著者

鈴木 重晴 嶋村 則人 関谷 徹治

出版者

弘前大学

雑誌

基盤研究(B)

巻号頁・発行日

2000

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聴覚神経系のなかでも、蝸牛神経(cochlear nerve, auditory nerve)は外力に対して極めて脆弱である。このことは、交通事故や労災事故後に経験される外傷性聴覚障害の一部が蝸牛神経損傷によって生じることによっても示されている。一方、脳神経外科の小脳橋角部手術では、蝸牛神経に直接的に外力が及ぶことがある。これによって、蝸牛神経変性が起こり、結果的に外傷性聴覚障害を生じる。このような手術合併症防止の重要性は、広く脳神経外科医には認識されてきた。そして、聴覚誘発電位の一つである聴性脳幹反応を術中に記録することによって、その波形変化から不可逆的な蝸牛神経損傷の発生を未然に防ごうとする試みがなされている。この神経保護手法の臨床的有効性は確立しているが、聴性脳幹反応の術中変化の判定基準は、これまでほとんどV波潜時の延長所見によってのみなされてきた。しかし、潜時のみではなく、V波の振幅の変化に着目して術中モニタリングを行う方が、より鋭敏に蝸牛神経に生じる変化を捉えうるのではないかという指摘もなされてきた。本研究は、上記のような背景のもとに、我々が確立した定量的蝸牛神経変性モデルに基づいて、聴性脳幹反応術中モニタリングにおけるV波振幅変化の意義について検討したものである。我々の本研究の結果は下記であった。すなわち、聴性脳幹反応を脳神経外科手術時の術中モニタリング法として使用するとき、その潜時変化によって不可逆的蝸牛神経損傷の発生を未然に防ぐことは可能である。しかし、これに加えてV波の振幅変化に着目することによって、さらに鋭敏な術中モニタリングが可能となることが証明された。この結果はこれまでにないものであり、蝸牛神経変性防止上、新たな研究成果であったと言える。

著者

Abigail Shrier

出版者

Swift Press

巻号頁・発行日

2021

著者

堀口 賢一 本澤 昌美 野村 価生

出版者

公益社団法人 計測自動制御学会

雑誌

計測と制御 (ISSN:04534662)

巻号頁・発行日

vol.60, no.11, pp.796-800, 2021-11-10 (Released:2021-11-19)

参考文献数

7

被引用文献数

1

著者

Aditya RAKHMADI Kazuyuki SAITO

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Electronics (ISSN:09168516)

巻号頁・発行日

vol.E106-C, no.12, pp.799-807, 2023-12-01

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Transcatheter renal denervation (RDN) is a novel treatment to reduce blood pressure in patients with resistant hypertension using an energy-based catheter, mostly radio frequency (RF) current, by eliminating renal sympathetic nerve. However, several inconsistent RDN treatments were reported, mainly due to RF current narrow heating area, and the inability to confirm a successful nerve ablation in a deep area. We proposed microwave energy as an alternative for creating a wider ablation area. However, confirming a successful ablation is still a problem. In this paper, we designed a prediction method for deep renal nerve ablation sites using hybrid numerical calculation-driven machine learning (ML) in combination with a microwave catheter. This work is a first-step investigation to check the hybrid ML prediction capability in a real-world situation. A catheter with a single-slot coaxial antenna at 2.45 GHz with a balloon catheter, combined with a thin thermometer probe on the balloon surface, is proposed. Lumen temperature measured by the probe is used as an ML input to predict the temperature rise at the ablation site. Heating experiments using 6 and 8 mm hole phantom with a 41.3 W excited power, and 8 mm with 36.4 W excited power, were done eight times each to check the feasibility and accuracy of the ML algorithm. In addition, the temperature on the ablation site is measured for reference. Prediction by ML algorithm agrees well with the reference, with a maximum difference of 6°C and 3°C in 6 and 8 mm (both power), respectively. Overall, the proposed ML algorithm is capable of predicting the ablation site temperature rise with high accuracy.

著者

高山 英勝

出版者

一般社団法人 日本風力エネルギー学会

雑誌

風力エネルギー利用シンポジウム (ISSN:18844588)

巻号頁・発行日

vol.13, pp.36-44, 1991 (Released:2011-07-11)

著者

桜井徳太郎 [著]

出版者

講談社

巻号頁・発行日

1996

著者

細川 洋一郎 門前 暁 寺嶋 真悟 羽澤 勝治 吉野 浩教

出版者

弘前大学

雑誌

基盤研究(C)

巻号頁・発行日

2009

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放射線治療の効果を高めることを目的に、アスコルビン酸併用放射線治療の研究を行った。白血病細胞、線維肉腫細胞、腺癌細胞、扁平上皮癌細胞の計4種類の癌細胞を使い、放射線照射単独とアスコルビン酸併用放射線照射の比較をすると、アスコルビン酸により細胞死が増加し、すべての細胞で、アスコルビン酸併用放射線照射群では生存率が有意に低下していた。今後、放射線にアスコルビン酸を併用することで、放射線治療の効果が高まることが期待され、臨床研究を行う必要がある。

著者

菅野 眞澄

出版者

一般社団法人 日本人類学会

雑誌

東京人類學會雜誌 (ISSN:18847641)

巻号頁・発行日

vol.22, no.250, pp.154-163, 1907-01-20 (Released:2010-06-28)

著者

西口 正之

出版者

一般社団法人 日本音響学会

雑誌

日本音響学会誌 (ISSN:03694232)

巻号頁・発行日

vol.78, no.3, pp.143-149, 2022-03-01 (Released:2022-04-01)

参考文献数

18

著者

神作 愛 今井 崇雄 高橋 一郎 澤田 茂樹 山内 美智子 長谷川 英美 石井 和浩 米重 成人

出版者

Japanese Society of Psychosomatic Dentistry

雑誌

日本歯科心身医学会雑誌 (ISSN:09136681)

巻号頁・発行日

vol.12, no.1, pp.29-35, 1997-06-25 (Released:2011-09-20)

参考文献数

15

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The effects of the traditional Chinese (Kampo) medicines, Hochu-ekki-to, Yoku-kansan and Saiko-ka-ryukotsu-borei-to, were compared to those of imipramine, a tricyclic antidepressant, in a mouse model of despair. Mice were placed in a water tank, from which there was no escape, for 15 min. The tank contained a water-wheel and the number of wheel rotations counted as escape attempts and, in accord with previous reports, imipramine (10 mg/kg i.p.), given either acutely or daily for 3 days 10 min before testing, markedly increased the number of wheel rotations. The Kampo medicines were administered for 14 consecutive days in the drinking water prior to testing. Hochu-ekki-to (60, 150 and 300 mg/kg/day) also increased wheel rotations but the effect was not dose-dependent. Yoku-kan-san markedly increased the number of wheel rotations at lower doses (60, 150 mg/kg/day), but decreased the number at the highest dose (300 mg/kg/day). Saiko-ka-ryukotsu-borei-to also increased the number of wheel rotations at the lowest dose (60 mg/kg/day), but decreased the number of rotations at higher doses (150, 300 mg/kg/day). These results suggest that these Kampo medicines, like imipramine, may ameliorate despair in mice.

著者

朴 光培 金 孝淑

出版者

法と心理学会

雑誌

法と心理 (ISSN:13468669)

巻号頁・発行日

vol.9, no.1, pp.66-81, 2010 (Released:2017-06-02)

著者

高橋 伸夫

出版者

一般財団法人 アジア政経学会

雑誌

アジア研究 (ISSN:00449237)

巻号頁・発行日

vol.34, no.4, pp.96-133, 1988 (Released:2014-09-15)

著者

Kevin M. Downard

出版者

The Mass Spectrometry Society of Japan

雑誌

Mass Spectrometry (ISSN:2187137X)

巻号頁・発行日

vol.12, no.1, pp.A0136, 2023-12-01 (Released:2023-12-01)

参考文献数

85

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This review article presents the development and application of mass spectrometry (MS) approaches, developed in the author’s laboratory over the past 25 years, to detect; characterise, type and subtype; and distinguish major variants and subvariants of respiratory viruses such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). All features make use of matrix-assisted laser desorption ionisation (MALDI) mass maps, recorded for individual viral proteins or whole virus digests. A MALDI-based immunoassay in which antibody–peptide complexes were preserved on conventional MALDI targets without their immobilisation led to an approach that enabled their indirect detection. The site of binding, and thus the molecular antigenicity of viruses, could be determined. The same approach was employed to study antivirals bound to their target viral protein, the nature of the binding residues, and relative binding affinities. The benefits of high-resolution MS were exploited to detect sequence-conserved signature peptides of unique mass within whole virus and single protein digests. These enabled viruses to be typed, subtyped, their lineage determined, and variants and subvariants to be distinguished. Their detection using selected ion monitoring improved analytical sensitivity limits to aid the identification of viruses in clinical specimens. The same high-resolution mass map data, for a wide range of viral strains, were input into a purpose-built algorithm (MassTree) in order to both chart and interrogate viral evolution. Without the need for gene or protein sequences, or any sequence alignment, this phylonumerics approach also determines and displays single-point mutations associated with viral protein evolution in a single-tree building step.

著者

大竹 弘哲 長嶋 和明 田中 聡一

出版者

北関東医学会

雑誌

北関東医学 (ISSN:13432826)

巻号頁・発行日

vol.57, no.1, pp.49-52, 2007 (Released:2007-06-13)

参考文献数

6

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症例は73 歳女性. 左上肢の筋力低下にて発症. 歩行障害が現れ, 筋萎縮性側索硬化症 (ALS) と診断. 後に構音障害と嚥下障害が現れ, 進行した. 患者本人とその家族共に延命治療を希望されなかった. 左上肢を中心に疼痛を訴えるようになり, 緩和ケアとしてリン酸コデインを開始して45日目に永眠された. 日米の神経学会治療ガイドラインで, ALS末期の疼痛緩和にオピオイドの使用を勧めている. 筋萎縮に伴って体重が減少するALS末期で, 欧米に比べ体格の小さい本邦の患者において, 強オピオイドではなくリン酸コデインから緩和ケアを開始することを検討すべきである.

著者

Kansei Fujimoto Taichi Tebakari

出版者

Japan Society of Hydrology and Water Resources (JSHWR) / Japanese Association of Groundwater Hydrology (JAGH) / Japanese Association of Hydrological Sciences (JAHS) / Japanese Society of Physical Hydrology (JSPH)

雑誌

Hydrological Research Letters (ISSN:18823416)

巻号頁・発行日

vol.17, no.4, pp.77-84, 2023 (Released:2023-11-29)

参考文献数

30

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Satellite products are expected to play important roles in water-related management and public welfare, particularly in developing countries. Higher-resolution precipitation products are required to cope with increasingly severe water-related disasters. In this study, we propose a new satellite precipitation estimation algorithm based on deep learning that uses data from multiple satellite infrared (IR) bands and geographic information (e.g. elevation, latitude, and longitude) as input. For the deep learning model component, we use various image segmentation models, including U-Net, PSPNet, and DeepLabv3+. Cosine similarity and correlation coefficients for precipitation rate were used to determine the IR bands of the input data; five bands were used as IR. Four input datasets were constructed: IR alone; IR and elevation data; IR and latitude/longitude; and IR, elevation data, and latitude/longitude. When PSPNet or DeepLabv3+ was used as the deep learning model, and elevation and latitude/longitude were added to IR as input data, the mean square error and fraction skill score showed improved accuracy over GSMaP_MVKv7 and PERSIANN-CCS; precipitation overestimation was eliminated. These results indicate that deep learning models can be used to estimate precipitation from satellite IR observations with high resolution and accuracy.

著者

Kazuki Nagashima Kojiro Hiruma Eri Nakamura Machiko Watanabe Yuko Sekine

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

pp.b23-00530, (Released:2023-11-16)

参考文献数

27

被引用文献数

1

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Overdose has become a global social problem. The Japanese government requires gatekeeper training to detect and prevent indicators of overdose and suicide. However, knowledge of necessary factors for the gatekeeper of overdose (patient intervention) is limited. This study aimed to investigate the characteristics of individuals who experienced intervening persons expected to overdose, and to identify the factors required of gatekeepers. A Google form was used to survey 298 pharmacists and registered sellers in Japan. We searched for factors by logistic analysis. Knowledge of prescription drugs used for overdose was higher among pharmacists than among registered sellers. Conversely, pharmacists and registered sellers had similar knowledge about OTC drugs. Overall multivariate logistic regression analysis revealed countermeasures against overdose at their workplace (odds ratio [OR]: 4.01, 95% confidence interval [CI]: 2.25–7.15, P  <  0.01) and knowledge that overdose is on the rise (OR: 1.93, 95% CI: 1.04–3.69, P  <  0.05) to be significantly associated with intervention experience as a gatekeeper. Countermeasures against overdose at their workplace (OR: 2.40, 95% CI: 1.10–5.25, P  <  0.05) in pharmacists and years of work experience (OR: 1.13, 95% CI: 1.04–1.24, P  <  0.05), countermeasure against overdose at their workplace (OR: 3.43, 95% CI: 1.18–10.0, P  <  0.05), and willingness to participate in study sessions and workshops on overdose (OR: 3.50, 95% CI: 1.51–8.10, P  <  0.05) in registered seller were significantly associated with intervention experience as a gatekeeper. These results are useful evidences for countermeasures and gatekeeper training for overdose at pharmacies and drugstores in the community.

著者

Yoshihito Kasanami Takashi Yamamoto Tomoyoshi Miyamoto Sumio Matzno Mikio Sakakibara Masahiro Iwaki Atsufumi Kawabata

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.12, pp.1699-1705, 2023-12-01 (Released:2023-12-01)

参考文献数

34

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Community pharmacists may play a key role in promoting deprescribing of potential inappropriate medications (PIMs) that are highly prevalent among community-dwelling elderly with dementia. To characterize PIMs categories that need a special attention for dementia patients, in the present study, we analyzed the anonymized pharmacy claims data of patients aged 65 years and older (n = 333869) who visited nationwide 905 community-based pharmacies of Sugi Pharmacy Co., Ltd. during December 1–31, 2019. A dementia group was defined as patients who received typical dementia medications marketed in Japan, i.e., donepezil, galantamine, memantine or rivastigmine, and a non-dementia group was defined as patients who received no such medications. After propensity score matching on the basis of patients’ age, gender and home healthcare insurance usage, the data of 11486 patients in each group were subjected to logistic regression analyses, to identify PIMs categories particularly important for dementia patients. Univariate analysis indicated that the proportions of dementia patients who received 1 and 2≤ of PIMs were significantly (p < 0.001) greater than those of non-dementia patients (odds ratios were 1.35 and 1.47, respectively). Multivariate analyses identified 5 categories of PIMs that were significantly more frequently prescribed in dementia patients, i.e., ‘H2 blockers,’ ‘drugs for overactive bladder,’ ‘anti-diabetes drugs’ and ‘sulpiride’ listed as PIMs categories for non-specific cases (adjusted odds ratios (aORs): 1.29, 1.91, 1.17, and 1.38, respectively), in addition to ‘antipsychotics’ listed only for dementia patients (aOR: 4.29). These results provide useful information to establish strategies for pharmacist-led deprescribing of PIMs in dementia patients.

著者

Susumu IWAIDE Yutaro NAKAYAMA James K CHAMBERS Kazuyuki UCHIDA Daisuke NAKAGAWA Yumi YAMANASHI Haruna BANDO Tomoaki MURAKAMI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.85, no.12, pp.1296-1300, 2023 (Released:2023-12-06)

参考文献数

30

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The brain of a rhesus monkey that died at 43 years of age with symptoms of suspected cognitive dysfunction was analyzed. pathological analyses revealed characteristic Alzheimer’s disease-related lesions: the aggregation of amyloid β (Aβ) in the form of senile plaques and phosphorylated tau proteins. We also revealed that Aβ43, which is prone to aggregation and toxicity in humans, is involved in senile plaques in the brain of the rhesus monkey, as well as several other Aβ species. Comparative studies of neuropathology using aged nonhuman primates lack behavioral descriptions compared to human medicine. This case report showed behavioral abnormalities and the detailed pathological changes that may have caused it in a super-aged rhesus monkey.

著者

小林 治文

出版者

一般社団法人エレクトロニクス実装学会

雑誌

エレクトロニクス実装学術講演大会講演論文集 第32回エレクトロニクス実装学術講演大会

巻号頁・発行日

pp.329-332, 2018 (Released:2019-03-29)

著者

若林 猛

出版者

一般社団法人 表面技術協会

雑誌

表面技術 (ISSN:09151869)

巻号頁・発行日

vol.67, no.8, pp.409-413, 2016-08-01 (Released:2017-08-01)

参考文献数

3

被引用文献数

1 1