著者

弦間 昭彦

出版者

一般社団法人 日本呼吸ケア・リハビリテーション学会

雑誌

日本呼吸ケア・リハビリテーション学会誌 (ISSN:18817319)

巻号頁・発行日

vol.25, no.1, pp.82-87, 2015-04-30 (Released:2015-09-11)

参考文献数

12

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肺非小細胞癌においては,分子標的治療研究が進み,多くの薬剤の開発がなされている.その中で,多くの問題点も浮かび上がっている.耐性機序,薬剤の使い分け,併用の在り方,個別化の方策など,枚挙に暇が無い.特に,治癒への治療戦略が視野に入ってきており,癌の多様性に基づく耐性獲得を想定した際,併用療法が一つの候補と言える.また,異なる視点での治療標的の併用が考えられる.間質との関係,免疫修飾,代謝の制御,ゲノム不安定性の制御,幹細胞へのアプローチなどが,現時点で候補となる標的といえる.

著者

Laurence D. Loeb

出版者

Gordon and Breach

巻号頁・発行日

1977

著者

明凌迪知撰

巻号頁・発行日

vol.[9], 1579

著者

徳増 伸二

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.83, no.1, pp.13-16, 2017-01-05 (Released:2017-01-05)

被引用文献数

1

著者

大橋 將

出版者

専門日本語教育学会

雑誌

専門日本語教育研究 (ISSN:13451995)

巻号頁・発行日

vol.12, pp.15-18, 2010-12-20 (Released:2011-07-22)

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一般的に、法律の文章は非常にわかりにくいと酷評されている。もちろん、法学初学者にとっても、この状況は決して歓迎されることではなく、初学者は昔から一様に嘆き悲しむ。しかし、法律家は、さまざまな非難にもかかわらず、この風潮を変えようとせず、かえって「法律学習の仕方」の類の書物を数多く世に送り出してきた。つまり、法律文書の晦渋さは自明の前提となっているといってよい。本稿では、なぜそうなっているのか、法律条文、判決文を素材に構造の一端を検討し、法律文理解のための指針を示す。

著者

Jin-Kyung Kim

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.8, pp.1138-1140, 2018 (Released:2018-08-07)

参考文献数

12

被引用文献数

6

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[Purpose] The purpose of this study was to learn about the effects of a home-oriented program based on sensorimotor activities on executive and motor functions in children with ADHD. [Participants and Methods] In this study, a home-based sensorimotor program was conducted for two male children diagnosed with ADHD. The participants performed the program with their parents four times a week, for forty minutes each time, over a 12-week period. The participants’executive functions and gross motor skills were evaluated using the Children’s Color Trails Test (CCTT) and the Bruininks-Oseretsky Test of Motor Proficiency-2 (BOT-2). [Results] After participating in the home-based sensorimotor program, the participants showed improvements in both their executive and motor functions. [Conclusion] This study confirmed that a home-based sensorimotor program was effective in improving executive and motor functions in children with ADHD. This conclusion suggests the need to develop various exercise programs that can relieve the symptoms of ADHD in children and improve their abilities to adapt at home or school.

著者

簗瀬 拓弥 増田 英孝 山田 剛一 荒牧 英治 中川 裕志

雑誌

研究報告情報基礎とアクセス技術(IFAT)

巻号頁・発行日

vol.2013-IFAT-110, no.1, pp.1-6, 2013-02-21

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本研究では電車の運行状況をリアルタイムに一般の Twitter のユーザのツイートから取得することを目的とする.対象として常磐線をキーワードとして含むパブリックタイムライン上のツイートを半年分収集した.このデータを用いて単位時間あたりのバースト数を元に定常時と異常時を判別し,通知を行うシステムを試作した.また,遅延や運転見合わせ時のユーザのツイートの特徴の分析を行った.

著者

Kazushi Takahashi Hirotaka Mutsuzaki Yuki Mataki Kenichi Yoshikawa Mayumi Matsuda Keiko Enomoto Kumiko Sano Aoi Kubota Masafumi Mizukami Nobuaki Iwasaki Masashi Yamazaki

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.8, pp.1009-1013, 2018 (Released:2018-07-24)

参考文献数

21

被引用文献数

16

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[Purpose] This study aimed to determine the safety and immediate effect of a single training session with the Hybrid Assistive Limb (CYBERDYNE) on walking ability in patients with cerebral palsy. [Participants and Methods] This study included 20 patients with cerebral palsy (15 males, 5 females, mean age 15.0 ± 6.3 years; 19 with spastic cerebral palsy, 1 with athetoid cerebral palsy; Gross Motor Function Classification System level I: 4, II: 3, III: 9, and IV: 4). Participants completed a single 20-minute gait training session using the Hybrid Assistive Limb. The safety and immediate effect were evaluated. The immediate outcomes were gait speed and mean step length, and cadence before and after training. [Results] Two participants were excluded because they were not tall enough to use the Hybrid Assistive Limb. Eighteen participants performed the training. There were no serious adverse events during the training. Since 14 participants were able to walk on their own, walking evaluations were performed before and after training. Statistically significant improvements were observed in gait speed and mean step length. [Conclusion] Gait training using the Hybrid Assistive Limb is safe for patients with cerebral palsy and can produce immediate effects on walking ability in ambulatory patients with cerebral palsy.

著者

渡辺 雄二 隅田 衣江 太田 徹

出版者

日本食生活学会

雑誌

日本食生活学会誌 (ISSN:13469770)

巻号頁・発行日

vol.25, no.1, pp.26-31, 2014 (Released:2014-07-25)

参考文献数

19

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A relationship between eating behavior and attitude to uncleanness of daily life in female college students and female high school students was statistically studied by method of questionnaire. Following results were obtained;1)  The fundamental factor of attitude to uncleanness on daily life was “hating to make use of goods placed public utility”.2)  274 subjects were classified into three groups by using their principal component scores.3)  In attitude to uncleanness, 44 subjects who showed over minus 0.9 score were liable to hate hanging on to straps of trains and buses, touching door knobs and keyboards of personal computers, using toilet seats, sofas and mules in public utility. On the other hand, 41 subjects who showed over plus 0.9 score were not.4)  In eating behavior, they who showed over minus 0.9 score were liable to pay attention to the dirt of tablewares and tables at the time of eating out. But they who showed over plus 0.9 score were not.  From above results, it was speculated their attitude to uncleanness on daily life closely related eating behavior of female college students and female high school students.

著者

中田 高 徳山 英一 隈元 崇 室井 翔太 渡辺 満久 鈴木 康弘 後藤 秀昭 西澤 あずさ 松浦 律子

出版者

The Association of Japanese Geographers

雑誌

日本地理学会発表要旨集

巻号頁・発行日

pp.240, 2013 (Released:2013-09-04)

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2011年東北地方太平洋沖地震以降,中央防災会議によって,南海トラフ沿いの巨大地震と津波の想定がなされているが,トラフ外れた海底活断層については詳しい検討は行われていない.縁者らは,詳細な数値標高モデルから作成した立体視可能な画像を判読し,南海トラフ東部の南方に位置する銭洲断層系活断層の位置・形状を明らかしたうえで.その特徴および歴史地震との関連を検討する.

著者

栗本瑞見

出版者

写

巻号頁・発行日

vol.[3],

出版者

誠文堂新光社

巻号頁・発行日

1947

著者

小林 義典

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.50, no.1, pp.7_2, 2014 (Released:2016-02-01)

著者

松平定信 編

出版者

刊

巻号頁・発行日

vol.[3],

出版者

谷岡七左衛門

巻号頁・発行日

vol.[3], 1654

著者

光冨 省吾

出版者

福岡大学研究推進部

雑誌

福岡大学研究部論集 A 人文科学編 (ISSN:13464698)

巻号頁・発行日

vol.7, no.4, pp.13-28, 2007-12

巻号頁・発行日

vol.[15], 1000

著者

葛葉山人正二 作

出版者

鶴屋喜右衛門

巻号頁・発行日

vol.前編, 1815

著者

曲田 浩和

出版者

日本福祉大学知多半島総合研究所

雑誌

知多半島の歴史と現在 = Chita Peninsula, its history and present (ISSN:09154833)

巻号頁・発行日

no.21, pp.151-171, 2017-10

著者

Yuhi SAITO Toshihiro MIHARA Mamoru OKI Takehisa KUMAGAI

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.37, no.3, pp.59-65, 2018 (Released:2018-07-26)

参考文献数

48

被引用文献数

5

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Lactobacillus casei subsp. casei 327 (L. casei 327) was isolated from brown rice. A preliminary study showed that intake of 50 mg of heat-killed L. casei 327 is effective in improving defecation. In this study, we conducted a randomized, double-blind, placebo-controlled, parallel-group trial to investigate the effect of intake of heat-killed L. casei 327 (25 mg: approximately 5 × 1010 bacteria) on defecation in healthy volunteers with relatively low defecation frequencies. We selected 104 healthy Japanese adults with relatively low defecation frequencies (approximately 3–5 times a week) by screening and pretrial tests. Subjects (n=52 in each group) were randomly given a tablet containing L. casei 327 (group A) or a placebo tablet (group P) daily for 2 weeks. After eliminating data for 9 subjects who met the exclusion criteria for efficacy analysis, data for 95 subjects were analyzed. The defecation frequency and number of defecation days during the intake period and their changes from the pretrial period were significantly higher in group A than in group P. The fecal volume during the intake period was higher in group A than group P, but the difference was not statistically significant. However, the change from the pretrial period was significantly higher in group A than in group P. There were no significant differences between groups in the values of fecal shape, color, odor, and feeling after defecation. These results suggested that intake of L. casei 327 improves defecation in healthy adults who have relatively low defecation frequencies.