著者

伊藤 貞嘉

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.96, no.1, pp.23-28, 2007 (Released:2009-12-01)

参考文献数

3

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二次性高血圧の頻度は高くないが,根治できるものがあるので見落とすことの無いようにすることが必要だ.早期に診断し,治療することが重要で,臓器障害が出現してからでは血圧を正常化させることが難しくなる.どんなに優れた降圧薬でも「no medicine」に優るものはない.ただ漫然と降圧薬を投与するのではなく,二次性高血圧の兆候を敏感に捉えてスクリーニングすることが重要である.

著者

夏原 由博 村上 真樹 青木 大輔 中山 祐一郎 前中 久行

出版者

公益社団法人 日本造園学会

雑誌

ランドスケープ研究 (ISSN:13408984)

巻号頁・発行日

vol.71, no.5, pp.565-568, 2008-03-31 (Released:2009-05-08)

参考文献数

31

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Identifying conservation units in a species and prioritizing their conservation were attempted in order to efficient conservation practice. We defined a conservation unit as a distinct populations between which individuals cannot be exchanged because of unique genetic and ecological characteristics. Conservation priority was given to conservation units that were restricted in distribution or those where habitats were not protected, because habitat loss is one of the most important factors leading to species extinction. We identified a gap between species distribution and conservation status using the land use master plan. We considered nature conservation areas, natural park areas, and protected forest areas as protected land, urbanization promotion areas as not protected, and agricultural promotion areas and private forest areas as at intermediate risk. The Japanese clouded salamander Hynobius nebulosus was used as a model species. An assessment was carried out after defining the conservation units of this species based on reported geographic variation in allozyme, mt-DNA, or morphology. The presence/absence of the species and land use regulation were recorded on a 1-km grid. The greatest numbers of records of species occurrence were in agriculture promotion areas (17.4%) and private forest areas (39.5%) with 791 records. Of the ten conservation units, the Tottori population was given at highest priority for conservation.

著者

秋吉 恵 重岡 恒彦 鳥居 慎一 牧 栄二 榎本 悟 高橋 宏正 平野 文也

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.119, no.3, pp.175-184, 2002 (Released:2002-12-24)

参考文献数

31

被引用文献数

2 3 3

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レボカバスチンは4-arylcyclohexylamine誘導体のひとつで,ベルギーのヤンセン社において合成された新規H1ブロッカーである.選択性が高く,特異的なヒスタミンH1受容体遮断作用のほかに,肥満細胞からのケミカルメディエーター遊離抑制作用や好中球·好酸球の遊走抑制作用を持つ.ヒスタミン点眼および感作動物への抗原点眼により誘発した結膜炎モデルにおいて,レボカバスチンは結膜炎症状を改善した.レボカバスチンはモルモットにおける抗原誘発結膜炎モデルの涙液中ヒスタミン量増加の抑制や,ヒスタミン点眼並びに抗原点眼による結膜炎モデルでの血管透過性亢進をレボカバスチンが抑制することが示された.また,ヒスタミンおよびサブスタンスP誘発鼻炎モデル並びに感作動物における抗原誘発鼻炎モデルにおいて,レボカバスチンは血管透過性亢進を抑制した.さらに,レボカバスチンの抗ヒスタミン作用用量と非特異的作用用量との差(特異性指数)は他の抗アレルギー薬と比べ非常に大きく,その非特異的作用としては眼瞼下垂が認められたのみであった.このような選択的,特異的な抗アレルギー作用と,局所投与経路の優位性を有するレボカバスチンは,臨床においてアレルギー性結膜炎並びに鼻炎治療薬としての有用性が期待され,国内外の臨床試験においてアレルギー性結膜炎や春季カタル,アレルギー性鼻炎の治療に有効かつ安全な薬剤であることが示されている.

著者

磯部 順子 清水 美和子 嶋 智子 木全 恵子 金谷 潤一 倉田 毅 綿引 正則

出版者

日本食品微生物学会

雑誌

日本食品微生物学会雑誌 (ISSN:13408267)

巻号頁・発行日

vol.27, no.3, pp.146-151, 2010-09-30 (Released:2010-12-13)

参考文献数

9

著者

木村 有里 眞鍋 佳嗣 浦西 友樹 千原 國宏

出版者

一般社団法人 映像情報メディア学会

雑誌

映像情報メディア学会誌 (ISSN:13426907)

巻号頁・発行日

vol.64, no.12, pp.1884-1891, 2010-12-01 (Released:2011-03-01)

参考文献数

18

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Wearing cosmetics or makeup has important implications for human. However, it is very hard for visually impaired people to apply make-up because the process of making up their face requires visual contacts. We propose a wind pressure display that shows the given position of the face. The proposed system takes a face image of the person using a camera installed in front of the person, and determines a given position such as the makeup spot in the image. Then, wind pressure provides the necessary position on the face to the person so they can effectively apply the necessary makeup. We measured two point thresholds of the wind pressure display in our experiment. Moreover, the position presentation on the face using the proposed system was also evaluated. The results of these experiments showed the proposed system could effectively present the necessary position on the face.

著者

服部 万里子

出版者

一般社団法人 日本老年歯科医学会

雑誌

老年歯科医学 (ISSN:09143866)

巻号頁・発行日

vol.26, no.2, pp.65-68, 2011 (Released:2012-01-20)

参考文献数

9

被引用文献数

4

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It has been twelve years since Nursing Care Insurance was introduced in Japan. The population of Needed Long-Term Care exceeded five million in 2012, which is twice of that in 2000, the year the insurance started. The majority of them are over 85 years old. Care manager supports nursing-care service synthetically by assessing the need of Needed Long-Term Care and preparing plans for care.At care management, the condition of oral is hard to figure out just by seeing from outside and it is also difficult to let people open their mouths. This is the reason why the observation of oral condition is missed in many assessments of care needs. Most of the time both senior citizens and caregivers do not mention about their oral conditions unless they have pain or problems in biting. The problems of oral are gathered as“consumption ability”.In the research Hattori did in 2011, which objected care managers, the existence of dentistry in assessments was asked. Thirty-one percent answered that it is barely included and 33 percent answered that 10 percent of the assessments includes it. For the question, which asked about cooperation with dentists in the stage of care planning, 36 percent answered almost none and 52 percent answered that it is carried only for about 10 percent of the total case. It is clear that the cooperation with dentists and care managers is very little in the actual situations.It is required to not giving up eating by using mouths, to prevent infectious diseases by oral care and to position the management of tooth loss or conformity of artificial tooth.

著者

Seong-Kyu KANG

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.50, no.1, pp.12-16, 2012 (Released:2012-02-11)

参考文献数

14

被引用文献数

2 5

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From the 1970s to 2000, the occupational accident rate in Korea showed a continuous decline. However, the rate has remained stagnant since 2000 even when the fatal injury rate has decreased 40% from that year. Injuries caused by being caught in objects have decreased while those caused by slips and falls on same level and falls from the height have increased. In 2010, the non-fatal injury rate per 100 employees was 0.63 while the fatal injury rate per 100,000 employees was 9.74. The construction industry accounted for 40.2% of all fatal injuries, and falls from the height caused 54.3% of the fatality. Musculoskeletal diseases accounted for 78.8% of the non-fatal occupational diseases while cardio-cerebrovascular diseases and pneumoconiosis are the two major fatal occupational diseases. Occupational diseases caused by chemical agents have decreased to 0.6% of all cases. However, there were several social disputes related to occupational diseases caused by low level of chemicals such as leukemia in a semiconductor company. Korea planned to reduce the fatal injury rate and total workday loss by 30% by 2015. In order to achieve this goal, the government will focus on vulnerable groups in collaboration with allies such as professional associations or organizations.

著者

Stephen Matthew Lyth Yuta Nabae Nazrul Md. Islam Teruaki Hayakawa Shigeki Kuroki Masa-aki Kakimoto Seizo Miyata

出版者

公益社団法人 日本表面科学会

雑誌

e-Journal of Surface Science and Nanotechnology (ISSN:13480391)

巻号頁・発行日

vol.10, pp.29-32, 2012-03-10 (Released:2012-03-10)

参考文献数

40

被引用文献数

5 18 6

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Graphene is ideally suited to electrochemistry by virtue of its high surface area and impressive electronic properties. Nitrogen incorporation can be used to tailor the properties of graphene. Here we present a simple solvothermal technique to produce a nitrogen-containing foam-like macroporous graphene powder doped with up to 15 wt% nitrogen. This is applied as an effective non-precious, metal-free electrochemical catalyst for oxygen reduction in acid media. [DOI: 10.1380/ejssnt.2012.29]

著者

反町 篤行 床次 眞司 Miroslaw JANIK 石川 徹夫 Sarata K. SAHOO 吉永 信治 米原 英典 酒井 一夫 山澤 弘実 秋葉 澄伯 古川 雅英 Quanfu SUN Yong-Jae KIM Supitcha CHANYOTHA Rakesh C. RAMOLA

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.45, no.1, pp.15-18, 2010 (Released:2011-02-04)

参考文献数

4

被引用文献数

1 1 1

著者

Martijn RHEBERGEN Frank VAN DIJK Carel HULSHOF

出版者

National Institute of Occupational Safety and Health

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

pp.1203250132, (Released:2012-03-28)

被引用文献数

8 11

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Many workers have questions about occupational safety and health (OSH). Answers to these questions empower them to further improve their knowledge about OSH, make good decisions about OSH matters and improve OSH practice when necessary. Nevertheless, many workers fail to find the answers to their questions. This paper explores the challenges workers may face when seeking answers to their OSH questions. Findings suggest that many workers may lack the skills, experience or motivation to formulate an answerable question, seek and find information, appraise information, compose correct answers and apply information in OSH practice. Simultaneously, OSH knowledge infrastructures often insufficiently support workers in answering their OSH questions. This paper discusses several potentially attractive strategies for developing and improving OSH knowledge infrastructures: 1) providing courses that teach workers to ask answerable questions and to train them to find, appraise and apply information, 2) developing information and communication technology tools or facilities that support workers as they complete one or more stages in the process from question to answer and 3) tailoring information and implementation strategies to the workers’ needs and context to ensure that the information can be applied to OSH practice more easily.

著者

加藤 弘亮 恩田 裕一 五味 高志

出版者

日本森林学会

雑誌

日本森林学会大会発表データベース 第123回日本森林学会大会

巻号頁・発行日

pp.I13, 2011 (Released:2012-02-29)

著者

Sayuri ITOI Rui KANO Atsuhiko HASEGAWA Hiroshi KAMATA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203280801, (Released:2012-04-02)

被引用文献数

3 27

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Although the susceptibility of dermatophytes to antifungal drugs is well documented in humans, the effectiveness in animals has not been previously investigated. The in vitro susceptibility of 54 clinical isolates from animal dermatophytoses to ketoconazole (KTZ), itaconazole (ITZ) and terbinafine (TFN) was measured using microdilution assay (CLSI M38-A2 test) and by the E-test (KTZ and ITZ). All 3 drugs showed antifungal activity, while KTZ displayed the broadest minimum inhibition concentration (MIC) range (0.125–16 μg/ml) against M. canis and M. gypseum. The MIC of KTZ and ITZ was almost the same for human and animal isolates of T. mentagrophytes and T. rubrum. The MIC of TFN was almost the same for dermatophytes isolated from humans and animals.

著者

Hidetaka NISHIDA Hiroshi TANAKA Masahiko KITAMURA Shingo HATOYA2 Kikuya SUGIURA2 Toshio INABA2 Masanari NAKAYAMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203280802, (Released:2012-04-02)

被引用文献数

3 9

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Progressive ataxia and paralysis in three Miniature Dachshunds were found to be caused by idiopathic sterile pyogranulomatous inflammation of epidural fat between T5 and L4. All dogs were managed by hemilaminectomy and removal of epidural compressive material. Surgical findings and histopathological evaluation were necessary to diagnose epidural pyogranulomatous inflammation. A dog did not regain motor and sensor function after the surgery. Two dogs had exhibited improved neurological function after the surgery, but they recurred. Oral cyclosporine treatment was useful for their long remission. Idiopathic sterile pyogranulomatous inflammation of epidural fat can be considered to be a cause of thoracolumbar myelopathy in dogs.

著者

Yoshinori TAKEUCHI Masashi TAKAHASHI Masaya TSUBOI Yasuhito FUJINO Kazuyuki UCHIDA Koichi OHNO Hiroyuki NAKAYAMA Hajime TSUJIMOTO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203220798, (Released:2012-03-28)

被引用文献数

6 20

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A Japanese domestic long-hair cat of about 8 years of age was presented with vomiting and hematochezia and was found to have significant hypereosinophilia. Bone marrow aspiration revealed moderate increases of eosinophilic lineages. Histopathological examination revealed mild eosinophilic and epitheliotropic T-lymphocytic infiltrations in the duodenum. Although the cat remained asymptomatic with only prednisolone administration, the cat presented with hematemesis, weight loss, and severe anorexia 512 days after the initial presentation. Subsequently, gastrointestinal perforation developed, and the cat died on Day 536. Histopathological examination of autopsy specimens revealed mixed cellular infiltration including eosinophils and neoplastic lymphocytes in the intestinal lymph nodes, intestine, liver, spleen, and pancreas. Immunohistochemical examination supports a diagnosis of intestinal T-cell lymphoma with severe hypereosinophilic syndrome.

出版者

国立研究開発法人 科学技術振興機構

雑誌

情報管理 (ISSN:00217298)

巻号頁・発行日

vol.55, no.1, pp.77-77, 2012 (Released:2012-04-01)

著者

Daisuke KOJIMA Hitoshi HATAI Toshifumi OYAMADA Chun-Ho PARK

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203160794, (Released:2012-03-22)

被引用文献数

6 9

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Extraskeletal myxoid chondrosarcoma was found in a five-month-old male Irish setter dog. At necropsy, the largest mass, measuring 15 × 13 × 13 cm, was found in the right caudal lobe of the lung, and metastatic small masses were observed in multiple organs. Microscopically, the tumor comprised mainly atypical mesenchymal cells and myxoid stroma, which stained positively with Alcian blue. Immunohistochemically, the tumor cells stained positively for vimentin, S-100 protein, neuron-specific enolase, calretinin, and chromogranin A. Ultrastructurally, the cytoplasm of the tumor cells was comprised abundant rough endoplasmic reticulum, mitochondria, Golgi complex, free ribosomes and short irregular microvillous processes extending from the cytoplasm. Based on these pathological findings, this tumor was diagnosed as extraskeletal myxoid chondrosarcoma.

著者

Kyohei ISHIGAKI Masahiko NOYA Yumiko KAGAWA Kazunori IKE Hiromitsu ORIMA Soichi IMAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203180796, (Released:2012-03-26)

被引用文献数

5 8

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A one-month male Greyhound dog presented with a swinging gait of the hindlimbs, and later developed muscular atrophy of the femoral region and hyperextension of hindlimbs. The dog had positive serum IFAT titers to Neospora caninum, but a negative titer in the cerebrospinal fluid (CSF). N. caninum-specific DNA was amplified from the CSF using a semi-nested polymerase chain reaction assay. Clusters of protozoa in biopsied muscle fibers were subsequently confirmed as N. caninum tachyzoites by immunohistochemical examination. Early recognition and treatment are necessary for effective recovery of clinical canine neosporosis, but antemortem diagnosis is difficult. We suggest that the detection of parasite deoxyribonucleic acid in the CSF is a useful antemortem diagnostic method in facilitating treatment of this disease.

著者

原田 隆史

出版者

情報知識学会

雑誌

情報知識学会誌 (ISSN:09171436)

巻号頁・発行日

vol.20, no.4, pp.383-390, 2010-12-04 (Released:2010-12-30)

参考文献数

30

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日本で用いられている電子書籍フォーマットとしては, EPUB, .Book, XMDF, PDF など,さまざまな観点から標準化された電子書籍フォーマットが存在する。本稿では,各種の電子書籍フォーマットについては概観するとともに,その学術情報流通への課題について検討する。

著者

Tsuyoshi KIMURA Machiko SEKIDO Naoki CHIMURA Sanae SHIBATA Naho KONDO Harumi KAMISHINA Hiroaki KAMISHINA Sadatoshi MAEDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.1203070790, (Released:2012-03-16)

被引用文献数

6 12

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House dust mite (HDM) allergens are the most common allergens for induction of IgE-mediated hypersensitivity. Recently, epicutaneous sensitization with HDM allergens has been emphasized in the development of atopic dermatitis (AD) by producing various soluble factors in keratinocytes. Among the soluble factors, GM-CSF is a key molecule that activates Langerhans cells, antigen-presenting cells in the epidermis. In the present study, we investigated the effects of Dermatophagoides farinae 1 (Der f 1) on GM-CSF production in a canine keratinocyte cell line, CPEK. CPEKs were found to produce GM-CSF upon stimulation by Der f 1. The GM-CSF production was suppressed by addition of a cysteine protease inhibitor. The present results suggest that cysteine protease-derived Der f may be an initiator of allergic inflammation by inducing the production of GM-CSF in keratinocytes.

著者

Ismail Sari Levent Kebapcilar Ahmet Alacacioglu Oktay Bilgir Yasar Yildiz Ali Taylan Arif Yuksel Didem L. Kozaci

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.48, no.16, pp.1363-1368, 2009 (Released:2009-08-17)

参考文献数

28

被引用文献数

29 35 28

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Objective Endothelial dysfunction is present in ankylosing spondylitis (AS). However, the etiology of events is still unclear. The aim of the present study was to investigate whether there are abnormalities in nitric oxide (NO) metabolism and endothelin-1 (ET-1) in AS patients. Methods Subjects without any classical cardiovascular (CV) risk factors were studied. Fasting glucose, serum lipids, high sensitive CRP (hsCRP), ESR, asymmetric dimethylarginine (ADMA) and ET-1 were studied. Patients were also evaluated with the Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Functional Index, and the Bath Ankylosing Spondylitis Disease Activity Index. Results A total of 48 AS patients (38.6±10.6 years; 36M/12F) and 38 controls (36.4±11.1 years; 27M/11F) were studied. Acute phase reactants including hsCRP, and ESR were significantly increased in the patients group (p<0.05). Serum ADMA concentrations were also significantly higher in AS than in controls. Plasma levels of ET-1 did not differ between the groups (p>0.05). Comparison of three groups (conventional and anti-TNF treatment groups and controls) revealed that ADMA was significantly higher in the conventional treated AS than in controls. The levels of ADMA were not different between anti-TNF group and healthy subjects. Plasma ET-1 concentrations were similar between groups (p>0.05). Correlation analysis yielded significant correlations between ADMA, hsCRP, LDL cholesterol, HDL cholesterol and triglycerides (p<0.05). Conclusion The increased ADMA levels obtained in a group of relatively young AS patients who did not have classical CV risk factors suggest that NO metabolism is impaired in AS. On the other hand, anti-TNF treatments may have a beneficial effect on vascular function in AS.