著者
岡田 陽介 高木 佐恵子 岩崎 慶 吉本 富士市
雑誌
情報処理学会研究報告グラフィクスとCAD(CG)
巻号頁・発行日
vol.2007, no.13(2007-CG-126), pp.103-108, 2007-02-20

本稿では、人間の顔の3次元形状データを、一般に美しいとされる顔がもつ特徴を有するように変形するシステムについて報告する。変形対象は、眉、目、鼻、口、輪郭とし、形状と配置の美化を行う。美化の程度は、入力パラメータによって制御可能であり、ユーザの好みに合わせた美化モデルを作成できる。提案システムおよび生成された顔モデルについて実験を行った結果、提案システムの有用性を確認した。
著者
藪内 英子 山本 啓之 遠藤 卓郎 八木田 健司 守尾 輝彦
出版者
Japanese Society of Environmental Infections
雑誌
環境感染 (ISSN:09183337)
巻号頁・発行日
vol.13, no.2, pp.137-140, 1998-04-30 (Released:2010-07-21)
参考文献数
14

On 9 March 1996, a 57-year-old Japanese drunken male drown in a public bath in Tokyo. He was transferred to a emergency hospital and recovered. After his discharge on 11 March by walking, he became febrile at night. Next day, because of high fever and dyspnea, he came to the medical attention, and was immediately hospitalized under the diagnosis of acute pneumonia. Although bacteriological, serological examinations and chemotherapy for suspected Legionella pneumonia, definite diagnosis was not obtained and the patient died on 6 April. Culture of the autopsied lung tissue yielded colonies of Legionella pneumophila serogroup (SG) 6, and reexamined serum antibody titer against. L. pneumophila serogroup 6 was 1: 1024 by microplate agglutination test.Examinations for legionellae and their host amobae in the water of 22 bath tubs of 6 public bath facilities located in the area including the facility concerned were carried out on 22 April without notification in advance. Free residual chlorine concentrations of the 22 bath water were from 0.1 to more than 5 mg/L, and water from 2 bath tubs (0.1%) of low chlorine level were legionellae-positive. Host amoebae for legionellae were detected from 10 bath tubs of 5 facilities.Though Naegleria was detected, the bath water where the patient drowned was negative for viable legionellae by repeated trials of culture, 3 times intraperitonal passages of guinea pigs, and coculture with amoebae. The 16S rRNA gene specific for legionellae was detected from the bath water by nested PCR method using primers, 225A-854B and 448A-854B. After filtration of 10 ml bath water, the membrane filter was stained by indirect fluorescent antibody (IFA) method. Rodshaped organisms trapped on the membrane filter were IFA-positive against L. pneumophila SG 6, same with the isolates from lug tissue, and their presumptive number in bath water was estimated as 102-103/ml. Based on the results of nested PCR and IFA staining of rod-shaped bacteria trapped on the membrane filter, the bath water was regarded as contained with viable legionellae due to unknown reason and could be the source of infection when the patient was drowned.
著者
高橋 英雄 植田 啓一 宮原 弘和 渡辺 紗綾 内田 詮三 鎗田 響子 村田 佳輝 板野 栄子 高山 明子 西田 和紀 猪股 智夫 矢口 貴志 佐野 文子 亀井 克彦
出版者
日本医真菌学会
雑誌
日本医真菌学会総会プログラム・抄録集
巻号頁・発行日
vol.51, pp.34, 2007

水族館飼育下イルカのnon-<I>albicans Candida</I> spp.保菌が健康管理および観客への安全上問題となっているので、飼育されているイルカ20頭の呼気と飼育プール水の病原性酵母叢を昨年8月および本年2月に調査した。さらに飼育関係者24名の口腔内と観客席空中浮遊菌の病原性酵母叢の調査を本年2月に行った。保菌イルカは14頭 (70%)、分離株は<I>C. albicans</I>、<I>C. tropicalis</I>、<I>C. glabrata</I>で、1頭を除き2回の調査とも保有菌種は同一で、大多数の株はアゾール薬に耐性傾向を示した。また、4個体は1呼気あたり数十から数百の病原性酵母を噴出していた。飼育プール水の検査では8箇所中5ヵ所から<I>C. albicans</I>および<I>Candida</I> spp. など、飼育関係者の口腔からは24名中5名から<I>C. albicans</I>および<I>Candida</I> spp. などが分離され、一部にアゾール薬に耐性傾向を示す株も含まれていた。観客席空中からは<I>Candida</I> spp.など数株の酵母が分離された。しかし、病原性酵母を噴出しているイルカの呼気が観客に直接かかるような状況はなく、実際に観客席空中からイルカとの共通菌種が分離されなかったため、イルカショーで発生するエアロゾルによる観客への影響は少ないと思われる。一方、イルカ、飼育環境、飼育関係者との間では<I>C. albicans</I>が共通して分離されていたので、現在,遺伝子パターンの解析を進めている。また、イルカの真菌保有の有無は健康状態の指標となりうると思われた。
著者
清多 英樹
出版者
創価大学
雑誌
一般教育部論集 (ISSN:03876284)
巻号頁・発行日
vol.27, pp.73-79, 2003-02

1 0 0 0 OA 日本経済史

著者
竹越与三郎 編
出版者
日本経済史編纂会
巻号頁・発行日
vol.第3巻, 1920
著者
中山 理加
出版者
東京女子医科大学
巻号頁・発行日
2015-07-17

博士(医学) 乙第2881号(主論文の要旨、要約、審査結果の要旨)
著者
邉見 由美 乾 隆帝 後藤 龍太郎 伊谷 行
出版者
日本魚類学会
雑誌
魚類学雑誌 (ISSN:00215090)
巻号頁・発行日
pp.18-021, (Released:2018-09-10)
参考文献数
24

Eight specimens of a threatened goby, Gymnogobius macrognathos (30.04– 38.87 mm in standard length), were collected on a mudflat characterized by abundant burrows of Upogebia major, at Akkeshi, Hokkaido, northern Japan in August 2017. Because G. macrognathos specimens were collected directly from U. major burrows by suction pump, and were also collected with U. major by digging sediment exposed at low tide, it was concluded that G. macrognathos utilized U. major burrows on the tidal flat. Gymnogobius mororanus and an unidentified species of Gymnogobius also utilized U. major burrows. The presence of G. macrognathos at Akkeshi represents the northernmost record of the species in Japanese waters, the isolated population being ca. 500 km north of the main distributional range of the species along the Pacific coast of Japan.
著者
Tao Tian Yajie Lu Jun Yao Xin Cao Qinjun Wei Qi Li
出版者
The Genetics Society of Japan
雑誌
Genes & Genetic Systems (ISSN:13417568)
巻号頁・発行日
pp.18-00006, (Released:2018-08-31)
参考文献数
27
被引用文献数
8

Autosomal dominant non-syndromic hearing loss (ADNSHL) is characterized by postlingual progressive onset. Due to its high genetic heterogeneity, it is difficult to perform a molecular diagnosis for most patients with ADNSHL. In our study, whole-exome sequencing (WES) was used to screen pathogenic gene candidates by analyzing genomic DNA samples from a large Chinese family (JSNY-067), including the proband and her father, who suffered from non-syndromic hearing loss. The pathogenicity of candidate nonsynonymous variants in ADNSHL genes was evaluated by co-segregation analysis in family members by direct PCR and Sanger sequencing. Furthermore, multiple in silico analyses (SIFT, Polyphen2, PROVEAN and MutationTaster) and molecular dynamics simulation were used to assess the potential pathogenicity of the candidate mutations. We identified a novel causative mutation, c.622A>G in MYO6 (DFNA22), that resulted in a p.K208E substitution. This mutation co-segregated with the hearing loss phenotype in extended family members, and was predicted to be pathogenic by SIFT, PolyPhen2, PROVEAN and MutationTaster. Furthermore, molecular dynamics simulation analysis revealed that the p.K208E substitution had a limited influence on the whole protein structure and stability, but that it could affect the locations of the sidechains of nearby hydrophilic residues, which in turn resulted in the sidechains of Asn186 and Glu190 being exposed more frequently at the surface of the protein. WES has thus been shown to be a useful molecular diagnostic tool in screening uncommon gene mutations associated with hereditary hearing loss.
著者
髙津戸 望 青山 真人 杉田 昭栄
出版者
日本家畜管理学会
雑誌
日本家畜管理学会誌・応用動物行動学会誌 (ISSN:18802133)
巻号頁・発行日
vol.52, no.2, pp.85-97, 2016-06-25 (Released:2016-12-27)
参考文献数
28

ヒヨドリによる果樹食害の対策法を検討するために、各種光波長の発光ダイオード(LED)を果実に照射し、ヒヨドリの採食行動がどのような影響を受けるかを試験した。実験には、野生から捕獲したヒヨドリを供試した。赤(630nm)、黄(590nm)、緑(525nm)、青(470nm)の4種のLEDと、対照として一般的な蛍光灯を用い、各個体を単独飼育下で実験した。ヒヨドリ5羽に8段階の成熟度の異なるイチゴを同時に提示する選択実験を行なった結果、蛍光灯を照射した対照区でヒヨドリは成熟度が最も高い果実を優先的に選択したが、各色LEDの照射時には、成熟度の高いイチゴを選択する行動に有意差があった。特に青色LED照射時は、ヒヨドリがイチゴを選択するまでの時間が有意に長くなり、イチゴを1つも選択せずに終了した試行が3個体で4試行観察された。一方、ヒヨドリ4羽に7段階の成熟度の異なるブドウを同時に提示する選択実験を行なった結果、いずれのLED照射時においてもヒヨドリは成熟度の高い果実を選択し、その選択行動に相違はなく、青色LED照射時も含め、果実を選択するまでの時間にLEDによる差はなかった。これらの結果より、イチゴでは青色LEDを照射することで、ヒヨドリの採食行動を抑制することが期待できたが、ブドウのようにこの効果が期待できない果実もあることが分かった。LEDの照射によるヒヨドリの果実採食行動への影響は、本来の果実の色により異なることが示唆された。
著者
鈴木 洋一 坂本 修 真下 陽一 羽田 明
出版者
公益社団法人 日本ビタミン学会
雑誌
ビタミン (ISSN:0006386X)
巻号頁・発行日
vol.86, no.9, pp.499-507, 2012-09-25 (Released:2017-10-10)
参考文献数
31

Biotin is a water-soluble vitamin and a cofactor of several types of carboxylases. Insufficient intake of biotin and a congenital deficiency of enzymes requiring biotin as a cofactor in cells cause clinical symptoms called multiple carboxylase deficiency (MCD). In recent years, several reports have shown that infants with food allergy and/or atopic eczema have developed MCD after being fed with peptide formulas. Peptide formulas available in Japan contain very little biotin because biotin has not been permitted to be added to regular foods as an additive. This, however, may lead to nutritional biotin deficiency in some infants fed with such a peptide milk. We investigated the incidence of nutritional biotin deficiency and congenital enzyme deficiency in Japan. We sent a questionnaire to 921 hospitals with a pediatric department to cover all areas of Japan. The response rate was 64%. The rate of hospitals that use peptide milk in the therapy of allergic diseases was 49%. The estimated incidence of biotin deficiency was at least 70 cases in the last 10 years. Since the first diagnosis of holocarboxylase synthetase deficiency (HCSD) in 1982, HCSD and biotinidase deficiency have been confirmed in 28 and 2 cases, respectively. These data suggest that the incidence of congenital enzyme deficiency is about 1 case per year. Supplementation of biotin is highly recommended when infants are fed with peptide milk in Japan.
著者
Yosuke Shibata Toshiyuki Ojima Mieko Nakamura Kazuyo Kuwabara Naoko Miyagawa Yoshino Saito Yasuyuki Nakamura Yutaka Kiyohara Hideaki Nakagawa Akira Fujiyoshi Aya Kadota Takayoshi Ohkubo Tomonori Okamura Hirotsugu Ueshima Akira Okayama Katsuyuki Miura
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20170229, (Released:2018-07-21)
参考文献数
40
被引用文献数
8

Background: The trend of association between overweight and high serum total cholesterol (TC) among the elderly is unclear. In addition, there is little evidence of risk of underweight for high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data.Methods: Data of the National Survey on Circulatory Disorders and National Health and Nutrition Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs) of overweight or underweight compared with normal body mass index participants for high TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia.Results: A total of 5,014, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980, 1990, 2000, and 2010, respectively. Although overweight was positively and significantly associated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83–3.24 and 0.92; 95% CI, 0.66–1.27 among men and 1.43; 95% CI, 1.18–1.72 and 1.08; 95% CI, 0.81–1.44 among women, respectively). While underweight was inversely and significantly associated with high TC in 1980, the association also gradually weakened among women (ORs in 1980 and 2010 were 0.28; 95% CI, 0.12–0.60 and 0.37; 95% CI, 0.10–1.28 among men and 0.39; 95% CI, 0.26–0.57 and 0.96; 95% CI, 0.58–1.57 among women, respectively).Conclusions: These findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.
著者
根本 知己
出版者
特定非営利活動法人 日本レーザー医学会
雑誌
日本レーザー医学会誌 = The Journal of Japan Society for Laser Medicine (ISSN:02886200)
巻号頁・発行日
vol.30, no.4, pp.435-440, 2010-01-30
参考文献数
29
被引用文献数
1

近赤外超短光パルスレーザー光によって引き起こされる多光子励起過程を利用する2光子顕微鏡は,その固有の物理学的,化学的特性のため,生組織や生細胞のイメージングに適している.特に,インタクトに近い組織の深部断層像を,高い空間分解能をもって長時間にわたり観察することが可能である.また開口放出現象の分子基盤やその病理学的研究にも有効であることを示してきた.本稿では2光子顕微鏡を中心に,新しいバイオ分子イメージングについて議論する.

1 0 0 0 OA 本草秘訣

出版者
巻号頁・発行日
vol.巻6, 1826