著者

仙石 正

出版者

炭素材料学会

雑誌

炭素 (ISSN:03715345)

巻号頁・発行日

vol.3, no.2, pp.72-76, 1953-05-04 (Released:2010-06-28)

参考文献数

10

著者

Hiroyuki Shimogawa Haruki Mori Atsushi Wakamiya Yasujiro Murata

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

pp.130360, (Released:2013-06-01)

被引用文献数

19

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Dibenzo[b,g]-fused and dithieno[b,g]-fused BODIPY derivatives were synthesized, and the electronic impacts of the introducing dibenzo- and dithieno-fused structures at both of the b and g bonds in the BODIPY skeleton were investigated. Electrochemical and photophysical measurements demonstrated that these structural modifications effectively enhance the electron accepting ability of the BODIPY skeleton leading to the red-shifted absorption.

著者

秦 季之 堀井 梢 松島 裕貴 廣瀬 順造 小野 行雄 佐藤 英治 吉富 博則

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.6, pp.691-701, 2013 (Released:2013-06-01)

参考文献数

30

被引用文献数

3 7

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The text mining and full-text searching function were used to analyze the digitalized daily reports of the practical training in pharmacology submitted to the web system in Fukuyama University. Collocations connected to the word “inspection” were searched in the daily reports using the text mining and the full-text search functions of the system. Many collocation groups connected to “inspection” were found in the daily reports and the greatest number of collocations was associated with “preparation of drugs”. Practical training in narcotic dispensing has two different aspects: inspection and experience training. The number of people who reported a relation between “inspection” and “narcotics dispensing” in the daily reports was very similar to those who reported a connection between “experience” and “narcotics”. Practical training to handle narcotic dispensing is the most fundamental training that the pharmacist must undertake. The progression of team-based medical care has caused medical personnel to recognize the practical training in pharmacology, and the number of the people who reported a relation between “inspection” and “team medical care” in 2011 increased in comparison to 2010. Moreover, the progression of cooperation among hospitals, pharmacies, and local blanches of the Japan Pharmaceutical Association is beneficial to practical training. Practical training in pharmacology is based on the core curriculum, but undergoes periodic modification due to societal circumstances. Therefore, these results suggest that the construction of web system for submitting daily reports is useful for analyzing the daily reports.

著者

前島 伸一郎 大沢 愛子 林 健 棚橋 紀夫

出版者

一般社団法人 日本脳卒中学会

雑誌

脳卒中 (ISSN:09120726)

巻号頁・発行日

vol.35, no.3, pp.187-194, 2013-05-20 (Released:2013-05-24)

参考文献数

21

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要旨:【目的】嚥下造影検査(VF)の実施に合わせて,5 mlと60 mlの段階的飲水試験を施行し,誤嚥の検出や経口摂取の可否,選択された食形態との関連について明らかにする.【対象と方法】経口摂取開始時の適切な食材を選ぶことを目的にVFを施行した183名(男性107,女性76)の脳卒中患者を対象とした.平均年齢は66.9±12.1歳で,原因疾患は脳梗塞98名,脳出血49名,くも膜下出血23名,その他の脳血管疾患13名,発症からVFまでの期間は18.0±12.0日であった.方法は,まず,VF実施の直前に段階的飲水試験にて臨床評価を行い,次にゼリーや粥などの模擬食品に加え,5 mlと60 mlの液体にてVFを行った.その後,段階的飲水試験の結果と実際のVF結果との関連について検討した.【結果】臨床所見の異常にて段階的飲水試験を途中で中止したのは46名(第1段階43名,第2段階3名)であった.段階的飲水試験での異常所見はVFの液体誤嚥と有意な関連を認め,VFにて観察される誤嚥に対する段階的飲水試験の感度は85.2%,特異度は41.8%であった.飲水速度(ml/秒)や1回嚥下量(ml)と誤嚥に明らかな関連はなかった.経口摂取の可否や選択された食形態は,VFの液体誤嚥との間に関連を認めたが,段階的飲水試験の臨床評価との間には関連はなかった.【まとめ】段階的飲水試験の臨床評価は液体誤嚥の検出には有用ではあるが,その結果と誤嚥予防のための適切な食形態との間には明らかな関係を見いだせず,経口摂取の開始前には嚥下造影検査などの詳細な評価を合わせて行うべきである.

著者

池田 宇一

出版者

信州医学会

雑誌

信州医学雑誌 (ISSN:00373826)

巻号頁・発行日

vol.61, no.1, pp.38-38, 2013-02-10 (Released:2013-04-05)

著者

河合 佳子

出版者

信州医学会

雑誌

信州医学雑誌 (ISSN:00373826)

巻号頁・発行日

vol.61, no.2, pp.45-56, 2013-04-10 (Released:2013-05-08)

参考文献数

49

被引用文献数

1

著者

山下 裕之 堀内 昭作 平 知明

出版者

園芸学会

雑誌

園芸学会雑誌 (ISSN:00137626)

巻号頁・発行日

vol.62, no.2, pp.249-255, 1993 (Released:2008-05-15)

参考文献数

16

被引用文献数

3 7

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本研究は4倍性品種と2倍性品種を用いて交配を行い,その雑種個体獲得効率の低い原因を明らかにするとともに,3倍体作出の効率を高めるための胚培養を行った.交配親には4倍性品種の'巨峰と'マスカット•オブ•アレキサンドリア4倍体および2倍性品種の'マスカット•オブ•アレキサンドリア'と'ジュライ•マスカット'を用いた.1.交配により得られた種子の発芽率,胚形成率および胚乳の発育は自然受粉から得た種子と比べて著しく劣っていた.特に2倍体を種子親にしたものにおいて顕著であった.2.2倍体を種子親にした場合の種子の生育は,自然受粉の種子より勝り,逆に4倍体を種子親にした場合は劣っていた.一方,交配後9週間目における2倍体を種子親にした胚の大きさは,自然受粉の胚と比較してその発達程度に著しい差異は認められなかったが4倍体を種子親にした場合には自然受粉の胚に比べて著しく劣った.3.交配60~70日に胚を無菌的に摘出し,MSの基本培地に麦芽抽出物500mg•liter-1を添加した培地に植え付けた.3倍性胚を発芽させ,その後生長させることに成功した.4.実生個体の根端を観察したところ,57本の染色体が認められ,3倍体であることが確認された.5.ブドウの4倍体と2倍体を交配して3倍体を育成する場合,4倍体を種子親にする方が効率的である事が示唆された.

著者

中村 伸也 西川 一 山田 秀夫 原 文宏 神保 正暢 平野 宜一

出版者

Japan Society of Civil Engineers

雑誌

海岸工学論文集 (ISSN:09167897)

巻号頁・発行日

vol.55, pp.176-180, 2008-10-10 (Released:2010-06-04)

参考文献数

2

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Historically, many disasters at Shimoniikawa Coast has occurred by high waves called Yorimawarinami from east. The direction of longshore sand transport of the Shimoniikawa Coast is eastward. In Nyuuzen-machi and Asahi-machi located in the east from the Kurobe River mouth which becomes the source of supply of the sand, many houses moved because of beach erosion. In such circumstances, intense high waves by the low pressure hit these areas on February 24, 2008, so that coastal protection facilities in Kurobe-shi, Nyuuzen-machi and Asahi-cho got damaged and, furthermore houses were flooded and destroyed by overtopping waves.In this paper, various observation data in Shimoniikawa Coast of Yorimawarinami was analyzed by and the cause of the disaster was considered.

著者

Takanori Shibata Kyoko Takami Yoshikazu Arai Kyoji Tsuchikama Shunsuke Maekawa

出版者

(社)日本化学会

雑誌

Bulletin of the Chemical Society of Japan (ISSN:00092673)

巻号頁・発行日

vol.77, no.10, pp.1937-1938, 2004 (Released:2004-10-09)

被引用文献数

1

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Lithium butatrienolates were prepared in situ by the 1,4-elimination from 2-butynyl trimethylsilyl ethers along with a retro-Brook rearrangement. The addition reaction of the enolates with the aldehydes afforded β-hydroxy-α-vinylidene acylsilanes.

著者

小川 幸男 関田 清司 梅村 隆志 斎藤 実 小野 敦 川崎 靖 内田 雄幸 松島 裕子 井上 達 菅野 純

出版者

公益社団法人 日本食品衛生学会

雑誌

食品衛生学雑誌 (ISSN:00156426)

巻号頁・発行日

vol.45, no.1, pp.8-18, 2004-02-25 (Released:2009-01-21)

参考文献数

29

被引用文献数

4 11

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雌雄のWistarラットに,0.00, 0.01, 0.10および1.00%の割合でギムネマ・シルベスタ葉の抽出粉末(GS)を基礎飼料に添加した餌を52週間与えた.試験期間中,GS投与に関連する動物の死亡はなく,体重,摂餌量,血液学,血液生化学および病理組織学的検査における変化は認められなかった.52週間のGS 1.00% 添加飼料(一日平均摂取量,雄504 mg/kg/day, 雌563 mg/kg/day)の摂取量は,ラットにおいて毒性変化の認められない用量(NOAEL)であると推論した.

著者

Risa Hayashi Kenji Nakai Akimune Fukushima Manabu Itoh Toru Sugiyama

出版者

一般社団法人 インターナショナル・ハート・ジャーナル刊行会

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.50, no.2, pp.161-171, 2009 (Released:2009-04-14)

参考文献数

26

被引用文献数

6 11

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Although ultrasonic diagnostic imaging and fetal heart monitors have undergone great technological improvements, the development and use of fetal electrocardiograms to evaluate fetal arrhythmias and autonomic nervous activity have not been fully established. We verified the clinical significance of the novel signal-averaged vector-projected high amplification ECG (SAVP-ECG) method in fetuses from 48 gravidas at 32-41 weeks of gestation and in 34 neonates. SAVP-ECGs from fetuses and newborns were recorded using a modified XYZ-leads system. Once noise and maternal QRS waves were removed, the P, QRS, and T wave intervals were measured from the signal-averaged fetal ECGs. We also compared fetal and neonatal heart rates (HRs), coefficients of variation of heart rate variability (CV) as a parasympathetic nervous activity, and the ratio of low to high frequency (LF/HF ratio) as a sympathetic nervous activity. The rate of detection of a fetal ECG by SAVP-ECG was 72.9%, and the fetal and neonatal QRS and QTc intervals were not significantly different. The neonatal CVs and LF/HF ratios were significantly increased compared with those in the fetus. In conclusion, we have developed a fetal ECG recording method using the SAVP-ECG system, which we used to evaluate autonomic nervous system development.

著者

下山 和弘 大芦 治 海野 雅浩 内田 達郎 長尾 正憲 小田切 一浩 山崎 久美子

雑誌

老年歯科医学 (ISSN:09143866)

巻号頁・発行日

vol.7, no.2, pp.132-140, 1993

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高齢歯科患者の主訴と抑うつ傾向との関連を明らかにするために, 東京医科歯科大学高齢者歯科治療部の外来患者 (男性88名, 女性132名, 平均年齢74.5歳) を対象にZungの自己評価式抑うつ性尺度 (SDS) により抑うっ傾向の調査を行った。SDSの質問項目よりQOLの因子と抑うつ感の因子を抽出し, SDSの総得点, QOLの因子得点, 抑うつ感の因子得点と口腔内状況との関連については以前報告した。今回は被検者を主訴により義歯不適合 (上下顎全部床義歯装着者) 群義歯不適合 (その他の義歯装着者) 群, 義歯破折群, 義歯不適合・歯疼痛動揺群歯疼痛動揺 (義歯装着者) 群, 歯疼痛動揺 (義歯非装着者) 群, 心身医学的対応症例群その他の主訴をもつ群に分類し, 上記の3得点について2 (男女別) ×2 (該当する主訴の分類) の分散分析を行った。歯疼痛動揺 (義歯装着者) 群ではその他の群と比較するとQOLの因子得点が有意に低く, SDSの総得点が低い傾向があった。また心身医学的対応症例群ではSDSの総得点および抑うつ感の因子得点が有意に高かった。SDSの総得点は主訴の相違によらず女性が男性よりも有意に高かった。すなわち主訴の相違は男女間の抑うっ傾向の差に影響していなかった。本研究の結果から高齢歯科患者の主訴と抑うっ傾向との問には関連があることが推察された。歯科治療時には顎口腔系における主訴の内容を踏まえたうえで, 患者の抑うっ傾向を含めた精神的身体的な状態の把握が必要であることが示唆された。

著者

志村 喬 稲葉 豊年

出版者

Japanese Society of Breeding

雑誌

育種学雑誌 (ISSN:05363683)

巻号頁・発行日

vol.2, no.4, pp.205-213, 1953-06-30 (Released:2008-05-16)

参考文献数

19

被引用文献数

1

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1. Several morphologicai and physiological characters of triploid varieties were compared with diploids. 2. There was no clear difference on the leaf size and shape between triploids and diploids, but triploid leaves were thicker than those of diploids. As a rule every internal tissue of triploid leaves was thicker than diploids. It is evident that triploid leaves had larger stomatas of which the distribution density vias lower, compared with diploids. 3. No difference between both the plants could be recognized on the res.istance to brown blight total nitrogen and tannin content in suminer, the reduced form vitamin C content in winter, and regeneration power in cutting. Triploid varieties was more hardy to cold, and some of them had extremely early growing spring bud. The water reserving ability of triploid leaves isolated from stem was greater than that of diploids in September, but the relation changed to be indifferent. in December. 4. Generally triploid fertility was very low but the difference of fertility between each triploid variety was noticed. The pollen grains of triploids showed high sterility. 5. From progenies of triploids, we discovered one aneuploid plant (2n=44). The characters were same like those of triploids and the meio. sis was proceeded abnormally. 6. With colchicine treatment to the growing point of germinated seeds, some tetraploid plants (2ri=60) were obtained. At present, tetraploid plants are growing slowly and they have, dwarf form.

著者

Di ZHANG Reina FUJIWARA Toshie ISERI Shotaro NAGAHAMA Kei KAKISHIMA Masatoshi KAMATA Manabu MOCHIZUKI Takayuki NAKAGAWA Nobuo SASAKI Ryohei NISHIMURA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.5, pp.663-666, 2013 (Released:2013-05-31)

参考文献数

16

被引用文献数

3 10

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The epidural distribution of iohexol (0.2 ml/kg) administered at thoracic vertebrae (Thoracic group) and lumbar vertebrae (Lumbar group) was compared by computed tomographic (CT) epidurography in dogs. The total spread of iohexol was similar between the 2 groups upon reaching a similar cranial level. The maximal CT values were higher at the C7/T1 and T4/T5 levels in Thoracic group, but they were higher at the T13/L1 and L4/L5 levels in Lumbar group (P<0.05). This result suggests that the distribution pattern of the drug administered epidurally at thoracic vertebrae and lumbar vertebrae is different in dogs.

著者

Takaharu ITAMI Kodai KAWASE Naomichi TAMARU Tomohito ISHIZUKA Jun TAMURA Kenjirou MIYOSHI Mohammed A. UMAR Hiroki INOUE Kazuto YAMASHITA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.5, pp.613-618, 2013 (Released:2013-05-31)

参考文献数

30

被引用文献数

5 14

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Tramadol is an atypical opioid analgesic widely used in small animal practice. This study was designed to determine the effect of a single intravenous (IV) dose of tramadol on the minimum alveolar concentration (MAC) of sevoflurane in dogs. Six beagle dogs were anesthetized twice to determine the sevoflurane MAC with or without an administration of tramadol (4 mg/kg, IV) at 7 days interval. The sevoflurane MAC was determined using a tail clamp method in each dog ventilated with positive pressure ventilation. The tramadol administration produced a significant reduction in the sevoflurane MAC by 22.3 ± 12.2% (1.44 ± 0.28% with tramadol versus 1.86 ± 0.30% without tramadol, P=0.010). This MAC reduction had been determined from 122 ± 19 to 180 ± 41 min following the tramadol administration. During this period, the plasma concentrations of tramadol and its metabolite, O-desmethyltramadol (M1), decreased from 429 ± 64 to 332 ± 55 ng/ml and from 136 ± 24 to 114 ± 68 ng/ml, respectively, but these changes were not statistically significant. There was no significant difference in heart rate, mean arterial blood pressure and SpO2 between the control and tramadol treatment. The dogs that received tramadol treatment sometimes breathed spontaneously. Therefore, their respiratory rates significantly increased, and PETCO2 decreased during the MAC determination. In conclusion, the single IV dose of tramadol produced a significant reduction in the sevoflurane MAC in dogs.

著者

Hitoshi HATAI Mitsuru IBA Daisuke KOJIMA Chun-Ho PARK Yasuhiko TSUCHIDA Toshifumi OYAMADA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.5, pp.639-641, 2013 (Released:2013-05-31)

参考文献数

13

被引用文献数

1 6

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A 13-year-old castrated male Labrador retriever dog presented with a mass caudal to the first molar of his left mandible. Although the tumor was excised, a recurrent tumor was detected one month later and resected. Both tumors displayed invasive growth and were composed of neoplastic proliferation arranged in irregular lobules, nests and cords continuous with mucosal epithelium. The most prominent feature of the tumors was the presence of many proliferating spindle cells admixed with palisading basal-like cells, acanthocytes and stellate cells. In immunohistochemical examinations, the spindle cells were found to be positive for vimentin; cytokeratin AE1/AE3, 5/6, 14 and 19; and p63. The other neoplastic cells were positive for all of these markers shown above except vimentin. Based on these findings, the tumors were diagnosed as spindle cell ameloblastic carcinoma.

著者

Hiroko MIZOOKU Yumiko KAGAWA Kazuya MATSUDA Minoru OKAMOTO Hiroyuki TANIYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.5, pp.597-603, 2013 (Released:2013-05-31)

参考文献数

35

被引用文献数

6

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Histological and immunohistochemical evaluations of lobular dissecting hepatitis (LDH) were performed in nine American cocker spaniel dogs. Histological examination showed diffuse fibrosis with weak inflammatory reaction of extensive neutrophils, macrophages, lymphocytes and plasma cells. Immunohistochemical examination revealed that the myofibroblastic cells positive for anti-α-smooth muscle actin and anti-vimentin antibodies produced reticular and collagen fibers and brought about the dissection of hepatic cords and diffuse disappearance of hepatocytes. Reticular fibers invading between hepatocytes and the surrounding small group of hepatocytes were strongly positive for anti-collagen type III and anti-collagen type IV antibodies. The positivity to anti-fibronectin and anti-laminin antibodies was frequently continuous on the basement membrane of the sinusoids of the remaining hepatic cords and between the hepatocytes. Positive findings for anti-E-cadherin antibody were not observed between the hepatocytes showing positive findings for anti-collagen type III and anti-collagen type IV antibodies. These results may explain the expression of fibronectin and laminin that occurs prior to the invasion of reticular fibers between hepatocytes. The present study further suggests that expression of an extracellular matrix mainly containing fibronectin and laminin between the hepatocytes and proliferation of collagen fibers and reticular fibers have a major role in the rupture of the hepatic cords and disappearance of hepatocytes.

著者

Ikuo INOUE Sanae SHIBATA Tsuneo FUKATA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.75, no.5, pp.657-658, 2013 (Released:2013-05-31)

参考文献数

20

被引用文献数

1 4

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The aim of this study was to determine the antimicrobial resistance of Escherichia coli isolated from the uteri of bitches with pyometra, and 38 E. coli isolates were used. The antimicrobials used were ampicillin (ABPC), amoxicillin/clavulanic acid, gentamicin, minocycline, cefazolin, levofloxacin (LVFX), trimethoprim-sulfamethoxazole (ST) and fosfomycin (FOM). Resistance to ABPC occurred most frequently, followed by LVFX and ST. Multi-drug resistance, defined as resistance against 3 or more classes of antimicrobials, was found in 23.7% of all isolates. Nine out of 13 resistant strains were multi-drug resistant, but no strain was found to be resistant to FOM. This suggests that FOM should be administered for E. coli from pyometra.

著者

Tetsuya UEBA Omi HAMADA Toshiyasu OGATA Tooru INOUE Etsuji SHIOTA Yoshiyuki SANKAI

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.53, no.5, pp.287-290, 2013 (Released:2013-05-24)

参考文献数

18

被引用文献数

10 51

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Acute phase rehabilitation is an important treatment for improving the functional outcome of patients after stroke. The present cohort study analyzed the feasibility and safety of acute phase rehabilitation using the hybrid assistive limb robot suit in 22 patients, 7 males and 15 females (mean age 66.6 ± 17.7 years). Neurological deterioration, mortality, or other accidents were recorded as adverse events. Baseline characteristics of each patient were recorded at the first hybrid assistive limb rehabilitation. Hybrid assistive limb rehabilitation was conducted for 12.1 ± 7.0 days with the patients in stable condition. Acute phase hybrid assistive limb rehabilitation was performed a total of 84 times with no adverse events recorded except for orthostatic hypotension. Good functional outcomes were obtained in 14 patients. Orthostatic hypotension was observed during the first hybrid assistive limb rehabilitation in four patients, and was significantly associated with intracerebral hemorrhage (p = 0.007) and lower Brunnstrom stage (p = 0.033). Acute phase rehabilitation using the hybrid assistive limb suit is feasible and safe. Patients with intracerebral hemorrhage and lower Brunnstrom stage should be carefully monitored for orthostatic hypotension.

著者

松本 浩幸 三ヶ田 均 大町 達夫 井上 修作

出版者

公益社団法人 土木学会

雑誌

海岸工学論文集 (ISSN:09167897)

巻号頁・発行日

vol.51, pp.281-285, 2004-10-08 (Released:2010-06-04)

参考文献数

13

被引用文献数

1 1

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本研究では, 津波地震の発生原因が「断層面上のゆっくりとした断層破壊」と仮定して, それに伴う「ゆっくりとした海底面変動」が津波を引き起こす過程および伝播の特性を数値計算によって検討した.ライズタイムが100s程度であれば断層破壊の影響は無視でき, 静的変位から予想される津波と同程度の津波が発生する. また, ライズタイムが500sのゆっくりとした海底面変動でも水塊移動を引き起こし津波が発生することを示した. ただし, 津波の波高が小さくなり, 周期が長くなる点は従来の予測とは大きく異なる.本研究は, ゆっくりとした断層破壊による地震津波に対しても, 沖合観測によって早期に津波を検知できることを示唆している.