著者

Spates C. Richard 瀧本 靖子 鷲尾 幸子

出版者

一般社団法人 日本行動分析学会

雑誌

行動分析学研究 (ISSN:09138013)

巻号頁・発行日

vol.17, no.2, pp.161-173, 2003

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PTSD(心的外傷後ストレス障害)とは、生死に関わるような恐ろしい体験をした人に見られる事の多い、行動的、情動的な反応のことである。全人口のおよそ7%の人がこの障害を持つと言われている。この障害は戦争、火事、交通事故、自然災害、暴力、テロ、などから引き起こされることが多い。この発表では、PTSDにみられる行動や情動などを行動分析の視点から解釈する。行動分析学からの解釈によって、発症のメカニズム、PTSDに対する正しい理解、より優れた治療方法についての幅広い発展が期待できる。治療方法について各種の方法を比較分析したデータも紹介する。

著者

小林 哲夫 奥野 充 ミラブエノ マリア ハナ

出版者

特定非営利活動法人 日本火山学会

雑誌

火山 (ISSN:04534360)

巻号頁・発行日

vol.59, no.4, pp.299-303, 2014-12-31 (Released:2017-03-20)

著者

小川原 純子 横山 祐子 森下 勇 一條 智康 加藤 直子 山岡 昌之

出版者

一般社団法人 日本心身医学会

雑誌

心身医学 (ISSN:03850307)

巻号頁・発行日

vol.55, no.12, pp.1335-1342, 2015-12-01 (Released:2017-08-01)

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思春期には体も心も大きく変化する.身体的発達のみならず,自我同一性(identity)の確立などこの時期の正常な心の発達を知ることは,思春期のうつ病や,摂食障害などの心身症を診察する際,その病態の基本的理解として欠かすことができない.また,思春期の患者がもつ生来の言語能力や社会適応力・認知力といった各人の能力を見極めることは,患者の感じている困難感の分析に有用である.さらに思春期に至るまでの生育環境や養育者との基本的信頼関係の構築の有無などの情報は,思春期の患者の心の発達過程での問題点を推測する重要な手掛かりとなる.

著者

天野 潤 平松 優佳 早川 直彦 加藤 基浩 岡野 健 木下 春喜 岡崎 彬

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.6, pp.1199-1212, 1993-12-30 (Released:2007-03-29)

参考文献数

31

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The metabolites of rG·CSF present in the serum were investigated in rats after intravenous administration of 125I-rG·CSF at the dose of 10μg/kg, or nonlabeled-rG·CSF at the dose of 100-400μg/kg. 1. Using gel filtration on the Superose 12 column, most of the radioactivity in rat serum at 30min after administration of 125I-rG·CSF was eluted at a point corresponding to molecular weight of 19kd, this point was the same as that of intact-rG·CSF. The radioactivity was immunoreactive with anti-rG·CSF antibody and showed biological activity against NFS-60 cell lines. At 2 and 6h after administration, the radioactivity present in the serum was eluted from the column at a point corresponding to molecular weight of 46kd and 19kd. The radioactivity corresponding to 46kd showed immunoreactivity, but was biologically inactive. 2. The SDS-polyacrylamide gel electrophoresis revealed that most of the radioactivity in the serum present at 30min after administration of 125I-rG·CSF was detected at a point corresponding to intact-rG·CSF (molecular weight of 19kd). The radioactivity was also detected at a point corresponding to molecular weight of 19kd and 5kd at 2h, 19kd, 14kd and 5kd at 6h after administration. 3. The chromatofocusing using Mono-P column showed that most of the radioactivity in the serum was focused at a point corresponding to isoelectric points of 5.8 and 5.5 at 30min after administration of 125I-rG·CSF, these points were related to monosialo-rG·CSF and disialo-rG· CSF, respectively. At 2 and 6h after administration, the radioactivity showing immunoreactivity was newly found at a point corresponding to isoelectric points of 5.2 and 4.5. 4. During immunoblotting of serum samples after administration of nonlabeled-rG·CSF, the presence of a band corresponding to molecular weight of 19kd was found in all sampling times after administration. Beside the band of 19kd, only bands at a point corresponding to molecular weight of 5kd and 14kd were detected at 6h after administration. 5. Based of the fact that only an intact form of rG·CSF exists at early stage after intrave nous administration of rG·CSF, and since 2h the metabolites which have not biological activity appeared in the serum, we have concluded that an intact form mainly participate in hematologic activity of rG·CSF in vivo.

著者

高橋 浩

出版者

研究・イノベーション学会

雑誌

年次学術大会講演要旨集

巻号頁・発行日

vol.32, pp.51-54, 2017-10-28

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一般講演要旨

著者

中村 吉明

出版者

研究・イノベーション学会

雑誌

年次学術大会講演要旨集

巻号頁・発行日

vol.32, pp.46-50, 2017-10-28

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一般講演要旨

著者

加藤 基浩 丹羽 一与 天野 潤 早川 直彦 神山 博 大久保 一三 岡崎 彬

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.4, pp.481-492, 1993-09-10 (Released:2007-03-29)

参考文献数

17

被引用文献数

1

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We studied the absorption, distribution, excretion and metabolism of 125I-EPOCH after single subcutaneous administration to rats. 1. The levels of immunoreactive rad ioactivity reached the maximum at 8 to 12 hours after dosing and declined monoexponentially with a half-life ranging from 5.77 to 7.47 hours at the doses of 0.5, 1, 5 and 25μg/kg. The MRT of immunoreactive radioactivity after sc dosing ranged from 13.83 to 17.01 hours at any dose levels. F value (AUCsc/AUCiv), which ranged from 0.31 to 0.48, tend to increase in proportion to the administered dose. 2. Most of tissues showed the highest level of total radioactivity at 10 hour after dosing. The level of radioactivity in tissues were lower, than that of serum, except the thyroid gland whose level was the highest. They declined parallel with disappearence of the radioactivity in serum. The level of radioactivity in brain was extremely low. The elimination half-life of radioactivity from the injection site was calculated to be 9h and 1.97% of the dose still remained there at 48 hour. 3. Until 96h after sc administration of 125I-EPOCH at the dose of 1μg/kg, urinary excretions of total, the TCA-precipitable and the immunoreactive radioactivity were 75.89%, 0.35%, 0.05%, respectively. Fecal excretion of total radioactivity was 2.97%, until 96h after dosing. 4. Gel filtration of the plasma showed that the radioactivity of low molecular weight was iodo ion, and that related to radioactivity of high molecular weight appeared mainly as an unchanged 125I-EPOCH.

著者

加藤 基浩 天野 潤 岡野 健 平松 優佳 木下 春喜 岡崎 彬

出版者

The Japanese Society for the Study of Xenobiotics

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.6, pp.1213-1218, 1993-12-30 (Released:2007-03-29)

参考文献数

15

被引用文献数

3

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To evaluate the role of the kidney in the elimination of rG·CSF, the pharmackinetics of rG·CSF was studied in rats upon removal of one (1/2-nephrectomized rat) or of two kidneys (nephrectomized rat). Plasma concentrations of rG·CSF were measured by enzyme immunoassay method. 1. The elimination half lives of rG·CSF in nephrectomized and 1/2-nephrectomized rats, which were 4.85h and 1.llh respectively, were longer than those in sham operated rats given rG·CSF 10μg/kg intravenously. Total nephrectomy and 1/2-nephrectomy resulted in 70% and 30% reduction of total body clearance of rG·CSF in rats, respectively. 2. The result suggested that the kidney is the major elimination site of rG·CSF.

著者

加藤 基浩 丹羽 一与 天野 潤 早川 直彦 神山 博 大久保 一三 岡崎 彬

出版者

日本薬物動態学会

雑誌

薬物動態 (ISSN:09161139)

巻号頁・発行日

vol.8, no.4, pp.493-503, 1993

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We studied the absorption, distribution and excretion of radioactivity after 4 times multiple subcutaneous administrations of <SUP>125</SUP>I-EPOCH at an interval of 48 hours.<BR> 1. Plasma levels of immunoreactive radioactivity at 10h and 48h following each multiple administration did not change during the experimental period. There were no pronounced differences in pharmacokinetics between first and fourth administration.<BR> 2. The levels of radioactivity in spleen and bone marrow after multiple administration were slightly higher than those after administration of a single dose. Those in other tissues except thyroid gland, were similar to those after administration of a single dose. The remained radioactivity in the injection site at 10h after multiple administration was 33.65%, which was similar to that of single administration.<BR> 3. Until 96h after final administration of <SUP>125</SUP>I-EPOCH, urinary excretions of total. the TCA-precipitable and the immunoreactive radioactivity were 76.43%, 0.97%, 0.49%, respectively. Fecal excretion of total radioactivity was 3.83%, until 96h after final administration.

著者

天野 潤 伊川 由利子 塩川 理絵 奥谷 太一 宮山 崇 名波 雅彦 麻生 良典

出版者

日本薬物動態学会

雑誌

日本薬物動態学会年会講演要旨集

巻号頁・発行日

vol.23, pp.195, 2008

著者

稲葉 浩一

出版者

尚絅大学

雑誌

尚絅大学研究紀要. A, 人文・社会科学編 (ISSN:21875235)

巻号頁・発行日

no.47, pp.89-106, 2015-03-31

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本稿は学校教育における,児童生徒の知的関心・意欲にもとづいた学習を導く「教育方法」に関し次のように論考を展開する。まず日常生活者である子どもたちにとっての「知識」の意味を確認し,そのうえで学校教育という制度的空間において求められる<児童生徒>としての知識の探求のありかた(=規範)を考察し,そこに潜在する根本的な困難を指摘する。そしてそのオルタナティブとしての児童生徒の「探求的学習」の方法を模索する。

著者

SHUNZO TAKAGI MASAYUKI TAGAWA

出版者

THE PHYSIOLOGICAL SOCIETY OF JAPAN

雑誌

The Japanese Journal of Physiology (ISSN:0021521X)

巻号頁・発行日

vol.5, pp.122-130, 1955 (Released:2011-06-07)

参考文献数

8

被引用文献数

3 4

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The direction of winding and the regularities in form and arrangement of the intraepidermal portion of the eccrine sweat ducts were studied in horizontal skin slices.Right-handed spirals definitely prevailed over left-handed and deformed. spirals in the sweat ducts in the skin on the pad of fingers and toes of 28 Japa-nese and 3 whites regardless of sex and side of the body. The predominance of right-handed spirals was shown to hold in the other regions of the palmar and plantar skin and, though to a lesser extent, in the general body skin.The sweat ducts in the skin on the volar surface of the hand and foot were in the form of fairly regular cylindrical spirals. In a small area of the skin, their girth and pitch were fairly constant and their axes were nearly parallel to each other and, therefore, inclined toward the skin surface with an approximately uniform angle. The sweat ducts in the eponychium were shaped like straightened spirals, wound oftener right-handedly.

著者

横山 昌弘 井沢 靖和 山中 千代衛

出版者

社団法人 プラズマ・核融合学会

雑誌

核融合研究 (ISSN:04512375)

巻号頁・発行日

vol.15, no.3, pp.217-223, 1965 (Released:2011-03-04)

参考文献数

9

著者

安藤 亮一

出版者

西筑摩書房

雑誌

シャ-ロック・ホ-ムズ紀要

巻号頁・発行日

vol.9, no.1, pp.81-96, 1999-11-11

著者

松尾 量子

出版者

国際服飾学会

雑誌

国際服飾学会誌 (ISSN:09176551)

巻号頁・発行日

no.30, pp.4-12, 2006

著者

池田 博 土井 浩一郎 福田 洋一 野口 隆志 中嶋 俊哉 飯村 憲 渋谷 和雄

出版者

公益社団法人 低温工学・超電導学会 (旧 社団法人 低温工学協会)

雑誌

低温工学 (ISSN:03892441)

巻号頁・発行日

vol.39, no.8, pp.348-353, 2004 (Released:2008-03-10)

参考文献数

8

被引用文献数

3 3

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From February 2003 to January 2004, a new superconducting gravimeter with a cryocooler was installed to replace the former device at the Syowa station in Antarctica. The new gravimeter has a high sensitivity of one nano-gal and is being used to survey the earth's core in the Global Geodynamics Project. A new type of diaphragm was confirmed to well isolate the vibration from the refrigerator cold-head and effectively prevent solid air contamination. A remote monitoring system from Japan is also going to be installed.

著者

山崎 慶太 奥田 清明 阿部 隆之 内川 義則 志村 徹 小谷 誠

出版者

公益社団法人 日本磁気学会

雑誌

日本応用磁気学会誌 (ISSN:02850192)

巻号頁・発行日

vol.16, no.6, pp.769-774, 1992-12-01 (Released:2013-01-11)

参考文献数

7

被引用文献数

6 7

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This paper describes the design and the development of a prefabricated magnetically-shielded-room (PMSR) of the hexagonal type for high sensitive measurement of neuro-magnetic fields such as magnetoencephalography (MEG) mainly using SQUIDs with first and/or second-order gradiometers. This PMSR consists of prefabricated plywood panels 1.2 m wide×2.4 m high×24 mm thick. It covers a floor area of about 9 m2. The panel is sandwiched by two layers of high-μ metal sheets 1 mm thick. The shielding factor at the center of PMSR against the external magnetic field is 20 to 40 dB in the range of DC to 120 Hz. Magnetic noise inside PMSR measured by a second-order gradiometer was less than hundreds fT above 0.5 Hz excepting 50 Hz. In this case, a second order gradiometer was able to eliminate the common mode magnetic noise of about 20 Hz, which was essentially observed by a magnetometer, caused by the vibration of PMSR. These results were discussed and compared with the calculations.

著者

中井 義勝 今井 浩 柏谷 久美 吉川 真里

出版者

一般社団法人 日本心身医学会

雑誌

心身医学 (ISSN:03850307)

巻号頁・発行日

vol.41, no.4, pp.281-286, 2001-04-01 (Released:2017-08-01)

参考文献数

9

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コンピューターに取り込んだ身体像を任意に変形できる装置を用いて, 健常女性(N), 神経性大食症(BN), 神経性無食欲症むちゃ食い/排出型(AN-B)と制限型(AN-R)の身体イメージ測定を行い, Eating Disorder Inventoryとの相関を検討した.Nはやせ願望に基づいて, BNは自己像不満に基づいてウエスト理想値やヒップ理想値を細くした.一方, AN-Bはやせ願望と過食に基づいて, AN-Rはやせ願望でなく, 無力感, 成熟恐怖や感情感覚の混乱に基づいてウエスト理想値やヒップ理想値を細くした.この成績から健常人と摂食障害患者は身体イメージの評価基準が異なり, とりわけAN-Rは身体イメージが無力感, 成熟恐怖や感情感覚の混乱に基づいていることが明らかとなった.

著者

小笠原 武 Boesten Ludwig

出版者

一般社団法人 日本物理学会

雑誌

日本物理学会誌 (ISSN:00290181)

巻号頁・発行日

vol.28, no.12, pp.1041-1049, 1973-12-05 (Released:2008-04-14)

参考文献数

26

著者

五味 勝也

出版者

公益社団法人 日本農芸化学会

雑誌

化学と生物 (ISSN:0453073X)

巻号頁・発行日

vol.28, no.2, pp.91-100, 1990-02-25 (Released:2009-05-25)

参考文献数

36