著者
篠原 尚吾 山本 悦生 田辺 牧人 辻 純 宗田 由紀 坂本 達則 金 泰秀 寺下 健洋
出版者
耳鼻咽喉科臨床学会
雑誌
耳鼻咽喉科臨床 (ISSN:00326313)
巻号頁・発行日
vol.92, no.7, pp.779-783, 1999-07-01 (Released:2011-11-04)
参考文献数
19
被引用文献数
2 2

Papillary microcarcinomas (PMCs) which are 1.0cm or less in diameter are a specific subgroup of thyroid cancer. As the prevalence of these tumors found in autopsy cases was reported to be 10 to 28.4% in Japan, the necessity of surgical treatment of PMCs has been questioned. However, PMCs are often found in conjunction with advanced metastases in cervical lymph nodes, lung, etc..We reviewed eight cases with PMCs revealed by the presence of cervical metastases over the past 10 years. Five cases were revealed by manifest cervical lymph node metastases. Two of the other three cases were operated on for treatment of metastatic lesions subsequent to other diagnoses, notably a parotid tumor and lateral cervical cyst. The PMCs were revealed in a postoperative histological study of these two cases. The remaining case was discovered incidentally during neck dissection for laryngeal cancer. Preoperative ultrasonography was undertaken in seven cases. Two cases showed multif ocal small high echoic spots without tumors and one case showed no abnormal findings in the thyroid.In all cases, total thyroidectomy, unilateral or bilateral neck dissection and postoperative radioiodine scintigraphy were performed. Multifocal tumors in the thyroid were proven histologically in four cases. In one case, the primary lesion was not found even in a postoperative histological study.In accordance with these observations, PMCs revealed by cervical metastases shoul be treated as advanced thyroid carcinomas.
著者
岩沢 久彰
出版者
日本爬虫両棲類学会
雑誌
爬虫両棲類学雑誌 (ISSN:02853191)
巻号頁・発行日
vol.6, no.4, pp.105-109, 1976-12-31 (Released:2009-03-27)
参考文献数
11
被引用文献数
2

Professional salamander collectors have worked in Hinoémata district of Fukushima Prefecture. They collect a huge number of the salamanders with a bamboo-made fishing apparatus called muiiri or uké in the breeding season. The salamanders are soaked and killed in a weak salt water, and are smoke-dried on spits. This work is carried out in a shabby hut built near the collecting place. Twenty smoke-dried salamnders are found into a bundle, and are sold for 1200 Yen as an aphrodisiac.
著者
橋本 秀実 伊藤 薫 山路 由実子 佐々木 由香 村嶋 正幸 柳澤 理子
出版者
日本国際保健医療学会
雑誌
国際保健医療 (ISSN:09176543)
巻号頁・発行日
vol.26, no.4, pp.281-293, 2011-12-20 (Released:2012-02-04)
参考文献数
26
被引用文献数
1

目的在日外国人女性の日本での妊娠・出産・育児の困難と、それを乗り越える方略を明らかにする。方法日本で出産、子育てを経験した外国人18名を対象に半構成的面接を行った。妊娠、出産と育児について、健康診断や予防接種などの受診状況や困ったこと、問題をどう克服したかなどについて自由に語ってもらった。逐語録から、テーマについての文脈を取り出しコード化した。コードの意味内容から類似性のあるものを集めてサブカテゴリを作り、抽象度の高いカテゴリを作成、コアカテゴリを抽出した。結果在日外国人女性の妊娠・出産・育児の困難では、≪育児の不安・ストレス≫、≪周りとのつながりの問題≫、≪社会・経済的問題≫、≪妊娠・出産・病気の不安≫、≪日本語による情報伝達困難に起因する問題≫、≪日本の保健医療についての理解の困難≫、≪出産国の選択≫の7つのコアカテゴリが、困難を乗り越える方略では≪自分で何とかする≫、≪家族に助けてもらう≫、≪友人や近所の人に助けてもらう≫、≪感情の表出≫、≪通訳の利用≫、≪日本の保健医療システムの利用≫、≪日本以外の保健医療システムの利用≫、≪やり過ごす≫の8つのコアカテゴリが抽出された。このコアカテゴリは次のように構造化できた。困難への対処方略の核は家族である。≪家族に助けてもらう≫中で≪自分で何とかする≫努力をする。受診を控えるなど≪やり過ごす≫こともあるが、十分な助けが得られれば、≪自分で何とかする≫方略へと移行することが可能である。家族で対処困難になると、直接あるいは友人や通訳の助けを得て、日本または日本以外の保健医療システムの利用を通じて専門家の助けを求めていた。結論外国人が保健医療にアクセスする際、日常の言葉以外にも、専門用語やシステムの理解といったヘルスリテラシーが必要となる。≪自分で何とかする≫女性の方略を支援するために、彼らの方略を理解し、強化する工夫が必要である。外国人女性は家族や友人などの支援を得て困難を乗り越えていたが、支援を得られにくい女性についてはネットワークづくりや保健医療従事者の積極的な介入が求められる。≪やり過ごす≫といったネガティブな方略や≪日本以外の保健医療システムの利用≫は、日本社会適応段階の途中とも考えられ、保健医療従事者は一概にその行動を否定するのでなく、不安を軽減するための方法として捉え、支援する必要がある。
著者
川上 ちひろ 西城 卓也 丹羽 雅之 鈴木 康之 藤崎 和彦
出版者
日本医学教育学会
雑誌
医学教育 (ISSN:03869644)
巻号頁・発行日
vol.47, no.5, pp.301-306, 2016-10-25 (Released:2017-08-10)
参考文献数
9

医療系専門職養成機関において教務事務職員が学生対応で難しいと感じる事例について調査した. 公私立大学医学部・歯学部教務事務職員研修に2013年度から2015年度に参加した教務事務職員143名から得た185事例を分析した.事例は, 学生に問題があるものが多くを占め136事例 (73.5%) であった一方で, システムや教員に問題があるものも含まれた. 医療系専門職養成機関において適切に難しい場面に対応するために, 教員, 事務職員の協働は欠かせないものである.
著者
石田 淳
出版者
日本社会学会
雑誌
社会学評論 (ISSN:00215414)
巻号頁・発行日
vol.61, no.1, pp.90-99, 2010-06-30 (Released:2012-03-01)
参考文献数
49
被引用文献数
3 1
著者
Yuhi SAITO Toshihiro MIHARA Kentaro MARUYAMA Jiro SAITO Masumi IKEDA Akihito TOMONAGA Takehisa KUMAGAI
出版者
BMFH出版会
雑誌
Bioscience of Microbiota, Food and Health (ISSN:21863342)
巻号頁・発行日
pp.16-031, (Released:2017-04-14)
被引用文献数
17

Lactic acid bacteria are gut flora that play key roles in intestinal homeostasis, which may affect a variety of physiological functions. Our preliminary double-blind, placebo-controlled, parallel-group trials have suggested that intake of heat-killed Lactobacillus casei subsp. casei 327 (designated lactobacillus K-1) is effective for improving skin conditions. The aim of this study was to confirm the effect of lactobacillus K-1 intake in a randomized, double-blind, placebo-controlled, parallel-group study in healthy female volunteers. Sixty-four subjects were allocated to either the placebo food group (group P, n=32) or active food group (group A, n=32), in which subjects consumed lactobacillus K-1 50 mg (approximately 1 × 1011 bacteria) daily for 8 weeks. After excluding subjects who declined to participate (n=1), violated restrictions (n=4), or were judged ineligible by the principal investigators (n=1), data obtained with 58 subjects (30 in group A and 28 in group P) were analyzed for efficacy by comparing differences from pretrial levels between the two groups. When the level of transepidermal water loss (TEWL) was measured at the arm, the level of TEWL at week 4 of the intake period was significantly lower in group A than group P (p=0.021), suggesting an improvement of skin barrier function. Analysis of skin condition questionnaire data revealed a significant reduction in skin flakiness on the face (week 4). No adverse events were associated with intake of the test foods. The safety of lactobacillus K-1 was also confirmed in an independent open-label trial in 11 healthy subjects who consumed excessive amounts of lactobacillus K-1 250 mg (approximately 5 × 1011 bacteria). Intake of lactobacillus K-1 may therefore be beneficial to skin condition improvement.
著者
中塚 幹也
出版者
岡山医学会
雑誌
岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日
vol.119, no.1, pp.27-32, 2007-05-01 (Released:2008-07-04)
参考文献数
31
著者
高橋 武雄
出版者
一般社団法人 火力原子力発電技術協会
雑誌
火力原子力発電大会論文集 (ISSN:2187929X)
巻号頁・発行日
vol.10, pp.107-110, 2014 (Released:2015-03-20)

東芝は革新的なCO2排出削減対策技術として超臨界CO2サイクル発電システムの開発に取り組んでいる。この新しいシステムは燃料を酸素燃焼し,高温高圧のCO2でタービン・発電機を駆動して発電すると同時に,CO2を分離・回収する設備を別に設置することなく高圧で回収することができる。
著者
Yuichi Fujii Junko Soga Shuji Nakamura Takayuki Hidaka Takaki Hata Naomi Idei Noritaka Fujimura Kenji Nishioka Kazuaki Chayama Yasuki Kihara Yukihito Higashi
出版者
日本循環器学会
雑誌
Circulation Journal (ISSN:13469843)
巻号頁・発行日
vol.74, no.8, pp.1684-1688, 2010 (Released:2010-07-23)
参考文献数
22
被引用文献数
9 20

Background: A corkscrew collateral appearance on angiography is one of the diagnostic criteria for Buerger's disease. The purpose of the present study was to classify the angiographic findings of corkscrew collaterals and to evaluate the relationship between corkscrew collateral type and the severity of Buerger's disease. Methods and Results: Corkscrew collaterals were assessed on digital subtraction angiography in lower extremities of 28 patients with Buerger's disease (55 limbs). The corkscrew sign was classified into 4 types by size and pattern as follows: type I, artery diameter >2 mm, large helical sign; type II, diameter >1.5 mm and ≤2 mm, medium helical sign; type III, diameter ≥1 mm and ≤1.5 mm, small helical sign; and type IV, diameter <1 mm, tiny helical sign. The prevalence of ischemic ulcers was significantly higher in patients with types III and IV corkscrew collaterals than in patients with types I and II corkscrew collaterals either below or above the knee. Multiple regression analysis indicated that types III and IV below the knee are independent predictors of risk of ischemic ulcers. Conclusions: The prevalence of ischemic ulcers is significantly higher in patients who have small corkscrew patterns in distal segments of limb collaterals than in patients who have large corkscrew collaterals.  (Circ J 2010; 74: 1684 - 1688)
著者
Tomoya Nagano Kaori Hayashibara Manabu Ueda-Wakagi Yoko Yamashita Hitoshi Ashida
出版者
社団法人 日本食品科学工学会
雑誌
Food Science and Technology Research (ISSN:13446606)
巻号頁・発行日
vol.21, no.3, pp.489-494, 2015 (Released:2015-09-10)
参考文献数
26
被引用文献数
13

We previously reported that the intake of black tea promotes translocation of the insulin-sensitive glucose transporter (GLUT) 4 in skeletal muscle. In this study, we investigated whether black tea polyphenols (BTP) promote GLUT4 translocation in L6 myotubes. BTP promoted glucose uptake accompanied by GLUT4 translocation in L6 myotubes. As the molecular mechanism, BTP induced the phosphorylation of insulin receptor substrate-1, atypical protein kinase C, Akt Thr308, Akt substrate 160, and AMP-activated protein kinase (AMPK), but did not affect that of Akt Ser473. BTP increased glycogen accumulation through inactivation of glycogen synthase kinase 3β (GSK-3β). Theaflavin, one of the major components in black tea, also promoted the glucose uptake accompanied by GLUT4 translocation observed with BTP in L6 myotubes. These results indicate that BTP activates both PI3K- and AMPK-dependent pathways to promote GLUT4 translocation and glycogen accumulation in skeletal muscle cells. Moreover, theaflavin is one of the active components in BTP.
著者
Rintaro HASHIZUME
出版者
社団法人 日本脳神経外科学会
雑誌
Neurologia medico-chirurgica (ISSN:04708105)
巻号頁・発行日
pp.ra.2017-0018, (Released:2017-06-07)
参考文献数
98
被引用文献数
34

Diffuse intrinsic pontine glioma (DIPG) is a rare but uniformly fatal cancer of the brain, with peak incidence in children of 5–7 years of age. In contrast to most types of human cancer, there has been no significant improvement in treatment outcomes for patients with DIPG. Since DIPG occurs in the brainstem, a vital region of the brain, there are no surgical options for providing relief to patients, and chemotherapy as well as radiation therapy provide palliative relief at best. To date, more than 250 clinical trials evaluating radiotherapy along with conventional cytotoxic chemotherapy, as well as newer biologic agents, have failed to improve the dismal outcome when compared with palliative radiation alone. The recent discovery of somatic oncogenic histone gene mutations affecting chromatin regulation in DIPG has dramatically improved our understanding of the disease pathogenesis in DIPG, and these findings have stimulated the development of novel therapeutic approaches targeting epigenetic regulators for disease treatment. This review will discuss about the role of histone modification in chromatin machinery and epigenetic therapeutic strategies for the treatment of DIPG.
著者
南 貴子
出版者
JAPAN SOCIETY FOR GENDER STUDIES
雑誌
日本ジェンダー研究 (ISSN:18841619)
巻号頁・発行日
vol.2005, no.8, pp.43-56, 2005-09-01 (Released:2010-03-17)
参考文献数
50

In recent years, there are various kinds of issues related to families, such as increase in the number of divorces, people who choose to remain single, and the decline in the number of children. People are now reconsidering the family which they had been accustomed to, and searching for new family styles. In this article, a new family style will be considered from the perspective of lesbian mothers. Lesbianheaded families are distinct from traditional heterosexual families and have not been fully accepted by society. Regardless of such circumstances, lesbian mothers, stigmatized as being “inappropriate mothers, ” are making their own families. What kinds of people are lesbian mothers? What kinds of relationships do they have with their children? What kinds of prejudice do they confront? Above all, what kinds of families are they aiming to be? To research their experiences would reveal some problems hidden in the traditional family system, such as patriarchy and heterosexism. Families seem to keep on changing dynamically as each person starts to strive for their own family style and challenge the notion of “the family.”
著者
村本 由紀子 遠藤 由美
出版者
日本社会心理学会
雑誌
社会心理学研究 (ISSN:09161503)
巻号頁・発行日
vol.30, no.3, pp.213-233, 2015-03-20 (Released:2015-06-07)
参考文献数
44
被引用文献数
2

This micro-ethnographic research focuses on a traditional custom on Toshi Island, in Japan. When first-born sons on the island graduate from junior high school, they form a small group of neya-ko (quasi-brothers) and sleep over at the house of their neya-oya (quasi-parents) every night until they reach the age of 26. They maintain the quasi-family relationship and help each other all their lives. Why does the neya custom still continue on this island, while most similar customs have already disappeared in other parts of Japan? To answer this question, we conducted participant observations and unstructured interviews. The results suggest that the ecological environment of the island has exerted an important influence on the neya custom. In spite of recent drastic social and economic changes in the islanders’ lives, the neya custom still plays a key role in building sustainability in the community. Based on these findings, we discuss how the multi-layered environments of the island interact with this specific custom that has been fostered through the years.
著者
谷 幸太郎 栗原 治 小佐古 敏荘
出版者
公益社団法人 日本アイソトープ協会
雑誌
RADIOISOTOPES (ISSN:00338303)
巻号頁・発行日
vol.63, no.10, pp.461-469, 2014-10-15 (Released:2014-10-29)
参考文献数
34

体内に摂取した放射性ヨウ素の甲状腺への摂取率は,安定ヨウ素剤の投与によって抑制することができる。本論文では,放射性ヨウ素摂取時及び安定ヨウ素剤投与時の体内動態モデルを使用し,日本人を対象とした131Iの急性吸入摂取に対する甲状腺残留率を解析した。安定ヨウ素剤投与時の解析にあたっては,安定ヨウ素を過剰に摂取した場合に一時的に甲状腺ホルモンの合成が阻害されるWolff-Chaikoff効果の影響を新たに考慮した。解析した安定ヨウ素剤投与の有無に対する甲状腺残留率を比較することにより,131I甲状腺摂取率抑制効果を評価した。その結果,抑制効果は2日前の投与で50%,1日前から直前までの投与で80%以上であった。一方,131Iを摂取した後に遅れて安定ヨウ素剤を投与した場合には,抑制効果は急激に減少し,12時間後で20%,1日後で7%未満であった。