著者
高野 勝弘 尾崎 由基男
出版者
一般社団法人 日本脳卒中学会
雑誌
脳卒中 (ISSN:09120726)
巻号頁・発行日
vol.30, no.6, pp.953-959, 2008 (Released:2009-01-13)
参考文献数
10
被引用文献数
5 1

To monitor the effectiveness of anti-platelet therapy should be important since anti-platelet drug "resistance" or non-compliance can be evaluated clearly by it. However, the anti-platelet therapy monitoring is not widely practiced, probably due to poorly-standardized platelet function test. Among the anti-platelet drug resistance, aspirin resistance is one of the most important topics in clinical thrombosis and hemostasis field. Also, clopidogrel resistance recently became a big issue. Monitoring of anti-platelet therapy is needed for further understanding of these anti-platelet drug resistances.
著者
増井 香名子 岩本 華子
出版者
一般社団法人 日本社会福祉学会
雑誌
社会福祉学 (ISSN:09110232)
巻号頁・発行日
vol.62, no.4, pp.72-85, 2022-02-28 (Released:2022-05-21)
参考文献数
14

本研究の目的は,DV被害者である親の子育ての実態を明らかにし,児童福祉分野における被害親の支援・介入方策の検討につなげることである.そのために子どものいるDV被害女性27人の半構造化インタビューの分析を行った.その結果,被害親の子育ては,加害親による暴力と支配により「親機能の奪われ」を経験すること,一方で暴力と支配に対抗し「親機能の必死の遂行」を行っているということが明らかになった.分析からは困難な状況のなかで子どもを守り子どもの成長を促進するという被害親のストレングスが見いだされた.また,子どもに関する多様な要因が関係の継続の有無に影響を与えていることが示された.分析結果から,加害親が被害親の子育てに影響をもたらす暴力と支配の内実とそれによる家族関係の力動をアセスメントすること,被害親のストレングスに焦点をあて,子どもの安全と福祉のために被害親と協働していくという新たな視点を提示した.
著者
Takeshi Yagyu Sayaka Funabashi Shuichi Yoneda Teruo Noguchi Satoshi Yasuda
出版者
The Japanese Circulation Society
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.84, no.11, pp.1990-1998, 2020-10-23 (Released:2020-10-23)
参考文献数
19
被引用文献数
4 10

Background:Duplex ultrasound scanning (DUS) plays a major role in less invasive diagnosis and assessment of lesion severity in lower extremity peripheral artery disease (PAD). In this study, we evaluated the efficacy of each DUS parameter measured in patients with PAD and established a simple method for PAD evaluation.Methods and Results:We retrospectively investigated 211 patients (270 limbs) who underwent assessment with both angiography and DUS. During DUS of the common femoral artery (CFA) and popliteal artery, we measured 3 parameters: acceleration time (AcT), peak systolic velocity (PSV), and waveform contour. We compared these parameters with the degree of angiographic stenosis. AcT at the CFA had a significantly higher value in prediction of aortoiliac artery lesions with >50% stenosis (c-index, 0.85; 95% confidence interval (CI), 0.79–0.91), with a sensitivity of 0.82 and specificity of 0.76 at the best cutoff point, compared with PSV and waveform contour (P<0.001, respectively). For femoropopliteal lesions, the ratio of AcT at the popliteal artery to AcT at the CFA is the most predictive parameter, with sensitivity of 0.86 and specificity of 0.92 at the best cutoff point (c-index, 0.93; 95% CI, 0.90–0.97), compared with others (P<0.001, respectively).Conclusions:For the assessment of PAD with DUS, AcT and AcT ratio are simple and reliable parameters for evaluating aortoiliac and femoropopliteal artery disease.
著者
高森 建二
出版者
日本香粧品学会
雑誌
日本香粧品学会誌 (ISSN:18802532)
巻号頁・発行日
vol.38, no.2, pp.92-95, 2014-06-30 (Released:2015-07-24)
参考文献数
12

Itch has been defined as an unpleasant sensation that provokes the desire to scratch itch. The itch in dry skin such as xerosis and atopic dermatitis is antihistamin-resistant itch (intractable itch). The itch in dry skin is induced easily by weak stimuli such as mechanical, chemical or physiological stimuli (alloknesis). Alloknesis may be induced by lowering of itch threshold. One of the cause of this phenomenon is the elongation (invasion) of nerve fibers into the epidermis. In this paper the invasion mechanisms of nerve fiber into the epidermis and the management of itch in dry skin were discussed.
著者
水野 真彦
出版者
一般社団法人 人文地理学会
雑誌
人文地理 (ISSN:00187216)
巻号頁・発行日
vol.62, no.5, pp.426-444, 2010 (Released:2018-01-19)
参考文献数
109
被引用文献数
2

This paper reviews studies focused on the economic and social restructuring of cities in developed countries in the 2000s (2000-2009) from the viewpoint of economic geography. Drawing on critical examinations of the global cities thesis and the creative class thesis by Saskia Sassen and Richard Florida, respectively, the author points out the following four features of urban restructuring during the decade.First, urban spaces that contain land and buildings have gradually been incorporated in global financial capitalism. In other words, they have become financial products that have been traded beyond local and national borders, which caused a growth in financial business and a rapid rise in housing prices and rent prior to the financial crisis. The surge of financial capitalism in the 2000s has had a tendency to destabilize urban spaces and the lives of the residents in these areas.Second, neo-liberal policy movements have emphasized intensifying intercity competition and the rise of urban entrepreneurialism. City governments increasingly tend to pay more attention to attracting mobile capital, and neglect social policy for city residents, who are relatively immobile.Third, according to Sassen, global cities are characterized by the economic and social polarization of urban residents. In the 2000s, many Japanese writers and researchers discussed the fact that Japan had been converted into a gap-widening society. The increasing job insecurity of younger workers is suggested as a cause of the widening of the income gap. In particular, some critics perceive the suburbs as a problem, partly because irregular and low-paid employment is often a feature of these regions. In addition, this decade has witnessed an increase in the regional disparity between Tokyo and the rest of Japan.Fourth, the intercity competition for attracting highly skilled talents has been accelerated in the 2000s. Richard Florida insists that attracting the creative class is fundamental to urban development. He suggests that diversity, openness, and tolerance are magnets that attract the creative class. Although his view has drawn the attention of local politicians and policymakers, a considerable number of scholars criticized it for several reasons. One of these criticisms is that urban development can be better explained in terms of locations that offer job opportunities rather than the residential preferences of people or urban amenities. Another criticism is that urban policies based on Florida’s view possibly deepen the social divide between the creative class and the rest of the population. We have to recognize the importance of job creation in production activities throughout the production chains in order to prevent the deepening of the social divide in urban societies.
著者
Jun HEMMI Seiya MAKINO Takehiro YOKOO Hiroshi KANO Yukio ASAMI Kazuyoshi TAKEDA Yoshio SUZUKI Sachio KAWAI Isao NAGAOKA Keisuke SAWAKI Ko OKUMURA
出版者
BMFH Press
雑誌
Bioscience of Microbiota, Food and Health (ISSN:21863342)
巻号頁・発行日
vol.42, no.1, pp.73-80, 2023 (Released:2023-01-01)
参考文献数
31
被引用文献数
3

Seasonal influenza is a major upper respiratory tract infection occurring in winter. Vaccination is the best method for preventing this infection. We conducted two randomized, double-blind, placebo-controlled trials to examine whether consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1, which has been reported to reduce the risk of catching the common cold, augments serum antibody titers against seasonal influenza vaccines. In the first trial, which included university students, serum antibody titers against influenza A (H3N2) and B viruses were significantly higher in the yogurt group than in the placebo group. According to the guidelines established by the European Medicines Agency (EMA) for the assessment of vaccines, the seroconversion rate and mean geometric increase of influenza A (H3N2) and seroprotection of influenza B met the criteria only in the yogurt group. In the second trial, which included healthy adults, serum antibody titers against influenza A (H1N1) and B viruses were significantly higher in the yogurt group than in the placebo group. The seroconversion rate and mean geometric increase of influenza B met the EMA criteria only in the yogurt group. Furthermore, the cumulative days of ill health, such as throat complaints, upper respiratory inflammation, and cold, were significantly lower in the yogurt group than in the placebo group. Therefore, daily intake of yogurt fermented with L. bulgaricus OLL1073R-1 could reduce the duration of symptoms caused by respiratory infections and act as a mucosal adjuvant enhancing acquired immune responses against vaccines, leading to the improvement of public health.
著者
猪阪 善隆 松井 功
出版者
一般社団法人 日本透析医学会
雑誌
日本透析医学会雑誌 (ISSN:13403451)
巻号頁・発行日
vol.51, no.11, pp.665-669, 2018 (Released:2018-11-28)
参考文献数
28

CKD-MBDに関わる因子のうちで, 最も生命予後と関係の深い因子である, リンの調整系が判明したのは最近のことである. fibroblast growth factor 23 (FGF23) は骨細胞より分泌されるが, KlothoとFGF受容体の複合体に結合すると, 近位尿細管でのナトリウム-リン共輸送体 (NaPi-Ⅱ) の発現が抑制され, リンの再吸収が低下する. また, 活性型ビタミンD [1,25(OH)2D] 産生を抑制し, 腸管からのリン再吸収を抑制する. KlothoはCKDの早期から発現が低下し始めるが, 動物実験などから腎保護作用を有することが確かめられている. FGF23もCKD早期から上昇を認めるが, 透析患者のみならず, 保存期CKD患者の予後とも関係が深い. また, FGF23は予後予測因子というだけでなく, 予後不良因子として, FGF23自体が左室肥大をきたすことも指摘されており, そのメカニズムも解明されつつある. さらには, 肥大心自体もFGF23を産生することが判明している.
著者
菅谷 佑樹
出版者
日本生物学的精神医学会
雑誌
日本生物学的精神医学会誌 (ISSN:21866619)
巻号頁・発行日
vol.27, no.3, pp.147-150, 2016 (Released:2018-04-24)

近年,医学部出身の基礎医学研究者が著しく減少していることが問題となっている。東京大学では2002年からMD-PhDコースを,2008年からMD研究者育成プログラムを立ち上げ,医学部出身の基礎医学研究者を増やす試みを続けてきた。その結果,学部生の基礎医学研究への関心や,その研究のレベルは確実に高まりつつあるといえる。 現行の研修制度では学部時代に基礎医学研究に注力した学生のほとんどが初期研修を選択している。しかし,これらの研修医は研修終了後に基礎医学系大学院進学を目指している者が多く,このような臨床知に根ざした基礎医学研究を担う人材を着実に増やすには,多様化するキャリアパス間をよりスムーズに乗換えできる仕組みを整える必要がある。このような仕組みの整備には基礎医学系の教室だけの取り組みでは足らず,臨床も含めた医学部全体の協力によって,キャリアパスの見えやすさを促進する制度設計が必要である。
著者
田淵 俊人
出版者
日本野鳥の会 神奈川支部
雑誌
BINOS (ISSN:13451227)
巻号頁・発行日
vol.20, pp.1-7, 2014-11-10 (Released:2016-07-25)
参考文献数
13

1987 年から2013 年までの27 年間に渡り、東京都町田市、神奈川県横浜市青葉区、および川崎市麻生区にまたがる多摩丘陵南端の人工建築物で集団繁殖したチョウゲンボウのヒナについて、ヒナが巣立つ様子を調べた。さらに、人間に保護されたヒナをどのようにして放鳥すべきかについても調査した。結果は以下のように要約される。 1 巣立ちに適するヒナの大きさは、親鳥とほぼ同じ大きさである。 2 人工建築物に営巣した場合、人工建築物のパイプから外に出てくることが即ち、巣立ちであるとみなすことができた。 3 巣立ちの時期は、27 年間平均で6 月24 日前後で、時間帯は午前中の8:30 から10:00 に集中し、午後には認められなかった。 4 27 年間を通して、巣立ち日の約7 日前になると、親鳥はヒナに対して給餌行動をやめた。 5 人工建築物のパイプから出たヒナは30 分程度で飛翔して上空を舞う個体と、降下して一旦、木々の茂みに身を隠す個体があった。 6 巣立ったものの、飛翔力にやや欠けるヒナは、降下して植木の間に身を隠し最低3 日間は親鳥から給餌を受けた。 7 「やむを得ない事情」により、人間に保護されたヒナは、軍手やゴム手袋を着用し、段ボール箱の上蓋を閉めて落ち着かせてから、保護された地点に持って行って放鳥するのが望ましい。 8 チョウゲンボウのヒナが巣立つ条件として、営巣場所の前面が開けていることが必要である。このことはチョウゲンボウの繁殖場所を決める要因になると推察される。
著者
青野 篤子
出版者
心理学評論刊行会
雑誌
心理学評論 (ISSN:03861058)
巻号頁・発行日
vol.60, no.1, pp.81-90, 2017 (Released:2018-07-20)
参考文献数
27
被引用文献数
1

The distinction between sex and gender differences is very ambiguous in the Japanese language as discussed in this special issue. It is important that we use these two terms correctly, i.e., sex differences have a biological basis, and gender differences are based on social behaviors and conventions. Within this special issue, the distinction between sex differences and gender differences are presented by several authors. Sasaki emphasizes the usefulness of sex/gender limitation analysis which could redefine sex/gender differences. Morinaga tries to explain women’s relative inferiority in the fields of science and mathematics by the stereotypic misnomer “not being good at mathematics”. Suzuki reviews the psychological factors, such as gender role attitudes that affect gender inequality. Yokota examines the popular “male warrior” hypothesis in evolutionary psychology through new findings in both experimental psychology and archeology. Numazaki’s article explains the origins of sex differences through both cultural and evolutionary approaches. Each article advances our understanding of the origins of sex/gender differences. On the other hand, the studies that redefine the origins of both sexist societies and institutions and promote ways to change gender differences, should be further evaluated. To that end, more in depth interactions among behavioral geneticists, evolutionary psychologists, and social psychologists are needed.

2 0 0 0 OA 味噌の調理

著者
伊東 清枝
出版者
一般社団法人 日本調理科学会
雑誌
調理科学 (ISSN:09105360)
巻号頁・発行日
vol.1, no.2, pp.75-79, 1968-07-25 (Released:2013-04-26)
参考文献数
10
著者
有森 茂 吉田 美代子 市村 香
出版者
The Japan Society for Clinical Immunology
雑誌
日本臨床免疫学会会誌 (ISSN:09114300)
巻号頁・発行日
vol.13, no.1, pp.80-86, 1990-02-28 (Released:2009-01-22)
参考文献数
13
被引用文献数
6 8

Ge-132, 1, 500mg per day, was administered to 47 y-o house wife who suffered from rheumatoid arthritis associated with Sjögren's syndrome and microcytic hypochromic anemia since 1983. Her clinical stage of rheumatoid arthritis was Stage II and class was 1. Polyarth-ralgia and joint swelling were getting worse even though she was administered both non-steroidal antiinflammatory drug and small dose of prednisolone. Treatment with Ge-132 brought her in a remission state of rheumatoid arthritis and MCV and MCH as well as Hb were improved within 5 months. Two-color flow cytometry of peripheral lymphocytes demonstrated an increase of lymphocyte, CD3-, CD21+ (B cell), CD3+, CD21- (T cell), CD4-, CD8+ (suppressor T cell), CD4+, CD8- (helper T cell), CD16+, DR- (NK cell) and all of double negative cells such as CD3-, CD21- cell, CD4-, C8- cell, and CD16-, DR-cell, parallel to clinical status.These data surely indicated that Ge-132 is effective to this patient.