著者

岩崎 学

出版者

日本行動計量学会

雑誌

行動計量学 (ISSN:03855481)

巻号頁・発行日

vol.26, no.1, pp.46-58, 1999-03-31 (Released:2010-06-28)

参考文献数

49

被引用文献数

2 3

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Recent vast development of high-speed computer and large storing facilities together with network environment enables us to construct very large or sometimes huge databases such as giga-byte level. In order to extract novel, useful and also interpretable information from those databases, new technology becomes potentially important and being called for in various research and commercial fields. Data mining and knowledge discovery in databases(KDD)are the names given to such activity which involves database technology, machine learning, data visualization and statistics. Since we deal with data, statistics and statisticians are to be expected to play an essential role in data mining and KDD as well. Data mining, however, differs from traditional statistics on some dimensions, in which?gscale?his the most important one. The present paper first reviews recent achievement of data mining and KDD from a statistical viewpoint. Although some differences between data mining and traditional statistics are pointed out, it will be emphasized here that those two areas are closely related and should be recognized as complement to each other. Some important research areas are also discussed. One important message of this review is that statisticians should be involved in this new activity and should play a vital role in developing new methodologies and also in finding various application areas in practice.

著者

末松 綾子 高柳 広

出版者

日本臨床免疫学会

雑誌

日本臨床免疫学会会誌 (ISSN:09114300)

巻号頁・発行日

vol.30, no.1, pp.22-28, 2007 (Released:2007-03-02)

参考文献数

29

被引用文献数

1 4

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骨格系と免疫系は,サイトカイン,シグナル分子,転写因子や膜受容体などの多くの制御分子を共有し,非常に密接な関係にある.関節リウマチ(RA)における炎症性骨破壊研究の発展が,両者の融合領域である骨免疫学に光をあてた.その後,種々の免疫制御分子の遺伝子改変マウスに骨異常が見い出され,骨免疫学の重要性が浮き彫りとなった.骨と免疫系をつなぐことになった最も重要な分子である破骨細胞分化因子(RANKL)は,破骨細胞分化を制御する中心的なサイトカインである.骨免疫学はRANKLを中心とした研究からRA骨破壊のメカニズムの解明や骨免疫疾患の新しい治療戦略にますます重要になっている.ここでは,免疫系と骨軟骨細胞のクロストークについて概説し,T細胞が産生する制御因子による破骨細胞分化制御,破骨細胞分化マスター転写因子NFATc1の同定,免疫グロブリン様受容体群を介したRANKL共刺激の発見やカルモジュリンキナーゼ(CaMK)による破骨細胞分化および機能の制御などの最新の知見を紹介する.

著者

Jean-Bernard Henrotin Cyndie Picot Myriam Bouslama Dorothée Collot-Fertey Anca Radauceanu Marie-thérèse Labro Béatrice Larroque Alain-Claude Roudot Nessryne Sater Mostafa Ould Elhkim Dominique Lafon

出版者

(公社)日本産業衛生学会

雑誌

Journal of Occupational Health (ISSN:13419145)

巻号頁・発行日

vol.57, no.6, pp.485-496, 2015 (Released:2015-12-25)

参考文献数

49

被引用文献数

11

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Objectives: The aim of this study was to perform a systematic review and to use a meta-analytical approach to assess quantitatively the risk of adverse pregnancy outcomes in hairdressers and cosmetologists. Methods: A systematic literature search up to 1 February 2012 was carried out using major bibliographic databases, grey literature, contacts with research teams working on the subject, review papers and reference lists of selected articles. Observational studies reporting measures of effects in relation with body care (hairdressers, cosmetologists, etc.) and reproductive disorders were included. Study quality was assessed by three reviewers. The estimated risk ratios (RR) from all studies reporting on identical outcomes were combined using an average of logarithm transformation of estimated RR weighted by their inverted variance. Statistical heterogeneity across studies was assessed using Cochran's Q test. To explore the sources of heterogeneity, several sensitivity analyses and subgroup analyses were conducted based on study quality, country, study period, alcohol consumption, smoking habit, jobs and control populations. Results: Nineteen studies were selected and reviewed in-depth. The combined risk ratios (RRcs) of five reproductive outcomes were calculated and found to be significantly increased for four outcomes: time to pregnancy, which had an RRc of 1.11 (95% CI: 1.03–1.19); premature birth, which had an RRc of 1.05 (95% CI: 0.99–1.11); small for gestational age, which had an RRc of 1.24 (95 CI%: 1.10–1.41); low birth weight, which had an RRc of 1.21 (95% CI: 1.06–1.39); and embryonic and fetal losses, which had an RRc of 1.19 (95% CI: 1.03–1.38). Conclusions: This work confirms a weak increase in risk of some reproductive disorders in female hairdressers/cosmetologists. However, the evidence level is rather weak, and a causal association between job and reproductive outcomes cannot be asserted.(J Occup Health 2015; 57: 485–496)

著者

徳守 淳也 小野 智司 木場 隆司 北山 信一 中山 茂

出版者

情報知識学会

雑誌

情報知識学会誌 (ISSN:09171436)

巻号頁・発行日

vol.17, no.1, pp.41-50, 2007 (Released:2007-03-06)

参考文献数

27

被引用文献数

2

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学術情報の円滑な流通を図るため,国立情報学研究所(NII )の主導のもと,大学などの研究機関において学術リポジトリの構築が進められている.しかし,学術情報のメタデータ作成は労力がかかるため,より簡便にメタデータを作成できるツールやサービスの開発が望まれている.本研究では,学術機関リポジトリの構築支援を目的として,理工系の研究者の間で研究者に広く用いられているBIBTEX 形式のメタデータを,NII メタデータ記述要素に準拠するメタデータに変換するシステムを開発する.提案するシステムを利用することで,メタデータ記述の労力を5 分の1 程度に抑えることができる.また,コンパイラ・コンパイラを利用することで,開発の労力を抑えることができた.

著者

左巻 健男

出版者

公益社団法人 日本工学教育協会

雑誌

工学教育 (ISSN:13412167)

巻号頁・発行日

vol.61, no.3, pp.3_19-3_21, 2013 (Released:2013-06-06)

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I am convinced that the important thing in science education is to teach the fundamental facts, concepts, and natural laws through learners’ experiences, experiments and manufacturing. Learning with an intelligent interest is essential to the class of science education. As typical examples, I can pick up the class dealing with the questions such as ; “If you drink 1 kilogram of juice, how do you think your weight will change?” “What is the silver substance which is coating the surface of a silver dragees (little silver balls sold for decorating cookies)? Is that a metal?”

著者

熊谷 進

出版者

JAPANESE ASSOCIATION OF INDIAN AND BUDDHIST STUDIES

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.27, no.2, pp.682-683, 1979-03-31 (Released:2010-03-09)

著者

山岸 俊男

出版者

北海道社会学会

雑誌

現代社会学研究 (ISSN:09151214)

巻号頁・発行日

vol.14, pp.160-162, 2001-06-29 (Released:2010-07-27)

著者

Sumio HIRATA Mami MATOBA Satoshi IZUMI Taku FURUKUBO Miyuki OTA Minori FUJITA Senji OKUNO Tomoyuki YAMAKAWA

出版者

日本臨床薬理学会

雑誌

臨床薬理 (ISSN:03881601)

巻号頁・発行日

vol.34, no.3, pp.87-90, 2003-05-31 (Released:2010-06-28)

参考文献数

15

被引用文献数

4 7

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We present a 68-year-old male case, hemodialysis patient (body weight 56.8 kg) with Clostridium difficile (C. difficile) induced pseudomembranous colitis. The colitis was treated with orally administered vancomycin (VCM), 2.0 g/day, for 14 days leading to high serum levels. At this time, the VCM treatment was discontinued following negative stool cultures for C. difficile, and the serum VCM concentration was 58.7 μg/ml, the highest level in oral VCM case reports up to the present. Mean bioavailability was estimated as 16.8% during the VCM administration period in this patient, and it was assumed that the intestinal absorption of VCM was increased with severe colitis. As the serum VCM levels continued to decrease gradually, the symptoms of colitis improved. Nevertheless, the patient's colitis relapsed after oral levofloxacin treatment for bronchitis and high fever, although the serum VCM levels were still far greater than the minimum inhibitory concentration of C. difficile infection.This finding suggests that VCM concentrations may remain insufficient in the colon despite the high serum levels. The high and persistent serum VCM concentrations in this patient may be due to the follow-ing: 1. increased absorption of VCM with severe colitis, 2. decreased excretion with renal impairment leading to VCM serum accumulation, and 3. too high a VCM dosage. We conclude that patients with both renal failure and severe intestinal disease may absorb and accumulate significant amounts of orally administered VCM. Therefore, a high dose oral VCM should be avoided in hemodialysis patients with severe pseudomembranous colitis.

著者

若林 大雅 高野 公徳 千葉 斉一 芹澤 博美 島津 元秀 河地 茂行

出版者

日本胆道学会

雑誌

胆道 (ISSN:09140077)

巻号頁・発行日

vol.30, no.1, pp.99-105, 2016-03-31 (Released:2016-04-05)

参考文献数

20

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症例は27歳,男性.眼球結膜黄染を主訴に受診し,閉塞性黄疸と診断され緊急入院した.十二指腸乳頭部癌と診断し,幽門輪温存膵頭十二指腸切除術を施行した.術後Gemcitabineによる補助化学療法を継続したが術後10カ月のCTで上腸間膜動脈および脾動脈幹近位リンパ節転移を認めた.化学療法をS-1に変更し,放射線治療を施行したところ再発巣の縮小とCA19-9の低下を認めた.しかし照射終了後に再発巣が増大しCA19-9も再上昇したため,術後26カ月よりS-1+Oxaliplatin併用療法(以下,SOX療法と略記)を開始したところ,一時CA19-9が低下し腫瘍縮小効果も示したが,徐々に無効となり術後40カ月で死亡された.本症例は,原発性硬化性胆管炎,膵・胆管合流異常,家族歴や印刷業の職業歴など胆道癌発症におけるリスク因子を認めない若年性十二指腸乳頭部癌である点に加え,術後のリンパ節転移再発に対して放射線治療やSOX療法といった集学的治療が予後延長効果を示した点において比較的まれな症例であった.

著者

小林 孝一 高橋 貞雄 川上 幸二

出版者

一般社団法人 照明学会

雑誌

照明学会誌 (ISSN:00192341)

巻号頁・発行日

vol.77, no.Appendix, pp.154-155, 1993 (Released:2011-07-19)

著者

Akira Matsumoto Mai Yuasa Hiroko Matsumoto Mai Sanjo Miyuki Tabata Tatsuro Goda Toru Hoshi Takao Aoyagi Yuji Miyahara

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.45, no.4, pp.460-462, 2016-04-05 (Released:2016-04-05)

参考文献数

30

被引用文献数

11

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In an attempt to develop a totally synthetic, self-regulated insulin delivery system to treat diabetes, N-substituted poly(acrylamide) copolymer gels bearing boronate functionality have been chemically optimized so as to undergo an abrupt and glucose-dependent change in hydration. This study highlights an importance of fine-tuning the mesh size of the gel relative to that of insulin in order to achieve the better controlled-release in a manner less sensitive to the temperature, even with an apparently marginal change of hydration.

著者

Masaharu Kodama Yuta Tanabe Masayoshi Nakayama

出版者

一般社団法人 園芸学会

雑誌

The Horticulture Journal (ISSN:21890102)

巻号頁・発行日

pp.MI-131, (Released:2016-04-05)

被引用文献数

13

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In many Hydrangea cultivars, sepal color depends on soil conditions. The traditional concept is that different levels of absorption of aluminum ions from soil and its accumulation in sepal vacuoles changes Hydrangea sepal color. To investigate how sepal coloration can be stabilized, we examined the components that may contribute to color variability according to the traditional concept. Using 10 cultivars and lines with sepals of stable red or stable blue color plants or with sepals of variable color (red or purple) plants grown in acid soils and alkaline soils, we analyzed sepal pH and sepal contents of anthocyanin, aluminum ion, 5-O-caffeoylquinic acid, and 3-O-caffeoylquinic acid. Sepals of all cultivars became bluer when plants were grown in acid soil than when they were grown in alkaline soil, even if the change in stable color plants was milder than that of variable color plants. The same component changes probably happen in sepals of both stable and variable color plants in response to different soil conditions to cause the coloration change. When the two soil conditions were compared, a statistically significant difference was detected for delphinidin 3-glucoside, which is a major anthocyanin of Hydrangea, in the variable-color line ‘HH2’ and for 3-O-caffeoylquinic acid in the stable red line ‘HH19’, but not for any other compound examined, including aluminum ions. Although there is possibility that localization of aluminum ions in vacuoles of the colored cells changes, it is assumed that changes in contents of aluminum ion chelaters such as phosphoric acid affect the sepal color change in response to different soil conditions, as well as the coloration stability or variability. When cultivars were compared in terms of properties of sepal coloration, although contents of aluminum ions and 5-O-caffeoylquinic acid tended to be higher in stable blue cultivars than in other cultivars, these differences were not statistically significant. In agreement with previous reports, our data indicate that a lower content of 3-O-caffeoylquinic acid is essential for blue Hydrangea sepals.

著者

Tatsuya HORI Hitoshi USHIJIMA Taku KIMURA Masanori KOBAYASHI Eiichi KAWAKAMI Toshihiko TSUTSUI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0037, (Released:2016-04-03)

被引用文献数

5

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Canine embryos (8-cell to blastocyst stages) frozen–thawed using the slow-freezing method with glycerol (four recipients) or dimethyl sulfoxide (three recipients) as a cryoprotectant and vitrified–warmed using the Cryotop method (five recipients) were surgically transferred into the unilateral uterine horn of recipient bitches. As a result, the morphology of embryos frozen–thawed using the slow-freezing method was judged to be normal, but no conception occurred in any of the recipient bitches. Two of the five bitches that received transferred embryos (morula to early blastocyst stages) vitrified–warmed using the Cryotop method became pregnant and produced normal pups (1/9 embryos, 11.1% and 1/6 embryos, 17.0%). It was concluded that the Cryotop method was more appropriate for canine embryo cryopreservation than the slow-freezing method, which is used for the cryopreservation of embryos of other mammalian species.

著者

Naoto ITO Gregory W. MOSELEY Makoto SUGIYAMA

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.16-0092, (Released:2016-04-02)

被引用文献数

33

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Rabies is a zoonotic disease caused by the Lyssavirus rabies virus (RABV) that can infect most mammals, including humans, where it has a case-fatality rate of almost 100%. Although preventable by vaccination, rabies causes c. 59,000 human fatalities every year worldwide. Thus, there exists an urgent need to establish an effective therapy and/or improve dissemination of vaccines for humans and animals. These outcomes require greater understanding of the mechanisms of RABV pathogenesis to identify new molecular targets for the development of therapeutics and/or live vaccines with high levels of safety. Importantly, a number of studies in recent years have indicated that RABV specifically suppresses host immunity through diverse mechanisms and that this is a key process in pathogenicity. Here, we review current understanding of immune modulation by RABV, with an emphasis on its significance to pathogenicity and the potential exploitation of this knowledge to develop new vaccines and antivirals.

著者

山田 英 林 毅俊

出版者

公益社団法人 精密工学会

雑誌

精密工学会誌 (ISSN:09120289)

巻号頁・発行日

vol.70, no.1, pp.26-30, 2004-01-05 (Released:2009-04-10)

参考文献数

2

被引用文献数

3

著者

Masanori Minagawa

出版者

日本小児内分泌学会

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.14, no.Supplement23, pp.S23_9-S23_16, 2005 (Released:2005-08-27)

参考文献数

5

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Pseudohypoparathyroidism (PHP) is composed of PHP-Ia and PHP-Ib. The former is characterized by multiple hormone resistance including parathyroid hormone associated with Albright hereditary osteodystrophy (AHO); but in the latter, AHO is not complicated. In the natural course of PHP-Ia, the time of onset, the degree of hypocalcemia and associated symptoms vary among patients. Since the symptoms of AHO, including brachydactyly, are often ambiguous, the criteria for clinical differential diagnosis between these two types are required. In our 10 cases of sporadic PHP-Ib, no patient had subcutaneous calcification. Currently, however, genetic analysis on the DNA methylation is necessary for the definite diagnosis. All of the 10 cases of sporadic PHP-Ib had complete methylation in NESP55 as well as complete demethylation in the AS and 1A regions of the GNAS gene, while the region of the abnormal methylation in XL were varied among the patients. There was no clear correlation among skewed X-inactivation, abnormal DNA methylation pattern, clinical phenotypes and other complications.

著者

筧 一彦

出版者

日本認知科学会

雑誌

認知科学 (ISSN:13417924)

巻号頁・発行日

vol.5, no.1, pp.1_1-1_1, 1998-03-01 (Released:2008-10-03)

著者

山口 恭治

出版者

Japanese Society for Mastication Science and Health Promotion

雑誌

日本咀嚼学会雑誌 (ISSN:09178090)

巻号頁・発行日

vol.3, no.1, pp.57-63, 1993-12-25 (Released:2010-07-21)

参考文献数

36

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There have heretofore been a variety of dental treatment methods in use, including mechanical treatment methods, those depending entirely upon the stabilized location of the mandible and others. However, not only have we not settled upon one specific method of treatment, in spite of a process of trial and error extending over a period of many years, we have even been witnessing lately a tendency toward an increase in the occurrence of temporomandibular arthrosis and other disorders. We carried out occlusion and mastication treatment in three cases of temporomandibular arthrosis and mastication dysfunction based on recent research and elucidation of the mastication system, involving improvements in occlusion restructuring and mastication patterns that take into consideration induction of the mandible into the physiologic location, making occlusion possible at that location, the elimination of hypertonia in mastication-related muscles and the control of temporomandibular joint inflammation and immune response. As a result of this treatment, there was an alleviation of the various constitutional dysphoria attendant upon the collagen disease, psychosomatic disorders, etc., that were manifested throughout the system. It became clear from this that the mastication system and the constitution are closely related and that there is a need for new developments from the standpoint of the dental treatment of the mastication system.

著者

片岡 邦光

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.54, no.Supplement, pp.s5-s6, 2012-10-25 (Released:2012-12-01)

著者

小川 桂一郎

出版者

日本結晶学会

雑誌

日本結晶学会誌 (ISSN:03694585)

巻号頁・発行日

vol.38, no.6, pp.363-377, 1996-12-30 (Released:2010-09-30)

参考文献数

5

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How to create and use CIF, which is required for submission of papers having the results of crystallographic structure analysis, is illustrated.