著者

町田洋 新井房夫著

出版者

東京大学出版会

巻号頁・発行日

2003

著者

町田洋著

出版者

蒼樹書房

巻号頁・発行日

1977

著者

田中 博道 内田 祐子 篠崎 操 早川 弘之 松田 彰 宮坂 貞

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.31, no.2, pp.787-790, 1983-02-25 (Released:2008-03-31)

参考文献数

17

被引用文献数

21 32

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6-Chloro-9-(2, 3-O-isopropylidene-β-D-ribofuranosyl) purine (1) was found to be a suitable substrate for the preparation of C-8 substituted purine nucleosides. Thus, upon lithiation of 1 with LDA and successive reaction with various types of electrophiles, the C-8 substituted products were obtained. The C-6 chlorine atoms in these products were readily replaced by an amino group, a mercapto group, or hydrogen, providing a facile preparation of 8-substituted adenosines, 6-thioinosines, or nebularines.

著者

寺田 忠史 藤本 勝彦 野村 誠 山下 純一 / 小武内 尚 武田 節夫 南 慶典 吉田 健一郎 山口 秀夫 山田 雄次 Yuji YAMADA

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.5, pp.907-912, 1993-05-15 (Released:2008-03-31)

参考文献数

58

被引用文献数

6 10

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1-β-Alkyl derivatives of 1-desoxypodophyllotoxin were synthesized, and their cytotoxicity and inhibitory effects on DNA topoisomerase II (Topo-II) and tubulin polymerization were examined.The reaction of epipodophyllotoxin derivatives (1a-c) with trimethylallylsilane in the presence of boron trifluoride etherate gave 1-β-allylated compounds (2a-c). The regiochemistry and the β-stereochemistry of the 1-allyl group were confirmed by comparison of the 13C-NMR spectra and NOE's (%) of 2c, podophyllotoxin (POD) and epipodophyllotoxin (1b). 1-β-Alkyl-1-desoxypodophyllotoxin derivatives (3-8) were prepared from 2b.None of the tested compounds (3-8) showed any inhibitory effect on Topo-II. 1-β-Propyl compound (3) and its 4'-demethyl compound (4) inhibited tubulin polymerization and the cytotoxicities of these compounds were equal to that of VP-16. 1-β-(2, 3-Dihydroxypropyl) compounds (5 and 8) and 1-β-(2, 3-diacetoxypropyl) compounds (6 and 7)showed no inhibitory effect on tubulin polymerization. Although 5 did not inhibit either Topo-II activity or tubulin polymerization, it showed a high cytotoxicity against sarcoma 180.

著者

Hiroyuki Hayakawa Hiromichi Tanaka Naoko Itoh Masako Nakajima Tadashi Miyasaka Kentaro Yamaguchi Yoichi Iitaka

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.6, pp.2605-2608, 1987-06-25 (Released:2009-10-19)

参考文献数

26

被引用文献数

30 43

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The reaction of organolithium, Grignard, and organoaluminum reagents with 2'- and 3'-ketouridine derivatives was examined. For the reaction of 2', 5'-bis-0- (tert-butyldimethylsilyl) -3'-ketouridine, both organolithiums and organoaluminums seem to be practically useful. But only organoaluminums gave satisfactory yields in the reaction of 3', 5'-0- (tetraisopropyldisiloxan-1, 3-diyl) -2'-ketouridine.

著者

関 未玲 セキ ミレイ

出版者

立教大学ランゲージセンター

雑誌

立教大学ランゲージセンター紀要 (ISSN:13448226)

巻号頁・発行日

no.31, pp.55-61, 2014-01

著者

近藤元粋 編

出版者

青木嵩山堂

巻号頁・発行日

vol.4, 1901

著者

HIROSHI SUEMUNE TETSUJI HARABE ZHUO-FENG XIE KIYOSHI SAKAI

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.36, no.11, pp.4337-4344, 1988-11-25 (Released:2011-02-08)

参考文献数

14

被引用文献数

20 33

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Asymmetric hydrolysis of 2, 2-bis (acetoxymethyl) cyclopentanone (5) using biocatalysts and its application to a formal synthesis of (-)-malyngolide are described.For the asymmetric induction at the quaternary carbon of 5, cholinesterase from electric eel was found to be effective to afford the (+)-monoacetate (6)(90%ee).Compound (+)-6 was easily converted to the synthetic intermediate (28) for (-)-malyngolide.

著者

末宗 洋 原部 哲治 酒井 浄

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.36, no.9, pp.3632-3637, 1988-09-25 (Released:2008-03-31)

参考文献数

10

被引用文献数

23 30

---

Two trihydroxy unsaturated C-18 fatty acids [(9S, 12S, 13S)-trihydroxyoctadeca-10E, 15Z-dienoic acid (methyl ester) and (9S, 12S, 13S)-trihydroxy-10E-octadecenoic acid (methyl ester)] isolated from rice plants as agents with activity against blast disease were synthesized from (+)-dimethyl tartrate.

著者

MASAHIRO SUZUKI HIROMICHI TANAKA TADASHI MIYASAKA

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.10, pp.4056-4063, 1987-10-25 (Released:2009-10-19)

参考文献数

14

被引用文献数

4 12

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Several 5-carbon-substituted 1-β-D-ribofuranosylimidazole-4-carboxamides were synthesized via the direct C-5 lithiation of a protected 4-carboxamide derivative as the key reaction step. Wittig reaction of a 5-formyl derivative was also examined.

著者

北村 尚子

出版者

横浜国立大学留学生センター

雑誌

横浜国立大学留学生センター教育研究論集 (ISSN:18810632)

巻号頁・発行日

no.18, pp.53-74, 2011

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The understanding of the learning subjects that is considered students should learn in an early stage has a basic consistency between teachers and teaching materials however no specific command of that has been given. In order to discover the command of learning subjects necessary for the early learners, this writing takes up the request expression of "~te kudasai" (please do~) and analyzes from two sides; the human relationship of the communicators such as hierarchy and the strength of the friendship, and the cost that the person who received the request needs to take, using the conversation written in elementary level Japanese textbook as the investigation object. As a result of the investigation, we found that it is important for the students in first half of the elementary level to be able to understand that "~te kudasai" has the "request" function and is used in situations when people ask requests. For the students in the second half of the elementary level, they need to be able to understand the "request" function in the word and be able to use it when they ask a small cost request. They also need to understand that the word is also often used as "order" and be able to differentiate this word from other requests words in different situation to not to be excuse to people, considering the hierarchical relationship and the size of cost.

著者

尾崎 庄一郎 秋山 隆彦 森田 剛夫 久米川 昌浩 長瀬 敏夫 上原 宣昭 星 昭夫

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.38, no.11, pp.3164-3166, 1990-11-25 (Released:2008-03-31)

参考文献数

17

被引用文献数

12 12

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Various kinds of 5'-O-unsaturated acyl 5-fluorouridines were synthesized to obtain 5-fluorouridine derivatives with low toxicity and high antitumor activity. Antitumor activity of the compounds against L-1210 leukemia in mice was examined, and the 5'-O-4-opentenoyl derivative showed the highest antitumor activity.

著者

尾崎 庄一郎 渡辺 裕 / 長瀬 敏雄 小笠原 富夫 古川 弘幸 上村 敦彦 石川 勝敏 / / 徳善 令子 AKIO HOSHI MASAAKI IIGO REIKO TOKUZEN

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.1, pp.150-157, 1986-01-25 (Released:2008-03-31)

参考文献数

14

被引用文献数

15 23

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With the aim of diminishing the toxicity of 5-fluorouracil (1) and obtaining biologically active derivatives of 1 suitable for oral administration, α-alkoxyalkyl groups were introduced at the 1-, 3-and 1, 3-positions of 1. Alkoxyalkylation can be effected by four methods : (i) reaction of 1-alkoxyalkyl chloride (2) with 1, (ii) reaction of acetal with 2, 4-bis (trimethylsiloxy)-5-fluoropy-rimidine, (iii) addition reaction of α-unsaturated ether with 1, (iv) aminolysis of 1-alkylthio-carbonyl-3-(1-alkoxyalkyl)-5-fluorouracil. The toxicity of the products was less than that of 1, and some of these compounds showed moderate antitumor activity against L-1210 leukemia.

著者

劉 博昊

出版者

東洋館出版社

雑誌

教育社会学研究 = The journal of educational sociology (ISSN:03873145)

巻号頁・発行日

vol.108, pp.163-183, 2021

著者

畠中 茉莉子

出版者

「宗教と社会」学会

雑誌

宗教と社会 = Religion & society (ISSN:13424726)

巻号頁・発行日

no.27, pp.33-47, 2021

著者

鈴木 篤

出版者

一般社団法人 日本教育学会

雑誌

教育学研究 (ISSN:03873161)

巻号頁・発行日

vol.88, no.1, pp.1-13, 2021

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<p> 近年、非対面型授業の可能性に注目が集まっているが、どの程度まで従来の対面型学校教育に代替可能なのかについて研究の蓄積は十分でない。実際には、非対面型授業は従来の学級が有していた機能を何らかの形で確保しない限り、対面型学校教育には代替しえないだろう。生徒の社会化には学級制度が大きな役割を果たしており、たとえ短期的には非対面型授業が「うまくいっている」ように見えても、実際には参加者自身の過去の(対面型の)学級を通した被教育経験によって支えられている可能性も存在するためである。</p>

著者

中野 元太 矢守 克也 Nakano Genta Yamori Katsuya ナカノ ゲンタ ヤモリ カツヤ

出版者

「災害と共生」研究会

雑誌

災害と共生 (ISSN:24332739)

巻号頁・発行日

vol.4, no.1, pp.83-94, 2020-09

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一般論文国際防災教育支援において、支援者と被支援者との間の社会的・経済的・文化的・教育環境的相異に配慮すべきとの主張は数多い。この主張は、相異に配慮しさえすれば、支援者が教える知識・技術は被支援者にとって有用であり、国際的防災教育支援という枠組・実践はどのような社会間にも適用可能であるとの前提に立つ。しかし、ルーマンの「リスク/危険」概念を導入すれば、防災教育の多くは自然災害をリスクとみなす〈リスク社会〉に特有の実践(【防災教育@〈リスク社会〉】)であり、自然災害を危険とみなす〈危険社会〉に対する有効性は確かではないこと、よって、無条件な適用が、かえって防災教育の不全を引き起こす可能性を指摘できる。このことをネパールでの防災教育実践事例やインタビューに基づく防災に対する姿勢から考察した。その上で「仕掛学」に理論的アイデアを借りて〈危険社会〉にも通用する【防災教育@〈危険社会〉】を提案するとともに、【防災教育@〈危険社会〉】の倫理的課題についても言及した。

著者

勝部 駿 佐原 宏典

出版者

一般社団法人 日本航空宇宙学会

雑誌

日本航空宇宙学会論文集 (ISSN:13446460)

巻号頁・発行日

vol.70, no.1, pp.1-6, 2022 (Released:2022-02-05)

参考文献数

5

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In spacecraft systems, it is important to quickly detect and deal with anomalies. However, the increasing complexity of spacecraft systems makes it difficult to avoid failures using previous anomaly detection methods. In recent years, anomaly detection methods based on machine learning have been studied. But it is difficult for a spacecraft to detect anomalies autonomously in orbit. In this study, we propose an anomaly detection method that defines and monitors a single variable representing the health status of a spacecraft system, instead of monitoring a huge amount of telemetry data. We have confirmed that the single variable can represent the health status of a spacecraft system and can be applied to the anomaly detection method.

著者

保積稲天 著

出版者

丸善

巻号頁・発行日

1927

著者

原田 弘道

出版者

Japanese Association of Indian and Buddhist Studies

雑誌

印度學佛教學研究 (ISSN:00194344)

巻号頁・発行日

vol.40, no.2, pp.744-750, 1992-03-20 (Released:2010-03-09)

被引用文献数

1