- 著者
-
大谷 道輝
- 出版者
- 一般社団法人日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.29, no.1, pp.1-10, 2003-02-10 (Released:2011-03-04)
- 参考文献数
- 22
- 被引用文献数
-
9
8
The dilution or mixing of commercially available corticosteroid formulations is a common practice in our country. We therefore evaluated the pharmaceutical stability and clinical effects of such admixtures.The quantities of the aqueuos phase separated by centrifugation employed as an index of the destructution of an emulsion after mixing were measured, with a high value being obtained with the admixtures of corticosteroid ointments and o/w-type moisuturizing creams. In contrast, the admixtures utilizing w/o-type creams were found to be physically stable for a month.To evaluate the preservative efficacy, we attempted to investigate the microbial contamination of these admixtures with Antebete® ointment. For all aqueous phases separated by centrifugation stored and at room either temperature or in a refrigerator for one week, and each mixture was touched by a human finger twice a day. As a result, it was impossible to prevent microbial contamination in these admixtures.The permeability of corticosteroids using hairless mice skin in the admixture of Lidomex® ointment, Antebete® ointment, and Myser® ointment and moisturizing creams through the skin was 5-, 2-, 3-fold greater, respectively, than that from each corticosteroid ointment alone. The extent of the stability of the emulsion after mixing was related to the permeability.The vasoconstrictor activity of humans in the admixture of Lidomex® ointment and moisturizing creams, urea or heparinoid, was about 2 fold greater than that from the corticosteroid ointments alone, and this difference was significant.When the concentration of corticosteroid was reduced by half using an admixture of corticosteroid ointment with vaseline or moisturizing creams, no difference was observed in the systemic side effects between the corticosteroid ointment alone and the admixtures.