimately included in our meta-analysis. Our primary analysis found significantly lower SARS-CoV-2 infection rate in the BCG vaccination group compared to the control group, with a odds ratio (OR) of 0.61, (95% confidence interval (CI) 0.39 to 0.95, P = 0.03; I2 = 31%, and P = 0.21 for heterogeneity). Our study indicated that BCG vaccination can protect against SARS-CoV-2 infection. However, there is insufficient evidence that BCG vaccination can reduce the severity of COVID-19.

著者

selected from his Luzum ma la yalzam and Suct uz-zand and first rendered into English by Ameen Rihani

出版者

[Kessinger Publishing]

巻号頁・発行日

0000

著者

Ju-Young Shin Kyu Rang Kim Yong Hee Lee

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2022-007, (Released:2022-01-26)

---

Determining the thresholds for risk assessment is critical for the successful implementation of thermal health warning systems. A risk assessment methodology with multiple thresholds must be developed to provide detailed warning information to the public and decision makers. This study developed a new methodology to identify multiple thresholds for different risk levels for heat or cold wave events by considering simultaneously impact on public health. A new objective function was designed to optimize segmented Poisson regression, which relates public health to temperature indicators. Thresholds were identified based on the values of the objective functions for all threshold candidates. A case study in identifying thresholds for cold and heat wave events in Seoul, South Korea, from 2014 to 2018, was conducted to evaluate the appropriateness of the proposed methodology. Daily minimum or maximum air temperature, mortality, and morbidity data were used for threshold identification and evaluation. The proposed methodology can successfully identify multiple thresholds to simultaneously represent different risk levels. These thresholds show comparable performance to those using the relative frequency approach.

著者

Chih-Chien Chang Shu-Chih Yang Stephen G. Penny

出版者

Meteorological Society of Japan

雑誌

SOLA (ISSN:13496476)

巻号頁・発行日

pp.2022-006, (Released:2022-01-20)

被引用文献数

2

---

A regional hybrid gain data assimilation (HGDA) system is newly developed using Weather Research and Forecasting model (WRF). The WRF-HGDA augments an ensemble-based Kalman filter (WRF-LETKF) with information from the variational analysis system (WRF-3DVAR) by combining their gain matrices. The performance of WRF-HGDA is evaluated by assimilating the GNSS radio occultation (RO) observations from the FORMOSAT-3/COSMIC (FS3/C) and the FORMOSAT-7/COSMIC2 (FS7/C2) under an Observing System Simulation Experiment (OSSE) framework. The results demonstrate that the variational correction improves the WRF-LETKF, with the equal-weighted WRF-HGDA outperforming its component DA systems in the moisture and wind fields when only conventional observations are assimilated. Assimilating additional RO data from FS7/C2 further improves the WRF-LETKF and WRF-HGDA systems. Although the variational correction for the mid-level temperature causes degradation in the WRF-HGDA analysis, this can be alleviated by adjusting the combination weight to include more flow-dependent information in WRF-HGDA at these levels. Further tuning of the static background error covariance used in WRF-3DVAR also brings some improvement in the WRF-HGDA wind analysis. Our results imply that a well-tuned variational system is critical for the accuracy of the regional HGDA analysis.