著者

Imari Mimura Tetsuhiro Tanaka Youichiro Wada Tatsuhiko Kodama Masaomi Nangaku

出版者

(公社)日本薬理学会

雑誌

Journal of Pharmacological Sciences (ISSN:13478613)

巻号頁・発行日

vol.115, no.4, pp.453-458, 2011 (Released:2011-04-15)

参考文献数

41

被引用文献数

18 29

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The hypoxia response regulated primarily by hypoxia-inducible factor (HIF) influences metabolism, cell survival, and angiogenesis to maintain biological homeostasis. In addition to the traditional transcriptional regulation by HIF, recent studies have shown that epigenetic modulation such as histone methylation, acetylation, and DNA methylation could change the regulation of the response to hypoxia. Eukaryotic chromatin is known to be modified by multiple post-translational histone methylation and demethylation, which result in the chromatin conformation change to adapt to hypoxic stimuli. Interestingly, some of the histone demethylase enzymes, which have the Jumonji domain–containing family, require oxygen to function and are induced by hypoxia in an HIF-1–dependent manner. Recent studies have demonstrated that histone modifiers play important roles in the hypoxic environment such as that in cancer cells and that they may become new therapeutic targets for cancer patients. It may lead to finding a new therapy for cancer to clarify a new epigenetic mechanism by HIF and histone demethylase such as JMJD1A (KDM3A) under hypoxia.

著者

TAKASHI HAYASHI

出版者

The Keio Journal of Medicine

雑誌

The Keio Journal of Medicine (ISSN:00229717)

巻号頁・発行日

vol.14, no.3, pp.135-144, 1965 (Released:2009-03-27)

参考文献数

20

被引用文献数

2 7

著者

森 一功 梅野 博仁

出版者

日本喉頭科学会

雑誌

喉頭 (ISSN:09156127)

巻号頁・発行日

vol.14, no.2, pp.78-82, 2002-12-01 (Released:2012-09-24)

参考文献数

10

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Various controversial problems have been pointed out for the treatment modality for patients with cicatricious stenosis of the larynx as follows : 1) successive change of the autografted mucosa and/or skin, 2) timing of complete closure of the tracheostoma, 3) influence of puberty upon the air-way, and 4) influence of puberty upon vocal functions. Thirty-six patients more than 15-year-old and 23 patienets less than 15-year-old, both with cicatricious stenosis of the larynx, were retrospectively reviewed in this study. As a result, following conclusions were obtained.1) Autografted mucosa/skin can be alive accompanying prominent cicatricious change below the grafted mucosa/skin, suggesting this histopathological change may bring re-stenosis of the air-way. 2) The trachestoma should be closed preferably after puberty, especially for patients undergoing posterior cricoid split (PCS) maneuver. For patients without PCS complete closure in childhood may cause no serious problem. 3) Patients treated their stenosis in childhood may have no restenosis of the air-way even in adulthood. 4) Patient with laryngeal stenosis may experience voice change at puberty as like ordinary children.

著者

Shinichiro Ikezaki Mizuho Takagi Kazutoshi Tamura

出版者

日本毒性病理学会

雑誌

Journal of Toxicologic Pathology (ISSN:09149198)

巻号頁・発行日

vol.24, no.1, pp.37-40, 2011 (Released:2011-04-17)

参考文献数

8

被引用文献数

8 32

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It is important for the assessment of toxicological effects of chemicals to know what kinds of neoplasms naturally occur in the early life of experimental animals. In the present study, we demonstrated spontaneous neoplasms in Sprague-Dawley rats used in 4-, 13- and 26-week toxicity studies conducted at Bozo Research Center in the last decade. The tumors, which were first observed in 19-week-old animals, included anterior adenoma of the pituitary, follicular cell adenocarcinoma and C cell adenoma of the thyroids, nephroblastoma of the kidneys, basal cell tumor of the skin and malignant lymphoma. Thereafter, hemangiosarcoma of the tongue, adenocarcinoma of the submandibular glands, histiocytic sarcoma of the spleen, oligodendroglioma of the brain and adenocarcinoma and fibroadenoma of the mammary glands were detected in 32-week-old animals. The incidences of mammary adenocarcinoma and pituitary anterior adenoma were higher than those of other tumors. The present results showed that the same tumors as reported in aged rats could also develop in younger rats.

著者

Sawane MITANI Akira YABUKI Mariko SAWA Hye-Sook CHANG Osamu YAMATO

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0314, (Released:2013-09-05)

被引用文献数

1 15

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Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system (RAS). ACE2 is a newly identified member of the RAS. The present immunohistochemical study focused on changes in intrarenal ACE and ACE2 immunoreactivity in feline and canine chronic kidney disease (CKD). ACE immunoreactivity was predominantly observed in the brush border of the proximal tubules in dogs and cats. ACE immunoreactivity was lower in CKD kidneys than in normal kidneys, and quantitative analysis demonstrated negative correlations between ACE and renal tissue damage in dogs. ACE2 immunoreactivity was also detected in the proximal tubules; it increased or decreased with CKD in dogs, depending on the renal region assessed. The changes in ACE and ACE2 in CKD were associated with the plasma creatinine concentration in dogs. Findings from dogs with glomerulonephritis were similar to those from dogs with non-glomerulonephritis. The present study suggests that changes in the intrarenal expression of ACE and ACE2 contribute to the pathological mechanisms of canine CKD, but not to the mechanisms of feline CKD.

著者

波多野 善大

出版者

一般財団法人 日本国際政治学会

雑誌

国際政治 (ISSN:04542215)

巻号頁・発行日

vol.1957, no.3, pp.153-182, 1957-10-20 (Released:2010-09-01)

参考文献数

142

著者

小西 良子

出版者

日本マイコトキシン学会

雑誌

マイコトキシン (ISSN:02851466)

巻号頁・発行日

vol.57, no.1, pp.31-36, 2007 (Released:2007-04-12)

参考文献数

4

被引用文献数

1

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オクラトキシンAは、Penicillium 属および Aspergillus属が産生するカビ毒である。ヒトにおいては腎毒性があることが疑われており、実験動物では腎毒性、腎臓がんを起こすことが実証されている。ヨーロッパでは、オクラトキシンAの実態調査が精力的に行われ、それを基に基準値の設定がなされている。コーデックス委員会でも、その基準値の策定が秒読み段階に来ている。しかし、わが国ではいまだ基準値設定が行われていない。そこで、本稿では国際的動向、オクラトキシンAの毒性、わが国での汚染実態、その分析法を紹介し、なぜオクラトキシンAは食品衛生上問題となるのか、今後基準値設定に向けてどのようにわが国は対処していくのかを述べる。

著者

黒田 登美雄 小澤 智生

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.105, no.3, pp.328-342, 1996-06-25 (Released:2009-11-12)

参考文献数

29

被引用文献数

9 15

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Paleoclimatic and vegetational changes during the Pleistocene and Holocene in the Ryukyu Islands were inferred from pollen assemblages. Pollen analyses of some early Pleistocene to Holocene sections in the Ryukyu Islands show several drastic vegetational changes with climatically meaningful variations.A mixed pollen assemblage containing the warm and cool temperate trees such as Cryptomeria, Abies and Tsuga, and the tropical-subtropical trees including Dacrydium, Liquidambar, , Lagerstroemia and Sapium occurred in the upper Pliocene to lower Pleistocene Shinzato Formation and the basal part of the lower Pleistocene Kunigami gravel formation. These pollen assemblages strongly support that there were high mountains over 1, 000 to 1, 500 m above the sea-level in the Ryukyu Islands in the late Pliocene to early Pleistocene. The warm and cool temperate forests in the mountainous areas were disappeared possibly by the subsidence of the basement rocks of the Islands in relation with the opening of the Okinawa Trough. Invasion of evergreen broad-leaved trees to the Ryukyu Islands in the early Pleistocene was indicated by the first occurrence of evergreen broad-leaved tree pollen in the lower Pleistocene Kunigami Gravel Formation.The pollen assemblages in the last Glacial period (ca. 22, 000 y.B.P) are dominated by the coniferous trees such as Pinus and Podocarpus, indicating that an arid climate was prevalent in the Ryukyu Islands. This evidence is consistent with the wide development of ancient dunes and paleosoil of aeolian sand origin in the islands during the last Glacial period. The pollen sequence of the uppermost Pleistocene to Holocene reveals the change of vegetation and climate from the pine forests of the late Glacial period to the climax forests of evergreen broad-leaved trees of the Climatic Optimum. It is suggested that the climatic condition in subtropical Ryukyu Islands around 20, 000 years B.P. was not so much cool but arid than the climate of the present day.

著者

Jun TAMURA Takaharu ITAMI Tomohito ISHIZUKA Sho FUKUI Norihiko OOYAMA Kenjiro MIYOSHI Tadashi SANO Kazuto YAMASHITA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0042, (Released:2013-09-04)

被引用文献数

1 8

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Robenacoxib is a newer nonsteroidal anti-inflammatory drug approved for dogs and cats. This study was designed to evaluate the effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Sevoflurane MAC-BAR was determined by judging dogs’ response to a noxious electrical stimulus (50 V, 50 Hz and 10 msec) for 10 sec in 6 beagle dogs on two occasions at least a 7-day interval. In each occasion, saline (0.1 ml/kg) or robenacoxib (2 mg/kg) was administered subcutaneously at 1 hr prior to the MAC-BAR determination. Robenacoxib significantly decreased the sevoflurane MAC-BAR (3.44 ± 0.53% for saline vs. 2.84 ± 0.38% for robenacoxib, P=0.039). These results suggest that subcutaneous robenacoxib provides a clinically relevant sparing effect on anesthetic requirement.

著者

Dong-Heon Lee Narasimha N. Murthy Kenneth D. Karlin

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.80, no.4, pp.732-742, 2007-04-15 (Released:2007-04-13)

参考文献数

80

被引用文献数

6

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Copper(I)–dioxygen reactivity studies utilizing new binucleating ligands are described. When catalytic quantities of either CuI or CuII salts were introduced to LH2, which is a dinucleating ligand with two tridentate donors connected via a methylene group at a bis(2-pyridyl)methane junction, dioxygen addition caused complete oxygenation to give bis(2-pyridyl)ketone product L=O. Isolated dicopper(I) complex [CuI2(LH2)]2+ (1) also reacted with excess O2 to give L=O. Additional observations were consistent with a mechanism that does not involve “oxygen-activation” in this process. Ketone hydration and gem-diol(ate) copper(II)-coordination occurred by addition of copper(II)–perchlorate to L=O, giving [CuII2{L(OH)(O−)}Cu2II(−OClO3)]2+ (4), with a bridging alkoxide moiety (X-ray). Oxygenation of [CuI2(L=O)(CH3CN)2]2+ (2) (2/O2 = 0.5, i.e., Cu/O2 = 4:1 manometry), gave [CuII2{L(O−)2}(−OClO3)]+ (5), where both oxygen atoms of the doubly deprotonated gem-diolate bind separate copper(II) ions; mass spectrometric data showed that one of the two oxygen atoms of the gem-diolate L(O−)2 came from O2. An oxo–dicopper(II) species is suggested as an important intermediate, which is supported by the observation that reaction of 2 with NO or iodosylbenzene also produced 5 in high yields. Complexes 4 and 5 are acid–base conjugate pairs and can be readily interconverted using Et3N or HClO4(aq) reagents.

著者

阿部 晃治

出版者

公益社団法人 日本水産学会

雑誌

日本水産学会誌 (ISSN:00215392)

巻号頁・発行日

vol.48, no.2, pp.157-163, 1982-02-25 (Released:2008-02-29)

参考文献数

24

被引用文献数

6 5

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This paper deals with the number of times of molting and the mean carapace length in instars estimated from the frequency distribution of carapace length of the edible horse crab Erimacrus isenbeckii collected in the coastal sea area of Eastern-Hokkaido, and with the experimental data of increase at molting. From size frequencies of female and male of 1091 individuals, under 50 millimeters, nine groups are recognized. The mean carapace length for each group being 5.2, 7.0, 8.7, 12.5, 15.6, 20.4, 27.4, 33.5 and 46.4mm. From 5572 male individuals, ranging from 50 to 124mm, five groups are recognized. The mean carapace length for each group being 59.1, 73.3, 88.2, 103.5 and 117.5mm. From 3884 female individuals, range 50-88mm, four groups are recognized. The mean carapace length for each group being 55.9, 65.8, 74.1 and 84.0mm. Applying these mean sizes to Hiatt's graphic method in which the post-exuvial lengths (Ln+1) were plotted against the initial lengths (Ln), the following formulas are obtained: male and female under 50 millimeters, Ln+1=1.336Ln-0.40; mature female, Ln+1=0.998 Ln+9.49; mature male, Ln+1=1.036Ln+11.68. Growth of the carapace length in instars fits the growth equation as follows: male, lt=177/(1+e3.765-0.269t-0.0035t2); female, lt=125/(1+e3.451-0.293t-0.0017t2).

著者

磯部 由香 阪 恵理子 松井 宏樹 成田 美代

出版者

一般社団法人 日本家政学会

雑誌

日本家政学会誌 (ISSN:09135227)

巻号頁・発行日

vol.62, no.10, pp.633-637, 2011-10-15 (Released:2013-09-02)

参考文献数

17

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The chemical composition and bacterial community structure of konoshiro-narezushi were analyzed, the latter by the 16S ribosomal RNA gene clone library method. The respective moisture and the lactic acid concentrations were 62.4% and 1.8%. One hundred randomly selected clones from the clone library were sequenced and analyzed. There were six operational taxonomic units, and the Shannon-Wiener index was1.037. The sequence similarity of all the clones obtained was equal to or higher than 99.6% of the sequence of cultivated bacteria in the public database. Lactobacillus sakei constituted 61% of the clones, suggesting that this bacterium plays an important role in the fermentation of konoshiro-narezushi.

著者

酒井 治己 桂 和彦 小野沢 茂好

出版者

日本魚類学会

雑誌

魚類学雑誌 (ISSN:00215090)

巻号頁・発行日

vol.37, no.4, pp.424-426, 1991-02-28 (Released:2010-06-28)

参考文献数

12

著者

加畑 雅章

出版者

日本魚類学会

雑誌

魚類学雑誌 (ISSN:00215090)

巻号頁・発行日

vol.28, no.3, pp.349-352, 1981-11-30 (Released:2011-07-04)

参考文献数

17

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Shapes of the swim bladders were studied for clarifying differences in three species of the genus Tribolodon, T.hakonensis (Günther), T.taczanowskii (Steindachner) and T.ezoe Okada et Ikeda, taken from several localities in Hokkaido. The feature of the tip of the posterior chamber of the swim bladder, with two types, is useful to distinguish between T.ezoe (round or grainy tip) on the one hand and T. hakonensis and T.taczanowskii (tapering or sharp tip) on the other hand. The length of the posterior chamber of the swim bladder was also different among the three species, i.e., it is longest in T.hakonensis, shortest in T.ezoe, and intermediate in T.taczanowskii.

著者

出口 慎二 岡太 彬訓 中山 厚穂

出版者

日本行動計量学会

雑誌

行動計量学 (ISSN:03855481)

巻号頁・発行日

vol.36, no.2, pp.105-114, 2009 (Released:2010-06-29)

参考文献数

13

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When we use multidimensional scaling (MDS) to analyze a dataset in which the magnitude of the values considerably differ (vary) among objects, for example, customer purchase history data, it often occurs that the only points of objects with large values scatter well in the configuration, but the others with small values do not scatter well. It is said that joint uses of MDS and cluster analysis is often desirable. In this study, we showed that the joint use of MDS and cluster analysis also worked well in the above case, through the analysis of two-mode three-way proximity data such as several variance-covariance matrices of objects obtained from each condition. We also used an external analysis with MDS to show the information about each of the two modes on the same configuration simultaneously, in order to easily observe the global structure of data through the configuration.

著者

Michael Balls

出版者

日本動物実験代替法学会

雑誌

Alternatives to Animal Testing and Experimentation (ISSN:13440411)

巻号頁・発行日

vol.16, no.3, pp.101-110, 2011-12-31 (Released:2012-01-23)

参考文献数

15

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Progress in the development and application of replacement alternative methods is discussed, with particular reference to the new technologies and their use in current initiatives to tackle the problem of drug-induced liver injury. The formidable challenges involved are discussed in terms of improving our understanding of the immense puzzles to be solved, our inability to control events, and the law of unintended consequences. Nevertheless, the future is bright, and the reign of the animal-models-tell-us-all and one-drug suits-all philosophies is rapidly coming to an end.

著者

小林 義和 齋藤 雅俊 藤野 玲子 西 真由美 柴田 壮一 厚田 幸一郎

出版者

一般社団法人日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.15, no.2, pp.90-96, 2013 (Released:2013-09-05)

参考文献数

5

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Objective: As part of the revision on remuneration for medical services in 2012, a new system has been implemented to allow an additional fee for inpatient pharmaceutical services to be added to the basic hospitalization fee.Methods: We at Kitasato University Kitasato Institute Hospital satisfied all institutional requirements for the new system and were preparing to introduce it from April 2012; however, there was concern about the increased workload due to the additional work of preparing diaries for pharmaceutical services used in calculating the additional fee.Results: We therefore developed a database titled Diary System for Inpatient Pharmaceutical Services for the preparation and management of diaries.  This system allows pharmacists from various divisions to enter data simultaneously and realizes the unified management of records of services performed at various places in the pharmacy.Conclusions: Since entered data are automatically reflected in the inpatient pharmaceutical service diary and the monthly summary, an advantage compared to paper diaries in terms of efficiency may be expected.  Furthermore, the monthly summary of the number of service hours by ward and service type may also be used for service analysis.

著者

黒田 喜寿 黒田 理子

出版者

日本失語症学会 (現 一般社団法人 日本高次脳機能障害学会)

雑誌

失語症研究 (ISSN:02859513)

巻号頁・発行日

vol.22, no.1, pp.1-8, 2002 (Released:2006-04-21)

参考文献数

16

被引用文献数

1 1

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失語症者18名に対して呼称課題と呼称目標語に関する意味判断課題を実施し,意味的障害と呼称課題における正答数および誤反応の出現傾向との関係を検討した。意味判断課題の成績は呼称正答数と有意な正の相関を示し,無反応数と有意な負の相関を示した。失語症群を意味判断課題の成績によって二分したところ,意味判断課題の成績は,意味的障害の重い群では呼称正答数と有意な正の相関を示し,意味的障害の軽い群では修正努力を伴わない意味性錯語と有意な負の相関を示した。これらの結果より,呼称障害に対する意味的障害の影響は意味的障害の強さによって異なることが示唆された。意味的障害が強い場合は,その影響は無反応として現れる傾向があり,意味的障害が軽い場合,その影響は誤りの自覚を伴わない意味性錯語として現れる場合が多いのではないかと考えられた。意味的障害と誤りの自覚を伴う意味性錯語との関係は支持されなかった。

著者

片野 修 中村 智幸 山本 祥一郎 阿部 信一郎

出版者

日本水産増殖学会

雑誌

水産増殖 (ISSN:03714217)

巻号頁・発行日

vol.53, no.2, pp.115-119, 2005-06-20 (Released:2010-03-09)

参考文献数

15

被引用文献数

3

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外来魚ブルーギルは日本全国の湖沼や河川に拡まっており, 水産有用魚種や生態系への影響が危惧されている。しかし日本の河川上中流域におけるブルーギルの生態についてはほとんど報告がない。著者らは長野県の千曲川の1支流である浦野川のAa-Bb移行型の河川形態区間で, 2003年の6月及び7月に75個体のブルーギルを電気ショッカーによって採捕した。すべてのブルーギルは岸から1m以内で採捕され, その空胃個体は75個体中8個体にすぎなかった。胃内容物充満度は平均0.63%で, 最大で2.86%に達した。ブルーギルは主にユスリカ科の幼虫を摂食し, そのほかカゲロウ科やトビケラ科の幼虫及び陸生昆虫を捕食していた。ブルーギルの食性は浦野川の在来魚の何種かといちじるしく重複していた。ブルーギルは河川の魚類群集に負の影響を与えると考えられ, 根絶される必要がある。

著者

中尾 博行 川端 健人 藤田 建太郎 中井 克樹 沢田 裕一

出版者

日本魚類学会

雑誌

魚類学雑誌 (ISSN:00215090)

巻号頁・発行日

vol.53, no.2, pp.167-173, 2006-11-25 (Released:2010-06-28)

参考文献数

20

被引用文献数

1

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Predation of eggs and larvae of bluegill (Lepomis macrochirus), by snails (Semisulcospira spp.and Sinotaia quadrata histrica) were examined during the bluegill reproductive period (July and August) in 2003 and 2005. At a littoral study site in the northern basin of Lake Biwa, population densities of snails were significantly higher in bluegill nests than in their surroundings, indicating deliberate aggregation of the former. Laboratory experiments to assess the degree of predation on bluegill eggs and larvae by snails showed a significant decrease in egg and larval numbers when established in aquaria together with Semisulcospira spp., and Sinotaia quadrata histrica, respectively. During experimentation, predatory behavior by snails was also directly observed, indicating that snails aggregating in bluegill nests probably predate eggs and larvae despite parental care of the latter.