著者

Risako Morishita Miki Shimada Minami Nagao Shin Shimizu Noriyasu Kamei Mariko Takeda-Morishita

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.2, pp.343-347, 2023-02-01 (Released:2023-02-01)

参考文献数

14

被引用文献数

1

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Owing to their unique physicochemical properties and diverse biological effects, ultrafine bubbles (UFBs) have recently been expected to be utilized for industrial and biological purposes. Thus, this study investigated the biological safety of UFBs in water for living beings in drinking the water with a view to future use in health sciences. In this study, we used H2-filled UFBs (NanoGAS®) that can hold hydrogen in the aqueous phase for a long time. Mice were randomly assigned to one of three groups: those receiving NanoGAS® water, reverse osmosis water, or natural mineral water, and they ingested it ad libitum for one month or three months. As a result, subchronic drinking of NanoGAS® water does not affect either the common blood biochemical parameters or the health of the organs and mucosal membranes. Our results, for the first time, scientifically demonstrated the biological safety of H2-filled UFBs water for subchronic oral consumption.

著者

漆葉 章典

出版者

日本神経治療学会

雑誌

神経治療学 (ISSN:09168443)

巻号頁・発行日

vol.37, no.2, pp.115-122, 2020 (Released:2020-08-31)

参考文献数

63

被引用文献数

2

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Immune–mediated necrotizing myopathy (IMNM) is a subgroup of idiopathic inflammatory myopathies, pathologically characterized by myofiber necrosis with little lymphocytic infiltration. Autoantibodies toward signal recognition particle (SRP) and 3–hydroxy–3–methylglutaryl–coenzyme A reductase (HMGCR) are two major autoantibodies specifically associated with IMNM. Anti–SRP autoantibody–associated IMNM patients are more likely to present with severe muscle weakness and atrophy, cervical muscle weakness, dysphagia, and respiratory insufficiency ; anti–HMGCR autoantibody–associated IMNM patients show a higher proportion of statin use, especially in elderly patients. It is occasionally challenging to distinguish from non–inflammatory myopathies such as muscular dystrophy without autoantibody testing when patients show a relatively slowly progressive course. RNA immunoprecipitation is the original detection method for anti–SRP antibodies, but it requires complicated techniques and is not suitable for clinical use. Therefore, immunoassays using recombinant 54kDa subunit protein of the SRP complex, e.g. immunodot assay and enzyme–linked immunosorbent assay, are commonly used in clinical settings. However, it should be kept in mind that false–negative results can occur in the assays because anti–SRP antibodies occasionally recognize epitopes other than the 54kDa subunit. The pathomechanism has been regarded to involve complement–mediated immunity. In light of recent advances in the pathogenesis, complement–targeting therapy for refractory patients is being discussed.

著者

神山 恵三

出版者

一般社団法人 表面技術協会

雑誌

金属表面技術 現場パンフレット (ISSN:03685527)

巻号頁・発行日

vol.9, no.5, pp.12-17, 1962-05-15 (Released:2009-10-07)

著者

荘田 崇人

出版者

一般社団法人 電気設備学会

雑誌

電気設備学会誌 (ISSN:09100350)

巻号頁・発行日

vol.37, no.9, pp.676-679, 2017 (Released:2017-09-14)

参考文献数

5

著者

右京 芳文 野間 久史

出版者

日本計量生物学会

雑誌

計量生物学 (ISSN:09184430)

巻号頁・発行日

vol.40, no.1, pp.15-34, 2019-08-01 (Released:2019-09-18)

参考文献数

27

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Missing data is a common problem in longitudinal clinical trials, and mixed-effects models for repeated measures (MMRM) have been widely applied to circumvent the resulting bias effectively. However, many standard inference methods of MMRM lead to the inflation of type I error rates for the tests of regression coefficient parameters when the longitudinal dataset is small and incomplete. Permutation inference methods have been established as accurate inference methods under small sample settings. In this article, we propose two effective permutation-based inference methods for the analyses using MMRM. One is the permutation of the treatment assignment variable and the other is the permutation of weighted residuals estimated by the reduced model under null hypothesis. We conducted numerical evaluations via simulation studies under realistic situations to evaluate performances of the proposed methods. The two methods generally provided valid inference results and performed relatively well compared with the current standard methods, even for small and incomplete datasets. Applications to a postnatal depression clinical trial are also presented.

著者

藤平 啓汰

巻号頁・発行日

2022-03

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Supervisor:池田 心

著者

森 正 後藤 惠之輔

出版者

長崎大学工学部

雑誌

長崎大学工学部研究報告 (ISSN:18805574)

巻号頁・発行日

vol.37, no.68, pp.61-66, 2007-02

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Recently, tourist spots in the whole country are taking measures to incorporate barrier-freeness in order to reduce fall in the number of visitors. This is also to invite aged and disabled persons having lower importance as customers so far. But this initiative would be welcomed by the aged and disabled persons. Accordingly, this study aimed at assessing the status of barrier-freeness on these tourist spots by taking Onomichi City as a case, which is also a slope city like Nagasaki. The findings of the investigation revealed that, in the tourist spots of Onomochi City there are problems such as: separate route for aged and disabled persons, lack of restroom facilities etc. This paper concluded with the suggestions to make the tourist spots barrier-free from the viewpoint of wheel-chair user.

著者

輪島 裕介

雑誌

大衆文化 = Popular culture

巻号頁・発行日

vol.20, pp.19-39, 2019-03-25

著者

渡辺 恒夫

出版者

日本質的心理学会

雑誌

質的心理学研究 (ISSN:24357065)

巻号頁・発行日

vol.18, no.1, pp.176-196, 2019 (Released:2021-04-12)

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コミュニケーションが極めて重視される社会にあって,「コミュ障」を抱えた者はいかに生きたらよいかを当事 者視点で問うために,「人づきあいが苦手」で検索したインターネット上の相談事例4 例を,ラングドリッジの 批判的ナラティヴ分析(CNA)を元に考案した批判的ナラティヴ現象学によって分析した。その結果,1 例で,多数のアドヴァイス・ナラティヴとの「地平融合」を通し,自己の問題が対人関係過敏に由来する対人回避にあるという自己洞察を得たことが分析された。職場の困難を抱えた他の例をも含めると,「要求水準を下げて対人ストレスの少ない環境を選び,何かに没頭することを通じて対人刺激に知らず知らずのうちに慣れてゆき,気がついたら居場所を何とか確保していた」という方向の自己経験に基づくアドヴァイスが優勢だったが,これは著者自身が身に着けた無意識裡の秘訣でもあったというように,当事者視点からの暗黙の参照点を介して「本質観取」がなされた。医療・マスメディアで話題の自閉性スペクトラム障害(ASD)圏の,共感性の遅れを伴う「コミュ障」と,これらネット上のコミュ障との異質性も示唆され,後者の理解にはユング派の通俗心理学的概念であるHSP(敏感すぎる人)が参考になるとされた。ASD 圏に対して提唱されている医療化・福祉化とは別の解決法の必要性が説かれ,異質なものの「共生」という福祉社会論の理念にも疑問が投げかけられた。

著者

土屋 和男

出版者

日本建築学会

雑誌

日本建築学会計画系論文集 (ISSN:13404210)

巻号頁・発行日

vol.78, no.687, pp.1151-1160, 2013-05-30 (Released:2013-06-10)

被引用文献数

1

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Kindai-Sukisha (a master of the tea ceremony in modern age) made many wooden high-class Japanese style residences. ‘Inakaya’ (country cottage) is a kind of teahouse by Kindai-Sukisha. This article regarded ‘Inakaya’ as a style of the residence in modernization. And it aims at clarifying the origin of ‘Inakaya’ and the process of change from the descriptions in the tea party records by Kindai-Sukisha. The house called an ‘Inakaya’ changed from the small hut to the reconstructed big farmhouse. The point of view of ‘Inakaya’ is that create new style of teahouse by Kindai-Sukisha himself, without an architect or a master of tea.

著者

玉木 奈美 久下 浩史 辻 涼太

出版者

公益社団法人 全日本鍼灸学会

雑誌

全日本鍼灸学会雑誌 (ISSN:02859955)

巻号頁・発行日

vol.71, no.4, pp.220-228, 2021 (Released:2022-08-10)

参考文献数

17

著者

棗田 学 温 城太郎 渡邉 潤 高橋 陽彦 塚本 佳広 岡田 正康 平石 哲也 吉村 淳一 大石 誠 藤井 幸彦

出版者

一般社団法人 日本小児神経外科学会

雑誌

小児の脳神経 (ISSN:03878023)

巻号頁・発行日

vol.47, no.4, pp.358-364, 2022 (Released:2023-01-30)

参考文献数

25

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Diffuse midline glioma(DMG)の80%以上がヒストンH3K27M変異を有する.橋に局在する病変は摘出術の適応はなく,針生検でも重篤な合併症が生じ得るためDMGに対してliquid biopsyの確立が切望される.我々は初発時に腰椎穿刺で採取した脳脊髄液よりH3K27Mを同定するのは困難と報告した.本稿では,多発病変および播種病変を有しliquid biopsyによりH3K27M変異と同定された2症例を紹介し,liquid biopsyの恩恵を受ける症例の特徴について迫る.

著者

服部 憲路

出版者

昭和大学学士会

雑誌

昭和学士会雑誌 (ISSN:2187719X)

巻号頁・発行日

vol.82, no.6, pp.570-573, 2022 (Released:2023-01-31)

著者

染川 憲一

出版者

公益社団法人 日本アイソトープ協会

雑誌

RADIOISOTOPES (ISSN:00338303)

巻号頁・発行日

vol.55, no.2, pp.97-107, 2006-02-15 (Released:2010-07-21)

参考文献数

17

著者

海老澤 圭

出版者

現代文化人類学会

雑誌

文化人類学研究 (ISSN:1346132X)

巻号頁・発行日

vol.23, pp.126-131, 2022 (Released:2023-01-28)

参考文献数

1

著者

Nicolas Girerd Matthieu Aubry Pierre Lantelme Olivier Huttin Patrick Rossignol

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.62, no.1, pp.193-196, 2021-01-30 (Released:2021-01-30)

参考文献数

9

被引用文献数

3 3

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Intravenous mineralocorticoid receptor antagonists (MRAs) have been used in some centers for decades to reduce the risk of hypokalemia and boost diuresis in acutely decompensated heart failure (ADHF). We report the well-tolerated use of intravenous MRAs as a rescue procedure in 3 patients admitted for ADHF with important diuretic resistance. Undertaking trials evaluating the effect of this therapeutic strategy in ADHF could represent a promising avenue.

著者

鈴木 大介 三村 泰成 廣井 美和

出版者

一般社団法人 日本機械学会

雑誌

シンポジウム: スポーツ・アンド・ヒューマン・ダイナミクス講演論文集 2015 (ISSN:24329509)

巻号頁・発行日

pp._B-32-1_-_B-32-9_, 2015-10-30 (Released:2017-06-19)

被引用文献数

1

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In recent years, in research fields such as gait analysis, ergonomics and sport, video processing has been used. A high speed camera can observe a motion slowly. We can get an animation of a slow motion by taking a number of frames at the time of photography. A motion capture is also a technique to record the movement of a real person and object digitally. We visualize a movement of the kendo, and analysis a motion of the lower limbs during swing of an experiencer or a beginner. The measurement contents are velocity measurement of the tip of the shinai. Motion analysis of lower limbs and analysis of tendon motion by floor reaction force. There was difference in velocity of the tip of the shinai by a person with experience and an inexperienced person. In the motion analysis on lower limbs, it has been understood that power to step is five times larger than power to kick.

著者

中江 智子 守田 秀則

出版者

農村計画学会

雑誌

農村計画学会誌 (ISSN:09129731)

巻号頁・発行日

vol.34, no.Special_Issue, pp.255-260, 2015-11-20 (Released:2016-11-30)

参考文献数

6

被引用文献数

1 1

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Reproduction and increase prevention of abandoned farmland is an important issue in rural. This study is intended to evaluation of social and geographic factors that affect the distribution of cultivation abandonment land in Lake Kojima basin, Okayama Prefecture. Regression analysis was used for analysis. The inclination angle, elevation, management cultivated area were related to condition of cultivation abandonment land and the distribution of cultivation abandonment land.

著者

Osamu Matsuoka Mugen Ujiie Hitoshi Kikuchi Sachiko Otake Danaya Chansinghakul Takahiro Inoue Kucku Varghese Nuchra Sirisuphmitr Tomoyuki Hashiguchi Betzana Zambrano Takahiro Nakama Carina Frago Emilia Jordanov Mandeep Singh Dhingra

出版者

National Institute of Infectious Diseases

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2022.272, (Released:2023-01-31)

参考文献数

33

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MenACYW-TT is a quadrivalent meningococcal tetanus toxoid-conjugate vaccine designed to prevent invasive meningococcal disease. The primary objective of this study was to demonstrate non-inferiority of the vaccine seroresponse to a single dose of MenACYW-TT compared to a licensed Meningococcal quadrivalent diphtheria-conjugate vaccine, MCV4-DT. This Phase III double-blind, multi-center study was conducted in meningococcal vaccine-naive participants aged 2-55 years in Japan (NCT04368429; JapicCTI-205288). Participants were randomized 1:1 to MenACYW-TT (n=180) or MCV4-DT (n=180). Functional antibodies against meningococcal serogroups A, C, W, and Y were measured using a serum bactericidal antibody assay with human complement (hSBA) at baseline (D0) and 30 days after vaccination (D30). Seroresponse was defined as post-vaccination titers ≥1:16 for participants with baseline titers <1:8; or ≥4-fold increase for participants with baseline titers ≥1:8. Safety data were collected for 30 days. Non-inferiority of the vaccine seroresponse vs MCV4-DT was demonstrated at D30 for each serogroup (A: 85.6% vs. 65.4%; C: 96.6% vs. 62.6%; W: 87.4% vs. 49.2%; Y: 97.7% vs. 63.5%, respectively). MenACYW-TT was well-tolerated, with no safety concerns identified. In conclusion, when administered as a single dose, MenACYW-TT was well tolerated with a non-inferior immune response compared to MCV4-DT, providing a potential alternative vaccine for this population.

著者

小坂 直敏 金子 仁美

出版者

一般社団法人 電気学会

雑誌

電気学会誌 (ISSN:13405551)

巻号頁・発行日

vol.120, no.1, pp.23-26, 2000-01-01 (Released:2008-04-17)

参考文献数

5