著者

Ryo SAITO James K CHAMBERS Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.23-0300, (Released:2023-08-09)

被引用文献数

1

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Feline meningiomas usually have benign biological behavior, while canine and human meningiomas are often classified as grade 2 or 3. Activation of the platelet-derived growth factor (PDGF) and its receptor signal pathway through PDGFβ/Rβ autocrine and paracrine is considered to play an important role in the tumor proliferation and malignant transformation of human meningiomas. However, there have been few studies about the expression of these molecules in canine meningiomas and no studies about their expression in feline meningiomas. We analyzed the PDGFα/Rα and PDGFβ/Rβ expression in canine and feline meningiomas by immunohistochemistry and western blotting. Immunohistochemically, most canine meningiomas showed the expression of PDGFα (42/44; 95.5%), PDGFRα (44/44; 100%) and PDGFRβ (35/44; 79.5%), and a few showed the expression of PDGFβ (8/44; 18.2%). In contrast, feline meningiomas were immunopositive for PDGFRα and PDGFRβ in all cases (14/14; 100%), while no or a few cases expressed PDGFα (0/14; 0%) and PDGFβ (2/14; 14.3%). Western blotting revealed specific bands for PDGFα, PDGFRα and PDGFRβ, but not for PDGFβ in a canine meningioma. In a feline meningioma, specific bands for PDGFRα and PDGFRβ were detected, but not for PDGFα and PDGFβ. These results suggested that canine meningiomas commonly express PDGFα/Rα, and thus autocrine or paracrine PDGFα/Rα signaling may be involved in their initiation and progression. Moreover, PDGF negativity may be related to benign biological behavior and a low histopathological grade in feline meningioma.

著者

Maamer Jlali Clémentine Hincelin Maria Francesch Tania Rougier Pierre Cozannet Sarper Ozbek Marcio Ceccantini Baris Yavuz Aurélie Preynat Estelle Devillard

出版者

Japan Poultry Science Association

雑誌

The Journal of Poultry Science (ISSN:13467395)

巻号頁・発行日

vol.60, no.2, pp.2023019, 2023 (Released:2023-08-05)

参考文献数

29

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Exogenous phytases are commonly added to low-phosphorus and low-calcium diets to improve P availability and reduce P excretion by poultry. This study investigated the effect of supplementation with a novel bacterial 6-phytase on egg production, egg quality, bone mineralization, and precaecal digestibility of P in laying hens fed corn-soybean meal-based diets. A total of 576 Hy-Line brown laying hens were used in a completely randomized block design at 25–45 weeks of age (woa). The three treatments included a positive control (PC) adequate-nutrient diet with 2840 kcal metabolizable energy/kg, 0.77% digestible lysine, 3.5% Ca, and 0.30% available P (avP); a negative control (NC) diet with 0.16% points less Ca and avP; and an NC diet supplemented with a novel bacterial 6-phytase at 300 phytase units/kg diet. Hen performance and the percentage of damaged eggs were measured every 4 weeks. Body weight, precaecal digestibility of P, and bone parameters at 45 woa were also measured. The reduction in avP and Ca in the NC diet did not compromise performance or egg quality. However, it decreased (P < 0.001) body weight, tibial dry matter, tibial ash and P content, and precaecal digestibility of P. Importantly, all these parameters were significantly improved (P < 0.001) and essentially restored to the levels measured in PC diet-fed hens upon supplementation with phytase. In summary, the present study demonstrates that the new bacterial 6-phytase could effectively counteract the negative effects of P and Ca deficiencies on body weight, bone mineralization, and P availability, thereby supporting high productivity without compromising the welfare of laying hens.

著者

中村 祐介 吉富 秀幸 清水 宏明 大塚 将之 加藤 厚 古川 勝規 高屋敷 吏 久保木 知 高野 重紹 岡村 大樹 鈴木 大亮 酒井 望 賀川 真吾 宮崎 勝

出版者

一般社団法人 日本膵臓学会

雑誌

膵臓 (ISSN:09130071)

巻号頁・発行日

vol.30, no.2, pp.258-264, 2015-04-20 (Released:2015-05-08)

参考文献数

16

被引用文献数

2 2

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【目的】膵腺房細胞癌(以下ACC)は稀な膵腫瘍であり,その発生頻度は全膵腫瘍の約0.4%とされる.本疾患の臨床病理学的特徴には未だ不明な点も多く,自験例での検討を行った.【対象】2004年から2011年までに当教室で経験し,組織学的に確認し得たACC 4症例.【結果】平均年齢は68.2歳,全例男性で,CT検査画像では境界明瞭で内部不均一な低濃度腫瘤影を呈し,血液検査では血清エラスターゼ1,AFP値の上昇を認めた.治療は3例に根治的切除が施行され,切除不能例には5-FU+放射線照射併用療法が施行された.切除例全例に肝転移再発を認め,追加切除または全身化学療法を施行した.治療成績では追加切除例で68.4ヶ月,切除不能例で70.0ヶ月の長期生存例を経験した.【結論】今後も症例の集積により,再発・転移例に対する積極的な制癌治療を含む治療戦略の検討が必要と考えられた.

著者

Tomoko TAKAHASHI Hitoshi SHIOZAWA Teita ISHIZAKI Kazuki OKADA Hirotaka KONDO

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.23-0136, (Released:2023-08-08)

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An 11-year-old spayed female French bulldog was referred on suspicion of nasal tumor. Anaplastic oligodendroglioma in the olfactory bulb that was suspected to have invaded the nasal cavity was diagnosed from imaging and histopathology. Metastasis to cervical lymph nodes was suspected, with no other metastases identified. The brain-to-nasal lesion and lymph nodes were treated with hypo-fractionated radiation therapy. Nasal congestion soon resolved. About 3 months later, follow-up computed tomography revealed multiple hepatic and splenic masses, which were cytologically suspected as metastatic oligodendroglioma. Nimustine, followed by toceranib phosphate, seemed to have no effect, and the dog died on day 167. Postmortem examination revealed the primary tumor disappearance and systemic metastases. Canine oligodendroglioma can grow outside the cranial vault, and systemically metastasize.

著者

尾崎 雄二 尾崎 由紀

出版者

伊丹市昆虫館

雑誌

伊丹市昆虫館研究報告 (ISSN:21877076)

巻号頁・発行日

vol.11, pp.15-23, 2023-03-31 (Released:2023-07-20)

著者

中村 晋 山口 道也 大石 光雄 葉山 隆

出版者

一般社団法人 日本アレルギー学会

雑誌

アレルギー (ISSN:00214884)

巻号頁・発行日

vol.23, no.8, pp.548-553,580, 1974-08-30 (Released:2017-02-10)

被引用文献数

3

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われわれのallergy clinicで診療する機会を得たそばアレルギー症9例について総括検討し, そばアレルギー症の臨床的特徴として次の諸点を指摘した.1) 喘息発作, 蕁麻疹, 胃腸症状, 鼻症状あるいは結膜充血などが組合さって発症するが, これら症状間に一線を画することはできない.2) そばによる過敏症状は, 抗原物質が経口的に体内に侵入する時も経気道的に侵入する時も発症する.3) 種々のアレルギー学的検索成績から, 上記の過敏症状は抗原抗体反応に基づく厳密な意味でのアレルギー機序によるものと考えられ, そばアレルギー症は Coombs and Gell のいわゆるI型アレルギー(即時型アレルギー)の model であるとみられる.4) そばの抗原性はきわめて強く, そばエキスの注射により全身のshock等の重篤な反応を惹起する危険性があるので, そばによる減感作療法は安易に行うべきではない.

著者

小沼 ルミ

出版者

公益社団法人 日本木材保存協会

雑誌

木材保存 (ISSN:02879255)

巻号頁・発行日

vol.42, no.1, pp.2-11, 2016 (Released:2016-04-01)

参考文献数

39

被引用文献数

1

著者

佐藤正広著

出版者

岩波書店

巻号頁・発行日

2015

著者

原口 耕一郎

出版者

名古屋市立大学

巻号頁・発行日

2018

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平成29年度

著者

沢田勲著

出版者

東方書店

巻号頁・発行日

1996

著者

日高 聡太 三枝 千尋

出版者

日本基礎心理学会

雑誌

基礎心理学研究 (ISSN:02877651)

巻号頁・発行日

vol.41, no.2, pp.144-145, 2023-03-31 (Released:2023-06-16)

参考文献数

7

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This note is a short report on the activities of the Young Researchers Committee of the Japanese Psychonomic Society (JPS). As the highlighted activity of the committee, we have held the oral session of the annual meeting of JPS both face-to-face and online formats nine times. We also have promoted interactive activities across the country through social networking services. By introducing public applications, we have tried to organize our committee with diverse members. We will continue to develop new activities to target a broader range of young or early-career researchers.

著者

今井 倫太

出版者

一般社団法人 人工知能学会

雑誌

人工知能学会全国大会論文集 第37回 (2023) (ISSN:27587347)

巻号頁・発行日

pp.2I6OS4a01, 2023 (Released:2023-07-10)

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インタラクションの文脈を捉える人工知能技術が出現しつつある。本稿では、ある情報を人同士の会話に合わせた情報と変換したり、ある人の発言を、既に進行中の会話に合わせた物へと適応したりする情報文脈化技術について提案する。情報文脈か技術の実例を検討することで、人や情報をインタラクションの文脈へ載せるコンテキストラインディング支援の可能性について考察する。

著者

橋本 良太 藤井 景子 吉田 和子 下路 静佳 正木 秀典 角山 香織 中村 敏明 恩田 光子

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.138, no.9, pp.1217-1225, 2018-09-01 (Released:2018-09-01)

参考文献数

20

被引用文献数

3 3

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The current study aimed to examine the outcomes of pharmacists' involvement with elderly people in special nursing homes. We analyzed 58 cases involving regular visits by community pharmacists to 41 residents. The residents' mean age was 87.8±6.9 years, and 68.3% were prescribed 6 or more types of medication. Antipsychotic and insomnia medication was taken by 24.4% and 31.8% of residents, respectively. Pharmaceutical consultation following medication use accounted for 60.3% of pharmacists' involvement with residents. The outcomes of these consultations included improvements in prescription content; the identification and prevention of adverse drug events; improvement in activities of daily living; and improvement in test results, sleep, and urination/bowel control. The results also suggested that pharmacists' intervention reduced drug costs. Information that facilitated involvement was most frequently acquired via conversations (67.2%) and conferences (24.1%) in the facilities. The most common information sources were care workers (72.4%), followed by nurses (37.9%), physicians (6.9%), and functional training instructors (6.9%). Information was also acquired from patients (3.4%) and their family members (5.2%). The findings indicated that regular visits by pharmacists to facilities for elderly people and conversations between residents, their family members, and physicians, nurses and various other professionals improved various pharmacotherapy outcomes.

著者

金 営三 鈴木 光郎 松岡 功

出版者

一般社団法人 資源・素材学会

雑誌

日本鉱業会誌 (ISSN:03694194)

巻号頁・発行日

vol.102, no.1176, pp.85-89, 1986-02-25 (Released:2011-07-13)

参考文献数

20

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As a basic research for the application of high gradient magnetic separation, the magnetic susceptibilities were measured in room temperature for some sulfide minerals;pyrite, chalcopyrite, bornite, chalcocite, covellite, sphalerite and galena. The susceptibilities of crystalline pyrites, except 0.46 × 10-6emu/g of colloform pyrite, gave low values of narrow range from 0.16 to 0.28 × 10-6 emu/g, which are independent of the magnetic force.Besides, pyrites from the metamorphic and metasomatic deposits caused to vary the magnetization intensity depending on magnetic force owing to the coexisting minor ferromagnetic minerals as magnetite, hematite and pyrrhotite.Against chalcopyrite, the susceptibility ranged the values from 2.8 to 7.0 × 10-6emu/g, but bornite showed a low value of 0.7 × 10-6emu/g.Sphalerites showed more positive susceptibilities with the increase of iron content, and the curve followed by the values is nonlinear which is similar to the curve, given by Keys et al.(1968).Chalcocite, covellite and galena are diamagnetic substantially.Nevertheless, the first one gave positive valueof 0.04 × 10-6emu/g and the second one 0.5 and 0.9 × 10-6emu/g.In galena only, the negative value was found as- 0.04 ×10-6 emu/g, but it is very small, as compared to pure synthetic PbS.It is thought that the deviations of susceptibilities of the above three minerals might have been caused by the presence of any magnetic impurity within them as iron in sphalerite.

著者

町 博光

出版者

日本総合学術学会

雑誌

総合学術学会誌 (ISSN:13474278)

巻号頁・発行日

vol.6, pp.5-12, 2007 (Released:2022-05-09)

著者

Yoshiaki Tai Kenji Obayashi Kazuki Okumura Yuki Yamagami Hiromitsu Negoro Norio Kurumatani Keigo Saeki

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20210471, (Released:2022-02-19)

参考文献数

34

被引用文献数

1

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Background Cold exposure induces lower urinary tract symptoms including nocturia. Cold-induced detrusor overactivity can be alleviated by increasing skin temperature in rats. However, no study has shown an association between passive heating with hot-water bathing and nocturia among humans.Methods We included 1,051 Japanese community-dwelling older adults (mean age 71.7 years) in this cross-sectional study from 2010 to 2014. The number of nocturnal voids was recorded in a self-administered urination diary. Nocturia was defined as ≥2 nocturnal voids. We evaluated bathing conditions in the participants’ houses.Results Hot-water bathing (n = 888) was associated with a lower prevalence of nocturia than no bathing (n = 163), independent of potential confounders including age, sex, obesity, income, physical activity, diabetes, medication (diuretics, nondiuretic antihypertensives, and hypnotics), depressive symptoms, indoor/outdoor temperature, and day length (odds ratio [OR]: 0.68, 95% confidence interval [CI]: 0.48–0.97; p = 0.035). Compared with the quartile group with the longest bath-to-bed interval (range: 161–576 min), the second and third quartile groups (range: 61–100 and 101–160 min, respectively) were associated with a lower prevalence of nocturia, after adjusting for water temperature and bathing duration besides the same covariates (OR: 0.60, 95% CI: 0.38–0.96; p = 0.031 and OR: 0.59, 95% CI: 0.37–0.94; p = 0.025, respectively).Conclusion Hot-water bathing, particularly with a bath-to-bed interval of 61–160 min, was significantly associated with a lower prevalence of nocturia among older adults.

著者

塩入 亮乗

出版者

Research Society of Buddhism and Cultural Heritage

雑誌

佛教文化学会紀要 (ISSN:09196943)

巻号頁・発行日

vol.1997, no.6, pp.45-59, 1997-11-10 (Released:2009-08-21)

参考文献数

3

著者

島村 玲雄

出版者

日本財政学会

雑誌

財政研究 (ISSN:24363421)

巻号頁・発行日

vol.10, pp.163-180, 2014 (Released:2021-10-26)

参考文献数

25

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オランダにおける1990年税制改革では,社会保険料と所得税の制度的「統合」が行われた。本稿は,この税と保険料が統合された背景を明らかにし,統合の意義について考察することを目的としている。この統合は保険料と税の一元徴収というだけでなく,課税ベースや税率構造といった点までをも統合したことが特徴として挙げられる。税改正は狭い課税ベースの是正が課題であった。さらに,パートタイム労働を積極的に推進した労働政策によって稼得世帯モデルが変化してきたことで,従来の税制と社会保険料制度に不満が出てきていた。この統合に加えて,社会保険料の事業主負担分が被用者負担となった。そのため「調整加給金」という新たな制度が導入され,使用者はそれまでの負担分に相当する額を被用者に対して賃金に上乗せする形で補償しなければならなくなった。

著者

桑山 三恵子 和地 陽二 瀬戸 進 柳 光男

出版者

The Society of Cosmetic Chemists of Japan

雑誌

日本化粧品技術者会誌 (ISSN:03875253)

巻号頁・発行日

vol.20, no.3, pp.167-179, 1986-12-25 (Released:2010-08-06)

参考文献数

20

被引用文献数

1 1

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The microbial flora of the facial skin was examined through the year for 41 healthy female subject. In order to study the relationship between microbial flora and skin surface conditions, physiological parameters (skin surface lipid, skin surface morphology and Transepidermal Water Loss) were also determined. The facial skin types were classified by skin surface lipid and skin surface morphology.The predominant microorganisms on the skin were Propionibacterium acnes as anaerobic bacteria and Staphylococcus S2, aerobic diphtheroids, micrococci as aerobic, and incidence of micrococci was increased in winter. Aerobic bacteria were clossly related to TWL and skin surface morphology and it was shown that micrococci were detected more frequently on the dry and flaky skin. In the relationship between microbial flora and skin type, it was shown that P. acnes was predominantly detected on every type skin. On the other hand Staphylococcus S2 was predominantly isolated on the “normal skin”. micrococci were found on the “dry-type, oily skin” and both Staphylococcus S2 and aerobic diphtheroids were on the “oily skin”, respectively. Furthermore, it was revealed that staphylococci and the supernatants of the culture fluid inhibit the growth of micrococci.From these results, it was suggested that dry and flaky skin or “dry-type, oily skin” would be improved by inhibition of growth of micrococci with staphylococci.

著者

佐々木 順二

出版者

筑波大学心身障害学系

雑誌

心身障害学研究 (ISSN:02851318)

巻号頁・発行日

vol.29, pp.1-16, 2005-03

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大正期の和歌山県立盲唖学校において和歌山聾唖興業界が設立される経緯と理由を、学校支援組織が果たした役割、卒業後問題、初代校長辻本與次郎の教育理念との関係の観点から解明した。和歌山県立盲唖学校は、小学校教育の目的・内容を準用した教育と、障害に応じた職業教育を提供することで、生徒には、精神面での自発性、身体面での健康、そして社会生活を営むための常識と職業的技能の装備を期待した。しかし、学校の財政的基盤は脆弱であり、教育力不足、教員への過重負担、自校校舎の不在という教育的課題に直面していた。これらの教育的課題には、和歌山市周辺の有志による人的・財政的支援を受けた学校後援会及び新築期成同盟会が対処していった。この過程で、和歌山聾唖興業界が比較的裕福な家族を中心に設立されたが、同会は卒業生の就労困難と社会的孤立への対処を目指しており、聾唖者の自活と国民としての人格の向上という辻本の教育理念を反映するものであった。