著者

Kai Yoshimura Masaaki Yamamoto Tomoya Inoue Hidenori Fukuoka Keiji Iida Wataru Ogawa

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.69, no.11, pp.1335-1342, 2022 (Released:2022-11-28)

参考文献数

54

被引用文献数

1 9

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Coronavirus disease 2019 (COVID-19) is associated with endocrine disorders, but their long-term clinical course remains unclear. We here report the 15-month clinical course for an individual with multiple endocrine disorders of the pituitary gland and testis likely triggered by COVID-19. A 65-year-old man with no history of endocrinopathy was admitted for acute COVID-19 pneumonia. Although his respiratory condition improved after administration of antiviral drugs, his blood pressure dropped suddenly to a preshock level and was refractory to vasopressors. The circulating adrenocorticotropic hormone (ACTH) and cortisol concentrations were low, and secondary adrenal insufficiency was suspected. Administration of hydrocortisone rapidly ameliorated the hypotension, and the patient was discharged taking 15 mg of hydrocortisone daily. An insulin tolerance test performed 3 months later revealed impaired ACTH, cortisol, and growth hormone (GH) responses, indicative of combined hypopituitarism. The patient also manifested symptoms of hypogonadism, and a hormonal workup suggested primary hypogonadism. At 12 months after discharge, GH and ACTH responses had recovered completely and partially, respectively. After another 3 months, basal ACTH and cortisol levels had been restored to the normal range and the patient discontinued hydrocortisone replacement without exacerbation of symptoms, although his hypogonadism persisted. The patient thus developed transient GH and ACTH deficiency that lasted for more than a year as well as persistent primary hypogonadism during intensive care for COVID-19. Certain prolonged symptoms of COVID-19 might be accounted for by such hormonal disturbance.

著者

石塚 吉浩

出版者

特定非営利活動法人 日本火山学会

雑誌

火山 (ISSN:04534360)

巻号頁・発行日

vol.44, no.1, pp.23-40, 1999-03-05 (Released:2017-03-20)

参考文献数

47

被引用文献数

8

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Rishiri volcano is situated off the northern coast of Hokkaido, Japan. Based on mode of eruption, migration of main vents, petrological features of the eruptive products and new K-Ar ages, the activity of the volcano can be divided into three main stages: Early, Middle, and Late. The Early and Late stages can each be further subdivided into two stages. The Early stage (<0.2-0.04 Ma) was characterized by the formation of a stratovolcano and flank lava domes which were aligned along a 17km-long NW-SE trend. The stratovolcano consisted of thin lava flows and pyroclastics, mainly of andesite with a small amount of basalt, whereas lava domes were dacite. During the Middle stage (ca. 0.04 Ma), thick lava flows and pyroclastics erupted from central vents and formed a main stratovolcano. The products were mainly andesite, with lesser dacite. After formation of the stratovolcano (<0.04 Ma), many flank vents (15 km-long NW-SE trend) were active in different eruption types, such as plinian, strombolian, and phreatomagmatic. The rocks were mainly basalt, with subordinate andesite and rhyolite. The most recent eruptions occurred several thousands years ago, but no volcanic activity including fumaroles can be observed at present. Eruption rate increased from >0.1 to >0.4 km3 (DRE)/ky during the Early stage, and also >0.4 km3 (DRE)/ky in the Middle stage. The rate then decreased from >0.35 to >0.09 km3 (DRE)/ky in the Late stage. Estimation of magmatic temperature was made from the presence or absence of hornblende in dacites. This suggests that magmatic temperature increased from the Early to Middle stages, and then decreased in the Late stage. Temporal variations in both eruption rate and magmatic temperature suggest that the volcanic activity of Rishiri volcano can be explained by ascent and cooling of a single heat source (diapir). Based on the diapir model and dormancy of activity during recent several thousands years, it seems that the life of Rishiri volcano as an active volcano is virtually over.

著者

Masato Takase Naoki Nakaya Tomohiro Nakamura Mana Kogure Rieko Hatanaka Kumi Nakaya Ippei Chiba Ikumi Kanno Kotaro Nochioka Naho Tsuchiya Takumi Hirata Akira Narita Taku Obara Mami Ishikuro Akira Uruno Tomoko Kobayashi Eiichi N Kodama Yohei Hamanaka Masatsugu Orui Soichi Ogishima Satoshi Nagaie Nobuo Fuse Junichi Sugawara Shinichi Kuriyama Ichiro Tsuji Gen Tamiya Atsushi Hozawa Masayuki Yamamoto the ToMMo investigators

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.64425, (Released:2023-10-06)

参考文献数

42

被引用文献数

1

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Aim: The influence of family history of diabetes, probably reflecting genetic and lifestyle factors, on the association of combined genetic and lifestyle risks with diabetes is unknown. We examined these associations. Methods: This cross-sectional study included 9,681 participants in the Tohoku Medical Megabank Community-based Cohort Study. A lifestyle score, which was categorized into ideal, intermediate, and poor lifestyles, was given. Family history was obtained through a self-reported questionnaire. A polygenic risk score (PRS) was constructed in the target data (n=1,936) using publicly available genome-wide association study summary statistics from BioBank Japan. For test data (n=7,745), we evaluated PRS performance and examined the associations of combined family history and genetic and lifestyle risks with diabetes. Diabetes was defined as non-fasting blood glucose ≥ 200 mmHg, HbA1c ≥ 6.5%, and/or self-reported diabetes treatment. Results: In test data, 467 (6.0%) participants had diabetes. Compared with a low genetic risk and an ideal lifestyle without a family history, the odds ratio (OR) was 3.73 (95% confidence interval [CI], 1.92–7.00) for a lower genetic risk and a poor lifestyle without a family history. Family history was significantly associated with diabetes (OR, 3.58 [95% CI, 1.73–6.98]), even in those with a low genetic risk and an ideal lifestyle. Even among participants who had an ideal lifestyle without a family history, a high genetic risk was associated with diabetes (OR, 2.49 [95% CI, 1.65–3.85]). Adding PRS to family history and conventional lifestyle risk factors improved the prediction ability for diabetes. Conclusions: Our findings support the notion that a healthy lifestyle is important to prevent diabetes regardless of genetic risk.

著者

森下 悟至 本村 浩之

出版者

日本動物分類学会

雑誌

タクサ:日本動物分類学会誌 (ISSN:13422367)

巻号頁・発行日

vol.44, pp.58-63, 2018-02-28 (Released:2018-03-20)

参考文献数

19

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Six specimens (39.9–81.4 mm standard length) of the Round Scorpionfish Neomerinthe erostris (Alcock, 1896) (Scorpaenidae), previously recorded from the Indo-West Pacific and in the western Pacific from Taiwan to New Caledonia and the Wallis and Futuna Islands, were collected from Uchinoura Bay, Osumi Peninsula; southern Okinawa Trough; and Iriomote Island, Yaeyama Islands, southern Japan. The six specimens represent the first records of N. erostris from Japanese waters and include the northernmost records (Uchinoura Bay) for the species. The Japanese specimens are described here in detail and the new Japanese name “Yabusame-kasago” is proposed for the species.

著者

Makoto Okamoto Hiroyuki Motomura Koichi Hoshino Takashi Yanagimoto Toshiro Saruwatari

出版者

The Japanese Society of Systematic Zoology

雑誌

Species Diversity (ISSN:13421670)

巻号頁・発行日

vol.17, no.1, pp.1-5, 2012-05-25 (Released:2018-03-30)

参考文献数

21

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Two specimens (124.0-148.6mm standard length) of a scorpionfish, Idiastion pacificum Ishida and Amaoka, 1992, were collected from the central North Pacific, representing the first record of the species from this area. This finding extends the distributional range of Idiastion pacificum, which was previously known only from the Kyushu-Palau Ridge, western North Pacific. This study provides new morphological data and a color photograph of I. pacificum based on these two additional specimens, with a comparison to Idiastion kyphos Eschmeyer, 1965.

著者

[ブハーリー著] 牧野信也訳

出版者

中央公論社

巻号頁・発行日

1993

著者

広河隆一著

出版者

岩波書店

巻号頁・発行日

2002

著者

ダン・コンシャーボク ダウド・アラミー [著]

出版者

岩波書店

巻号頁・発行日

2011

著者

ヤコヴ・M・ラブキン著 菅野賢治訳

出版者

平凡社

巻号頁・発行日

2012

著者

森本 大翔 村井 源

出版者

一般社団法人 日本デジタルゲーム学会

雑誌

日本デジタルゲーム学会 年次大会 予稿集 第13回 年次大会 (ISSN:27586480)

巻号頁・発行日

pp.123-128, 2023 (Released:2023-03-30)

参考文献数

33

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従来のゲームの種々の要素に関する自動生成技術は,研究段階にとどまらず商品化などにも応用されてきている.しかし,既存の物語の続編を自動生成する試みはゲームにおいても他のメディアにおいてもほとんど行われていない.本研究では,人気のある続編の共通性や,ユーザーが前作の続き として続編を受け入れる条件などを明らかにした.具体的には,続編に評価軸を設け,選定した作品に対し評価軸が前作とどの程度合致するかを問うアンケートを行い,その結果によって続編の基準を設定し,続編と認められた作品に関して分析を行った.また,ロールプレイングゲームとシューティングゲームの続編のそれぞれの特徴を分析し,その違いを明らかにした.

著者

粕川 禮司

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.91, no.9, pp.2591-2594, 2002-09-10 (Released:2008-06-12)

参考文献数

6

著者

肥田 音市 豐田 秀造

出版者

日本細菌学会

雑誌

細菌學雜誌 (ISSN:18836925)

巻号頁・発行日

vol.1907, no.138, pp.322-329, 1907 (Released:2009-07-09)

著者

鈴木 智之

出版者

法政大学社会学部学会

雑誌

社会志林 = Hosei journal of sociology and social sciences (ISSN:13445952)

巻号頁・発行日

vol.52, no.2, pp.19-47, 2005-09

出版者

北海道大学埋蔵文化財調査センター

巻号頁・発行日

2019-03

著者

宮田 秀介 藤田 正治 堤 大三 市田 児太朗

出版者

公益社団法人 砂防学会

雑誌

砂防学会誌 (ISSN:02868385)

巻号頁・発行日

vol.66, no.5, pp.92-95, 2014-01-15 (Released:2015-11-30)

参考文献数

6

著者

居谷 滋郎

出版者

一般社団法人 色材協会

雑誌

色材協会誌 (ISSN:0010180X)

巻号頁・発行日

vol.56, no.11, pp.729-736, 1983-11-20 (Released:2012-11-20)

参考文献数

6

著者

植田 彰裕

出版者

公益社団法人 日本船舶海洋工学会

雑誌

らん:纜 (ISSN:09160981)

巻号頁・発行日

vol.46, pp.19-25, 1999-12-30 (Released:2018-02-25)

著者

黒木 直美 宮下 奈々 日野 義之 茅嶋 康太郎 藤野 善久 高田 幹夫 永田 智久 山瀧 一 櫻木 園子 菅 裕彦 森田 哲也 伊藤 昭好 森 晃爾

出版者

公益社団法人 日本産業衛生学会

雑誌

産業衛生学雑誌 (ISSN:13410725)

巻号頁・発行日

vol.51, no.5, pp.49-59, 2009 (Released:2009-10-08)

参考文献数

28

被引用文献数

2 1

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小規模事業場において良好実践を行っている事業者の産業保健ニーズに関する質的調査:黒木直美ほか.産業医科大学医学部公衆衛生学―本研究では,小規模事業場における事業者の産業保健ニーズあるいは良好実践の動機を把握することを目的とした.これまでの調査では小規模事業場における産業保健活動の遅れが報告されている.これらの知見は主に質問紙調査から得られたものである.しかし,小規模事業場には事業者の意識が直接反映されるという特徴があり,積極的に産業保健活動に取り組んでいる事業場も存在している.このような小規模事業場の良好実践例において,事業者のニーズを分析した研究はこれまでにない.産業保健に対する事業者の動機を明らかにすることは小規模事業場間に良好実践を水平展開する一助となると考えられる.そこで,我々は産業保健活動の良好実践が行われている小規模事業場10社の事業者と半構造化面接を行い,その逐語録をKJ法を用いた質的手法で分析した.その結果,事業者はもっぱら「よい会社」,「よい経営」を強く意識していることが明らかになった.「よい経営」のための要素には「人材確保」,「取引先の信用」,「社会的信用」,「社長自身の健康」という4つがあった.事業者はこれらの要素を達成するため職場の安全,従業員の健康に関する活動は当たり前であると考えていた.さらに,具体的な活動には「コストの問題」,「担当者の問題」,「時間がない」,「外部資源」という既知の制約があった.調査結果から,経営と安全衛生活動を関連づけることが小規模事業場における安全衛生活動の向上に寄与すると考えられた. (産衛誌2009; 51: 49-59)

著者

कन्हैयालाल लोढ़ा

出版者

शंकर फाउण्डेशन

巻号頁・発行日

2007

著者

Yoshiyuki MATSUMOTO Ryuta NAKAE Fumihiro MATANO Asami KUBOTA Akio MORITA Yasuo MURAI Shoji YOKOBORI

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.10, pp.259-263, 2023-12-31 (Released:2023-09-29)

参考文献数

29

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Ruptured cerebral aneurysms that occur in the anterior wall of the internal carotid artery (ICA) are known as blood blister-like aneurysms (BBAs); they have been reported to account for 0.3% to 1% of all ruptured ICA aneurysms. In this report, we describe the treatment of an unusual traumatic BBA (tBBA) with high-flow bypass using a radial artery graft, which resulted in a favorable outcome. A 59-year-old female suffered from an acute epidural hematoma, traumatic subarachnoid hemorrhage, and traumatic carotid-cavernous sinus fistula (tCCF) after being involved in a motor vehicle accident. Her angiography results showed tCCF and a tBBA on the anterior wall of the right ICA. On the fourth day after injury, we found rebleeding from the tBBA and performed an emergency high-flow bypass using a radial artery graft with lesion trapping as a curative procedure for the tCCF and tBBA. Postoperatively, right abducens nerve palsy appeared, but no other neurological symptoms were noted; the patient was thereafter transferred to a rehabilitation hospital 49 days after injury. Traumatic ICA aneurysms commonly occur close to the anterior clinoid process, form within 1 to 2 weeks of injury, and often rupture around 2 weeks after trauma. This case was considered rare as the ICA was likely injured and bleeding at the time of injury, resulting in a form of tBBA; this allowed early detection and appropriate treatment that resulted in a good outcome.