著者

Wesley W. HSIAO Hsien-Shun LIAO Hsing-Hung LIN Yueh-Lun LEE Chia-Kwung FAN Chien-Wei LIAO Po-Yen LIN En-Te HWU Chia-Seng CHANG

出版者

(社)日本分析化学会

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.29, no.9, pp.885-892, 2013-09-10 (Released:2013-09-10)

参考文献数

29

被引用文献数

4 12

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Toxocarosis is a zoonosis caused by the transmission of the Toxocara canis (T. canis) larvae to humans. Its infectious third-stage larvae can invade the brains of paratenic hosts. The resultant brain damage can result in cerebral toxocarosis (CT). Astrocytes have important neurotrophic and neuroprotective functions in the brain. Substantial studies have shown that astrocyte apoptosis may contribute to the pathogenesis of many acute and chronic neurodegenerative disorders. We propose an alternation detection method, a combination of the astigmatic detection microscopy (ADM) and atomic force microscopy (AFM) techniques, to investigate the apoptosis of astrocytes triggered with T. canis larval excretory/secretory (Tc E/S) antigen. The variation in the pathology of a cell’s morphological changes was investigated with ADM and AFM analyses and then confirmed by western blotting. The results showed that the round cells increased as the concentration of Tc E/S antigen and incubated time increased. In addition, the mean height of apoptotic cells was approximately twice that of untreated normal cells, which meant there was correlation between the Tc E/S antigen treatment and cell height. For each cleaved caspase-3 in the cells cocultured with Tc E/S antigen and incubated for 9 h, the corresponding intensities increased about 34-fold (34.4 ± 1.8) compared with those of the control cells. This method can provide researchers with a perspective for understanding the limited information on the mechanism of astroglial injury and death during a T. canis larval invasion in a brain infection.

著者

Alexander SUVOROV

出版者

BMFH出版会

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.32, no.3, pp.81-91, 2013 (Released:2013-07-25)

参考文献数

79

被引用文献数

2 37

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The review is devoted to the problems of microbiota and the ways of it correction employing beneficial life bacteria- probiotics. It covers the issues related to the functioning of human microbiota and its importance for the health, individual variability of microbial content, functioning of the probiotics in the human organism and the history of probiotic studies with particular focus on the microbiological investigations in the USSR. The article discusses the safety issues related to probiotics and the problems with probiotic therapy, trying to explain the reasons for the side effects caused by probiotics. The necessity of personified selection of the probiotic strain or individual microbial therapy autoprobiotics is also discussed.

著者

白井 滋 後藤 友明 廣瀬 太郎

出版者

日本魚類学会

雑誌

魚類学雑誌 (ISSN:00215090)

巻号頁・発行日

vol.54, no.1, pp.47-58, 2007-05-25 (Released:2011-06-08)

参考文献数

19

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In February to March, 2004, 17 specimens of sail-fin sandfish, Arctoscopus japonicus, were collected off the Iwate area, Pacific coast of northern Honshu, Japan, during research on fishery resources by Iwate Fisheries Technology Center. Using all the specimens, a sequencing analysis of the mitochondrial control region was performed, and we found that they have a genetic composition closely approximating to the western Japan population distributed north of Oki Islands, the Sea of Japan. These specimens were estimated to be three years old, belonging the 2001 year-class. This year-class from the Akita coast area became a very large resource, and this may have led to the expansion of their distribution. The occurrence of sandfish off the Iwate area in 2004, should be an event through the enlargement of distribution area of the 2001 year-class that hatched along the Akita coast area.

著者

甲本 亮太 工藤 裕紀 高津 哲也

出版者

日本水産増殖学会

雑誌

水産増殖 (ISSN:03714217)

巻号頁・発行日

vol.59, no.4, pp.615-630, 2011-09-20 (Released:2012-12-27)

参考文献数

45

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秋田県沿岸におけるハタハタ仔稚魚の水深別分布と摂餌生態を調べるため,2009年2-5月に仔稚魚の分布密度と食物組成および餌サイズ組成を調査した。仔稚魚は水温7.3-12.2°Cの底層に分布し,水深0.5-5 m の産卵場から個体発生的に水深60 m 以深に移動した。また稚魚は,水温13.2°C以上の底層には分布しなかった。ハタハタの孵化仔魚は脊索長が約12 mm あり,他の海産魚類の仔魚に比べて口器および形態が発達した段階で孵化していた。体長12-30 mm の仔魚の餌は浮遊性あるいは底生性のカイアシ類コペポダイトが高い割合を占め,40 mm 以上ではアミ類が優占した。コブヒゲハマアミはハタハタ稚魚の成育場に同期的に出現し,他の浮遊性あるいは底生性の甲殻類に比べて大型であることから,稚魚の重要な餌生物の一つであると考えられた。

著者

友田 努 堀田 和夫 森岡 泰三

出版者

公益社団法人 日本水産学会

雑誌

日本水産学会誌 (ISSN:00215392)

巻号頁・発行日

vol.72, no.6, pp.1039-1045, 2006 (Released:2006-12-01)

参考文献数

26

被引用文献数

3 2

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ハタハタ人工種苗の生態を把握するため,2000 年 4 月に計 2 群 6,966 尾(平均全長 10.4 cm)を七尾湾と富山湾で標識放流した。2005 年 1 月までに計 123 尾(1.8%)が再捕され,再捕の 9 割強が産卵群と考えられる 2 歳以上の親魚であった。両放流群とも,過半数が富山湾内で再捕され,その他の多くが新潟,山形および秋田県沖で再捕された。本結果は,七尾湾,富山湾に放流した人工種苗が主に富山湾内に滞留し成育,産卵するものの,一部は北上し日本海北部系群や新潟周辺の地域群と交流していることを示すものである。

著者

Satoshi UEHARA Makusu TSUTSUI Kentaro DOI Masateru TANIGUCHI Satoyuki KAWANO Tomoji KAWAI

出版者

一般社団法人 日本機械学会

雑誌

Journal of Biomechanical Science and Engineering (ISSN:18809863)

巻号頁・発行日

vol.8, no.3, pp.244-256, 2013 (Released:2013-07-31)

参考文献数

23

被引用文献数

3 4

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In the present study, we address theoretical approaches for the experimental results to investigate the flow dynamics of λDNA through a nanochannel in which two nanoelectrodes are integrated. In order to elucidate the relationship between the longitudinal ionic current and the electrophoresis of λDNA in the specific micro/nanofluidics, we develop a theoretical model for the macroscopic fluid dynamics in a Lagrangian framework. The measured current change associated with a single molecule translocation through the channel is explained by the principle of the Coulter counter that allowed to predict the conformation of λDNA. We also analyze the local velocity of λDNA passing through a nanoscaled confined channel. A result from the model is in considerable agreement with the experimental observations for the electrophoretic flow of λDNA. The basic knowledge obtained here may be useful in developing electrical methods for controlling the electrophoretic velocity of single-molecule DNA for realizing the nanopore sequencer.

著者

Tatsushi Toda Hidenao Sasaki

出版者

日本神経学会

雑誌

臨床神経学 (ISSN:0009918X)

巻号頁・発行日

vol.50, no.11, pp.951-951, 2010 (Released:2011-03-28)

著者

Kei Yamamoto Yasuyuki Kato Takuma Shindo Mugen Ujiie Nozomi Takeshita Shuzo Kanagawa Junwa Kunimatsu Yuiichi Tamori Toshikazu Kano Rumi Okuno Hideyuki Takahashi Norio Ohmagari

出版者

国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.66, no.5, pp.443-445, 2013 (Released:2013-09-19)

参考文献数

10

被引用文献数

1 5

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We present the first reported case of systemic infection with Neisseria meningitidis serogroup W-135 sequence type (ST)-11 in Japan. A 44-year-old woman presented with high fever, sore throat, and fatigue and was diagnosed with N. meningitidis bacteremia. The causative strain was identified as serogroup W-135 ST-11 by polymerase chain reaction and multilocus sequence typing. Approximately 1 month after treatment, she developed high fever, dyspnea, chest pain, and shoulder pain due to pericarditis, polyarthritis, and tenosynovitis, which are all relatively common immunoreactive complications of W-135 ST-11 meningococcal infections. This causative strain was the same as that responsible for an outbreak of meningitis among Hajj pilgrims in 2000. The strain is now found worldwide because it can attain a high carriage rate and has a long duration of carriage. We suspect that our patient's infection was acquired from an imported chronic carrier.

著者

Masayuki Takada Yoko Fukuda Shin-ichiro Iwamiya

出版者

一般社団法人 日本音響学会

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.34, no.3, pp.187-196, 2013-03-01 (Released:2013-05-01)

参考文献数

20

被引用文献数

1 4

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The Japanese Road Traffic Law states that a vehicle horn should be used only in an emergency or in dangerous locations where a horn sign has been installed. However, drivers frequently use their vehicle horn as a signal when passing each other. Furthermore, pedestrians and cyclists are also honked at by drivers. There may be a negative effect of vehicle horn use on people outside the vehicle. Therefore, a questionnaire survey was carried out to ascertain the current circumstances of vehicle horn use. Respondents were asked about the latest or last-remembered instance of horn use in various situations, both when they were driving and when they were pedestrians. With regard to experiences of being honked at by another driver, the questionnaire included questions concerning place, traffic volume, the aim of horn use, the timing pattern of horn use, and the respondent's psychological reaction when honked at by another driver. It was found that drivers briefly honked their horn to express gratitude, or to gain another's attention, in various places. Long honks such as one long honk or two long honks mostly evoked negative psychological reactions in drivers, such as a feeling that the sound of the horn was startling, noisy, or irritating. Furthermore, pedestrians frequently had negative psychological reactions to horns used to gain their attention or to alert them to danger. More than 40% of nondrivers were displeased with the volume and sound quality of horns.

著者

Naofumi Tsuchizaki Masa Hamada Kunimoto Hotta

出版者

日本放線菌学会

雑誌

日本放線菌学会誌 (ISSN:09145818)

巻号頁・発行日

vol.15, no.2, pp.23-29, 2001-12-25 (Released:2008-03-04)

参考文献数

26

被引用文献数

2 3

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(Using colony direct PCR we established, kan gene (GenBank accession No. AB028210) coding for an aminoglycoside acetyltransferase, AAC(3), was surveyed among strains of Streptomyces griseus and its related taxa (S. anulatus group). The regulatory and ORF regions of kan gene were targeted by the use of original primers. With the regulatory region primers, the target fragment (518 bp) amplification was observed in all the streptomycin (SM)-producing strains of S. griseus and in several strains of S. anulatus group. The other target fragment (930 bp) amplification using the ORF primers was observed only in the SM-producing strains of S. griseus including ‘S. ornatus’ that has substantially identical properties to those of S. griseus. It was thus conclusive that kan gene is highly conserved in SM-producing strains of S. griseus and distributed in taxa related to S. griseus. There were numbers of strains that provided no amplification upon PCR but hybridization bands upon Southern hybridization, suggesting the lack or alteration of kan gene. Characterization by colony direct PCR using appropriate primers will be a big help for taxonomic as well as ecological characterization of actinomycetes.

著者

高野 晴成 森本 卓哉 伊藤 浩 須原 哲也

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.38, no.3, pp.145-148, 2007-05-31 (Released:2008-10-31)

参考文献数

26

著者

伊里 綾子 望月 聡

出版者

日本感情心理学会

雑誌

感情心理学研究 (ISSN:18828817)

巻号頁・発行日

vol.20, no.Supplement, pp.36-36, 2013 (Released:2013-04-10)

著者

大角 哲也 新谷 和文 臼田 滋

出版者

理学療法科学学会

雑誌

理学療法科学 (ISSN:13411667)

巻号頁・発行日

vol.28, no.2, pp.151-155, 2013 (Released:2013-06-25)

参考文献数

16

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〔目的〕脳卒中患者におけるDual-Taskの指示の仕方の違いによるパフォーマンスへの影響を検討すること.〔対象〕歩行が自立または監視下で可能な脳卒中患者47名とした.〔方法〕Dual-Taskは10 m歩行テストと3桁の数字の逆唱の同時遂行とし,指示の仕方を「歩行と逆唱の両方に同じぐらい集中して下さい」(Dual-Task Complex:DTC)と「主に逆唱に集中して下さい」(Dual-Task Backward digit span:DTB)の2種類で計測した.〔結果〕DTCに比較してDTBにて歩行速度,ケイデンスが低下し,逆唱の回答数,正答数が増加した.〔結語〕脳卒中患者を対象に転倒予測や歩行能力の評価指標としてDual-Taskを用いる場合には,指示の仕方を明確に規定する必要がある.

著者

矢神 真奈美 加藤 大也 林 安津美 脇阪 涼子 小林 憲司 鷲野 香織 山本 絢子 立石 早祐美 澤井 喜邦 稲垣 一道 金山 均 片田 直幸 伊藤 光泰

出版者

一般社団法人 日本糖尿病学会

雑誌

糖尿病 (ISSN:0021437X)

巻号頁・発行日

vol.54, no.6, pp.430-435, 2011 (Released:2011-07-15)

参考文献数

18

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2型糖尿病患者(60名)に対して食品交換表にて指導を24週間介入後,さらにカーボカウント基礎編を上乗せする指導(カーボカウント上乗せ群;30名:男性/女性=14/16)と,食品交換表による指導(食品交換表継続群;30名:男性/女性=16/14)に無作為に振り分け24週間介入し,各群介入前後で糖代謝,脂質代謝,BMI及びメンタル面の比較検討を行った.介入後両群共にHbA1c及びLDL-Cは有意な改善が認められた,さらにカーボカウント上乗せ群では,HDL-C,BMIの有意な改善が認められた.両群間の変化率の比較では,カーボカウント上乗せ群は食品交換表継続群に比べてHbA1c(-13.0±12.8vs-3.8±15.5%;p=0.014)及びHDL-C(12.7±19.5vs 3.0±15.1%;p=0.038)の有意な改善が認められた.メンタル面の評価では,カーボカウント上乗せ群では有意に食事の満足度が高く,食事療法継続の苦痛感が少ないことが認められた.故にカーボカウント上乗せ群では食品交換表継続群に比べてより糖代謝を改善し,さらに患者QOLを高める可能性が示唆された.

著者

折戸 武郎 越田 吉郎 前川 龍一 平木 辰之助 古賀 佑彦 竹内 昭

出版者

日本保健物理学会

雑誌

保健物理 (ISSN:03676110)

巻号頁・発行日

vol.20, no.2, pp.145-150, 1985 (Released:2010-02-25)

参考文献数

11

被引用文献数

1 1

著者

ABDUL SHAKOOR TATSUO MURAKAMI FUMIO YAMASHITA

出版者

久留米大学医学部

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.38, no.3, pp.211-220, 1991-11-01 (Released:2009-08-11)

参考文献数

21

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A study was undertaken to compare Pediatric Malignancy at Kurume (Japan) and Karachi (Pakistan) with reference to international data collected over the years, in order to identify essential differences between developed and developing conditions and factors influencing the etio-pathogenesis of pediatric cancer. The study was retrospective encompassing all types of cancer in children over a period of three years i-e 1988-1990. Essential factors related to present study were: 1. Population: The population of Karachi is about 10 million while that of Kurume is only half a million. 2. Socio-economic conditions: The average socioeconomic condition of people in Karachi is poor while in Kurume it appears to be good. 3. Educational status: Only 25% people in Karachi are educated beyond middle class while Kurume reveals a 100% education up to high school level. 4. Environmental conditions: The environmental conditions of Kurume and surrounding areas arevery clean and free from pollution, sewage problems and traffic hazards. Karachi and its surroundings on the other hand pose very serious air and water industries! It was concluded that whereas genetic predisposition predominates, the environmental conditions, educational and socio-economic status of a society immensely influence the pattern and trends of pediatric carcinogenesis.

著者

菅野 利助

出版者

公益社団法人 日本水産学会

雑誌

日本水産学会誌 (ISSN:00215392)

巻号頁・発行日

vol.2, no.5, pp.217-228, 1934-01-05 (Released:2008-02-29)

参考文献数

21

被引用文献数

2 2

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1. The filamentous fronds of the algae of the genus Aegagropila often form spherical tballi or hollow balls mostly due to rolling about on the bottom when they are at the mercy of waves and currents. The ball of each species and variety differs in shape and appearance in accordance with the nature of the filaments, viz., their height, type of branching, firmness, etc. 2. The ball of Aegagropila Sauteri from Lake Akan, Hokkaido, is rather compact in texture, composed of comparatively firm filaments radially arranged, and the cells at the peripheral layers of the ball are often worn off, being rubbed against the gravels on the bed of the lake. The cells of the underlying layers gradually grow until they come out from the surface to undergo the rubbing again. Where such trimming repeats effectively we find well-finished, velvety balls. 3. In A. Lagerheimii from Lake Toba, Prov. Tonnai, Saghalien, the ball is rather flexible, consisting of soft and delicate filaments, and consequently under a less effect of friction. Thus the ball doesnot assume a spherical shape, its surface being dishevelled with decumbent filaments. 4. In two small marshes near Lake Akan, i.e., Lake Toro and Lake Chimikeppu, where the rotatory movement of water near the shore is by no means active, we do not find A. Sauteri in its normal shape, but in the forms of irregular masses which are referable to forma profunda and var. Borgeana respectively. It is hoped that we can decide the relation between those va-rietal forms and the typical one by an experiment of transplantation. 5. The ball of A. Sauteri var. Borgeana from Lake Naiho, Etorofu Isl., Kuriles, is provided often with one or more pebbles in its hollow cavity. The wall of the ball consists of one to three layers of entangled filaments. Each layer is about 5mm in thickness, woolen cloth-like in texture. 6. Above mentioned pebbles in the hollow cavity of the ball are considered to beprimarily a part of substrata on the bottom of the lake on which this alga is found to attach forming compact cushions. A small part of this decumbent cushion sometimes becomes free from the substratum through the death of many of the basal cells, while smaller pebbles often do not detach from the under-surface of the free cushion and later on are enclosed by the latter. 7. Those cushion-like fronds detached from the substrata after having rolled near the shore first become hollow spindle in shape enclosing pebbles, if they attach, and then gradually become spherical by their further tumbling. 8. When the wall of a ball is composed of two or three distinct layers, they have no cellular connection between them and are separated without difficulty, though they closely contact with each other. The inner surface of each layer is occupied by dead cells which we take as the remains of the holdfasts of the primary frond of sedentary habit. The outer of surface the inner balls is vivid green in colour, as fresh as that of the outermost. 9. In other words, we have sometimes compound balls, so to speak, composed of two or three concentric balls of different origins. The primary or innermost ball has been enclosed by the secondary one transformed de noco from a free-floationg cushion newly detached from the substratum. As a result, there is no sign of cellular connection between these two hall; showing the growth of the outer ball from the filaments at the inner. In general, the compound balls are of large diameter, being more than 5cm.

著者

三嶋 康七

出版者

日本陸水学会

雑誌

陸水学雑誌 (ISSN:00215104)

巻号頁・発行日

vol.4, no.1, pp.28-30_5, 1934-06-15 (Released:2009-06-12)

著者

三木 泰治

出版者

一般社団法人 園芸学会

雑誌

園芸学会雑誌 (ISSN:00137626)

巻号頁・発行日

vol.6, no.1, pp.8-25, 1935 (Released:2007-05-31)

参考文献数

3

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1. 梨の果肉中の石細胞の發育過程及之が大小分布等に就き日本梨を材料として觀察研究する所があつた。2. 日本梨の石細胞は開花又は授粉後10日内外にして柔細胞中に形成せられ, 其後急速に發達し, 40-55日にして其彈性を失ひ收縮し, 爲に周圍の柔細胞を牽引して放射状を呈せしむる。3. 石細胞膜は發現後急激に肥厚し, 60-70日にして最高の厚さに達し, 其後は成熟期に至るに從ひ少しく其厚度を減ずる。日本梨の品種に依り其發育過程及成熟果に於ける石細胞膜の厚度を異にする。4. 日本梨の品種に依り果心の中央を通ずる横斷面及縱斷面に於ける石細胞群の分布密度及大小石細胞群の混合比率を異にする。此事は日本梨の果實の品質を決定する上に於て相當考慮すべき重要事項の一に屬する。

著者

吉田 聡

出版者

社団法人 プラズマ・核融合学会

雑誌

プラズマ・核融合学会誌 (ISSN:09187928)

巻号頁・発行日

vol.78, no.7, pp.641-645, 2002 (Released:2005-12-08)

参考文献数

35

被引用文献数

1

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Applications of inductively coupled plasma mass spectrometry (ICP-MS) to the determination of long-lived radionuclides in environmental samples were summarized. In order to predict the long-term behavior of the radionuclides, related stable elements were also determined. Compared with radioactivity measurements, the ICP-MS method has advantages in terms of its simple analytical procedures, prompt measurement time, and capability of determining the isotope ratio such as240Pu/239Pu, which can not be separated by radiation. Concentration of U and Th in Japanese surface soils were determined in order to determine the background level of the natural radionuclides. The 235U/238U ratio was successfully used to detect the release of enriched U from reconversion facilities to the environment and to understand the source term. The 240Pu/239Pu ratios in environmental samples varied widely depending on the Pu sources. Applications of ICP-MS to the measurement of I and Tc isotopes were also described. The ratio between radiocesium and stable Cs is useful for judging the equilibrium of deposited radiocesium in a forest ecosystem.