著者

古畑 昌巳 帖佐 直 大角 壮弘 松村 修

出版者

日本作物学会

雑誌

日本作物学会紀事 (ISSN:00111848)

巻号頁・発行日

vol.81, no.1, pp.10-17, 2012 (Released:2012-01-26)

参考文献数

32

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寒冷地の湛水直播栽培条件における水稲品種の出芽・苗立ち性およびそれに寄与する特性について十分明らかにされていないため,寒冷地で育苗箱を利用して低温土中出芽検定を行うと同時に,出芽・苗立ちに寄与する可能性がある発芽特性および嫌気発芽条件における鞘葉の伸長性についても調査を行った.その結果,低温土中出芽検定における出芽速度は,初期生育量と高い正の相関関係(r=0.773)を示し,低温での嫌気発芽条件における鞘葉の伸長速度との間に有意な正の相関関係(r=0.528)が認められた.また,低温でのシャーレ発芽条件における発芽係数と低温土中出芽検定における出芽率(r=0.376)および初期生育量(r=0.215)との有意な正の相関関係は認められたが,この要因については明らかにできなかった.

著者

今村 寿一 青葉 千春 小島 邦彦

出版者

社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.45, no.9, pp.909-913, 1987-09-01 (Released:2009-11-13)

参考文献数

60

被引用文献数

1 4

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Tetramethylammonium hydroxide (TMAH) is a relatively strong base among organic compounds, and decomposes at 130-140°C into gaseous substances (Me3N, Me2O, MeOH, and H2O). TMAH has been prepared by alkali treatment of tetramethylammonium chloride (TMAC) obtainable from trimethylamine and methyl chloride, but use is made recently of developer electrolysis of TMAC in the presence of ion exchange membrane. The latter method gives rise to a highly pure TMAH aqueous solution free from chloride anions. TMAH currently finds some utilities in the production of highly functional materials such as developer for positive-working photoresist and the surface treatment of fibers, glasses, and plastics, and also as reagent for the methyl esterification of fatty acids and phospholipids, reagent for organic synthesis and preparation of catalysts, etc.

著者

明崎 禎輝 山崎 裕司 野村 卓生 吉本 好延 吉村 晋 浜岡 克伺 中田 裕士 佐藤 厚

出版者

理学療法科学学会

雑誌

理学療法科学 (ISSN:13411667)

巻号頁・発行日

vol.23, no.2, pp.301-305, 2008 (Released:2008-06-11)

参考文献数

16

被引用文献数

4 3

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本研究では,階段昇降の自立獲得に必要な麻痺側下肢荷重率を検討した。対象は脳血管障害片麻痺患者110名である。これらの対象者に対して,年齢,体格指数,発症からの期間,非麻痺側下肢筋力,下肢ブルンストロームステージ,深部感覚障害の有無,非麻痺側・麻痺側下肢荷重率などを調査・測定した。2項ロジスティック回帰分析の結果,麻痺側下肢荷重率のみが階段昇降自立の有無に関係する有意な因子であった。さらに,階段昇降の自立獲得には麻痺側下肢荷重率のカットオフ値が84.0%において高い判別精度を示した。

著者

西村 正雄 三浦 章宏 山際 源二郎 貞包 剛男 大橋 忠 中条 弘 上田 喜一

出版者

Japanese Society of Oral and Maxillofacial Surgeons

雑誌

口腔外科学会雑誌 (ISSN:04541693)

巻号頁・発行日

vol.6, no.2, pp.384-390, 1960-07-01 (Released:2011-07-25)

参考文献数

17

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The amalgam restoration is regarded as the simplest and best method for the mass treatment of earlier carious lesions in pre-ventive dentistry but there are still some practical problems that remain unsolved.More efficient technics is to be divised and also the suppresson of mercury absorption by the operators is the important point in such severe exposure to mercury.This investigation was designed to improve the usual procedure by combining the use of an mechanical amalgamator and pre-prepared amalgam kept in a vacuum bottle containing dry ice.The air turbine (Air Dent Unit) was also applied in full through this experiment to reduce the cutting time and the pain or uncomfortable feeling of the children.1) The mechanical amalgamator which can mix mercury and alloy even at the weight ratio of 6 to 5 involed no need to sequeeze out mercury. Therefore, the time for restoration was markedly reduced to 71.5 sec.in comparison with 150 sec.in the routine manual procedure when the mixing time was set constant as 40 sec.in both methods.2) Urinary mercury excretion of three mixing operators following constantly mixing amalgam far 50 min.showed on the average the increase of 80 μ g Hg per day in the usual procedure, while using amalgamator, it only increased by 15 μ g Hg per day.3) After shaking with the amalgamator, the amalgam enough for three treatment was put in a small polyethylene tube and heat-sealed and instantly researved in a vacuum bottle containing dry ice.On the next day after 24 hours, each small tube was pulled out and kept at room temperature for halt an minute to wait softening and then the amalgam was applied.4) Physical properties of the reserved amalgam were tested with methods approved in J.I.S.(Japan Industrial Standards) and no significant differences were found.5) The time required for treating one caries tooth was 10 min.in the routine procedure, whlie combining the use of Air Dent Unit and pre-prepared amalgam reserved in dry ice bottle, it was exceedingly shortened to 1 min.and 49.5 sec.6) As a field experiment, 80 school children were successively treated by two dentists by this devised procedures in one day.The over-all time needed for the treatment of one children was 144.9 sec.on the average.7) Thus the mass amalgam restoration in preventive dentistry might be applied with high efficiency by our devised procedures.

著者

斎藤 嘉朗 鹿庭 なほ子 頭金 正博 黒瀬 光一 長谷川 隆一 SJS/ TEN遺伝子多型研究班

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.40, no.2, pp.57S-58S, 2009 (Released:2009-08-12)

参考文献数

5

著者

早川 裕二 大津 史子 矢野 玲子 三輪 一智 後藤 伸之

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.33, no.6, pp.488-495, 2007 (Released:2009-02-02)

参考文献数

20

被引用文献数

2 1

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The purpose of this study was to identify drugs with a risk of causing Stevens-Johnson syndrome (SJS),toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) and the risk factors involved.From the CARPIS (Case Reports of Adverse Drug Reactions and Poisoning Information System) database,which contains 40,000 case reports of adverse drug reactions,we determined 258 cases (case group) matching the criteria for SJS/TEN/DIHS stated by the Japanese Ministry of Health,Labour and Welfare.We also selected 774 control cases (control group) which were sex- and age- matched (±1)with the case group.Next,various data were compared between the case group and the control group and the results analyzed statistically.In this regard,logistic regression analysis identified 2 drugs - carbamazepine (odds ratio : OR=5.21,95% confidence interval : 95% CI=2.68-10.06)and acetaminophen (OR=3.41,95% CI=1.12-10.51)that were associated with a significant elevation of the risk of SJS and TEN.Further,mexiletine hydrochloride (OR=205.48,95% CI=28.04-2330.89)and diaminodiphenylsulfone (OR=981.56,95% CI=94.84-25212.82),were found to be associated with a significant elevation of the risk of DIHS.By identifying certain risk factors for SJS,TEN and DIHS,the results of the present study would be useful in preventing severe drug reactions.

著者

飯島 正文

出版者

一般社団法人 日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.35, no.2, pp.309S-310S, 2004-03-31 (Released:2010-06-28)

参考文献数

13

著者

HIROSHI SASAKI TOMOYOSHI HOSOKAWA MIKIO SAWADA KUNIO ANDO

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.26, no.11, pp.676-680, 1973-11-25 (Released:2006-04-12)

参考文献数

15

被引用文献数

43 68

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A new antibiotic with hypolipidemic activity, ascofuranone, C23H29C1O5, and related substance, ascofuranol, C23H31C1O5, were isolated from the filter cake of the fermented broth of Ascochyta viciae LIBERT, an ascochlorin-producing fungus, and their structures were elucidated. They possess 3-substituted-5-chloro-orcylaldehyde moiety with novel sesquiterpenyl side chains.

著者

MIKIO SAWADA TOMOYOSHI HOSOKAWA TSUNEO OKUTOMI KUNIO ANDO

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.26, no.11, pp.681-686, 1973-11-25 (Released:2006-04-12)

参考文献数

15

被引用文献数

24 28

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Ascofuranone significantly reduced serum lipid levels of rats fed with normal diet 6 hours after a single oral administration of 108 mg/kg. When the antibiotic was orally given for consecutive 10 days to normolipidemic rats, the treatment resulted in marked reduction of serum cholesterol, triglycerides, phospholipids and free fatty acids without affecting organ weight gain, serum total protein, albumin/globulin ratio and serum transaminases. Reduction was also noted with cardiac cholesterol content but liver total sterol and fecal sterol excretion were unchanged. Acute toxicity of ascofuranone is weak to mice and rats and the antibiotic did not induce hepatomegaly which is the main side effect of a positive control agent, ethyl-p-chlorophenoxyisobutyrate.

著者

Junji MAGAE Kazuo NAGAI Kunio ANDO Gakuzo TAMURA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Agricultural and Biological Chemistry (ISSN:00021369)

巻号頁・発行日

vol.52, no.12, pp.3143-3147, 1988 (Released:2006-04-05)

参考文献数

12

被引用文献数

9 1

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Mouse myeloid leukemia cells, Ml, were induced to differentiate into phagocytes by treatment with ascofuranone (AF). AF also induced differentiation of human promyelocytic leukemia HL60 cells and human erythroid leukemia K562 cells into granulocytes and erythrocytes, as detected by nitroblue tetrazolium reducing activity and benzidine staining, respectively. The antibiotic enhanced acetate incorporation of K562 cells. The increase was not observed with the cells of HL60 and two human B lymphoma lines, Daudi and Raji. The increase was diminished by the addition of a glycolysis inhibitor, deoxyglucose. Inhibitors of respiration, antimycin and sodium azide, also enhanced acetate incorporation of K562 cells specifically, which was diminished by the addition of deoxyglucose. Furthermore, antimycin induced differentiation of K562 and HL60 cells. These results suggest a possible relationship between cell differentiation and inhibition of respiration.

著者

JUNJI MAGAE JUNICHI HAYASAKI YUKO MATSUDA MITSUYUKI HOTTA TOMOYOSHI HOSOKAWA SEIKICHI SUZUKI KAZUO NAGAI KUNIO ANDO GAKUZO TAMURA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.41, no.7, pp.959-965, 1988-07-25 (Released:2006-04-19)

参考文献数

20

被引用文献数

34 41

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Ascofuranone demonstrated antitumor activity against FM3A murine mammary carcinoma, implanted in the peritoneal cavity of syngeneic mice, C3H/He. It was more effective by treatment prior to implantation than by that after implantation. Treatment with ascofuranone also increased splenic cytotoxicity and phagocytic activity of host animal cells. Moreover, ascofuranone induced inflammatory cells in the peritoneal cavity which are mainly composed of polymorpho-nuclear leukocytes and macrophages. These cells are more potent in cytotoxicity against FM3A cells than with resident peritoneal cells. The antitumor activity of ascofuranone was suppressed by ip administration of silica, just prior to tumor implantation. These results suggest that the prophylactic antitumor activity of ascofuranone is expressed through the activation of phagocytes. Ascofuranone also suppressed pulmonary metastasis of B16 melanoma and Lewis lung carcinoma. Treatment after tumor implantaion failed to suppress the metastasis. Single treatment of ascofuranone 4 days prior to implantation decreased the metastasis of Lewis lung carcinoma but not that of B16, whereas single treatment of ascofuranone 24 hours prior to the tumor implantation decreased the metastasis of B16 but not that of Lewis lung carcinoma.

著者

今西 康次 緒方 健志 松塚 敦子 田崎 貴子 藤岡 利生 明石 光伸 牧野 芳大 西園 晃

出版者

社団法人 日本感染症学会

雑誌

感染症学雑誌 (ISSN:03875911)

巻号頁・発行日

vol.77, no.1, pp.18-23, 2003-01-20 (Released:2011-02-07)

参考文献数

10

被引用文献数

2 4

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慢性活動性胃炎, 消化性潰瘍の原因のみならず, その長期にわたる感染が胃MALTリンパ腫や胃癌の発生にも関係すると考えられているHelicobacter pyloriの感染経路については口-口, 糞-口感染, 特に飲料水がその主なものと考えられているが不明な点も多い. 今回, 大分県内で飲用に供されている井戸水中のH. pylori混入の可能性を探るために, 同県内39箇所43検体の井戸水 (開放式, 閉鎖式, 湧き水式) について, H. pylori特異的PCR法と培養による検討を行った. その結果, ureA遺伝子領域で4カ所, 16SrRNA領域で1カ所, H. pylori遺伝子が検出されたが, 培養ではいずれも陰性であった. これよりH. pyloriの飲料水, 特に井戸水を介した感染の可能性が改めて示唆された.

著者

木村 昌三

出版者

公益社団法人 東京地学協会

雑誌

地学雑誌 (ISSN:0022135X)

巻号頁・発行日

vol.110, no.4, pp.581-591, 2001-08-25 (Released:2009-11-12)

参考文献数

32

被引用文献数

2 2

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Seismicity characteristics in and around Shikoku, southwest Japan are investigated using recent data from microearthquake observations. Earthquakes occurring in the regions are distinctly divided into crustal and mantle earthquakes according to about 22 km in focal depth. Crustal and mantle earthquakes have predominantly the strike-slip type with P axes in the east-west and north-south directions, respectively. Although the Philippine Sea plate is subducting under Shikoku in the northwest direction from the Nankai trough, the P axis of mantle earthquakes in eastern Shikoku is inferred to be stable in the N-S direction during the period before the 1946 Nankai earthquake until today. On the other hand, earthquakes with normal fault type occur infrequently in the aseismic portion deeper than the north dipping mantle earthquake zone.A gradual lowering of crustal earthquake activity has continued since 1968 in which our microearthquake observation started in central Shikoku. Taking the abrupt decreasing of events in Shikoku before the 1946 Nankai earthquake by JMA data into consideration, the present activity is expected to become lower extremely just before the next Nankai earthquake.

著者

小林 昭夫 真砂 礼宏 吉田 明夫

出版者

日本測地学会

雑誌

測地学会誌 (ISSN:00380830)

巻号頁・発行日

vol.48, no.1, pp.1-12, 2002-03-25 (Released:2011-03-01)

参考文献数

28

被引用文献数

1

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We examined tide gauge records at stations in and around the Kui peninsula to find if a precursory crustal deformation occurred before the 1946 Nankai earthquake. First, we removed effects of atmospheric pressure and astronomical tide on the records. Then, we tried to get rid of the effects of the oceanic current by taking the difference of the records betweentwo stations. After these corrections we found that sea level at Uragami where is located on the southeastern coast of the Kui peninsula had risen about 10 cm just before the Nankai earthquake. The sea level change, if we consider that to represent real subsidence of land near Uragami, could be explained by supposing that a slow fault slip corresponding to moment magnitude 6.9 occurred on the plate boundary in the offing of southeast of the Kui peninsula near the hypocenter of the Nankai earthquake.

著者

小林 昭夫 吉田 明夫

出版者

日本測地学会

雑誌

測地学会誌 (ISSN:00380830)

巻号頁・発行日

vol.50, no.1, pp.39-42, 2004-03-25 (Released:2010-09-07)

参考文献数

11

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We investigated crustal deformation after the 1946 Nankai earthquake using tide gauge records. Although resolution of tide gauge records is not so high for seeing the temporal change in detail, vertical crustal movements whose relaxation times are between several months to years can be detected by them. It was reported that there had been a postseismic crustal deformation with a time constant of 4-5 months in southern Kui Peninsula (Kobayashi et al., 2002). In this paper we show that crustal deformations with a longer relaxation time of a few years were observed in northern Shikoku, examining tide gauge records at such stations as Takamatsu, Sumoto and Kobe. These observations suggest that there was a time lag in the development of postseismic slip between shallow and deeper parts on the plate interface after the Nankai earthquake.

著者

Tatsuya Suzuki Kenzo Oba Yoshimasa Igari Noriaki Matsumura Kentaro Watanabe Shoko Futami-Suda Hiroko Yasuoka Motoshi Ouchi Kazunari Suzuki Yoshiaki Kigawa Hiroshi Nakano

出版者

日本医科大学医学会

雑誌

Journal of Nippon Medical School (ISSN:13454676)

巻号頁・発行日

vol.74, no.5, pp.338-343, 2007 (Released:2007-10-26)

参考文献数

20

被引用文献数

45 75

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Background: Colestimide has been reported to lower blood glucose levels in patients with type 2 diabetes complicated by hypercholesterolemia. Aim: To examine the mechanism by which colestimide decreases plasma glucose levels in the above patients. Methods: A total of 16 inpatients with type 2 diabetes complicated by hypercholesterolemia received colestimide for 1 week after their plasma glucose levels stabilized. We measured plasma glucose, serum immunoreactive insulin (IRI), serum lipid, plasma glucagon, and plasma glucagon-like peptide-1 (GLP-1) levels. These variables at baseline and 1 week of colestimide administration were compared. Results: Preprandial plasma glucose levels (baseline: 132 ± 33 mg/dL vs. completion: 118 ± 43 mg/dL, P=0.073) tended to decrease after colestimide administration, while 1-hr postprandial plasma glucose levels (baseline: 208 ± 49 mg/dL vs. completion: 166 ± 30 mg/dL, P<0.001) and 2-hr postprandial plasma glucose levels (baseline: 209 ± 56 mg/dL vs. completion: 178 ± 39 mg/dL, P=0.015) decreased significantly at 1 week of colestimide administration. The 2-hr postprandial plasma GLP-1 level was significantly (P=0.015) higher at 1 week of colestimide administration as compared with the baseline level, while there were no significant changes in preprandial and 1-hr postprandial plasma GLP-1 levels. Conclusions: The GLP-1-increasing activity of colestimide may explain, at least in part, the mechanism of its blood glucose-lowering activity in patients with type 2 diabetes complicated by hypercholesterolemia.

著者

浅香 正博

出版者

一般社団法人 日本内科学会

雑誌

日本内科学会雑誌 (ISSN:00215384)

巻号頁・発行日

vol.85, no.5, pp.767-771, 1996-05-10 (Released:2008-06-12)

参考文献数

18

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最近の報告を総合すると,ヘリコバクター・ピロリ(HP)感染から始まり,慢性胃炎,慢性萎縮性胃炎,腸上皮化生,早期胃癌を経て進行癌に至る胃癌の自然史の流れが急速に解明されつつある.もちろん,胃癌の発生はHP感染のみですべて説明可能という訳ではなく,食事,環境など多数の要因が入り組んで引き起こされると考えられるが,消化性潰瘍の再発と同様に, HPの除菌により胃癌の発生が予防できる可能性も示唆されることより,この方面の研究のますますの発展が期待される.

著者

Hisatoshi Konishi Hidekazu Nakamaru Hideki Nakatani Tsuyoshi Ueyama Kazuhiro Kobayashi Osamu Morikawa

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.26, no.2, pp.185-186, 1997 (Released:2004-05-01)

参考文献数

12

被引用文献数

11 6

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The partial bromination of calix[4]resorcinarene with a limited amount of N-bromosuccinimide was examined. The ratio of the two dibromo derivatives, distal- and proximal-isomers, was 10:1, which is much different from the statistical value of 1:2. The simple procedure for the preparation of the distal-dibromo derivative is described.

著者

So Young Lee Jai-Ok Kim Jiunn-Ger Li

出版者

日本建築学会(AIJ)、大韓建築学会(AIK)、中国建築学会(ASC) 編集事務局:AIJ jaabe(at)aij.or.jp

雑誌

Journal of Asian Architecture and Building Engineering (ISSN:13467581)

巻号頁・発行日

vol.10, no.1, pp.133-140, 2011-05-13 (Released:2011-05-13)

参考文献数

36

被引用文献数

5 25 2

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The perception of crowding and the shopping environment can influence consumers' decisions on where to shop as well as their buying decision and store image. The purpose of the study is to investigate the effects of store layout design and factors about the consumer on the perception of store crowding and in turn analyze the impact of perceived crowding on shopping behavior and store image. Surveys were conducted at two discount stores in Taipei City, Taiwan. A total of 532 questionnaires were used for analysis. Spatial crowding was assessed using physical area factors including floor layout designs, aisle table area, and ceiling height. Perceptions of crowding resulted from the spatial arrangement, while human crowding contributed to the feeling of overall store crowding. Among a store's physical area factors, aisle table area most strongly impacts the overall degree of perceived store crowding, followed by free-flow layout and grid layout areas. Among various individual factors, age and prior experience of crowding are significantly related to perceived crowding. The results showed that perceptions of spatial crowding had a negative relationship to promotional image while perceptions of human crowding had a positive relationship to discount store image.

著者

塩谷 治彦

出版者

北海道社会学会

雑誌

現代社会学研究 (ISSN:09151214)

巻号頁・発行日

vol.8, pp.60-83, 1995-04-15 (Released:2009-11-16)

参考文献数

33

被引用文献数

1

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この論文は、今日の暴走族や不良生徒集団など青少年の非行や逸脱行動を社会病理学的に理解しようとする試みである。エリクソンの自己同一性に関する発達理論は、青年期の非行や逸脱行動を理解するための枠組みとして貢献してきたが、それは概ね発達心理学的アプローチであって、非行を社会病理学的に理解しようとするものではなかった。そこで本論では諸価値の凋落による価値の主観化、またそれに伴う競争社会化という視点を青少年の病理を解明するために導入した。そして今日の大人になりたがらない青少年の心理の背景に世界の脱価値化に伴う競争社会の浸透という事態があることを示した。暴走族などの非行を理解するため、同一性危機や青年期危機による非行という概念が提示されてきたが、これらの理論は概ね非行を発達上の危機の現れと見ているため、青少年の病理の社会学的要因を十分に解明していない。現代的な非行現象には世界の非価値化と競争社会状況に対する反感が認められるのであり、それが彼らを暴走族や不良集団などへの参加と逸脱にかりたてる重要な動機であることを示した。