著者
Masaya Inoue Junji Kitao Yoshihiro Miyama Moriyuki Hazeyama Hitoshi Isoda Hideaki Arita Koji Nishizawa Tatsuo Nishimura Masatsugu Nakano
出版者
The Institute of Electrical Engineers of Japan
雑誌
IEEJ Journal of Industry Applications (ISSN:21871094)
巻号頁・発行日
vol.11, no.3, pp.388-395, 2022-05-01 (Released:2022-05-01)
参考文献数
20
被引用文献数
6

This paper presents the development of a 48V integrated starter generator (ISG) for mild hybrid vehicles. The motor needs to satisfy power and torque performances requirements under the 48V system voltage as well as the passenger vehicle's specific requirements, such as acoustic noise and layout space. Several processes have been explored to obtain a 48V ISG such as the pole number selection process, the electromagnetic design approach for reducing acoustic noise, and a novel position sensor topology. By using the developed technologies, a 48V ISG motor is designed, built, and tested. Furthermore, the developed motor is demonstrated to achieve 180Nm, 15kW exceeding the 95% motor efficiency with acoustic noise reduction design and thin axial motor length.
著者
松本,仲子
出版者
日本家政学会
雑誌
日本家政学会誌
巻号頁・発行日
vol.43, no.9, 1992-09-15

All examples of egg dishes described in cookery books published over the Edo period were collected and examined. Eggs, which has characteristics of heat coagualation and foaming, have been widely used not only as the material but also as a side material in various dishes. These cooking properties of eggs were fully utilized in the Edo period. Therefore the egg dishes collected from the literature include almost all those which have been known today. Egg dishes appeared in the literature of the Edo period for the first time. However some egg dishes, for example, "Fuwafuwa" and "Funoyaki" reached the golden age in early Edo period. This fact suggests that these dishes might have been known before the Edo period.
著者
Yuta Takamura Ken-ichi Morishita Shota Kikuzawa Masaki Watanabe Hiroki Kakuta
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.70, no.2, pp.146-154, 2022-02-01 (Released:2022-02-01)
参考文献数
28
被引用文献数
2

Small-molecular drugs, which are generally inexpensive compared with biopharmaceuticals and can often be taken orally, may contribute to the Sustainable Development Goals (SDGs) adopted by the United Nations. We previously reported the retinoid X receptor (RXR) agonist 4-(ethyl(3-isobutoxy-4-isopropylphenyl)amino)benzoic acid (NEt-3IB, 1) as a small-molecular drug candidate to replace biopharmaceuticals for the treatment of inflammatory bowel disease. The previous synthetic method to 1 required a large amount of organic solvent and extensive purification. In line with the SDGs, we aimed to develop an environmentally friendly, inexpensive method for the large-scale synthesis of 1. The developed method requires only a hydrophobic ether and EtOH as reaction and extraction solvents. The product was purified by recrystallization twice to afford 99% pure 1 at 100 mmol scale in about 30% yield. The optimized process showed a 35-fold improvement of the E-factor (an index of environmental impact) compared to the original method. This work, which changes the solvent used to environmentally preferable ones based on the existing synthetic method for 1, illustrates how synthetic methods for small-molecular drugs can be adapted and improved to contribute to the SDGs.
著者
永山 敏廣 真木 俊夫 観 公子 飯田 真美 田村 行弘 二島 太一郎
出版者
日本農薬学会
雑誌
Journal of Pesticide Science (ISSN:1348589X)
巻号頁・発行日
vol.14, no.1, pp.39-45, 1989-02-20 (Released:2010-08-05)
参考文献数
12
被引用文献数
5 5

日本茶の茶葉中に検出された有機リン系農薬は, 茶の種類や生産地により特徴が見られた. また, 多種の農薬が同一の茶葉に残留し, とくに, MEP, EPNおよびイソキサチオンの検出率が高かった. さらに, CVP, イソキサチオンおよびプロチオホスは, 1ppmを超えて残留した茶葉が見られた. これら残留量の多かった農薬のうち, イソキサチオンおよびプロチオホスは茶湯中への浸出率が低く, 飲用上とくに問題はないと考えられる. しかし, CVPは3ppmを超えて残留した茶葉があり, 浸出率も高かった.今回の調査では, 茶葉中の有機リン系農薬の残留量は全般的には微量であり, 食品衛生上とくに問題があるとは考えられない. しかし, 登録保留基準値を超える農薬の残留するものが1検体とはいえ見いだされており, また, 同一の茶葉に多種の農薬が同時に残留していたことから, 今後生産者は農薬散布に当たり, その使用時期や使用方法などに十分配慮して, 茶葉中残留農薬量を極力減らし, 消費者の安全を図らなければならないと考える.
著者
山城 広周 野中 尋史
雑誌
第83回全国大会講演論文集
巻号頁・発行日
vol.2021, no.1, pp.507-508, 2021-03-04

既存研究では,作業時間が既知である場合や,単純な分布に従うと仮定している.しかし,実際の工場における作業時間は,未知である場合が多く,複雑な分布に従っている可能性が高い.そこで,本研究では,機械学習モデルを用いて作業時間を推定することを考える.本研究では,実際の工場データにおいて作業時間が複雑な分布に従う場合に,機械学習モデルを用いて作業時間を推定し,スケジューリング最適化を行うシステムを提案した.研究協力企業より提供された製造サンプルごとにまとめられた作業時間が既知である工程情報を用いて,提案手法を評価した.MAPEを用いて機械学習モデルの評価を行った結果,LightGBMが22.5%で最も良かった.推定作業時間を用いて,並列機械スケジューリングの最適化を行った結果,makespanの平均短縮率は,29.5%であった.
著者
稲田 豊
出版者
獣医麻酔外科学会
雑誌
獣医麻酔 (ISSN:02852209)
巻号頁・発行日
vol.5, pp.1-18, 1974-04-01 (Released:2010-09-09)
参考文献数
44
被引用文献数
1

1 0 0 0 新撰亀相記

出版者
大学書院
巻号頁・発行日
1958
著者
Ryosuke Tomio Tsuyoshi Uesugi Kazunori Akaji
出版者
特定非営利活動法人 日本脳神経血管内治療学会
雑誌
Journal of Neuroendovascular Therapy (ISSN:18824072)
巻号頁・発行日
vol.14, no.3, pp.85-89, 2020 (Released:2020-03-20)
参考文献数
4
被引用文献数
1

Objective: The optimal heating temperature and time for the Echelon10 and Excelsior SL-10 microcatheters using a heat gun was investigated. The durability of the microcatheters after heat gun shaping for the second and third times was also examined.Methods: HAKKO FV-310 was used as the heat gun in this study. This heat gun can be set to 115°C, 125°C, and others. We measured the temperature at 2.5 cm from the nozzle of the heat gun. The Echelon10 and SL-10 microcatheters were shaped under two temperature conditions (115°C and 125°C) and three heating times (30 sec, 60 sec, and 90 sec). The microcatheter shape before heating had twice the curvature of the targeted shape.Results: The temperatures at 2.5 cm from the nozzle were 120.6°C and 127.8°C with the heat gun set at 115°C and 125°C, respectively. There was no macroscopic difference in the results of heat gun shaping of the Echelon10 among temperature settings (115°C and 125°C) or heating times (30 sec, 60 sec, and 90 sec). As degeneration of the heated tip of the SL-10 at 125°C occurred in four of five trials, heat gun shaping was performed using the 115°C setting. There was no macroscopic difference in the results of heat gun shaping of the SL-10 among heating times. Shaping for the second and third times was successful at 115°C and 30-sec heating time.Conclusions: The Echelon10 and SL-10 can be successfully shaped from twice the curvature of the targeted shape using a heat gun at 120°C for 30 sec. Shaping for the second and third times was successful using the same settings. Degeneration of the SL-10 was noted at temperatures above 130°C.
著者
Akihiko Adachi Eiichi Kobayashi Ken Kado Naokatsu Saeki
出版者
The Japanese Society for Neuroendovascular Therapy
雑誌
Journal of Neuroendovascular Therapy (ISSN:18824072)
巻号頁・発行日
vol.10, no.5, pp.236-242, 2016 (Released:2016-11-30)
参考文献数
8
被引用文献数
7 6

Objectives: Manual shaping of a straight microcatheter is required when guiding or retention of a microcatheter with a pre-shaped tip is difficult. According to the manufacturer’s instructions, it is recommended that the microcatheter be shaped by steaming “for 30s” and “25 mm away from the steam source”. However, insufficient shaping and blunting can occasionally occur during the procedure. In this technical note, we present the optimal conditions of shaping for a microcatheter system.Methods: In this study, we used a hot air gun (BOSCH, Gerlingen, Germany) as the shaping source and a Headway microcatheter (Microvention, CA, USA; Terumo, Tokyo, Japan). After measuring the difference between the preset and the actual temperature value, shaping was performed at different temperatures (preset temperature of 110°C–140°C) and time intervals (30s–120s).Results: The actual temperature was constant at 20°C below the preset temperature, at a distance of 2.5 cm from the hot air outlet. We performed shaping at a preset temperature of 110°C–140°C (i.e., 90°C–120°C actual temperature) for 30s–120s. Because the Headway microcatheter could not tolerate preset temperature higher than 130°C (i.e., actual temperature of 110°C), the distal tip fluffed, bubbled, and perforated. We examined the durability under each condition, comparing the shape just after mandrel removal, after micro-guidewire manipulation, and after stretching in a vascular model. The highest moldability and durability were achieved at a time interval of 90s–120s, and a preset temperature of 120°C (i.e., 100°C actual temperature).Conclusion: The Headway microcatheter showed the best performance at a heating time of 90s and a preset temperature of 120°C (i.e., 100°C actual temperature) in hot air gun shaping, although the optimal temperature and time interval may vary with the used microcatheter, depending on each instrument structure and materials.